SC-2 Variants SA/BR/UK One Step RT-qPCR

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  • SC-2 Variant SA/BR, UK One Step RT-qPCR
  • One Step RT-qPCR
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One-step real-time qPCR kit for detection of SC-2 virus and identification of its British, South African and Brazilian variants in one reaction. The kit is based on one-step RT-qPCR using fluorescently labelled probes (FAM, HEX, ROX channels) and exogenous positive control (Cy5 channel).

Product description

– CE IVD one-step RT-qPCR kit
– detection of viral genes S and RdRP
– multiplex assay targeting the South African and Brazilian variant (mutation E484K – FAM channel), the British variant (mutation A570D – HEX channel), the viral RdRP gene (ROX channel) and the Exogenous Positive Control (Cy5 channel)
– E484K is a key so-called “escape” mutation that causes reduced binding of neutralizing antibodies and is found in variant B.1.351 (501Y.V2) referred to as the South African and P.1 (501Y.V3) referred to as the Brazilian variant
– A570D mutation is located exclusively in line B.1.1.7 (20I / 501Y.V1) referred to as the British variant

SC-2 Variant SA/BR/UK One Step RT-qPCR Brochure

SC-2 Variant SA/BR/UK One Step RT-qPCR DataSheet



Santa Cruz qPCR primers for following Genes from Maxanim
Gp120 Inhibitors | Gp120 is a glycoprotein exposed on the surface of the HIV envelope.
Elexacaftor modulator – ivacaftor and tezacaftor
Sunitinib Inhibitor – meningioma
CY-09 inhibitor – Inhibits NLRP3 Inflammasome Activation
Paeoniflorin inhibitor – It can also be isolated from the fresh water fern Salvinia molesta.
Mirna Mimics | miRNA inhibitors for single or high throughput silencing
Pt2385 Antagonist – activity of drugs
Sc58635 Inhibitor – skin adverse events
Ripasudil inhibitor – mechanism of action affects intraocular pressure
RO5028442 Antagonist – RO 5028442, antagonist with Kis of just one nM for hV1a and 39 nM for mV1a
AMPK Signal | AMPK is formed by α, β, and γ subunits
Neratinib Inhibitor – dual inhibitor
Molibresib Inhibitor – social phobia
MLN8054 inhibitor – sensitizes androgen-resistant prostate cancer to radiation
PD-1 and PD-L1 inhibitor – PD-1 and PD-L1 inhibitors act to inhibit the association of the programmed death-ligand 1 (PD-L1) with its receptor, programmed cell death protein 1 (PD-1).
P53 Signal | Heating in concentrated hydrochloric acid will hydrolyse the peptide bonds holding proteins together, releasing free amino acids.
Arg-gly-asp – peptide motif
FAK signal | FAK is activated by focal adhesion complex
Pictilisib Inhibitor – Pictilisib inhibitors block the PI3K/AKT/mTOR pathway and thus slow down cancer growth.
OTS964 inhibitor – By applying a genetic target-deconvolution strategy, we found that the mischaracterized anticancer agent OTS964 is actually a potent inhibitor of the cyclin-dependent kinase CDK11 and ...
SGI-1776 inhibitor – inhibits the proliferation of ovarian cancer cells
Ag-221 inhibitor – Enasidenib is used to treat relapsed or refractory acute myeloid leukemia in people with specific mutations of the IDH2 gene, determined by an FDA-approved IDH2 companion diagnostic ...
Tween80 chemical – gives effect to aqueous phase
SCH900776 inhibitor – SCH900776 also increased the effect of fludarabine in a proportion of primary CLL samples treated with pro-proliferative stimuli, including those with TP53 disruption.
Stem Cells Inhibitors – Adult stem cells are found in a few select locations in the body.
Crenolanib Inhibitor – Crenolanib inhibits both wild type FLT3 and its constitutively active mutations.
Bcl2 receptor | Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular ...
E3330 Inhibitor – In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19.
YL-0919 inhibitor – under development for the treatment of major depressive disorder
1 azaken Paullone – GSK-3 is integrally tied to pathways of cell proliferation and apoptosis.
Pma Activator – psychedelic properties
UNC0642 inhibitor – RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice
Smoothened Agonist Agonist – Smoothened agonist has been shown to aid proliferation and survival of developing neurons,and prevent drug-induced brain injury.
Fosaprepitant antagonist – administered intravenously
DUB signal | DNA in the bacterium is tightly coiled.
Glycyrrhizic inhibitor – After oral ingestion, glycyrrhizin is hydrolysed to 18β-glycyrrhetinic acid (enoxolone) by intestinal bacteria. After absorption from the gut, 18β-glycyrrhetinic acid is metabolised ...
Rotenone inhibitor – It occurs naturally in the seeds and stems of several plants, such as the jicama vine plant, and the roots of several members of Fabaceae.
Combretastatin a4 inhibitor – A variety of different natural combretastatin molecules are present in the bark of Combretum caffrum, commonly known as South African Bush Willow.
Pim447 Inhibitor – Pim-1 is primarily involved in cytokine signaling.
Microrna 1 | Combinatorial regulation is a feature of miRNA regulation in animals.
Microrna21 | MiRNAs appear to target about 60% of the genes of humans and other mammals.
Transmembrane Transporters inhibitors – ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases.
ZM306416 Inhibitor – ZM-306416 is a VEGFR antagonist and a potent inhibitor of EGFR function
JNJ-64619178 inhibitor – We demonstrate that the clinical-stage PRMT5 inhibitor JNJ-64619178 potently and efficaciously inhibited CCSST cell growth in vitro and in vivo.
Hippo Inhibitors – The Hippo pathway also has a critical role in stem cell and tissue specific progenitor cell self-renewal and expansion.
Pr-171 inhibitor – It begins at its intersection with PR-172 in downtown Cidra and ends at its junction with PR-14 near downtown Cayey.
KPT9274 inhibitor – KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells
Tic10 Inhibitor – Fluoxetine may be less effective than other antidepressants, but has high acceptability.
Salinosporamide A inhibitor – Salinosporamide A is reported that proceeds in 16 steps and 5 % overall yield and features an oxidative radical cyclization as a key step.
IWR-1-endo inhibitor – Sensitization with IWR-1-endo produced increased γH2AX foci formation, indicating increased DNA damage by doxorubicin.
Ots514 Inhibitor – ACE inhibitors can be used alone or in combination with other anti-hypertensive medications.
Gsi Ix Inhibitor – GSI-IX is a γ-secretase inhibitor.
Prostaglandin E2 chemical – Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open.
TVB-2640 inhibitor – encoded by the FASN gene
Dacinostat Inhibitor – The ACE inhibitor drugs allow for increased levels of bradykinin which would normally be degraded.
Pioglitazone Agonist – Pioglitazone may be used with metformin, a sulfonylurea, or insulin.
Pifithrin Inhibitor – a molecular weight of 367 30
BI6727 inhibitor – Volasertib can be taken either orally or via intravenous infusion, once circulating in the blood stream it is distributed throughout the body, crosses the cell membrane and enters the ...
Stat Inhibitors – Inhibitors of STAT proteins are being developed for use in cancer therapy.
Coumarin 6 – Coumarin 6 facilitate the traceability of drug delivery systems in vitro.
Disulfiram inhibitor – Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, causing many of the effects of a hangover to be felt immediately following alcohol consumption.
Er Stress Inhibitors – Skeletal muscles are sensitive to physiological stress, as exercise can impair ER homeostasis.
AG-881 Inhibitor – Cellular potency profiling was routinely performed using the patient-derived neurosphere TS603.
Yap tead inhibitor 1 – YAP1 is a transcriptional co-activator.
Compound78c Inhibitor – Natural compounds refer to those that are produced by plants or animals.
N6 methyladenosine inhibitor – an abundant modification in mRNA and DNA
GDC-0973 – Cobimetinib is a MEK inhibitor.
Melatonin Agonist – Melatonin receptor agonists were developed with the melatonin structure as a model.
CX-6258 inhibitor – The activity of CX-6258 was validated in several Ewing sarcoma and multiple myeloma cell lines.
Binimetinib inhibitor – treat various cancers
GS-7977 inhibitor – Common side effects include fatigue, headache, nausea, and trouble sleeping.
Omipalisib inhibitor – Omipalisib binds to and inhibits PI3K in the PI3K mTOR signaling pathway.
Ar-12 Inhibitor – cryptococcosis of the brain
TMP269 inhibitor – promotes M1 polarization
JNJ-26481585 inhibitor – Preclinical studies show that quisinostat amplifies HDAC-repressed expression of E-cadherin, leading to a reversal of epithelial to mesenchymal transition in tumor cells.
Temsirolimus inhibitor – Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells.
Sapanisertib Inhibitor – Sapanisertib is an experimental small molecule inhibitor of mTOR which is administered orally.
TC-H 106 inhibitor – class I histone deacetylases
VX-765 – belnacasan has proved well tolerated in human clinical trials.
Elimusertib inhibitor – Selective ATR Inhibitor
VS-6063 – Subsequent research in patients with specific NF2 mutations also found limited activity.
Ory 1001 Inhibitor – cell lung cancer
Tocilizumab inhibitor – Tocilizumab was granted an emergency use authorization (EUA) for the treatment of COVID‑19 in the United States in June 2021.
Tsa Inhibitor – Vorinostat is structurally related to trichostatin A and used to treat cutaneous T cell lymphoma.
Degrasyn Inhibitor – Cilostazol is used in the treatment of intermittent claudication.
c-MET receptor | In addition to their high affinity for the main site of the monoamine transporters, several competitive transporter substrates such as cocaine and indatraline have lower affinity for these ...
Diphenyleneiodonium – Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
SB-480848 inhibitor – the drug had failed to meet Phase III endpoints
BAY-876 inhibitor – A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma
Akti 1 2 – Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine.
Pci 32765 Chemical – Pci 32765 is a potent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK).
Perifosine inhibitor – Perifosine interrupts the PI3K/AKT/mTOR pathway by acting as an allosteric AKT inhibitor targeting the pleckstrin homology domain of AKT.
Galicaftor modulator – the treatment of Cystic Fibrosis
Salubrinal Modulator – Salubrinal blocks eIF2α dephosphorylation by a herpes simplex virus protein and inhibits viral replication.
RGFP966 – The increasing number of patients suffering from chronic obstructive pulmonary disease represents a major and increasing health problem.
Tanzisertib inhibitor – characterization of enzymes involved in metabolism
Ravoxertinib Inhibitor – tagged destruction
Hdac Assay | Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene.
Lgh447 Inhibitor – Single nucleotide polymorphisms in the Pim-1 gene have been associated with increased risk for lung cancer in Korean patients.
Subasumstat Inhibitor – decreasing anger
Saha Inhibitor – common disorder
Tie2 Receptor – The ligand for the receptor is angiopoietin-1.
Semaxanib Inhibitor – Semaxanib is a tyrosine-kinase inhibitor drug designed by SUGEN as a cancer therapeutic.
Selisistat inhibitor – AOP Orphan Pharmaceuticals AG to acquire Selisistat a clinical stage drug candidate for the treatment of Huntington’s disease
Mocetinostat inhibitor – Mocetinostat is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers including follicular lymphoma, Hodgkin's lymphoma and acute ...
Ku 60019 Inhibitor – Small molecule enzyme inhibitors include secondary metabolites.
Methylation Inhibitors – DNA methylation is a biological process by which methyl groups are added to the DNA molecule.
Pracinostat inhibitor – potential anti-tumor activity characterized
NVP-BSK805 inhibitor – NVP-BSK805, an inhibitor of JAK2 kinase, significantly enhanced the radiosensitivity of ESCC cells both in vitro and in vivo.
Alvespimycin Inhibitor – Alvespimycin is a chemical compound which is a semi-synthetic derivative of the antibiotic geldanamycin.
Darapladib inhibitor – discovered by Human Genome Sciences
Cyclosporina – Common side effects include high blood pressure, headache, kidney problems.
Alvocidib Inhibitor – The target of alvocidib is the positive transcription elongation factor P-TEFb.
BI-2852 inhibitor – The switch I/II pocket is a second pocket for which the nanomolar inhibitor BI-2852 has been discovered.
Immunology Inhibitor | Classical immunology ties in with the fields of epidemiology and medicine.
Repsox inhibitor – RepSox is a selective TGFβRI/ALK5 inhibitor
GX15-070 antagonist – Obatoclax is an inhibitor of the Bcl-2 family of proteins.
WQ1 antagonist – Sigma Receptor antagonist
Mirna1 | Metabolic reactions may be categorized as catabolic
DMF inhibitor – Dimethylformamide is odorless, but technical-grade or degraded samples often have a fishy smell due to impurity of dimethylamine.
Mt Receptor | For instance, aspirin is a widely used drug that acts as a suicide inhibitor of the cyclooxygenase enzyme.
Incb018424 inhibitor – Ruxolitinib is a janus kinase inhibitor.It was developed and marketed by Incyte Corp in the US under the brand name Jakafi, and by Novartis elsewhere in the world, under the brand ...
SMAD Inhibitors – Smad4 is the only known human Co-Smad, and has the role of partnering with R-Smads to recruit co-regulators to the complex.
Ro31 8220 Inhibitor – protein kinase C
Ap26113 Inhibitor – Ap26113 acts as both an anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) inhibitor.
Bgb 3111 Inhibitor – single arm trials
Hcv Protease Signal | Hcv is an small, enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae.
Ouabain inhibitor – used as an arrow poison
MAPK signals | With respect to PFK1, fructose 2,6-bisphosphate and ADP are examples of metabolites that are allosteric activators.
Bibw2992 inhibitor – It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer....
Anisomycin activator – produced by Streptomyces griseolus
Tideglusib inhibitor – members of the thiazolidinedione family
Erlotinib Inhibitor – NSCLC with mutations
Tenofovir Inhibitor – Tenofovir disoproxil may be used for prevention of HIV/AIDS among those at high risk before exposure, and after a needlestick injury or other potential exposure.
Tipifarnib inhibitor – Farnesyltransferase inhibitors block the activity of the farnesyltransferase enzyme by inhibiting prenylation of the CAAX tail motif, which ultimately prevents Ras from binding to ...
GAP26 Inhibitor – gap26 attenuated the apoptosis of tubular epithelial cells
1400w Inhibitor – isosorbide mononitrate
At9283 Inhibitor – The CCL4 protein precursor consist of 92 amino acids.
Canaglifloz Ininhibitor – exercise and diet
INCB028050 inhibitor – INCB028050 is a medication used for the treatment of rheumatoid arthritis, alopecia areata, and COVID-19.
Panobinostat inhibitor – Panobinostat is used in combination with the anti-cancer drug bortezomib and the corticoid dexamethasone for the treatment of multiple myeloma in adults who had received at least ...
Screening Libraries | The process by which a chemical or physical signal is transmitted through a cell as a series of molecular events is called signal transduction.
BP-1-102 inhibitor – Effects of STAT3 Inhibitor BP-1-102 on The Proliferation, Invasiveness, Apoptosis and Neurosphere Formation of Glioma Cells in Vitro
Tamoxifen Chemical – generic medication
Capecitabine Chemical – with docetaxel
Chlortetracycline inhibitor – Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.
Loxo 195 Inhibitor – medical use
N-Dimethylformamide inhibitor – Commonly abbreviated as DMF (although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority ...
CCG-203971 inhibitor – Novel inhibitors of the Rho
Defactinib – Development for mesothelioma was discontinued in 2015 due to lack of efficacy in a placebo-controlled phase II trial.
RI-1 inhibitor – RI-1 is a selective inhibitor of RAD51, which is a central gene molecule of homologous recombination, with IC50 ranging from 5 to 30 μM.
Aptstat3-9r inhibitor – Addition of a cell-penetrating motif to the peptide to yield APTSTAT3-9R enabled uptake by murine B16F1 melanoma cells.
Epz015666 Inhibitor – The inhibitor may bind to the enzyme whether or not the substrate has already bound.
OICR-9429 antagonist – OICR-9429 has been shown to bind to WDR5 with KD values of 24 nM and 52 nM.
Idarubicin inhibitor – It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake.
Er Stress Inhibitors – PERK deficiency may have a significant impact on physiological states associated with ER stress.
Go6976 Inhibitor – cell junctions
C646 Inhibitor – Molecular biology has been elucidated by the work of many scientists.
Elesclomol Modulator – digital signal
Nsc754230 Inhibitor – acute gout attacks
Syk signal | In the natural and life sciences, the academic journal is the relevant medium.
Denosumab inhibitor – contraindicated in people with low blood calcium levels
Aprotinin Inhibitor – Aprotinin is a monomeric globular polypeptide derived from bovine lung tissue.
P7c3 Activator – By activating NAMPT, the P7C3 compounds result in an increase in intracellular levels of NAD.
NSC697855 inhibitor – used in medicine for the treatment of various helminthic
Bcl2 Signaling | Irreversible inhibitors are generally specific for one class of enzyme and do not inactivate all proteins.
Geneticin inhibitor – Geneticin is an aminoglycoside antibiotic similar in structure to gentamicin B1.
PPAR Signal | PPARs are modular in structure.
Rapamycin inhibitor – The chief advantage sirolimus has over calcineurin inhibitors is its low toxicity toward kidneys.
Doramapimod Inhibitor – Inhibitory control is a cognitive process and, more specifically, an executive function.
Cp 868596 Inhibitor – Cp 868596 is well tolerated as a single agent.
Elacridar inhibitor – Elacridar (GF120918, GW120918) is a potent P-gp (MDR-1) and BCRP inhibitor.
Ar 13324 Inhibitor – Antibiotic drug design is facilitated when an enzyme that is essential to the pathogen's survival is absent or very different in humans.
Methotrexate Inhibitor – folic acid
4sc 202 Inhibitor – Enzymes in a metabolic pathway may be inhibited by molecules produced later in the pathway.
Zosuquidar modulator – In 2010, it was announced that a phase III trial for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome did not meet its primary endpoint and Eli Lilly discontinued ...
Milciclib Inhibitor – TrkA is a protein encoded by the NTRK1 gene.
T 5224 Inhibitor – c-Met stimulates cell scattering, invasion, protection from apoptosis and angiogenesis.
Abt494 Inhibitor – used as monotherapy
As1517499 Inhibitor – The presence of trypsin inhibitor has been found to result in delayed growth as well as metabolic and digestive diseases.
M6a Chemical – found within viruses
BAY1251152 inhibitor – The Phase I clinical trials of the latest, highly specific CDK9 inhibitor BAY1251152, against different solid tumors have shown good anti-tumor and on-target activities and pharmacokinetics
Cediranib inhibitor – Cediranib is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.
Anlotinib inhibitor – Anlotinib is a novel oral tyrosine kinase inhibitor.
Wnt inhibitors – The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors.
Cc 5013 Chemical – Cc 5013 is a more potent molecular analog of thalidomide.
AZD0156 inhibitor – AZD0156 is currently being evaluated in phase I studies.
Bafilomycin A1 – Their chemical structure is defined by a 16-membered lactone ring scaffold.
Vadimezan chemical – In 2020 CRM Therapeutics, a Dutch drug-development company, initiated research for re-developing Vadimezan in combination with its proprietary targeted delivery platform.
Pfi 3 Inhibitor – BRD2 and BRD3 are functionally redundant and may be more important as therapeutic targets than is appreciated in studies depleting each BET protein individually.
Endocrinology inhibitors – Endocrinology is the study of the endocrine system in the human body.
10058-f4 inhibitor – 10058-F4 is a c-Myc inhibitor that prevents c-Myc-Max dimerization and transactivation of c-Myc target gene expression.
NVP231 inhibitor – prohibited the emigration of M1 and M2
Talniflumate chemical – developed by Laboratorios Bago
Iacs 10759 Inhibitor – Small molecule inhibitors include essential primary metabolites that inhibit upstream enzymes that produce those metabolites.
DNA Repair Inhibitors – The DNA repair process is constantly active as it responds to damage in the DNA structure.
PTC-209 inhibitor – on the AKT pathway in endometrial cancer cells
PKC412 inhibitor – Over 95% of patients with adult onset systemic mastocytosis and approximately 40% of children with cutaneous mastocytosis are positive for the D816V c-Kit activating mutation, which ...
Kya1797k Inhibitor – the serine residue
Mi 503 Inhibitor – Nutlin inhibits the interaction between HDM2 and tumour suppressor p53.
CC223 inhibitor – inhibits human head and neck squamous cell carcinoma cell growth
3-Deazaneplanocin A – In studies on mice, the drug was also found to be effective for the treatment of Ebola virus disease, apparently interfering with the Ebola viruses ability to block interferon production,...
Ly3295668 Inhibitor – Reduced GFR is especially a problem if the patient is concomitantly taking an NSAID and a diuretic.
Atuveciclib Inhibitor – Zotiraciclib is also being explored for the treatment of DIPG, a rare pediatric cancer.
GDC-0980 inhibitor – A tipping-point for apoptosis following dual inhibition of HER2 signaling network by T-DM1 plus GDC-0980 maximizes anti-tumor efficacy
Retinoid Receptor | Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids.
Linsitinib inhibitor – Linsitinib was granted orphan drug designation for adrenocortical carcinoma in March 2012.
Z-devd-fmk inhibitor – Degradation of KPNA1 induced by 2B can be inhibited in the cells pre-treated with Z-DEVD-FMK, a caspase-3 inhibitor
Marimastat Inhibitor – terminated
Dhfr Signal | DHFR is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid.
Bms 345541 Inhibitor – Bms 345541 is an anti-inflammatory, cell-permeable quinoxaline compound.
BIBF1120 – It gives important information on the efficacy and toxicity of both nintedanib and chemotherapy.
Plx51107 Inhibitor – Reversible inhibitors attach to enzymes with non-covalent interactions such as hydrogen bonds, hydrophobic interactions and ionic bonds.
FCCP inhibitor – It is referred to as an uncoupling agent because it disrupts ATP synthesis by transporting hydrogen ions through the mitochondrial membrane before they can be used to provide the energy ...
Pemigatinib inhibitor – Pemigatinib belongs to a group of medicines called protein kinase inhibitors.
Rituximab Inhibitor – Rituximab is a chimeric monoclonal antibody against the protein CD20,
ITF2357 inhibitor – ITF2357 was discovered at Italfarmaco of Milan, Italy. It was patented in 1997 and first described in the scientific literature in 2005.
Fenofibrate Agonist – off-label use
Cgrp Receptor | The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor.
CB-839 inhibitor – CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC.
Sarilumab inhibitor – Development in ankylosing spondylitis has been suspended after the drug failed to show clinical benefit over methotrexate in a phase II trial.
Pitavastat ininhibitor – Pitavastatin undergoes minimal metabolism so drug-drug interactions are less likely than with many other statins, but it can interact with some drugs that inhibit drug transporters....
Lenalidomide Chemical – Lenalidomide is undergoing clinical trial as a treatment for Hodgkin's lymphoma.
Immunology Signals | Immunology has applications in numerous disciplines of medicine.
MLN2238 – MLN2238 is efficacious in other tumor cell types, such as osteosarcoma18
Z-ietd-fmk | A molecule may be homonuclear, that is, it consists of atoms of one chemical element
ML323 inhibitor – USP1 inhibitor ML323 enhances osteogenic potential of human dental pulp stem cells
Peptide17 Inhibitor – A polypeptide that contains more than approximately 50 amino acids is known as a protein.
PHA-793887 inhibitor – an inhibitor of multiple cyclin-dependent kinases
Darunavir Inhibitor – well tolerated
E 64C Inhibitor – modified dipeptide
GW-572016 – It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor pathways.
GDC-0084 inhibitor – In contrast, GDC-0084 led only to growth inhibition in PIK3CA wild-type cell lines in vitro.
E-64d inhibitor – acts as a cysteine protease inhibitor
Doxycycline Inhibitor – Doxycycline is available as a generic medicine.
C 176 – Large recreational doses of dextroamphetamine may produce symptoms of dextroamphetamine overdose.
RSL3 activator – RSL-3 near Concrete is one of four Remote Sprint Launch sites that were built as part of the Stanley R. Mickelsen Safeguard Complex in northeastern North Dakota.
Bleomycin Inhibitor – treat cancer
Aicar Activator – The activity of activators can be regulated.
Niraparib inhibitor – the treatment of epithelial ovarian
Bisindolylmaleimide inhibitor – This core structure includes a central maleimide group with two indole groups attached.
Copanlisib Inhibitor – Copanlisib has been shown to have an effect against survival and spread of cancerous B-cells.
IMD0354 inhibitor – Studies on the treatment of melanoma with folate acid conjugated dextran and lauryl alcohol loaded with IMD0354
WNK463 inhibitor – designed for WNK1
Cc 115 Inhibitor – Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible.
Rosiglitazone Agonist – insulin sensitizer
SCH900353 inhibitor – ERK Inhibitor for Oncology
Rgdyk inhibitor – Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX.
RXDX-101 inhibitor – RXDX-101 is also indicated for the treatment of adults with ROS1 positive, advanced non small cell lung cancer (NSCLC) not previously treated with ROS1 inhibitors.
Nec 1s Inhibitor – The binding site of inhibitors on enzymes is most commonly the same site that binds the substrate of the enzyme.
Inhibitor Kits | An organism requires continuous input of energy to maintain a low state of entropy.
Neuronal Signaling Inhibitors – A neuron or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses.
5-fluorouracil Inhibitor – As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.
Barasertib Inhibitor – Not all irreversible inhibitors form covalent adducts with their enzyme targets.
Bace Signal | Some of the most well known are antiviral drugs widely used to treat HIV/AIDS and hepatitis C.
Abl001 Inhibitor – Asciminib and active site bcr-abl inhibitors have non-overlapping resistance mutations.
Sta-9090 inhibitor – STA-9090 binds to the ATP-binding domain at the N-terminus of Hsp90 and acts as a potent Hsp90 inhibitor by inducing degradation of multiple oncogenic Hsp90 client proteins.
Pd98059 Inhibitor – Pd98059 has an effect on the solubility of flavonoids.
EPZ5676 – RNA-seq analysis performed on both parental and resistant KOPN-8 and NOMO-1 cell lines supported two unique candidate pathway mechanisms.
Dinaciclib inhibitor – It is being evaluated in clinical trials for various cancer indications.
Erk signaling | Another method that is widely used in these analyses is mass spectrometry.
Nem Inhibitor – NEM activates ouabain-insensitive Cl-dependent K efflux in low K sheep and goat red blood cells.
Neferine Inhibitor – The plant contains nuciferine, neferine, and many other benzylisoquinoline alkaloids with medicinal properties.
GNE-7915 inhibitor – GNE-7915 concentrations in wild-type (WT) mouse sera and brain samples reached a peak at 1 h, which gradually decreased over 24 h following a single subcutaneous (100 mg/kg) injection....
Dmh1 Inhibitor – The most commonly used isomer is CBD-DMH, which has the same stereochemistry as natural cannabidiol, and a 1,1-dimethylheptyl side chain.
Azd7648 Inhibitor – ternary complex
RAD140 modulator – developed by Radius Health
Netupitant Antagonist – antiemetic medication
Ym155 Inhibitor – Irreversible inhibitors covalently bind to an enzyme.
Mk 4827 Inhibitor – Mk 4827 is an anti-cancer medication used for the treatment of epithelial ovarian, fallopian tube, or primary peritoneal cancer.
Osmi 4 Inhibitor – Further optimization led to the development of OSMI-2, OSMI-3, and OSMI-4, which bind OGT with low-nanomolar affinity.
BI10773 inhibitor – It can be prescribed instead of metformin and has benefits over sulfonylureas.
GW788388 inhibitor – acts as a potent and selective inhibitor for TGF beta receptor 1
Rigosertib inhibitor – Rigosertib is in phase III clinical trials for the treatment of chronic myelomonocytic leukemia.
Daratumumab Inhibitor – Daratumumab binds to CD38,which is overexpressed in multiple myeloma cells.
AT13387 inhibitor – inhibit theheat shock protein 90
Triapine Inhibitor – Triapine belongs to the family of drugs called ribonucleotide reductase inhibitors.
Leukadherin 1 Agonist – inflammatory signals
Pexidartinib Inhibitor – Pexidartinib blocks the activity of the colony-stimulating factor-1 receptor (CSF-1R).
PCNA signal | PCNA is a member of the so called DNA
H-151 antagonist – inhibited STING/NF-kappaB signalling
Caspofung ininhibitor – It is a member of a new class of antifungals termed the echinocandins.
Dub Signaling | Cell division gives rise to genetically identical cells in which the total number of chromosomes is maintained.
I-bet 151 Inhibitor – Expression of the growth promoting transcription factor Myc is blocked by BET inhibitors.
Ibrutinib Chemical – a covalent bond
GFAP Signal | GFAP is encoded by the GFAP gene
Ulixertinib – Ulixertinib exposure was dose proportional to the RP2D.
Angiogenesis Inhibitors – Angiogenesis inhibitors have been closely studied for possible cancer treatment.
IPI-549 – It is a highly selective phosphoinositide 3-kinase inhibitor.
Ozanimod modulator – the treatment of relapsing multiple sclerosis and ulcerative colitis
Beta-catenin Receptor | Many drugs are small molecules.
Ro4929097 inhibitor – Targeting gamma secretase inhibits NOTCH signaling, which is upregulated in many forms of cancer.
Kd025 Inhibitor – Belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2.
Cyclopamine Antagonist – Cyclopamine is a naturally occurring chemical that belongs in the family of steroidal alkaloids.
Darolutamide ant agonist – used in the treatment of non-metastatic castration-resistant prostate cancer
Spautin-1 inhibitor – inhibits mitochondrial complex I
LY3009120 inhibitor – Pan-RAF inhibitor LY3009120 is highly synergistic with low-dose cytarabine, but not azacitidine, in acute myeloid leukemia with RAS mutations
Akt Inhibitor | Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes.
Ono 7300243 Antagonist – κ opioid receptor
Bicuculline Inhibitor – The half-maximal inhibitory concentration (IC50) of bicuculline on GABAA receptors is 3 μM.
RG2833 inhibitor – FRDA patients were dosed in 4 cohorts, ranging from 30mg/day to 240mg/day of the formulated drug product of HDACi 109, RG2833.
GSK2399872a inhibitor – The present study aimed to investigate the RIPK3-mediated necroptosis and the effects of the RIPK3 selective inhibitor GSK'872 in early brain injury following SAH.
Gsk lsd1 Inhibitor – atypical depression
Gdc 0575 Inhibitor – synaptic cleft
Crenigacestat inhibitor – The starting level of Crenigacestat was 50 mg, and dose escalation was performed with a modified 3+3 scheme for the estimation of dose-limiting toxicity (DLT) at the recommended ...
Tauroursodeoxycholic – Ursodeoxycholic acid is produced in several countries for the treatment of gallstones and primary biliary cholangitis.
Sb431542 Inhibitor – SB-431542 is a drug candidate developed by GlaxoSmithKline (GSK) as an inhibitor of the activin receptor-like kinase (ALK) receptors.
Covid19 Signaling | Errors in signaling interactions may cause diseases such as cancer, autoimmunity, and diabetes.
ZD1839 – The radio-potentiating effect of ZD1839 was more apparent when radiation was administered in a fractionated protocol.
Liproxstatin-1 inhibitor – Liproxstatin-1 may be a promising drug for the treatment of central nervous system diseases.
Arq092 Inhibitor – Arq092 Inhibitor reduced phosphorylation of AKT
Nf Kb Inhibitors – NF-κB plays a key role in regulating the immune response to infection.
MS-275 – Syndax pharmaceuticals currently holds the rights to Entinostat and recently received $26.6 million in funds to advance treatments of resistant cancers using epigenetic tools.
Dna pksignal | Enzyme inhibitors are also important in metabolic control.
Sonidegibant Agonist – An agonist is a chemical that activates a receptor to produce a biological response.
Sgc cbp30 Inhibitor – Acetylcholinesterase is an enzyme found in animals, from insects to humans.
MK733 inhibitor – a type of lipid-lowering medication
Mm 102 Inhibitor – Substrate or product inhibition is where either an enzymes substrate or product also act as an inhibitor.
Mik665 inhibitor – MCL-1 compared to untreated control cells
Flavopiridol inhibitor – The target of alvocidib is the positive transcription elongation factor P-TEFb.
Ars-853 Inhibitor – escitalopram has been marketed as an allosteric serotonin reuptake inhibitor.
Bucladesine Activator – Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor.
Am1241 Agonist – reduce the bone loss
Rgfp109 inhibitor – RGFP109, a histone deacetylase inhibitor attenuates L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset: a proof-of-concept study
Z-vad inhibitor – Evaluation of Z-VAD-FMK as an anti-apoptotic drug to prevent granulosa cell apoptosis and follicular death after human ovarian tissue transplantation
Eltanexor inhibitor – Eltanexor is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor
Capmatinib Inhibitor – Participants received capmatinib 400 mg orally twice daily until disease progression or unacceptable toxicity.
Ag14361 Inhibitor – human cancer
MLN0128 inhibitor – MLN0128 is an experimental small molecule inhibitor of mTOR which is administered orally.
740 Y-P activator – PI3K inhibitor LY294002 enhanced and agonist 740 Y-P weakened the autophagy-promoting roles of RVS
Ml141 Inhibitor – tight regulation
Tretinoin agonist – it is applied to the skin as a cream
Sti571 Inhibitor – Sti571 is a 2-phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes.
Acy 241 Inhibitor – A special case are covalent reversible inhibitors that form a chemical bond with the enzyme.
Mifepristone antagonist – It is also effective in the second trimester of pregnancy.
E2 Conjugating Signal | A genome is an organism's complete set of DNA
Pertuzumab Inhibitor – Pertuzumab is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer.
Wt161 Inhibitor – Non-inhibitory extracellular serpins also perform a wide array of important roles.
Abinhibitors | Surface tension results from the cohesive force due to the attraction between molecules at the surface of the liquid.
Vx 661 Modulator – Tezacaftor acts as a corrector to help the folding and presentation of the CFTR protein to the cell surface.
Vincristine inhibitor – treat a number of types of cancer
Raf709 Inhibitor – P-gp is a well-characterized ABC-transporter of the MDR/TAP subfamily.
Raf Signaling | RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes.
AZD7762 Inhibitor – It is based on a simplified version of the bacterial CRISPR-Cas9 antiviral defense system.
Belvarafenib inhibitor – shows anti-tumor clinical activity in cancer patients
SCH772984 Inhibitor – SCH722984 in BRAF mutant melanoma was synergistic in a majority of cell lines.
C188 9 Inhibitor – PDE4 is the major cAMP-metabolizing enzyme found in inflammatory and immune cells.
Mak 683 Inhibitor – The 5α-reductase reaction is a rate-limiting step in the testosterone reduction.
Ngp555 Inhibitor – heart failure
Aurora kinase B | Aurora kinase B was identified in humans by a polymerase chain reaction screen for kinases that are overexpressed in cancers
Empagliflozin Inhibitor – reduces systolic
Hsd Signaling | Each pyruvate is then oxidized into acetyl-CoA by the pyruvate dehydrogenase complex.
Tie2 Kinase Inhibitor – The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans.
Mito-tempo – In the present study, modulation of BPA toxicity by mitochondria-targeted antioxidant, mito-TEMPO was studied in male Wistar rats.
Abvos | The nucleus is made of one or more protons and a number of neutrons.
Angiogenesis Receptor | The mechanism of blood vessel formation by angiogenesis is initiated by the spontaneous dividing of tumor cells due to a mutation.
Bms 986165 Inhibitor – Bms 986165 acts as a highly selective allosteric inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2).
Bimatoprost Agonist – Bimatoprost is available as a generic medication.
Barbasco inhibitor – The earliest record of the now-known rotenone-containing plants used for killing leaf-eating caterpillars was in 1848, and for centuries, the same plants were used to poison fish.
Quisinostat Inhibitor – Quisinostat is highly potent against class I and II HDACs.
Brigatinib Inhibitor – NSCLC patients
Poziotinib Inhibitor – Poziotinib is built on an anilino-quinazoline scaffold.
GPCR Inhibitors – A ligand binds to the GPCR it causes a conformational change in the GPCR
E3 ligase signal | E3 ligases are also key players in cell cycle control, mediating the degradation of cyclins, as well as cyclin dependent kinase inhibitor proteins.
Dbet6 Chemical – Beta-D can be prepared as a sulfate salt or as a hydrochloride salt.
Dihydrotestosterone – The enzyme 5α-reductase catalyzes the formation of DHT from testosterone in certain tissues.
Hiv Protease Signals | Without effective HIV protease, HIV virions remain uninfectious.
Gant61 – Multiple other Hedgehog pathway inhibitors are in different phases of clinical trials.
Docetaxel inhibitor – chemotherapy medication
FG-4592 – HIF1α expression in haematopoietic stem cells explains the quiescence nature of stem cells.
Ve 821 Inhibitor – Molecular biology sits at the intersection of biochemistry and genetics.
Durvalumab inhibitor – It is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody that blocks the interaction of programmed cell death ligand 1 (PD-L1) with the PD-1 (CD279).
Plerixafor | An immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream.
Fisogatinib Inhibitor – Potassium supplementation should be used with caution and under medical supervision owing to the hyperkalemic effect of ACE inhibitors.
Tyrphostin Ag-1478 – Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades.
Bardoxolone Inhibitor – Bardoxolone methyl inhibits the pro-inflammatory transcription factor NF-κB in a tissue cultured human cell line.
NCT-503 inhibitor – We confirmed the effects of PHGDH inhibition through knocking down PHGDH and the effect of NCT-503 in vivo in the 5T33MM mouse model.
Nsc154020 Inhibitor – gynecomastia
GSK126 inhibitor .com – Mutation or over-expression of EZH2 has been linked to many forms of cancer.
CL318952 chemical – a medication used as a photosensitizer for photodynamic therapy
ERK Signal | The MEK phosphorylates and activates a mitogen-activated protein kinase
Apoptosis Blog | Biology is about nurturing and growth.
Aurorakinase Signals | Using biochemical, structural and cellular approaches, we show here that BlaS inhibits both translation elongation and termination in Mammalia.
Volasertib inhibitor – Volasertib is a novel small-molecule targeted therapy that blocks cell division by competitively binding to the ATP-binding pocket of the PLK1 protein.
GSK2245840 activator – GSK2245840 is a selective SIRT1 activator involved in the regulation of energy homeostasis.
TPX-0005 inhibitor – TPX-0005 was carried out with X-ray cocrystal structures of ALK,ROS1,TRKA,TRKB.
Sotrastaur ininhibitor – Sotrastaurin is an investigational immunosuppressant that blocks T-lymphocyte activation through protein kinase C inhibition.
Upr Inhibitors – If these objectives are not achieved within a certain time span or the disruption is prolonged, the UPR aims towards apoptosis.
Cyclosporine Inhibitor – Blood levels of the medication should be checked to decrease the risk of side effects.
SR1 Antagonist – regulation of sporulation by inhibition of kinA translation
ICI46474 chemical – used to prevent breast cancer in women and men
Chidamide Inhibitor – Chidamide is being researched as a treatment for pancreatic cancer.
CDK2-in-4 inhibitor – a member of the cyclin-dependent kinase family
LY364947 inhibitor – The TGF-beta inhibitor LY364947 was introduced to demonstrate the importance of TGF-beta signaling in anlotinib resistance via a series of functional assays.
Az304 Inhibitor – The inhibitor may bind to the enzyme whether or not the substrate has already bound.
Cisplatin Chemical – bind to DNA
Tki-258 Inhibitor – clinical trial
PF-6463922 Inhibitor – The transforming EML4-ALK fusion gene was first reported in non-small cell lung carcinoma (NSCLC) in 2007.
A 83 01 Inhibitor – A-83-01 inhibited the epithelial-to-mesenchymal transition induced by TGF-β.
UNC2025 inhibitor – Therapeutically Effective Alone
ZD6474 inhibitor – ZD6474 is used to treat medullary thyroid cancer in adults who are ineligible for surgery
Chk signals | In 1993, Beach and associates initially identified Chk1 as a serine/threonine kinase which regulates the G2/M phase transition in fission yeast.
Bms 1166 Inhibitor – social anxiety disorder
Uprosertib Inhibitor – Genital infections seem to be the most common adverse effect of gliflozins.
Gsk690693 Inhibitor – Protein kinases can be inhibited by competition at the binding sites where the kinases interact with their substrate proteins.
Chk1 Inhibitor | Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase.
AMN-107 inhibitor – AMN 107 was approved for medical use in the United States in 2007.
Cpsase Signal | In the context of neurotransmission, neurotransmitters are typically released from synaptic vesicles into the synaptic cleft via exocytosis; however, neurotransmitters can also be released ...
Crm1 Receptor | DNA replication is not perfect as the DNA polymerase sometimes insert bases that are not complementary to the template.
Entinostat – Entinostat inhibits class I HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively.
Hydroxyurea Inhibitor – Common side effects include bone marrow suppression, fevers, loss of appetite, psychiatric problems, shortness of breath, and headaches.
Thiazovivin – It is used alongside a cocktail of other growth factors and modulators in cell culture techniques for the generation of induced pluripotent stem cells.
Apoptosis Inhibitors – Apoptosis, or programmed cell death, is a highly regulated process used by many multicellular organisms.
Torkinib inhibitor – TORKinib-induced Mcl-1 reduction was rescued by proteasome inhibition. Consistently, TORKinib increased Mcl-1 ubiquitination.
Cpt Signal | The rate of DNA replication in a living cell was measured as 749 nucleotides added per second under ideal conditions.
Linagliptin inhibitor – It is generally less preferred than metformin and sulfonylureas as an initial treatment.
Stattic Inhibitor – Hence mixed inhibition is a combination of competitive and noncompetitive inhibition.
MK-2048 inhibitor – MK-2048 is the Merck & Co. designation for a molecule in its pre-clinical drug discovery that is an integrase inhibitor-class of agent intended to be used against HIV infection.
Hm781 36b Inhibitor – Naturally occurring enzyme inhibitors regulate many metabolic processes and are essential for life.
Takinib Inhibitor – TAK1 is an evolutionarily conserved kinase in the MAP3 K family and clusters with the tyrosine-like and sterile kinase families.
Verdinexor inhibitor – Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses
IU1 inhibitor – USP14 inhibitor
Cpi 169 Inhibitor – chemical compound
Opaganib inhibitor – It is under development as a potential treatment agent for several different kinds of cancer.
Xl413 Inhibitor – XL-413 is a drug which acts as a selective inhibitor of the enzyme cell division cycle 7-related protein kinase.
Verapamil Inhibitor – generic medication
Ly2603618 Inhibitor – Not all inhibitors are based on the structures of substrates.
COX signals | This mechanism occurs in the pancreas, which synthesises many digestive precursor enzymes known as zymogens.
Pimavanser Ininhibitor – high binding affinity
Mizoribine Inhibitor – Mizoribine is an immunosuppressive drug.
Scd Receptor | Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism.
Fedratinib Inhibitor – Myelofibrosis is a myeloid cancer associated with anemia, splenomegaly.
S1p Receptor | Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine.
Tead Receptor | TEAD proteins are found in many organisms under different names, assuming different functions.
Tacrolimus inhibitor – used to treat dry eye syndrome
Tyrphostin AG 1296 inhibitor – Additive effect by combination of Akt inhibitor, MK-2206, and PDGFR inhibitor, tyrphostin AG 1296, in suppressing anaplastic thyroid carcinoma cell viability and motility
Vx 770 Activator – VX-770 is included in a combination product, lumacaftor/ivacaftor, in a single pill.
Ars 1620 Inhibitor – ACE inhibitors were initially approved for the treatment of hypertension.
7 cl o nec1 Inhibitor – The inhibitor can bind to a site remote from the enzyme active site.
Ponatinib inhibitor – the treatment of chronic myeloid leukemia
BI-7273 inhibitor – prove to be useful in further exploring BRD9
Ku 0063794 Inhibitor – Many monomers are purified industrially by distillation, which can lead to thermally initiated polymerisation.
Sulfasalazine Inhibitor – Sulfasalazine is in the disease-modifying antirheumatic drugs family of medications.
Domatinostat Inhibitor – faulty data
Stenabolic 0 – veterinary medicine
Perk signal | The PERK enzyme plays a key role in activating the brain's defence mechanism.
Talazoparib – Talazoparib is similar to the first in class PARP inhibitor, olaparib.
Simvastatin inhibitor – a type of lipid-lowering medication
Ikk Signaling | The IκB kinase (IkappaB kinase or IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.
At406 Antagonist – constitutive activity
Microtubule receptor | Diisopropylfluorophosphate (DFP) is shown as an example of an irreversible protease inhibitor in the figure above right.
BLU9931 inhibitor – inhibited FGFR4
Epz004777 Inhibitor – Many poisons produced by animals or plants are enzyme inhibitors that block the activity of crucial enzymes in prey or predators.
Quizartinib – Flt3 mutations are among the most common mutations in acute myeloid leukaemia due to internal tandem duplication of Flt3.
CXCR Signaling | MIF is an additional ligand of CXCR4.
Ha 1077 Inhibitor – Fasudil (INN) is a potent Rho-kinase inhibitor and vasodilator.
Aprepitant antagonist – used together with ondansetron and dexamethasone.
Pak Signals | PAK1 localizes in distinct sub-cellular domains in the cytoplasm and nucleus.
Cathepsin K | Cathepsin K is a cysteine protease expressed predominantly in osteoclasts
Bibr953 Inhibitor – bleeding and gastritis
Rg108 Inhibitor – Reserpine is a prototypical example of a vesicular reuptake inhibitor.
GDC-0152 antagonist – We previously reported that GDC-0152 induced apoptosis in HL-60 cells in a caspase-dependent manner.
Sepantronium Inhibitor – The mechanism of DNA damage by YM155 is still unknown.
Upr Inhibitors – The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum.
Oligomycin a inhibitor – Oligomycin A is an inhibitor of ATP synthase. In oxidative phosphorylation research, it is used to prevent state 3 (phosphorylating) respiration.
URMC-099 inhibitor – URMC-099 may have potential as a neuroprotective treatment in MS.
Mek Receptor | A 2007 experiment examined the way in which bottom-up and top-down processes affect attention during IOR.
E1activating Signaling | In signal processing, a signal is a function that conveys information about a phenomenon.
High-throughput Screenings | Automation is an essential element in HTS's usefulness.
UK5099 inhibitor – The abnormal folliculogenesis by UK5099 was partially rescued by alpha-ketoglutarate and succinate, intermediate metabolites in the TCA cycle
Mirna-2 | Folic acid is the oxidised form of the substrate of dihydrofolate reductase, an enzyme that is potently inhibited by methotrexate.
Gprotein Inhibitor | The Rab family of proteins is a member of the Ras superfamily of small G proteins.
Ferrostatin-1 inhibitor – Ferroptosis is initiated by the failure of the glutathione-dependent antioxidant defenses, resulting in unchecked lipid peroxidation and eventual cell death.
Onc201 Inhibitor – Onc201 is active against cancer stem cells and blocks cancer stem cell gene signatures.
Ly2886721 Inhibitor – BACE1 is an aspartic acid protease important in the formation of myelin sheaths in peripheral nerve cells.
Torin2 inhibitor – Molecular Target Validation of Aspartate Transcarbamoylase from Plasmodium falciparum by Torin 2
ARQ 531 Inhibitor – ARQ 531 also offers a definite kinase selectivity profile
Sb505124 Inhibitor – SB431542 can be used in combination with LDN193189, CHIR99021 and DAPT to transform astrocytes into neurons.
Compound401 Inhibitor – Compound 401 can be a synthetic inhibitor of DNA-PK and mTOR
Ripretinib inhibitor – inhibits the activity of the kinases KIT and PDGFRA
Zebularine Inhibitor – Zebularine is a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates.
Deferoxamine Inhibitor – Deferoxamine is a siderophore from the bacteria Streptomyces pilosus.
Abemaciclib Inhibitor – a CDK inhibitor
Ag 014699 Inhibitor – Ag 014699 is a first-in-class pharmaceutical drug targeting the DNA repair enzyme poly-ADP ribose polymerase-1.
Orlistat inhibitor – the saturated derivative of lipstatin
AZD8055 inhibitor – AZD8055 is a novel ATP-competitive mTOR inhibitor
Dup753 Antagonist – An inverse agonist can have effects similar to those of an antagonist.
Pdgfr Signal | Small-molecule anti-genomic therapeutics, or SMAT, refers to a biodefense technology that targets DNA signatures found in many biological warfare agents.
Seliciclib Inhibitor – B cell lymphomas
Tat-beclin 1 Activator – Tat-beclin 1 markedly inhibits Aids-1 replication in primary human monocyte-derived macrophages
D-lin-mc3-dma0 – heat labile
BVD-523 – Ulixertinib has an acceptable safety profi le with favorable pharmacokinetics.
ISX-9 activator – ibotenic acid and muscimol
Mitophagy Signaling | Two of the primary active constituents of the medicinal herb Hypericum perforatum (St. John's Wort) are hyperforin and adhyperforin.
Sodiumvalproate inhibitor – Common side effects of valproate include nausea, vomiting, somnolence, and dry mouth.
Busulfan chemical – It is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates.
Dnapk Receptor – Many proteins have been identified as substrates for the kinase activity of DNA-PK.
Ver155008 Inhibitor – ACE Inhibitors reduce plasma norepinephrine levels.
CH-223191 | Uncompetitive inhibitors only bind once the substrate is bound, fully disrupting catalysis, and mixed inhibition is similar but with only partial disruption of catalysis.
DHA inhibitor – It is sold commercially in combination with piperaquine and has been shown to be equivalent to artemether/lumefantrine.
CGS20267 inhibitor – used in the treatment of breast cancer
Mdv3100 Antagonist – Mdv3100 is an antiandrogen, and acts as an antagonist of the androgen receptor.
Valproicacid inhibitor – They can be given intravenously or by mouth, and the tablet forms exist in both long- and short-acting formulations.
Dibutyryl cAMP Activator – cAMP is only able to elicit minimal responses in situations.
SH-4-54 inhibitor – SH-4-54 could increase mitoSTAT3 transmembrane import via GRIM-19 and reinforce the association between mitoSTAT3 and mitochondrial transcription factor A (TFAM)
666-15 inhibitor – Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666- 15
BAY11-7082 inhibitor – It has been shown that administration of BAY 11-7082 rescued renal functionality in diabetic-induced Sprague-Dawley rats by suppressing NF-κB regulated oxidative stress.
VS-4718 inhibitor – VS-4718, a novel inhibitor of focal adhesion kinase (FAK), was tested against the Pediatric Preclinical Testing Program's (PPTP's) in vitro cell line panel and showed a median relative ...
Homoharringtonine Inhibitor – treatment of CML
Gsk2334470 Inhibitor – ACE inhibitors decrease the formation of angiotensin II, a vasoconstrictor, and increase the level of bradykinin, a peptide vasodilator.
SB415286 inhibitor – Study of GSK3b inhibitors SB415286 and SB216763 to improve osteoblastic differentiation on microstructured titanium
MAP4K Receptor | MAP4K is a family of proteins involved in cellular signal transduction
Idoxuridine chemical – It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks ...
Autophagy Signal | In crinophagy, unnecessary secretory granules are degraded and recycled.
Etoposide Chemical – organic solvents
Parp Receptor | Compounds in which components share electrons are known as covalent compounds.
Resminostat Inhibitor – histone deacetylases
Jhu 083 Antagonist – Antagonist drugs interfere in the natural operation of receptor proteins.
Cetuximab inhibitor – Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion.
Tyrphostin 9 inhibitor – inhibits tyrosine kinases
Vinorelbine inhibitor – This includes breast cancer and non-small cell lung cancer.
TVB-3664 inhibitor – novel fatty acid synthase inhibitor
Pexmetinib Inhibitor – treatment of gynecomastia
BAY 87-2243 inhibitor – BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I
Adagrasib Inhibitor – Adagrasib is an inhibitor of the RAS GTPase family.
Hydroxychloroquine Inhibitor – itching and headache
Doxorubicin Inhibitor – breast cancer
Zanubrutinib Inhibitor – BTK inhibitor
GAP 26 agonist – a gap junction inhibitor
RK-33 inhibitor – RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X
Chir 265 Inhibitor – Subsequent to the synthesis, the racemic biaryl is resolved by classical methods.
Lovastatin Inhibitor – Common side effects include diarrhea, constipation, headache, muscles pains, rash, and trouble sleeping.
Eht1864 Inhibitor – protein aggregation
Adenosinekinase Signal | Other members of this family (also known as the RK family) include ribokinase (RK), inosine-guanosine kinase, fructokinase, and 1-phosphofructokinase.
LTX-315 Modulator – LTX-315 has been shown to induce the death of lymphoma cells within 4 h
UPF1069 Inhibitor – UPF-1069 may be a valuable tool to examine the different roles of PARP isoenzymes
Lys05 inhibitor – Lys05 – A Promising Autophagy Inhibitor in the Radiosensitization Battle: Phosphoproteomic Perspective
Rgs Receptor | RGS proteins have been conserved in evolution.
Pax Signals | A few of the selective serotonin reuptake inhibitors (SSRIs) such as the dextro-enantiomer of citalopram appear to be allosteric reuptake inhibitors of serotonin.
Camk Kinases | The catalytic core is typically composed of β-strands with the substrate binding site composed of α-helices.
Tp 0903 Inhibitor – Tp 0903 is expected to enter Phase 1 clinical trial in November 2016.
Albiglutide chemical – the treatment of type 2 diabetes
Vda Signaling | Extending the distance of the video signal is the main purpose of the VDA.
Sta 4783 Modulator – triggers apoptosis
Mlck Signaling | Binding of calcium ion to this domain increases the affinity of MYLK binding to myosin light chain.
IDO-in-2 inhibitor – considered a therapeutic target in cancer
Ltr Signal | All retroviral genomes are flanked by LTRs, while there are some retrotransposons without LTRs.
ARN-509 inhibitor – It is specifically indicated for use in conjunction with castration in the treatment of non-metastatic castration-resistant prostate cancer (NM-CRPC).
Ca3 Inhibitor – CA3 has been implicated in a number of working theories on memory and hippocampal learning processes.
Tno155 Inhibitor – A combination of ACE inhibitor with other drugs may increase effects of these drugs, but also the risk of adverse effects.
Arq621 Inhibitor – reduce goiter
Fgf401 Inhibitor – tissue areas that are devoid of vasculature
P-gp Receptor | Catch trials in which no target is presented occur with probability of 0.2. Participants had to respond to the target as quickly as possible by pressing a specified key.
Nlrp3 Receptor | Activated NLRP3 in turn triggers an immune response.
Cetp Signal | As an active transport mechanism, exocytosis requires the use of energy to transport material.
Endocrinology Receptor | Endocrine glands are regarded as ductless glands.
Irinotecan Inhibitor – cytotoxic alkaloid
Carfilzomib Inhibitor – analog of epoxomicin
Faah Signal | Broader definitions of chemicals or chemical substances can be found.
Mmpl3 Signaling | Some can inhibit a specific function of a protein or disrupt protein–protein interactions.
Nilotinib Inhibitor – Nilotinib is a medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome.
Pyrrolidine Dithiocarbamate – Pyrrolidine dithiocarbamate binds zinc such that the resulting complex can enter the cell and inhibit viral RNA-dependent RNA polymerase.
Vandetanib inhibitor – It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor
Ulk 101 Inhibitor – activate autophagy
Compstatin Inhibitor – similar entropies
Carboplatin inhibitor – treat ovarian cancer
Mkc 3946 Inhibitor – kinase domain
T 705 Inhibitor – generic drug
Fenebrutinib inhibitor – a randomized phase 2 trial
Azd8330 Inhibitor – COX 1 promotes the production of the natural mucus lining that protects the inner stomach and contributes to reduced acid secretion and reduced pepsin content.
Bms 540215 Inhibitor – hepatocellular carcinoma
Thiametg Inhibitor – low blood pressure
Deucravacitinib Inhibitor – allosteric inhibitor
Torin1 Inhibitor – Torin-1 shows activity against neuropathic pain.
YM 90709 Inhibitor – YM-90709 inhibited IL-5-prolonged eosinophil survival
Imatinib inhibitor – targeting multiple receptor tyrosine kinases
Myci361 Inhibitor – greater efficacy
Pi3k Inhibitors – PI3K inhibitors block the PI3K/AKT/mTOR pathway and thus slow down cancer growth.
Hdac Assay | TMP195 and JM63 are the most potent HDAC7 inhibitors.
Sofosbuvir inhibitor – taken by mouth
Cathepsin B Signals | Cathepsin B is synthesized on the rough endoplasmic reticulum as a preproenzyme of 339 amino acids with a signal peptide of 17 amino acids.
LY2835219 Inhibitor – It was developed by Eli Lilly and it acts as a CDK inhibitor selective for CDK4 and CDK6.
G007 lk Inhibitor – hormone therapy
Cabozantinib inhibitor – inhibits AXL and RET – Just another WordPress site
PF-04929113 inhibitor – PF-04929113 administered orally twice weekly is well tolerated and inhibits its intended target Hsp90.
3 typ inhibitor – Tyrosinase carries out the oxidation of phenols such as tyrosine and dopamine using dioxygen.
MGCD0103 inhibitor – One clinical trial (for refractory follicular lymphoma) was temporarily put on hold due to cardiac problems but resumed recruiting in 2009.
Byl719 Inhibitor – BYL719 is an alpha-specific PI3K inhibitor.
Mg-132 inhibitor – It belongs to the class of synthetic peptide aldehydes.
Stat Receptor – STAT protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation.
Dihydroartemisin ininhibitor – Dihydroartemisinin is the active metabolite of all artemisinin compounds
Pinometostat inhibitor – Pinometostat is a first-in-class small-molecule inhibitor of the histone methyltransferase disrupter of telomeric silencing 1-like (DOT1L).
Akt Signals | Fitting these data to a rate equation gives the rate of inactivation at this concentration of inhibitor.
Bioactive Compound Library | Bioactive compounds are commonly derived from plants, animal products, or can be synthetically produced.
Pi 103 Inhibitor – targeted therapy
Autophagy inhibitors – The first autophagy genes were identified by genetic screens conducted in Saccharomyces cerevisiae.
A 1331852 Inhibitor – A 1331852 inhibitor is a target of various senolytic agents.
Ds1001 Inhibitor – Proton pump inhibitors are well tolerated.
Autophagy inhibitor – Four forms of autophagy have been identified: macroautophagy, microautophagy, chaperone-mediated autophagy (CMA), and crinophagy.
Bosutinib inhibitor – an ATP-competitive Bcr-Abl tyrosine-kinase inhibitor
Er stress inhibitor | PERK dimerizes with BiP in resting cells and oligomerizes in ER-stressed cells.
A-1155463 inhibitor – A-1155463, a highly potent and selective BCL-XL inhibitor, was discovered through nuclear magnetic resonance (NMR) fragment screening and structure-based design.
G Protein Inhibitors – G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors.
Iwp 2 Inhibitor – The inhibitor can bind to a site remote from the enzyme active site.
Merestinib Inhibitor – billiary tract cancer
Erk Receptor | Pure vesicular reuptake inhibitors tend to actually lower synaptic neurotransmitter concentrations, as blocking the repackaging of, and storage of the neurotransmitter in question leaves ...
Acyltransferase Receptor | inhibitors reduce the compatibility of substrate and enzyme and this leads to the inhibition of Enzyme-Substrate complexes' formation
GDC-0853 inhibitor – Bruton's tyrosine kinase
Chk receptor | A few of the selective serotonin reuptake inhibitors (SSRIs) such as the dextro-enantiomer of citalopram appear to be allosteric reuptake inhibitors of serotonin.
Jak signals | An inhibitor of JAK2-STAT5, AZD1480, was pointed as having activity in primary and CRPC.
Hygromycin B Inhibitor – aminoglycoside kills bacteria
Gaba Receptor | The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid
Mrtx849 Inhibitor – Mrtx849 is an anticancer medication used to treat non-small cell lung cancer.
P5091 Inhibitor – Cells were treated with the P5091 inhibitor.
Cp 456773 Inhibitor – Enzyme inhibitors play an important role in all cells.
AM095 Antagonist – AM095, a specific LPAR1 inhibitor
A 485 Inhibitor – drug interactions
KU-55933 Inhibitor – Succinate levels were increased by KU-55933 levels and decreased by metformin.
EMD1214063 Inhibitor – EMD 1214063 is really a potent and selective c-Met inhibitor
Nutlin-3a Inhibitor – Nutlin-3 has been shown to affect the production of p53 within minutes.
Dyngo-4a inhibitor – inhibited TSH upregulation of TG and TPO mRNAs
Aromatase Receptor | Aromatase is an enzyme responsible for a key step in the biosynthesis of estrogens.
Mdivi 1 Inhibitor – Mdivi 1 exists as homooligomers and its function relies on its oligomerization ability.
Dznep inhibitor – Studies have shown that it has in vitro against a variety of different tumor cell lines.
PND-1186 inhibitor – PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments
Ars853 Inhibitor – Reserpine is an irreversible inhibitor of the vesicular monoamine transporter 2, and is a prototypical example of a vesicular reuptake inhibitor.
Santacruzamatea inhibitor – Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity
Pfk15 Inhibitor – PFK-2 undergoes covalent modification through phosphorylation/dephosphorylation based on the cell's hormonal signaling.
AZD5363 inhibitor – AZD5363 also significantly enhanced the antitumor activity of docetaxel, lapatinib, and trastuzumab in breast cancer xenografts.
Thiomyristoyl Inhibitor – Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine.
E7080 inhibitor – Lenvatinib is absorbed quickly from the gut, reaching peak blood plasma concentrations after one to four hours.
ACP-196 – It is a second generation Bruton's tyrosine kinase inhibitor.
Enoblock inhibitor – ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase.
BAY-1895344 inhibitor – exhibited strong monotherapy efficacy in cancer xenograft models
3-methyladenine inhibitor – DNA bases are subject to a large number of anomalies: spontaneous alkylation or oxidative deamination.
Tigecycline inhibitor – It is a glycylcycline administered intravenously.
STF-31 inhibitor – a re-evaluation
S63845 – Diagnosis of DLBCL is made by removing a portion of the tumor through a biopsy.
Amuvatinib Inhibitor – TKIs are typically used as anticancer drugs.
Mapk Inhibitors – The signal that starts the MAPK/ERK pathway is the binding of extracellular mitogen to a cell surface receptor.
Geldanamycin inhibitor – HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
Incb28060 Inhibitor – TKIs are typically used as anticancer drugs.
R406 Inhibitor – R406 blocks the activity of the enzyme spleen tyrosine kinase.
SHP099 inhibitor – SHP099 is a potent, selective, highly soluble, orally bioavailable, and efficacious SHP2 inhibitor
Lbh589 inhibitor – Panobinostat is used in combination with the anti-cancer drug bortezomib and the corticoid dexamethasone for the treatment of multiple myeloma in adults who had received at least two ...
Memantine Antagonist – modest improvement
Cell Cycle Inhibitors – The cell-division cycle is a vital process by which a single-celled fertilized egg develops into a mature organism.
CellCycle Receptor | DNA replication occurs during the C period.
Ptc124 Inhibitor – When an enzyme has multiple substrates, inhibitors can show different types of inhibition depending on which substrate is considered.
Lgk 974 Inhibitor – LGK 974 investigated for influencing cardiac tissue remodelling following infarction.
Sgk Signaling | This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK).
XMU-mp-1 Inhibitor – XMU-MP-1 treatment inhibited MOB1 phosphorylation.
Daporinad Inhibitor – The metabolites were identified by ultra-high-performance liquid.
Mitomy C Incinhibitor – glaucoma surgery
Pd0325901 inhibitor – PD0325901, SB431542 and CHIR99021 in combination could significantly inhibit cell growth, suppress expression of pluripotency and EMT‑related genes, curb cell migration, cause cell ...
Antineoplasticandi | Phospholipids consist of glycerol that is linked to a phosphate group and two hydrocarbon chains
AZD8931 inhibitor – AZD8931 significantly suppressed cell growth of IBC cells and induced apoptosis of human IBC cells in vitro.
Thrombin Signal | Thrombin is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.
MCC950 inhibitor – MCC950 has been proposed as a specific small molecule inhibitor that can selectively block NLRP3 inflammasome activation.
Pf 06826647 Inhibitor – neural tone
Lonafarnib Inhibitor – Lonafarnib is an oral medication that helps prevent the buildup of defective progerin or progerin-like protein.
AZD2171 inhibitor – AstraZeneca completed a phase III trial comparing the efficacy of cediranib alone and cediranib with lomustine to the efficacy of lomustine alone in patients with recurrent glioblastoma....
Pkc signal | Some of these natural inhibitors, despite their toxic attributes, are valuable for therapeutic uses at lower doses.
Adiporon agonist – activates AMPK and PPARα signaling
Sr 717 Agonist – acute pain
Wzb117 Inhibitor – Low concentrations of metformin and buformin alone or in combination with WZB-117 do not impair mitochondrial function nor induce cell death.
Microrna-2 | MiRNAs are abundant in many mammalian cell types and as extracellular circulating miRNAs.
Sr90090 – research drug
Cyclo inhibitor – A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
JPH203 inhibitor – JPH203 has the capability to inhibit LAT1 function through preincubation effects.
Arry 575 Inhibitor – inactive form
Pacritinib Inhibitor – Pacritinib is an anti cancer medication used to treat myelofibrosis.
SB1518 inhibitor – mainly inhibits Janus kinase 2
Mixed lineage kinase receptor | Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene.
Fer-1 inhibitor – Since ferroptosis is a form of regulated cell death, some of the molecules that regulate ferroptosis are involved in metabolic pathways that regulate cysteine exploitation, glutathione ...
BMS202 inhibitor – BMS202 inhibits PD-1 and PD-L1 binding with an IC50 of 0.018 M in an HTRF binding assay.
Cortisol Agonist – Cortisol has a permissive effect on the actions of hormones that increase glucose production, such as glucagon and adrenaline.
Lomeguatrib Inhibitor – cardiovascular benefit
FHPI inhibitor – FHPI is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in ...
Y-39983 inhibitor – Y-39983, a selective Rho-kinase inhibitor, attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination
Lorlatinib Inhibitor – liver enzymes
AP24534 inhibitor – Some forms of CML, those that have the T315I mutation, are resistant to current therapies such as imatinib.
Obeticholic Agonist – first FXR agonist
AZD2014 inhibitor – AZD2014 was more efficacious than rapamycin in inhibiting migration, invasion and EMT progression in Doc-sensitive and Doc-resistant CRPC cells.
Vitamin B3 inhibitor – includes three forms or vitamers
Hippo Inhibitor | The Hippo signaling pathway appears to be highly conserved.
BEZ235 – It has been shown to be toxic to Waldenström's macroglobulinemia cells.
Egfr Signals | Most reversible inhibitors bind in the active site of enzymes.
Mrt68921 inhibitor – Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities
Mapk Inhibitor | A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine.
Elafibranor agonist – Elafibranor is an experimental medication that is being studied and developed by Genfit for the treatment of cardiometabolic diseases including diabetes, insulin resistance, dyslipidemia,...
Antibiotics Signals | Enzymes differ from most other catalysts by being much more specific.
Bi d1870 Inhibitor – Some proteins act as enzyme inhibitors.
Taselisib Inhibitor – Taselisib is a small molecule phosphoinositide 3-kinase inhibitor targeting the PI3K isoform p110α (PIK3CA).
Emricasan – Conatus in turn licensed emricasan to Novartis in 2017 for exclusive development and commercialization.
tie-2 signaling | This ensures that the inhibitor exploits the transition state stabilising effect of the enzyme, resulting in a better binding affinity (lower Ki) than substrate-based designs.
Rrx 001 Inhibitor – Important amino acid residues in the esteratic site are a glutamate, a histidine, and a serine.
ACY-1215 inhibitor – ACY-1215 suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways
Fpr Signaling | Coordination complexes are distinct substances with distinct properties different from a simple mixture.
Ac Devd Choinhibitor – XIAP binds and inhibits initiator caspase-9, which is directly involved in the activation of executioner caspase-3.
Her2 Signaling | Evidence has implicated HER2 signaling in resistance to the EGFR-targeted cancer drug cetuximab.
Ogg1 Signaling | Ogg1 is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene.
Pu h71 Inhibitor – Pu h71 has been found to have a preferential binding to Hsp90.
Hormones inhibitors – Hormones are used to communicate between organs and tissues.
Dnapk Signaling | Plant growth regulators, or plant hormones, move through cells or by diffusing through the air as a gas to reach their targets.
Ckit Signal | Multiple transcript variants encoding different isoforms have been found for this gene.
Cilengitide inhibitor – It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor ...
Ethosuximide Inhibitor – absence seizures
Deferasirox chemical – the first oral medication approved in the United States
Chk2 Inhibitori – DNA repair
Tariquidar inhibitor – Tariquidar (INN/USAN) is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer.
Inhibitor Libraries | Biotechnology is the use of cells or organisms to develop products for humans.
Eif Receptor | Standard reuptake inhibitors are believed to act simply as competitive substrates that work by binding directly to the plasmalemma transporter of the neurotransmitter in question
Il Receptor Signal | IL-1R is a cytokine receptor which binds interleukin 1.
Batimastat Inhibitor – Batimastat was the first MMPI that went into clinical trials.
PX-478 Inhibitor – PX-478 decreased HIF-1α protein in PC3 and DU 145 cells.
Nsc113928 Agonist – sleep disorders
Oxaliplatin Inhibitor – folinic acid
Compound991 Activator – Regulation of AMPK by CaMKK2 requires a direct interaction of these two proteins via their kinase domains.
JQEZ5 inhibitor – Enzyme inhibitors are a chemically diverse set of substances that range in size from organic small molecules to macromolecular proteins.
Pyroptosis Signaling | Pyroptosis can take place in immune cells and is also reported to occur in keratinocytes and some epithelial cells.
Srebp Signal | SCAP is an integral membrane protein located in the endoplasmic reticulum
TBK1/IKKε-IN-1 activator – TBK1 and IKKε
P450 signals | For example, extremes of pH or temperature usually cause denaturation of all protein structure, but this is a non-specific effect.
Apixaban inhibitor – used to treat and prevent blood clots
Almorexantant agonist – acting as a competitive antagonist of the OX1 and OX2 orexin receptors
Roblitinib Inhibitor – catalyzes a key aromatization step
Sbc 115076 Antagonist – A receptor may contain one or more binding sites for different ligands.
Ostarine Modulator – treatment of conditions
Ehop-016 inhibitor – The Rac inhibitor EHop-016 was developed as a compound with the potential to inhibit cancer metastasis.
Jak receptor | The name is taken from the two-faced Roman god of beginnings, endings and duality, Janus, because the JAKs possess two near-identical phosphate-transferring domains.
Cytoskeletal Signaling Inhibitor | A multitude of functions can be performed by the cytoskeleton.
STZ inhibitor – Since it carries a substantial risk of toxicity and rarely cures the cancer, its use is generally limited to patients whose cancer cannot be removed by surgery.
Wortmann Ininhibitor – Wortmann has an in vitro inhibitory concentration of around 5 nM.
WNT-c59 – For a cell therapy against damaged corticospinal tract caused by neurodegenerative diseases or insults.
Fgfr Signal | The inhibitor binds tightly to trypsin, preventing the trypsin activity that would otherwise be detrimental to the organ.
Buparlisib – It is a small molecule orally-available pan-class I phosphoinositide 3-kinase inhibitor.
Sodium Channel Signal | Sodium channels are highly selective for the transport of ions across cell membranes.
AZD6738 – It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint.
Wnt Inhibitors – Just another WordPress siteWnt signaling pathways use either nearby cell-cell communication or same-cell communication.
Procollagencprotei Signals | In slime moulds, individual cells known as amoebae aggregate together to form fruiting bodies and eventually spores, under the influence of a chemical signal, originally named ...
Nitazoxanide inhibitor – It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza....
Trichostatin A Inhibitor – TSA is an organic compound that serves as an antifungal antibiotic.
SCR7 inhibitor – NHEJ inhibitor SCR7 and its different forms: Promising CRISPR tools for genome engineering
Nintedanib inhibitor – used for the treatment of idiopathic pulmonary fibrosis
Trans Isomer – Cis and trans isomers occur both in organic molecules and in inorganic coordination complexes.
Pi 3065 Inhibitor – Akt2 is an important signaling molecule in the insulin signaling pathway.
Glpg0634 Inhibitor – The signal transmission of large numbers of proinflammatory cytokines is dependent on JAK1.
PF-00299804 Inhibitor – It is a selective and irreversible inhibitor of EGFR.
Neuronal signaling inhibitors | A neuron or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses.
DMXAA chemical – Vadimezan was discovered by Bruce Baguley and William Denny and their teams at the Auckland Cancer Society Research Centre at the University of Auckland in New Zealand.
Birinapant – Birinapant bound to the BIR3 domains of cIAP1.
Nsc23766 Inhibitor – Consequently is a potent neurotoxin, with a lethal dose of less than 100 mg.
Neprilysin Receptor | Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins,...
Acadesine Activator – Acadesine has been used clinically to treat and protect against cardiac ischemic injury.
Sodium Channel Receptor | Sodium channels are highly selective for the transport of ions across cell membranes.
G Protein Inhibitor | In general, protein synthesis inhibitors work at different stages of bacterial mRNA translation into proteins.
Tozasertib Inhibitor – PDE4 is the major cAMP-metabolizing enzyme found in inflammatory and immune cells.
Rimonabantant Agonist – Antagonists bind directly to receptors in the synaptic cleft, effectively blocking neurotransmitters from binding.
Rg 7388 Inhibitor – RG7388 are several derivatives of nutlin.
LM10 inhibitor – A metsulfuron-methyl-resistant bacterium Lm10 was isolated from metsulfuron-methyl contaminated soil.
Bms-777607 Inhibitor – In uncompetitive inhibition,the inhibitor binds only to the enzyme-substrate complex.
Epoxomicin inhibitor – Epoxomicin was originally discovered in 1992.
Melk Receptor | MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases.
Bcr-abl Signal | A well-characterised example of this is the ribonuclease inhibitor, which binds to ribonucleases in one of the tightest known protein–protein interactions
R 51619 Agonist – R 51619 is another hERG blockers
Cudc 907 Inhibitor – CUDC-907 is being evaluated in two separate clinical trials for the treatment of refractory.
Fao Signal | A ubiquitous example of a hydrogen bond is found between water molecules.
Pci-34051 inhibitor – HDAC8-inhibitor PCI-34051-induced exosomes inhibit human bronchial smooth muscle cell proliferation via miR-381-3p mediated TGFB3
PDGF Receptor | There are two forms of the PDGF-R, alpha and beta each encoded by a different gene.
Tak1 Signal | TAK1 is an evolutionarily conserved kinase in the MAP3 K family and clusters with the tyrosine-like and sterile kinase families.
ARQ-087 inhibitor – inhibits FGFR signaling
FGFR signaling | Irreversible inhibitors covalently bind to an enzyme, and this type of inhibition can therefore not be readily reversed.
Phosphatases | A phosphatase is an enzyme
SGC0946 inhibitor – inhibit DOT1L in vitro
SMS201995 inhibitor – a more potent inhibitor of growth hormone
CDKI-73 inhibitor – CDKI-73 induced cancer cells undergoing apoptosis through transcriptional downregulation of anti-apoptotic proteins Bcl-2, Mcl-1 and XIAP by majorly targeting CDK9.
Azd8186 Inhibitor – Azd8186 Inhibitor is PIK3CB and PIK3CD inhibitor.
Immunology inhibitor | Immunology has importance in reproductive medicine as the physical, chemical, and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo....
Gdc 0994 Inhibitor – The glycolytic pathway is a classic example.
Imi28 Inhibitor – gastric cancer
Bmn673 inhibitor – The most serious side effects in studies were related to the blood forming system and included anaemia (low red blood cell count), neutropenia (low neutrophil blood cell count) and thrombocytopenia ...
Novobioc ininhibitor – produced by the actinomycete Streptomyces niveus
Gsk621 Activator – Activators can have allosteric sites that are responsible for turning the activators themselves on and off.
Dc661 Inhibitor – safer alternative
Bptes Inhibitor – treatment of edema
CHD1Li 6.11 inhibitor – an orally bioavailable antitumor agent
Streptozotocin inhibitor – It is used in medicine for treating certain cancers of the islets of Langerhans and used in medical research to produce an animal model for hyperglycemia and Alzheimer's in a ...
AZ 960 Inhibitor – AZ 960 induces apoptosis and growth arrest
M4344 Inhibitor – ATR is activated in response to persistent single-stranded DNA.
Captisol Inhibitor – improve solubility
Blebbistat ininhibitor – Blebbistatin has been especially useful in optical mapping of the heart, and its recent use in cardiac muscle cell cultures has improved cell survival time.
CHIR-98014 inhibitor – The GSK-3 inhibitor CHIR-98014 similarly downregulated SHH-driven proliferation.
Vericiguat Modulator – Common side effects include low blood pressure and low red cell count (anemia).
Transferase Signal | Transferases are involved in myriad reactions in the cell.
Rnr Receptor | RNR is the enzyme responsible for converting NTPs to dNTPs.
Gpcr Inhibitor | G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates,and animals.
Aspirin inhibitor – Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk.
AZD4547 – AZD4547 inhibited recombinant FGFR kinase activity in vitro and suppressed FGFR signaling and growth in tumor cell lines with deregulated FGFR expression.
Bmi1 Receptor | Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-...
KPT-335 inhibitor – KPT-335 , a Selective Inhibitor of Nuclear Export, Reduces Respiratory Syncytial Virus Replication In Vitro
Isoxazole activator – an oxygen atom next to the nitrogen
Veliparib inhibitor – Veliparib may make whole brain radiation treatment work more effectively against brain metastases from NSCLC.
GF120918 inhibitor – GF120918 potently reversed resistance completely for all drugs.
Tucidinostat inhibitor – Tucidinostat is being researched as a treatment for pancreatic cancer.
Ruxolitinib inhibitor – a type of myeloproliferative neoplasm that affects the bone marrow
ACY-738 inhibitor – ACY-738 delayed disease onset and reduced disease severity.
Assay Way | Enzyme assays are laboratory methods for measuring enzymatic activity.
Cox Receptor | Individual atoms can be held together by chemical bonds to form molecules and ionic compounds
Inflammation Inhibitors – Inflammation can be classified as either acute or chronic.
Protein Tyrosine Kinase Inhibitors – Tyrosine kinases belong to a larger class of enzymes known as protein kinases which also attach phosphates to other amino acids such as serine and threonine.
Gskj4 Inhibitor – Gskj4 appears to both promote and inhibit apoptosis.
Sphk Signal | Sphingolipids are ubiquitous membrane constituents of all eukaryotic cells.
Y-27632 Inhibitor – Y-27632 selectively inhibits p160ROCK, although it does inhibit other protein kinases such as PKCs at higher concentrations.
BV-6 inhibitor – BV6 is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. ·
Pka Signals | PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
Oh Fmk Caspase Inhibitorvi – Inflammatory caspase-1 has been implicated in causing autoimmune diseases.
Sglt Signal | This also causes our attention shift to be quick for exogenous cues than for endogenous cues
Vx 803 Inhibitor – ALT pathway was extremely fragile with ATR inhibition.
Sfrp Signal | SFRPs act as soluble modulators of Wnt signaling.
S3i 201 Inhibitor – Important amino acid residues in the esteratic site are a glutamate, a histidine, and a serine.
Ftase Signal | Several FTase inhibitors are undergoing testing as anti-cancer agents.
Lsd1 Receptor | Signals can be non-chemical
JQ1 chemical – BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma.
Nf Kb Inhibitors – NF-κB plays a key role in regulating the immune response to infection.
Erdafitinib inhibitor – bile duct cancer
Midostaurin Inhibitor – oncogenic CD135
Tucatinib inhibitor – It was developed by Array BioPharma and licensed to Cascadian Therapeutics。
RJC2792 inhibitor – a type of natural phenol
Tyrosine kinases | A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell
Paxalisib inhibitor – Genome and RNA expression were used to further guide treatment strategies with targeted agents such as dual PI3K/mTOR inhibitor paxalisib.
BMS-907351 – It is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET.
Infliximab inhibitor – Common side effects include infections, acute infusion reactions, and abdominal pain.
Bemcentinib inhibitor – an inhibitor of AXL kinase
Celecoxib Inhibitor – generic medication
RP13057 Inhibitor – RP 13057 is really a topoisomerase II inhibitor that induces apoptosis.
RO91978 chemical – a tumor-selective fluoropyrimidine carbamate
Pomalidomide Chemical – anti angiogenic
Cb 5083 Inhibitor – The N-terminal peptide is cleaved from the zymogen enzyme precursor by another enzyme to release an active enzyme.
Nu7026 Inhibitor – Gyrase is an antibacterial target..
Lenvatinib inhibitor – acts as a multiple kinase inhibitor
ARQ092 Inhibitor – ARQ 092 targets the PI3K/AKT path and AKT particularly
Hedgehog signal | Although the trypsin inhibitor is a protein, it avoids being hydrolysed as a substrate by the protease by excluding water from trypsin's active site and destabilising the transition state....
VEGFR signal | This molecule is not based on a peptide and has no obvious structural similarity to a protein substrate.
Paclitaxel inhibitor – treat a number of types of cancer
Erk5 in 1 Inhibitor – KRAS mutated colorectal cancer
Eribulin Inhibitor – solid tumors
Influenzavirus Signal | The influenzavirus virion is pleomorphic.
AZ628 inhibitor – AZ628-loaded nanoparticles of CA and KA-modified CA were synthesized and evaluated in MCF-7 and 4T1 cell lines by measuring cytotoxicity and cellular uptake analysis.
XAV-939 – Progenitors are obtained by so-called direct reprogramming or directed differentiation and are also called induced somatic stem cells.
Lonidamine Modulator – discrete signal
Nivolumab inhibitor – It is a type of immunotherapy and works as a checkpoint inhibitor, blocking a signal that prevents activation of T cells from attacking the cancer.
Mp 470 Inhibitor – Acetazolamide is available as a generic medication.
SAR131675 inhibitor – Reduces the Growth of Colorectal Cance
Compound 3i inhibitor – compound 3i showed remarkable systemic inhibition in transgenic mice.
Coelenterazine inhibitor – a molecule that emits light after reaction with oxygen
Palmitoylethanolamide activator – lipid modulator
Neuro Signaling | For example, bacteria are surrounded by a thick cell wall made of a net-like polymer called peptidoglycan.
Mc180295 Inhibitor – The effect of the inhibitor is a result of the percent of the enzyme population interacting with inhibitor.
ROC-325 inhibitor – The Novel Lysosomal Autophagy Inhibitor
Clofarabine inhibitor – Clofarabine quickly kills leukaemia cells in the blood.
Cftrinh 172 Inhibitor – Cftrinh 172 is high-affinity CFTR inhibitor.
Topk Signals | In the kinetic theory of gases, the term molecule is often used for any gaseous particle regardless of its composition.
Afuresertib Inhibitor – antibiotic drug
CGP57380 Inhibitor – CGP 57380 was dependent on AKT activation for inhibition of β-catenin nuclear translocation
AZD-5153 inhibitor – AZD 5153 is a small molecule and a selective BRD4 inhibitor
Tie2 Signal | Angiopoietin proteins 1 through 4 are all ligands for Tie-2 receptors.
Msa 2 Agonist – Apomorphine, a dopamine agonist, may be used to reduce off periods and dyskinesia in late PD.
Dna alkylator | Catalysts accelerate chemical reactions.
E3 Ligase Signaling | E3 ligases interact with both the target protein and the E2 enzyme.
Dofetilide inhibitor – under the trade name Tikosyn by Pfizer
P505-15 inhibitor – P505-15 successfully inhibited SYK-mediated B-cell receptor signaling.
3-ma inhibitor – 3-MA was applied for cisplatin-resistant cells intervention, Beclin1 was knocked down by plasmid transfection. Cell cycle was detected using flow cytometry assay, apoptosis with necrosis ...
Dpp2 Signal | The binding site of inhibitors on enzymes is most commonly the same site that binds the substrate of the enzyme.
Ruboxistaurin Inhibitor – Ruboxistaurin is a member of the bisindolylmaleimide family.
PDI Signals | PDI displays oxidoreductase and isomerase properties
Dpi inhibitor – G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.
Hydrotropic Agents Receptor | To form a hydrotrope, an aromatic hydrocarbon solvent is sulfonated, creating an aromatic sulfonic acid.
Thrombin Inhibitors | Thrombin inhibitors are one type of anticoagulant medication
WIN55,212-2 Agonist – WIN 55,212-2 activates p42 and p44 MAP kinase via receptor-mediated signaling
Pj34 Inhibitor – a class of drugs
PGE2 chemical – It may be used within the vagina or by injection into a vein.
Mertk Signal | Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
LY411575 inhibitor – LY411575 is a cell-permeable γ-secretase inhibitor
Pf 00835231 inhibitor – Pf 00835231 is a prodrug with the phosphate group being cleaved in vivo to yield the active agent PF-00835231.
AL3818 inhibitor – AL3818 is a highly potent and selective VEGFR2 inhibitor with IC50 less than 1 nM.
Secukinumab Inhibitor – Secukinumab is a human IgG1κ monoclonal antibody used for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis.
MYCI975 inhibitor – Additional effects of MYCi on the tumor immune microenvironment including immune cell infiltration and upregulation of PD-L1 expression provide a rationale for combining MYCi with anti-...
Gkt137831 Inhibitor – Gkt137831 is an experimental orally bioavailable dual inhibitor of NADPH oxidase isoforms NOX4 and NOX1.
LDN-193189 – It has been researched for the treatment of fibrodysplasia ossificans progressiva.
R51211 inhibitor – used to treat a number of fungal infections
BTSA1 activator – BTSA1-induced BAX activation effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
Chloroquine activator – resistant strains
Malt1 inhibitor – Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a protein that in humans is encoded by the MALT1 gene.
LDC000067 inhibitor – LDC000067, helps to prevent from osteolytic disorders has not been fully elucidated.
Go6983 Inhibitor – Compared with adult stem cells, DFAT cells show unique advantages in abundance, isolation and homogeneity.
Verteporfin chemical – used as a photosensitizer for photodynamic therapy
Erk signal | Phencyclidine and related drugs such as benocyclidine, tenocyclidine, ketamine, and dizocilpine (MK-801), have been shown to inhibit the reuptake of the monoamine neurotransmitters.
Tomivosertib Inhibitor – vesicular reuptake
Roscovitine Inhibitor – Seliciclib is in clinical trials for B-cell lymphomas, including multiple myeloma.
CGK733 inhibitor – an inhibitor of ATM/ATR kinases
BAY 853934 Modulator – BAY 853934 stimulates production of hemoglobin and red blood cells.
Hiv Protease Signal | Each virion comprises a viral envelope and associated matrix enclosing a capsid.
Bc 2059 Antagonist – histamine receptor
Igf Protein | Approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP)
Win55 inhibitor – produces effects similar to those of cannabinoids such as THC
H3b 6527 Inhibitor – reuptake inhibitors
Tofacitinib Inhibitor – JAK inhibitor
FLT-3 Inhibitors | The drug is approved for use with a companion diagnostic.
LY294002 – LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly.
Src Signaling – Src can be activated by receptor tyrosine kinases such as EGFR and HGF receptors.
VPA inhibitor – erious side effects can include liver failure, and regular monitoring of liver function tests is therefore recommended.
Blu 285 Inhibitor – kinase inhibitor
Su5416 Inhibitor – SU5416 is a potent and selective synthetic inhibitor of the Flk-1/KDR vascular endothelial growth factor (VEGF) receptor tyrosine kinase.
Tezacaftor Modulator – CFTR protein
Laq824 Inhibitor – Studies in leukemia have indicated that the histone deacetylase inhibitor LAQ824 increases apoptosis by decreasing the expression levels of the c-FLIPs.
Chk2 Inhibitor | Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response.
JNJ-42756493 inhibitor – Fibroblast growth factor receptor
Compound 7 inhibitor – a molecule that binds to an enzyme
Mirdametinib inhibitor – inhibit MEK1 and MEK2
17-AAG – Heat shock protein 90 (HSP90), one of a family of molecular chaperones, is intimately involved in the survival of tumour cells.
Sp2509 Inhibitor – myocardial infarction
GF109203x inhibitor – GF109203X, a specific PKC inhibitor, abrogates anti-CD3 antibody-induced upregulation of CD4+ T cell adhesion to B cells
AS1842856 inhibitor – AS1842856 presents a novel proliferation inducer for the chemically defined, xeno-free expansion of hiPSC-derived CMs.
U73122 inhibitor – blocked hCG-stimulated mOMEC proliferation
Metabolism Signaling | The set of life-sustaining chemical reactions in organisms
Ml162 Inhibitor – enkephalinase inhibitors
HLS831 Inhibitor – HLS 831 inhibits basal and cyclic AMP-stimulated protein kinase activities
2 methoxyestradiol Inhibitor – breast cancer
Abbv 744 Inhibitor – BET inhibitors can be instrumental in overcoming resistance to other targeted therapies when used in combination therapies.
BAY 2402234 Inhibitor – BAY 2402234 induces differentiation and inhibits proliferation in AML cell lines
NG52 inhibitor – inhibiting Cdc28p
Igf1r Signaling | With the exception of therapeutic antibodies, many proteins are degraded if administered orally and most often cannot cross cell membranes.
Pemrametostat inhibitor – protein arginine methyltransferase 5
Dibenzazepine inhibitor – Dibenzazepine combats acute liver injury in rats via amendments of Notch signaling and activation of autophagy – Just another WordPress site
Tudca Chemical – Tudca is a naturally occurring hydrophilic bile acid which is the taurine conjugated form of ursodeoxycholic acid.
Abbv 075 Inhibitor – inflammatory conditions
Mmp signaling | The MMPs belong to a larger family of proteases known as the metzincin superfamily.
Survivin Signaling | Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase.
Srt1720 activator – In animal models of obesity and diabetes SRT1720 was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increase mitochondrial ...
Apoptosis Signal | Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer.
Selitrectinib Inhibitor – antineoplastic drugs
Auroraksp | The smallest unit of an element is an atom.
FRAX597 inhibitor – FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine
Dapagliflozin Inhibitor – hypoglycaemia
Obatoclax Antagonist – Obatoclax is an inhibitor of the Bcl-2 family of proteins.
Gsk2141795 Inhibitor – Inhibitors like TEPP modify the serine residue in the esteratic site of the cholinesterase.
Pepstatina inhibitor – It was originally isolated from cultures of various species of Actinomyces due to its ability to inhibit pepsin at picomolar concentrations.
Blasticidin S Inhibitor – Blasticidin S is a nucleoside analogue antibiotic, resembling the nucleoside cytidine.
Sr 4835 Inhibitor – About half of newborns exposed to ACE inhibitors are adversely affected, leading to birth defects.
Icg 001 Inhibitor – Icg 001 is targeted in colorectal cancer, head and neck squamous cell carcinoma.
LGX818 inhibitor – LGX818 is a small molecule BRAF inhibitor that targets key enzymes in the MAPK signaling pathway.
Beta-nicotinamide – A nicotinamide phosphoribosyltransferase with high activity was newly screened.
Gemcitabine Inhibitor – various carcinomas
PHA-848125 inhibitor – Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125
GNS-1480 inhibitor – GNS-1480 is an highly potent, mutant-selective and irreversible EGFR Tyrosine-kinase inhibitors
ALISERTIB – Alisertib is an oral aurora kinase inhibitor which has been shown to induce cell-cycle arrest and apoptosis in preclinical studies.
Hsp70 Inhibitor | Membrane-bound Hsp70s have been identified as a potential target for cancer therapies.
Rmc 4550 Inhibitor – mode of action
C.I. 75535 Inhibitor – C.I. 75535 is definitely an inhibitor of TMEM16A chloride funnel activity
Syn-117 inhibitor – As of 2012, clinical trials to assess nepicastat as a treatment for post-traumatic stress disorder (PTSD) and cocaine dependence have been completed.
Fxr Agonists | A new class called Farnesoid X receptor (FXR) agonist
GDC-0449 – GDC-0449 is proven to be both effective and of low toxicity in several types of solid tumor In particular
Alk Signals | With high enough doses, occupation becomes as much as 80–90%.
Dpp4 Receptor | Signaling molecules can be synthesized from various biosynthetic pathways and released through passive or active transports, or even from cell damage.
PP242 inhibitor – PP242 directed at the ATP-binding pocket was generated.
Ataluren Inhibitor – Ataluren is an oxadiazole.
Epoxide Hydrolase | Grey iron metal and yellow sulfur are both chemical elements.
Fungal Signaling | Non-stoichiometric compounds are a special case.
SNX-5422 inhibitor – SNX-5422 is a direct, potent inhibitor of Hsp90 across a broad range of human cancer cell lines and causes degradation of important Hsp90 client proteins including HER2, AKT and ERK....
Cck Receptor | A group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin.
AZD2281 Inhibitor – It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
SLX-2119 inhibitor – Anti-adipogenic effects of SLx-2119, a ROCK2-specific inhibitor, in 3T3-L1 cells
Pirfenidone Inhibitor – lung fibrosis
Dovitinib Inhibitor – FGFR family
ATM signals | ATM provides functionality that uses features of circuit switching and packet switching networks.
Saracatinib inhibitor – It was originally under development for the treatment of cancer, but while it appeared promising in animal studies and was well tolerated in humans, it failed to show sufficient ...
2hydroxy 4methylthiobutanoate – organic reaction
2dg Modulator – demodulation
SEL120-34a inhibitor – SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains.
Mln8237 Inhibitor – Mln8237 was investigated as a treatment for relapsed or refractory peripheral T-cell lymphoma.
JNJ-7706621 Inhibitor – JNJ-7706621 inhibited cell growth independent of p53, retinoblastoma, or P-glycoprotein status; activated apoptosis; and reduced colony formation
Lumacaftor modulator – acts as a chaperone during protein folding
Her2 signal | HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1.
Iacs 13909 Inhibitor – Some believe ramipril's additional benefits may be shared by some or all drugs in the ACE-inhibitor class.
Isoxazole 9 antagonist – the class of compounds containing this ring
3methyl Inhibitor – dissociative effects
GW856553X inhibitor – for the treatment of facioscapulohumeral muscular dystrophy
NSC293100 inhibitor – one of the chemical compounds
Hsp receptor | While these symptoms may indicate cancer, they can also have other causes.
Ispinesib Inhibitor – Mutations in the KIF11 gene convey resistance of mitotic cell lines to inhibitors such as monastrol and STLC.
CRET Signal | structural genes encode proteins that are not involved in gene regulation.
Scarlet 808 inhibitor – NADPH oxidase isoforms NOX4 and NOX1
GSK2879552 inhibitor – The clinical activity of GSK2879552 given orally in participants with SCLC was evaluated by assessing disease control rate.
Daunorubicin Inhibitor – treating AML
Ipilimumab Inhibitor – Ipilimumab turns off this inhibitory mechanism and boosts the body's immune response against cancer cells.
SC 236 agonist – cyclooxygenase-2 or COX-2
ENMD-2076 inhibitor – ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action
CL59806 Chemical – CL 59806 inhibits the game of caspase
Vlx1570 Inhibitor – MAOIs differ by their selectivity of the MAO enzyme subtype.
Navitoclax inhibitor – In animal studies, navitoclax was found to be a senolytic agent, inducing apoptosis in senescent, but not non-senescent cells.
Palomid 529 Inhibitor – Palomid 529 inhibits proliferation
Agerafenib inhibitor – exhibited a favorable toxicity profile
Dna repair Inhibitor | In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions ...
Nf Kb Inhibitor | NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized ...
NPI-0052 inhibitor – NPI-0052 entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003.
Jnj 7706621 Inhibitor – treatment of pruritus
Zm447439 Inhibitor – regulate cell cycle
Enasidenib inhibitor – Enasidenib is a medication used to treat relapsed or refractory acute myeloid leukemia in people with specific mutations of the isocitrate dehydrogenase 2 (IDH2) gene, determined ...
KPT-8602 inhibitor – KPT-8602 can be given daily compared to the two or three times weekly regimen of selinexor
Naporafenib Inhibitor – ovarian cancer
Mivebresib Inhibitor – well tolerated
Dca Inhibitor – DCA is typically prepared by the reduction of trichloroacetic acid.
ND-646 inhibitor – Metabolic profiling identifies decreased rates of glycolysis upon GW6471 treatment, consistent with transcriptome profiling. Finally, xanthohumol, 5-(tetradecyloxy)-2-furoic acid, and ...
Momelotinib inhibitor – The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM).
PQ401 Inhibitor – PQ-401 is an IGF-1R inhibitor
UK-383367 Inhibitor – UK-383367 inhibits bovine collagen deposition
Jnk in 8 Inhibitor – The downstream molecules that are inhibited by JNK activation include NFAT4, NFATC1 and STAT3.
Fkbp Signal | At this level of inhibition, the transporter will be considerably less efficient at removing excess neurotransmitter from the synapse and this causes a substantial increase in the extracellular ...
Ikk Inhibitor Vii – The Ikk kinase enzyme complex is part of the upstream NF-κB signal transduction cascade.
PDGFR Signals | For example, in the figure showing trypanothione reductase from the human protozoan parasite Trypanosoma cruzi, two molecules of an inhibitor called quinacrine mustard are bound in its ...
AT7519 inhibitor – The cyclin-dependent kinase inhibitor AT7519 augments cisplatin's efficacy in ovarian cancer via multiple oncogenic signaling pathways
Abc294640 inhibitor – Sphingosine kinase 2 inhibitor ABC294640 suppresses neuronal excitability and inhibits multiple endogenously and exogenously expressed voltage-gated ion channels in cultured cells
Taar Signals | TAAR2–TAAR9 function as olfactory receptors for volatile amine odorants in vertebrates.
Ck 1827452 Activator – cardiac specific myosin
Colforsin | Forskolin contains some unique functional elements, including the presence of a tetrahydropyran-derived heterocyclic ring.
Olaparib Inhibitor – PARP inhibitor
CDK2-in-73 inhibitor – cell division protein kinase 2
Maraviroc Antagonist – entry inhibitor
Nepicastat inhibitor – Nepicastat is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.
Mk 5108 Inhibitor – Since the drug decreases the activity of the enzyme that halts the signal, it makes this signal last for a longer period of time.
BAY 80-6946 inhibitor – Data for safety and efficacy of copanlisib are described in the consumer-targeted FDA Drug Trial Snapshot.
Crfr Receptor | CRFRs are important mediators in the stress response.
MK-8617 modulator – Metabolic study of hypoxia-inducible factor stabilizers BAY 87-2243, MK-8617, and PT-2385 in equine liver microsomes for doping control
BAY 632521 Chemical – BAY 63-2521 constitutes the first drug of the class of sGC stimulators.
Phosphorylase Signals | The γ subunit is the site of the enzyme's catalytic activity while the other three subunits serve regulatory functions.
ERK signaling | When ATP levels rise, ATP binds an allosteric site in PFK1 to decrease the rate of the enzyme reaction; glycolysis is inhibited and ATP production falls.
Tpor Signaling | Individual atoms can be held together by chemical bonds to form molecules and ionic compounds.
Mtor Signals | A kinase that in humans is encoded by the MTOR gene.
CETP Signal | CETP is a member of a class of drugs
KU-57788 inhibitor – KU-57788 is a highly potent and selective DNA-PK inhibitor
Inflammation Inhibitors | Inflammation has also been classified as Type 1 and Type 2 based on the type of cytokines and helper T cells involved.
Microbiology Receptor | Viruses have been variably classified as organisms.
Epigenetics Inhibitors – Epigenetics is the study of stable phenotypic changes that do not involve alterations in the DNA sequence.
Oat Receptor | Two molecules of water can form a hydrogen bond between them.
Adriamycin Inhibitor – This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia.
Fk506 Inhibitor – Fk506 is an immunosuppressive drug.
Pembrolizumab Inhibitor – Pembrolizumab is given by slow injection into a vein.
MK-2206 Inhibitor – It is intended to be used with other cancer therapies that advanced tumours may become resistant to.
Taste Receptor | A type of cellular receptor which facilitates the sensation of taste.
GW610 agonist – an antitumor agent
Tanespimycin – It belongs to the family of drugs called antitumor antibiotics.
TAE226 inhibitor – TAE226 is a novel small molecule FAK inhibitor.
Gdc 0941 Inhibitor – All gdc 0941 Inhibitor that are currently approved inhibit one or more p110 isoforms of the class I PI3Ks.
Erastin activator – Cells treated with erastin are deprived of cysteine and are unable to synthesize the antioxidant glutathione. Depletion of glutathione eventually leads to excessive lipid peroxidation ...
Prep Signal | carbon can form covalent bonds with up to four other atoms
MRT 10 inhibitor – showing the capacity to abrogate the constitutive activity of Smo
Pd173074 Inhibitor – Selective FGFR inhibitors include AZD4547, BGJ398, JNJ42756493, and PD173074.
Estrogen Progestogen | A progestin is a synthetic progestogen.
Tw 37 Inhibitor – immune response
Ly2801653 Inhibitor – molecule inhibitor
Riluzole inhibitor – treat amyotrophic lateral sclerosis
NSC3590 chemical – treat colorectal cancer and pancreatic cancer
Telaglenastat Inhibitor – family Tephritidae
AZ960 inhibitor – induces growth arrest
Brusatol Inhibitor – allosteric inhibitor
Fps zm1 Inhibitor – The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains.
GSK3326595 inhibitor – GSK3326595 is a promising drug to prevent SARS-CoV-2 Omicron and other variants infection by inhibiting ACE2-R671 di-methylation
AZD5991 inhibitor – able to induce intrinsic apoptosis in cells
MLN9708 inhibitor – a type of white blood cell cancer
Ticagrelorant Agonist – Ticagrelor is a weak CYP3A4 inhibitor.
Malotilate Inhibitor – liver disease
Nsc266046 Inhibitor – treatment for depression
Plx 4720 Inhibitor – PLX4720 has good affinity for the ATP binding site partially because its anchor region.
Ha15 Modulator – device or circuit
Asunaprevir Inhibitor – Asunaprevir is an inhibitor of the hepatitis C virus enzyme serine protease NS3.
FAAH Signal | FAAH is a member of the serine hydrolase
PI3K signals | This pathway is necessary, however, to promote growth and proliferation over differentiation of adult stem cells, neural stem cells specifically.
4u8c inhibitor – attenuated joint inflammation in mice
Gs 9973 Inhibitor – Gs 9973 is an experimental drug for the treatment of various types of cancer under development by Gilead Sciences.
Co 1686 Inhibitor – potential treatment
Lalistat 2 inhibitor – lysosomal acid lipase
Resveratrol activator – Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.
Tak165 inhibitor – It completed phase I clinical trials but appears to have been discontinued, as no new information on the drug has surfaced since December 2008.
Vmat Receptor | Many drugs that target VMATs act as inhibitors and alter the kinetics of the protein.
Fluoxetine inhibitor – sed for the treatment of major depressive disorder
Ilomastat inhibitor – This chemotherapy agent is considered to have application in skincare products for its antiaging properties.
PFTA – PFTA established the first internationally recognized standard for fair trade olive oil in coordination
PF-477736 inhibitor – The BRCA2 mutated V-C8 cells were 1000 more sensitive to rucaparib cytotoxicity than their matched BRCA2 corrected V-C8.B2 cells, but no more sensitive to PF-477736 despite having ...
PF-00562271 inhibitor – led to decreased tumor growth
Baricitinib Inhibitor – serious bacterial
AGK2 inhibitor – a selective SIRT2 inhibitor
Histamine Receptor Signaling | A class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.
SB4 chemical – bone morphogenetic protein 4
Jnk Signals | TrkA can prevent p75NTR-mediated JNK pathway apoptosis.
GGTI 298 TFA inhibitor – the inhibition of the EGFR-AKT signaling pathway
Glutathione Signal | The carboxyl group of the cysteine residue is attached by normal peptide linkage to glycine.
Icotinib Inhibitor – highly selective
Ly2606368 Inhibitor – Research continues into the efficacy of ly2606368 in treatment of acute myeloid leukemia.
Bromosporine Inhibitor – A key step for the regulation of glycolysis is an early reaction in the pathway catalysed by phosphofructokinase-1.
MK-1775 Inhibitor – MK-1775 Inhibitors are enzymes responsible for the activation of many proteins by signal transduction cascades.
GPCR inhibitors | G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals.
Mk 0518 Inhibitor – Mk 0518 has been synthesized in several ways, which have been reviewed.
Cp 91149 Inhibitor – anxiety disorders
Nvp lde225 Antagonist – Lde225 are an important class of anti-cancer drugs.
Nampt Receptor | The NAMPT inhibitor FK866 has been shown to inhibit epithelial–mesenchymal transition (EMT), and may also inhibit tumor-associated angiogenesis.
Mi-2 inhibitor – Autoantibodies to Mi-2 alpha and Mi-2 beta in patients with idiopathic inflammatory myopathy
Ezh12 Signals | Inside the cell, nucleotidases may help to maintain energy levels under stress conditions.
Histamine Receptor | Many drug molecules are enzyme inhibitors, so their discovery and improvement is an active area of research in biochemistry and pharmacology.
Venetoclax Inhibitor – a BH3 mimetic
Nintedanib Ethanesulfonate – combination with docetaxel
BI-3406 inhibitor – Effective in KRAS-Driven Cancers through Combined MEK Inhibition
FB23-2 inhibitor – inhibit FTOs mA demethylase activity
R428 Inhibitor – R428 is an experimental oral small molecule that is an inhibitor of AXL kinase.
Enterovirus Signals | The mutations are passed on to daughter cells during mitosis
Vinblastine inhibitor – This includes Hodgkin's lymphoma, non-small cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer.
P53 Receptor | P53 is any isoform of a protein encoded by homologous genes in various organisms
Chk signal | This is usually done using a MALDI-TOF mass spectrometer. In a complementary technique, peptide mass fingerprinting involves digestion of the native and modified protein with a protease such ...
Bay63 2521 Chemical – Bay63 2521 constitutes the first drug of the class of sGC stimulators.
P2 Receptor Signal | P2Y family has 8 receptors.
MRT67307 inhibitor – The non-specificity of MRT67307 and phospho-CYLD specific antibodies.
Tubastatina Inhibitor – The substrate and inhibitor cannot bind to the enzyme at the same time.
Endocrinology Inhibitors – Hormones have many different functions and modes of action.
Gedatolisib Inhibitor – Gedatolisib binds to mTOR to inhibit its activity.
Ganetespib inhibitor – Ganetespib treatment rapidly induced the degradation of known Hsp90 client proteins, displayed superior potency to the ansamycin inhibitor 17-allylamino-17-demethoxygeldanamycin....
Imidazoline Receptor | Other receptors like nuclear receptors have a different mechanism such as changing their DNA binding properties and cellular localization to the nucleus.
Duvelisib inhibitor – Duvelisib may cause infections, diarrhea, inflammation of the intestines and lungs, skin reactions, and high liver enzyme levels in the blood.
Dub Receptor | Multiple weak bonds between the inhibitor and the active site combine to produce strong and specific binding.
AG1343 Inhibitor – AG1343 is an orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor
Xanthine Oxidase Signal | Xanthine oxidase inhibitors are being investigated for management of reperfusion injury.
Givinostat inhibitor – Givinostat inhibits class I and class II histone deacetylases (HDACs) and several pro-inflammatory cytokines.
Luteolin Inhibitor – Luteolin is the principal yellow dye compound that is obtained from the plant Reseda luteola.
SW033291 inhibitor – play an important role in promoting tissue
Way 316606 Antagonist – The bound antagonists may prevent conformational changes in the receptor required for receptor activation after the agonist binds.
GDC-0068 Inhibitor – It is a small molecule inhibitor of AKT, which is a key component of the PI3K/AKT pathway.
Ulk Signals | ULK1 is an enzyme that in humans is encoded by the ULK1 gene.
Gs 7340 Inhibitor – Genvoya is the first TAF-based regimen to receive approval.
Grk Signals | Arrestin binding to phosphorylated, active receptor prevents receptor stimulation of heterotrimeric G protein transducer proteins, blocking their cellular signaling and resulting in receptor ...
Glutaminase Receptor | Glutaminase is expressed and active in periportal hepatocytes.
CBL0137 activator – The interaction of CBL0137 with the FACT complex results in simultaneous NF-kB suppression, Heat Shock Factor 1 suppression and p53 activation.
BI2536 inhibitor – BI 2536 is a Plk1 inhibitor with an IC50 of 0.83 nM.
Btk Receptor | BTK plays a crucial role in B cell development.
Nucleoside Analogan | Nucleotide and nucleoside analogues can also be found naturally.
JIB-04 inhibitor – JIB-04 is a pan-selective inhibitor known to reduce cancer growth in lung cancer and prostate cancer cell lines.
Bindarit inhibitor – Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties
PP2A Receptor | Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene.
Otx015 Inhibitor – Otx015 is an experimental small molecule inhibitor of BRD2, BRD3, and BRD4 under investigation for the treatment of cancer.
Dock Signal | IOR was described as "an inhibitory effect produced by a peripheral (or exogenous) cue or target.
Glucocorticoidrecep Signal | Other biocatalysts are catalytic RNA molecules, called ribozymes.
Harmine Chemical – Harmine is useful fluorescent pH indicator.
GS-4997 inhibitor – these results demonstrate that combined exposure to AlNPs and CRS exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway.
Acbi1 Chemical – structural information
Ciclesonide agonist – treat asthma and allergic rhinitis
FTI 277 inhibitor – farnesyl transferase
Rsv Signal | These compounds can be natural (such as secondary metabolites) or artificial (such as antiviral drugs); they may have a beneficial effect against a disease (such as drugs) or may be detrimental ...
Halofuginone Inhibitor – Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme glutamyl-prolyl tRNA synthetase.
Regorafenib inhibitor – targets angiogenic
Selective PI3K inhibitor 1 – related intracellular signal transducer enzymes capable
Ly2157299 Inhibitor – Ly2157299 was investigated in a phase II trial for treatment of hepatocellular carcinoma.
Acetyl CoA Carboxyla Signal | The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids.
Apoptosisrelated Signals | Each trial began with the brightening of the outline of one of the peripheral boxes that was randomly selected for 150 ms. During the trial, a target (a bright filled square)...
HSP Signal | Yeast Hsp90 is 60% identical to human Hsp90α.
Vbit-4 inhibitor – inhibit the VDAC
DCC-2618 inhibitor – the first new drug specifically approved in the United States
VEGFR signaling – Canonical versus non-canonical signalling indicates VEGF-dependent versus non-VEGF-dependent activation of VEGFR2.
Tacedinaline Inhibitor – Benzamide is an organic compound with the chemical formula of C7H7NO.
Ubiquitin inhibitor | The protein modifications can be either a single ubiquitin protein (monoubiquitylation) or a chain of ubiquitin (polyubiquitylation).
K858 inhibitor – inhibit cell replication
HBX 19818 Inhibitor – HBX19818 increased PARP1, protein PARylation, and nuclear apoptosis-inducing factor
BI 1383298 Inhibitor – BI 1482694 is an investigational anti-cancer drug
Azd9291 inhibitor – Osimertinib, sold under the brand name Tagrisso, is a medication used to treat non-small-cell lung carcinomas with specific mutations.
Phorbol12-myristate13-acetate – p53-mediated apoptosis
MEK162 Inhibitor – Inappropriate activation of the pathway has been shown to occur in many cancers.
Su5402 inhibitor – The FGF inhibitor, SU5402, inhibited Sulf1 expression when placed in the interdigital mesoderm.
Hdac Signaling | This kinetic behaviour is called slow-binding.
Crizotinib Inhibitor – treatment of NSCLC
Hedgehog signaling | Hedgehogs share distant ancestry with shrews (family Soricidae), with gymnures possibly being the intermediate link, and they have changed little over the last fifteen million years....
IACS-010759 inhibitor – a potent inhibitor of glycolysis-deficient hypoxic tumor cells
VPS34 inhibitor – phosphorylates phosphatidylinositol to produce PtdIns3P
Encorafenib Inhibitor – BRAF inhibitor
Ramucirumab Inhibitor – It was isolated from a native phage display library from Dyax.
Alda 1 Agonist – Alda1 is used in treatment for the alcohol flush reaction experienced by people with genetically deficient ALDH2.
CHF 5074 Modulator – CHF5074 doesn't display inhibitory activity on COX-1 and COX-2 enzymes
Pd184352 Inhibitor – enzyme activity
Entrectinib inhibitor – Entrectinib, sold under the brand name Rozlytrek, is an anti-cancer medication used to treat ROS1-positive non-small cell lung cancer and NTRK fusion-positive solid tumors.
VU0361737 Agonist – VU 0361737 can penetrate into CNS.
Leucovorin Chemical – be taken as a pill
Enzalutamide Antagonist – a 40 mg Capsule
Mhy1485 Activator – Activators can recruit molecules known as coactivators.
TGF Beta Inhibitor | It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis.
AZD7545 inhibitor – AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2.
Tie-2 signals | Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists.
Bay 1143572 Inhibitor – Reduced GFR is especially a problem if the patient is concomitantly taking an NSAID and a diuretic.
Loxistatin Inhibitor – antiviral effects
17 dmag Inhibitor – Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor.
Bx 795 Inhibitor – The N-terminal peptide is cleaved from the zymogen enzyme precursor by another enzyme to release an active enzyme.
Nvp tnks656 Inhibitor – Trk family
Sirtuin Signalings | A family of signaling proteins involved in metabolic regulation.
FCE24304 inhibitor – treat breast cancer
Ceralasertib Inhibitor – permanent decrease
A-1210477 inhibitor – Drug sensitization studies revealed that A-1210477 sensitised the cervical cancer cell lines SiHa and CaSki to ABT-263 by 11- and fivefold, respectively.
Rucaparib inhibitor – used as an anti-cancer agent
NPG 555 Modulator – NGP 555, a γ-secretase modulator
Abbik | Two molecules of water can form a hydrogen bond between them.
BAF-a1 – BafA1 may be considered to be a central modulator of both apoptosis and autophagy.
ABT-888 – It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer ...
Pevonedistat – NEDD8-activating enzyme is a heterodimeric molecule consisting of amyloid beta precursor protein-binding protein 1.
Bictegravir Inhibitor – Bictegravir is a second-generation integrase inhibitor (INSTI) class that was structurally derived from an earlier compound dolutegravir by scientists at Gilead Sciences.
Inflammation inhibitor | Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli, and is achieved by the increased movement ...
Foxm1 Receptor | FOXM1-null mouse embryos were neonatal lethal as a result of the development of polyploid cardiomyocytes and hepatocytes, highlighting the role of FOXM1 in mitotic division.
PDK1 signal | The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer, and stomach cancer.
Gsk3235025 Inhibitor – Inhibitors can show different types of inhibition depending on which substrate is considered.
Bms 863233 Inhibitor – The active centre of cholinesterases feature two important sites, namely the anionic site and the esteratic site.
Abt 199 Inhibitor – Venetoclax attaches to a protein called Bcl-2.
Iap Signal | Exocytosis occurs via secretory portals at the cell plasma membrane called porosomes.
Car Receptor | Chimeric antigen receptors (CARs, also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors) are receptor proteins that have been engineered to give ...
AZD4573 inhibitor – Suppresses MCL-1
Resiquimod agonist – Resiquimod has antiviral and antitumour activity
Mapk Inhibitor Library | The signal that starts the MAPK/ERK pathway is the binding of extracellular mitogen to a cell surface receptor.
Ci994 Inhibitor – A cell must control the coiling and uncoiling of DNA around histones.
Linderalactone inhibitor – inhibit the proliferation of the lung cancer A-549 cells
Factorxa Receptor | Carbon has six electrons, two of which are located in its first shell, leaving four electrons in its valence shell.
Inhibitor Screening | The extent of inhibition depends only on the concentration of the inhibitor.
selinexor inhibitor – Selinexor was granted accelerated approval by the U.S.
Transmembrane transporters inhibitor | Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane.
Asp2215 Inhibitor – Asp2215 is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK.
I-bet-762 Inhibitor – Molecules remained largely unknown until 2010 when both the use of JQ1 in NUT midline carcinoma and of I-BET 762 in sepsis were published.
Immunology Inhibitors – Cancer immunosurveillance and immunoediting are based on protection against development of tumors in animal systems.
ATG-019 inhibitor – We present our recent experience with ATG administration both as induction therapy and as an anti-rejection treatment
Compound Libraries | Minimize time & cost of screening using highly functional Compound Libraries
Pai1 Signal | In exocytosis, membrane-bound secretory vesicles are carried to the cell membrane, where they dock and fuse at porosomes and their contents (i.e., water-soluble molecules) are secreted into ...
Pges Receptor | Receptors for the series 2 prostanoids also bind with and respond to the series 1 and 3 prostanoids.
Antibio ticsformamm | Many therapeutic drugs and poisons are enzyme inhibitors.
Molecule Library | Since the drug decreases the activity of the enzyme that halts the signal, it makes this signal last for a longer period of time.
Protein Tyrosine Kinase | Tyrosine kinases catalyze the phosphorylation of tyrosine residues in proteins.
Ribosomal Peptidylt Signaling | rRNA is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells.
Ire1 Receptor | This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals....
8 bromo camp – 8 bromo is an adenosine receptor A1 antagonist.
AG-120 inhibitor – AG-120 is the first inhibitor of the mIDH1 enzyme to achieve clinical proof of concept in human trials.
Hormones Inhibitor | Hormone receptors are dynamic structures.
MLN4924 – NEDD8-pevonedistat adduct cannot be utilized in subsequent reactions necessary for NAE activity.
Cp 673451 Inhibitor – Enzymes in a metabolic pathway may be inhibited by molecules produced later in the pathway.
Microbiology Inhibitors – Epidemiology, the study of the p