Perforin Rabbit pAb | A0093
- SKU:
- A0093
- Availability:
- In Stock
- Host species:
- Rabbit
- Purification method:
- Affinity purification
- Isotype:
- IgG
- Reactivity:
- Human, Mouse, Rat
- Storage buffer:
- Store at -20℃
Frequently bought together:
Description
Perforin Rabbit pAb | A0093
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
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