Goat Anti-Human Apolipoprotein E Sepharose 4B™Gel | ABMC-G05

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Description

Goat Anti-Human Apolipoprotein E Sepharose 4B™Gel | ABMC-G05

Host Species:	Goat
Concentration:	≥ 5 mg/ml
Source:	Polyclonal goat antibody human apo E coupled with CNBr-activated Sepharose 4B™.
Preservation:	75 mM PBS, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, 0.1mM PMSF, pH 7.3.
Specificity	Specifically binds to human apo E.
Use:	Affinity purification column.
Storage:	2-8ºC store in buffer with 0.5 mM EDTA and 0.02% NaN3, 0.1 mM PMSF. DO NOT FREEZE!

*Sepharose is a trademark of GE Healthcare Life Sciences, Sweden.

** These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.

IMPORTANCE

Apo E contains 299 amino acid residues. It is a 34-37 kDa glycosylated protein (Rall et al., 1983).

Apo E is involved with triglyceride, phospholipid, cholesteryl ester, and cholesterol transport in and out of cells and is a ligand for LDL receptors. Apo E has also been implicated in immune and nerve degeneration. It has been found to suppress lymphocyte proliferation. Late-onset familial and sporadic Alzheimer disease patients have been found to have a higher occurrence of one of the three common Apo E isoforms, Apo E4. The Apo E4 isoform has been detected in senile plaques and neurofibrillary tangles of Alzheimer disease patients. Apo E4 is associated with rapid chylomicron-remnant clearance and increased total cholesterol levels.

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