Goat Anti-Human Apolipoprotein AII Sepharose 4B™ Gel | ABMC-G02

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Description

Goat Anti-Human Apolipoprotein AII Sepharose 4B™ Gel | ABMC-G02

Host Species:	Goat
Concentration:	≥ 5 mg/ml
Source:	Polyclonal goat antibody human apo AII coupled with CNBr-activated Sepharose 4B™.
Preservation:	75 mM PBS, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, 0.1mM PMSF, pH 7.3.
Specificity	Specifically binds to human apo AII.
Use:	Affinity purification column.
Storage:	2-8ºC store in buffer with 0.5 mM EDTA and 0.02% NaN3, 0.1 mM PMSF. DO NOT FREEZE!

*Sepharose is a trademark of GE Healthcare Life Sciences, Sweden.

** These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.

IMPORTANCE

Apo AII comprises 25% of HDL. It exists in human plasma as a dimer of 2 identical chains of 77 amino acid residues, joined by disulfide. The molecular weight is reported to be 8.7 kDa for a single chain (Brewer et al., 1972).

Studies on mouse reported that apo AII may be proatherogenic (Warden et al., 1993); however, case-control study in the large European Prospective Investigation demonstrated that plasma Apo AII concentrations were strongly inversely correlated with CHD events (Birjmohun et al., 2007).

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