HPK1, Active | M23-11BG

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SKU:: M23-11BG-05 | M23-11BG-10
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Availability:: In Stock
Storage:: –70°C

£288.29 - £416.42

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Description

HPK1, Active | M23-11BG

Recombinant mouse HPK1 (1-346) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Overview:

HPK1 or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. HPK1 is also known as mitogen-activated protein kinase kinase kinase kinase 1(MAP4K1). HPK1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway (1). HPK1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76 (2).

Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping:

Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~65 kDa

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