HRP-conjugated Sheep Anti-Human Apolipoprotein (a) | ABMC-H02

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HRP-conjugated Sheep Anti-Human Apolipoprotein (a) | ABMC-H02

Host Species:	Sheep
Concentration:	0.8 mg/ml (OD 1.35 / 280 nm)
Antigen:	Human Apolipoprotein (a)
Purification:	Affinity purified
Buffer:	50 mM PBS, 0.1 M NaCl, and 0.01% Thiomersal, pH 7.4.
Specificity	Specifically binds to human Lp (a) and apo (a). No cross- reaction to Apo B-100/48; minor to plasminogen. Dilution for immunoblot and ELISA range: 1,000 to 8,000.
Use:	The antibody can be used for detection of human albumin in plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation.
Storage:	-20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing.
Form:	Freeze dried powder
Stabilizer:	10 mg / ml Bovine Serum Albumin.
Reconstitution and Storage:	Freeze-dried product should be stored refrigerated until opened. After opening, restore to suggested ml volume with distilled water. If it is not completely clear after standing for 1-2 hours at room temperature, centrifuge the product. It is stable for several weeks at 4°C as an undiluted liquid. Do not use for more than one day after dilution. For extended storage after reconstitution, we suggest aliquot to avoid repeated freezing and thawing; or the addition of an equal volume of glycerol to make a final glycerol concentration of 50%, followed by storage at -20°C. The concentration of protein and buffer salts will decrease to one-half of the original after the addition of glycerol.

*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.

IMPORTANCE

The Lipoprotein (a) [Lp(a)] structure is similar to that of low density lipoprotein (LDL), regarding size and lipid composition of the particles and the presence of apolipoprotein B-100 (apo B-100). In addition to apo B-100, Lp(a) has a second protein, apolipoprotein (a) [apo (a)], which the molecular weight of that glycoprotein varies widely from 400 to 700 kDa. (Maranhão et al., 2013)

Previous research has shown that apo (a) has a similar structure with plasminogen and contains a serine protease domain and two types of plasminogen-like kringle domains. (McLean et al., 1987) The plasma concentration of human lipoprotein[a], Lp[a], is highly correlated with coronary artery disease. (Gaubatz et al., 1990)

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