Malaria IgG/IgM ELISA

Malaria is the most common tropical parasitic disease and is by now also of importance through returning travelers in non-endemic areas. The transmission of Plasmodium (P. ovale, P. malariae, P. vivax, P. falciparum) occurs by the bite of the Anopheles female mosquito. P. falciparum and P. vivax are the most common types.

The initial symptoms of infection are nonspecific (headache, fever, chills, dizziness, nausea) and may persist for several days. Several days or weeks later it comes to periodic fever attacks every 3 to 4 days depending on the species. For the Tropical Malaria these periodic phases are often not pronounced.

Especially at risk are children and non-immune adults from non-endemic areas (tourists from USA and Europe) as well as children from endemic areas between 6 months and 3 years of age. Adults in endemic regions develop a kind of resistance to malaria. Alternative routes of infection are transplacentally, through blood transfusion or contaminated syringes among drug addicts.

References:

• Bruce-Chwatt, L. J. (1982): Transfusion malaria revisited. In Tropical diseases bulletin 79 (10), pp. 827–840.
• Chiodini et al. (1997): Evaluation of a malaria antibody ELISA and its value in reducing potential wastage of red cell donations from blood donors exposed to malaria, with a note on a case of transfusion-transmitted malaria. In Vox sanguinis 73 (3), pp. 143–148.
• Dodd, R. Y. (1998): Transmission of parasites by blood transfusion. In Vox sanguinis 74 Suppl 2, pp. 161–163.
• Doderer et al. (2007): A new ELISA kit which uses a combination of Plasmodium falciparum extract and recombinant Plasmodium vivax antigens as an alternative to IFAT for detection of malaria antibodies. In Malaria journal 6, p. 19. DOI: 10.1186/1475-2875-6-19.
• Hoffman et al. (2006): Malaria. In Richard L. Guerrant, David H. Walker, Peter F. Weller (Eds.): Tropical infectious diseases. Principles, pathogens & practice. 2nd ed. Philadelphia: Churchill Livingstone, pp. 1024–1062.