Monoclonal Antibodies to AAT | NBP0232

Monoclonal Antibodies to AAT | NBP0232 | Bioworld

Host: mouse

Expression: N/A

Tag: N/A

Isotype: IgG1 kappa

Determination Method: immunochromatography or chemiluminescent immunoassay

Application: N/A

General Information: Cumulative damage to lung tissue by neutrophil elastase is responsible for the development of pulmonary emphysema, an irreversible lung disease character ized by loss of lung elasticity. α1-antitrypsin (AAT), a 394 amino-acid hepatic acute phase protein, predominatly inhibits Neutrophil Elastase. AAT is highly expressed in liver and in cultured hepatoma cells and, to a lesser extent, in macrophages. ATT is a highly polymorphic glycosylated serum protein with characteristic isoelectric-focusing patterns for most variants. AAT maps to a region of human chromosome 14q32.13 that includes a related serine protease inhibitor (serpin) gene which encodes corticosteroid-binding globulin. Oxidation of the Methionine 358 residue located at the active center of AAT results in a dramatic decrease in inhibitory activity towards elastase which effectively inactivates the protective function. AAT also has a moderate affinity for plasmin and Thrombin. AAT deficiency associates with a 20-30 fold increased risk of precocious pulmonary emphysema.

Recomendation: N/A

Product Buffer: PBS, pH7.4.

Purity: >95% as determined by SDS-PAGE.

Storage: Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

Specificity: Recognizes native AAT

Source: N/A

Molecular weight: N/A

Note: N/A