The illustration showing that a healthy bone formation which nourished by nutrient artery (arteria nutrica) system.
Soon after a bone fracture, inflammation and fracture hematoma (clotted blood around fracture) was developed in the region. White blood cells move in and start formation of inflammation reaction. Subsequently, inflammatory reaction (infiltration of macrophages and neutrophils) starts growth of new blood cells.
The fracture hematoma is slowly replaced by granulation tissue which is containing collagen fibers. Fibrocartilage matrix is being formed and take position of granulation tissue. New fibrocartilage matrix produce a soft calculus.
New osteoblasts initiate new bone formation outside surface of the soft calculus formation. Gradually, freshly deposited bone produce hard calculus.
Depending on severetiy and location of the fracture, healing usually takes 6 to 12 weeks.