Synthetic polypeptides from n-terminal domaine of p63
Background:
P63 consists of two major isoforms-tap63 and dnp63. These isoforms differ in the structure of the n-terminal domains. The tap63 isoform (identified by anti-p63 antibody) contains a transactivation-competent ‘ta’ domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, dnp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive ‘dn’ domain, which antagonizes the activity of tap63 and p53.
