IgE Mediated (Type I) Hypersensitivity

IgE Mediated (Type I) Hypersensitivity Animation

Type I (immediate) hypersensitivity occurs when an immunoglobulin E (IgE) response is directed against innocuous environmental antigens, such as pollen, house- dust mites or animal dander. The resulting release of pharmacological mediators by IgE sensitized mast cells produces an acute inflammatory reaction with symptoms such as asthma or rhinitis. Type I hypersensitivity is characterized by an allergic reaction that occurs immediately following contact with the antigen, referred to as the allergen. The term allergy meaning “changed receptivity of the host when meeting an agent” on a second or subsequent occasion.

Typical examples of allergic reactivity;

1. Hay fever

2. Asthma

3. Atopic eczema

4. Drug allergy