Perforin Rabbit pAb | A0093

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SKU:
A0093
Availability:
In Stock
Host species:
Rabbit
Purification method:
Affinity purification
Isotype:
IgG
Reactivity:
Human, Mouse, Rat
Storage buffer:
Store at -20℃
  • Perforin Rabbit pAb | A0093
  • Perforin Rabbit pAb | A0093
$211.13 - $722.67

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Description

Perforin Rabbit pAb | A0093

The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

 

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