AffiAB® Goat Anti-ATXN3 Polyclonal IgG Antibody

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SKU:
AFG-AB-028/029
Availability:
3 to 5 Days Shipment
Size:
600 µg
Concentration:
3 mg/ml
Select Currency //340.00 - Select Currency //470.00

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Description

Goat Anti-Human ATXN3 IgG Polyclonal AntibodyAB0089

Overview: Goat polyclonal antibody to ATXN3. This protein appears to be a component of the ubiquitin proteasome system and has deubiquitinase activity. It may also have roles in neuroprotection, protein homeostasis maintenance, transcriptional and cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. The protein contains Qn repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease also known as spinocerebellar ataxia-3, an autosomal dominant neurologic disorder.

Other Names: AT3, ATX3, ataxin-3, ataxin 3 variant h, autosomal dominant ataxin 3, ataxin 3 variant m, ataxin 3 variant ref, JOS, josephin, Machado-Joseph, Machado-Joseph disease protein 1, MJD, MJD1, SCA3, spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, spinocerebellar ataxia type 3 protein antibody.

Other Names: AT3, ATX3, ataxin-3, ataxin 3 variant h, autosomal dominant ataxin 3, ataxin 3 variant m, ataxin 3 variant ref, JOS, josephin, Machado-Joseph, Machado-Joseph disease protein 1, MJD, MJD1, SCA3, spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, spinocerebellar ataxia type 3 protein antibody.

Concentration: 3 mg/ml

Antibody Type: Primary

Target Type: Anti-ATXN3

Accession Number: ENSG00000066427

Host Species: Goat

Immunogen Species: Human

Immunogen Type: Recombinant protein

Immunogen: Purified recombinant peptide derived from within residues 120 aa to 250 aa of human ATXN3 produced in E. coli.

Isotype: IgG

Clonality: Polyclonal

Confirmed Reactive Species: Human, mouse, rat, bovine, canine, chicken/avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep, simian, other

Specificity Detail: Detects levels of ATXN3 protein in transfected cells with GFP-ATXN3 and endogenous levels in U118, SH-SY5Y, At-T20 and hTERT cell lysates by Western blot. This Ab is similar to AB10089.

Buffer: PBS, 20% glycerol and 0.05% sodium azide

Purification: Epitope affinity purified

Conjugation: Unconjugated

Format: N/A

Application: WB

Concentration/Dilution: WB:1:250-1:2,000

Storage:

References: N/A

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