GelRed® and GelGreen® are highly sensitive gel stains designed to be non-toxic and non-mutagenic by virtue of being cell membrane-impermeant, so they cannot enter living cells.
ULTRA-SENSITIVE DNA STAINS
Much more sensitive than EtBr and SYBR® Safe.
SAFER THAN ETBR
Shown by Ames test and other tests to be non-mutagenic and non-cytotoxic.
Passed environmental safety tests for disposal down the drain or in regular trash.
Use in either precast or post electrophoresis staining.
Compatible with cloning and sequencing.
GelRed® & GelGreen® DNA stains are stable at room temperature for long-term storage.
BROAD INSTRUMENT COMPATIBILITY
Use UV and EtBr settings for GelRed®.
Use UV or blue LED for GelGreen® with SYBR® settings.
Safer alternatives to EtBr, SYBR® Safe, and others
EtBr has been the predominant dye used for nucleic acid staining for decades because of its low price and generally sufficient sensitivity. However, EtBr is a highly mutagenic material. The safety hazard and costs associated with decontamination and waste disposal can ultimately make the nucleic acid dye expensive to use. For this reason, various ethidium bromide alternative DNA gel stains have become commercially available in recent years. Although these alternative nucleic acid staining dyes are marketed as having low mutagenicity, they often have to sacrifice other aspects of the dyes. For example, SYBR® Safe has very limited sensitivity while SYBR® Green and SYBR® Gold are much less stable than EtBr. In addition, many so-called “safe” DNA dyes like Midori Green, GreenSafe, SafeView™, and RedSafe™ not only have low sensitivity, but also readily penetrate living cells to bind DNA, and some are cytotoxic. See our Gel Stains Comparison for details.
Non-toxic, non-mutagenic, and non-hazardous for disposal