Neuromuscular Junction
Muscle contraction is
controlled by motor neurons that release the
neurotransmitter acetylcholine at neuromuscular
junctions. Acetylcholine than diffuses across
the narrow synaptic cleft and binds to
acetylcholine receptors on the membrane of the
muscle cell. This results in the opening of ion
channels within the receptor molecules, in such
a way that a depolarizing, synaptic ion current
can flow. This current triggers an
all-or-nothing response in the form of an action
potential across the plasma membrane of the
muscle cells.
The action
potential moves out in all directions from the
neuromuscular junctions, resulting in
stimulation of the entire muscle fiber within a
few milliseconds, the contractile mechanism
responds and the fiber contracts.
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