Recombinant Streptococcal Protein G (r-SPG)

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G protein is a bacterial cell wall protein expressed on the cell surface of certain strains of group C and G streptococci that binds to the Fc region of immunoglobulin G (IgG) with high affinity. The G protein binds to all IgG subclasses of human species, mice and rats. It also binds to IgG from guinea pig, rabbit, goat, cow, sheep and horse. G protein exhibits a wider range of binding to IgG subclasses than staphylococcal protein A. Some of the most important areas of application of G protein are the isolation and purification or removal of IgG from serum, purification of monoclonal antibodies and isolation of immune complexes. G protein conjugates are commonly used as affinity adsorbents to purify immunoglobulins (antibodies) and immunoglobulin subtypes from serum, hybridoma ascites, tissue culture supernatants, and other biological fluids.

In addition to the Fc receptor, intact G protein has membrane spanning regions as well as specific binding sites for albumin and for the Fab region of immunoglobins. The albumin and cell surface binding domains were removed from the recombinant G protein to ensure maximum specific IgG binding capacity.

Recombinant Streptococcal Protein G (r-SPG) DataSheet

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Additional Information

95% min
White powder
Shelf life:
2 years of proper storage
Test method:
Storage room:
Cryopreservation, transport at normal temperature
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