Dextran based magnetic nanoparticles (perimag®)

• show excellent properties as a contrast medium for magnetic resonance imaging and magnetic particle imaging (Eberbeck et al. 2013, Konkle et al. 2015 and Zheng et al. 2016),
• are suitable for homing and tracking of stem cells in regenerative medicine and for hyperthermia applications (Kilian et al. 2016),
• are produced by the precipitation of iron oxide in the presence of dextran,
• are available with a diameter of 130 nm,
• cannot be separated with conventional permanent magnets, but only in a high gradient magnetic field,
• are offered with the surface groups OH (plain), NH2 and COOH for the covalent binding of proteins, antibodies and other molecules (Drews et al. 2013),
• are available with covalently bound streptavidin for binding biotinylated molecules,
• can be manufactured with higher iron concentrations on request.