Perforin Rabbit pAb | A0093

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SKU:: A0093
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Availability:: In Stock
Host species:: Rabbit
Purification method:: Affinity purification
Isotype:: IgG
Reactivity:: Human, Mouse, Rat
Storage buffer:: Store at -20℃

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Perforin Rabbit pAb | A0093

The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

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