Description
One-step real-time qPCR kit for detection of SC-2 virus and identification of its British, South African and Brazilian variants in one reaction. The kit is based on one-step RT-qPCR using fluorescently labelled probes (FAM, HEX, ROX channels) and exogenous positive control (Cy5 channel).
Product description
– CE IVD one-step RT-qPCR kit
– detection of viral genes S and RdRP
– multiplex assay targeting the South African and Brazilian variant (mutation E484K – FAM channel), the British variant (mutation A570D – HEX channel), the viral RdRP gene (ROX channel) and the Exogenous Positive Control (Cy5 channel)
– E484K is a key so-called “escape” mutation that causes reduced binding of neutralizing antibodies and is found in variant B.1.351 (501Y.V2) referred to as the South African and P.1 (501Y.V3) referred to as the Brazilian variant
– A570D mutation is located exclusively in line B.1.1.7 (20I / 501Y.V1) referred to as the British variant
SC-2 Variant SA/BR/UK One Step RT-qPCR Brochure
SC-2 Variant SA/BR/UK One Step RT-qPCR DataSheet
| Santa Cruz qPCR primers for following Genes from Maxanim |
| Gp120 Inhibitors | Gp120 is a glycoprotein exposed on the surface of the HIV envelope. |
| Elexacaftor modulator – ivacaftor and tezacaftor |
| Sunitinib Inhibitor – meningioma |
| CY-09 inhibitor – Inhibits NLRP3 Inflammasome Activation |
| Paeoniflorin inhibitor – It can also be isolated from the fresh water fern Salvinia molesta. |
| Mirna Mimics | miRNA inhibitors for single or high throughput silencing |
| Pt2385 Antagonist – activity of drugs |
| Sc58635 Inhibitor – skin adverse events |
| Ripasudil inhibitor – mechanism of action affects intraocular pressure |
| RO5028442 Antagonist – RO 5028442, antagonist with Kis of just one nM for hV1a and 39 nM for mV1a |
| AMPK Signal | AMPK is formed by α, β, and γ subunits |
| Neratinib Inhibitor – dual inhibitor |
| Molibresib Inhibitor – social phobia |
| MLN8054 inhibitor – sensitizes androgen-resistant prostate cancer to radiation |
| PD-1 and PD-L1 inhibitor – PD-1 and PD-L1 inhibitors act to inhibit the association of the programmed death-ligand 1 (PD-L1) with its receptor, programmed cell death protein 1 (PD-1). |
| P53 Signal | Heating in concentrated hydrochloric acid will hydrolyse the peptide bonds holding proteins together, releasing free amino acids. |
| Arg-gly-asp Inhibitor.com – peptide motif |
| FAK signal | FAK is activated by focal adhesion complex |
| Pictilisib Inhibitor – Pictilisib inhibitors block the PI3K/AKT/mTOR pathway and thus slow down cancer growth. |
| OTS964 inhibitor – By applying a genetic target-deconvolution strategy, we found that the mischaracterized anticancer agent OTS964 is actually a potent inhibitor of the cyclin-dependent kinase CDK11 and ... |
| SGI-1776 inhibitor – inhibits the proliferation of ovarian cancer cells |
| Ag-221 inhibitor – Enasidenib is used to treat relapsed or refractory acute myeloid leukemia in people with specific mutations of the IDH2 gene, determined by an FDA-approved IDH2 companion diagnostic ... |
| Tween80 chemical – gives effect to aqueous phase |
| SCH900776 inhibitor – SCH900776 also increased the effect of fludarabine in a proportion of primary CLL samples treated with pro-proliferative stimuli, including those with TP53 disruption. |
| Stem Cells Inhibitors – Adult stem cells are found in a few select locations in the body. |
| Crenolanib Inhibitor – Crenolanib inhibits both wild type FLT3 and its constitutively active mutations. |
| Bcl2 receptor | Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular ... |
| E3330 Inhibitor – In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. |
| YL-0919 inhibitor – under development for the treatment of major depressive disorder |
| 1 azaken Paullone – GSK-3 is integrally tied to pathways of cell proliferation and apoptosis. |
| Pma Activator – psychedelic properties |
| UNC0642 inhibitor – RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice |
| Smoothened Agonist Agonist – Smoothened agonist has been shown to aid proliferation and survival of developing neurons,and prevent drug-induced brain injury. |
| Fosaprepitant antagonist – administered intravenously |
| DUB signal | DNA in the bacterium is tightly coiled. |
| Glycyrrhizic inhibitor – After oral ingestion, glycyrrhizin is hydrolysed to 18β-glycyrrhetinic acid (enoxolone) by intestinal bacteria. After absorption from the gut, 18β-glycyrrhetinic acid is metabolised ... |
| Rotenone inhibitor – It occurs naturally in the seeds and stems of several plants, such as the jicama vine plant, and the roots of several members of Fabaceae. |
| Combretastatin a4 inhibitor – A variety of different natural combretastatin molecules are present in the bark of Combretum caffrum, commonly known as South African Bush Willow. |
| Pim447 Inhibitor – Pim-1 is primarily involved in cytokine signaling. |
| Microrna 1 | Combinatorial regulation is a feature of miRNA regulation in animals. |
| Microrna21 | MiRNAs appear to target about 60% of the genes of humans and other mammals. |
| Transmembrane Transporters inhibitors – ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. |
| ZM306416 Inhibitor – ZM-306416 is a VEGFR antagonist and a potent inhibitor of EGFR function |
| JNJ-64619178 inhibitor – We demonstrate that the clinical-stage PRMT5 inhibitor JNJ-64619178 potently and efficaciously inhibited CCSST cell growth in vitro and in vivo. |
| Hippo Inhibitors – The Hippo pathway also has a critical role in stem cell and tissue specific progenitor cell self-renewal and expansion. |
| Pr-171 inhibitor – It begins at its intersection with PR-172 in downtown Cidra and ends at its junction with PR-14 near downtown Cayey. |
| KPT9274 inhibitor – KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells |
| Tic10 Inhibitor – Fluoxetine may be less effective than other antidepressants, but has high acceptability. |
| Salinosporamide A inhibitor – Salinosporamide A is reported that proceeds in 16 steps and 5 % overall yield and features an oxidative radical cyclization as a key step. |
| IWR-1-endo inhibitor – Sensitization with IWR-1-endo produced increased γH2AX foci formation, indicating increased DNA damage by doxorubicin. |
| Ots514 Inhibitor – ACE inhibitors can be used alone or in combination with other anti-hypertensive medications. |
| Gsi Ix Inhibitor – GSI-IX is a γ-secretase inhibitor. |
| Prostaglandin E2 chemical – Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open. |
| TVB-2640 inhibitor – encoded by the FASN gene |
| Dacinostat Inhibitor – The ACE inhibitor drugs allow for increased levels of bradykinin which would normally be degraded. |
| Pioglitazone Agonist – Pioglitazone may be used with metformin, a sulfonylurea, or insulin. |
| Pifithrin Inhibitor – a molecular weight of 367 30 |
| BI6727 inhibitor – Volasertib can be taken either orally or via intravenous infusion, once circulating in the blood stream it is distributed throughout the body, crosses the cell membrane and enters the ... |
| Stat Inhibitors – Inhibitors of STAT proteins are being developed for use in cancer therapy. |
| Coumarin 6 – Coumarin 6 facilitate the traceability of drug delivery systems in vitro. |
| Disulfiram inhibitor – Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, causing many of the effects of a hangover to be felt immediately following alcohol consumption. |
| Er Stress Inhibitors – Skeletal muscles are sensitive to physiological stress, as exercise can impair ER homeostasis. |
| AG-881 Inhibitor – Cellular potency profiling was routinely performed using the patient-derived neurosphere TS603. |
| Yap tead inhibitor 1 – YAP1 is a transcriptional co-activator. |
| Compound78c Inhibitor – Natural compounds refer to those that are produced by plants or animals. |
| N6 methyladenosine inhibitor – an abundant modification in mRNA and DNA |
| GDC-0973 Inhibitor.com – Cobimetinib is a MEK inhibitor. |
| Melatonin Agonist – Melatonin receptor agonists were developed with the melatonin structure as a model. |
| CX-6258 inhibitor – The activity of CX-6258 was validated in several Ewing sarcoma and multiple myeloma cell lines. |
| Binimetinib inhibitor – treat various cancers |
| GS-7977 inhibitor – Common side effects include fatigue, headache, nausea, and trouble sleeping. |
| Omipalisib inhibitor – Omipalisib binds to and inhibits PI3K in the PI3K mTOR signaling pathway. |
| Ar-12 Inhibitor – cryptococcosis of the brain |
| TMP269 inhibitor – promotes M1 polarization |
| JNJ-26481585 inhibitor – Preclinical studies show that quisinostat amplifies HDAC-repressed expression of E-cadherin, leading to a reversal of epithelial to mesenchymal transition in tumor cells. |
| Temsirolimus inhibitor – Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. |
| Sapanisertib Inhibitor – Sapanisertib is an experimental small molecule inhibitor of mTOR which is administered orally. |
| TC-H 106 inhibitor – class I histone deacetylases |
| VX-765 Inhibitor.com – belnacasan has proved well tolerated in human clinical trials. |
| Elimusertib inhibitor – Selective ATR Inhibitor |
| VS-6063 Inhibitor.com – Subsequent research in patients with specific NF2 mutations also found limited activity. |
| Ory 1001 Inhibitor – cell lung cancer |
| Tocilizumab inhibitor – Tocilizumab was granted an emergency use authorization (EUA) for the treatment of COVID‑19 in the United States in June 2021. |
| Tsa Inhibitor – Vorinostat is structurally related to trichostatin A and used to treat cutaneous T cell lymphoma. |
| Degrasyn Inhibitor – Cilostazol is used in the treatment of intermittent claudication. |
| c-MET receptor | In addition to their high affinity for the main site of the monoamine transporters, several competitive transporter substrates such as cocaine and indatraline have lower affinity for these ... |
| Diphenyleneiodonium – Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS). |
| SB-480848 inhibitor – the drug had failed to meet Phase III endpoints |
| BAY-876 inhibitor – A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma |
| Akti 1 2 – Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. |
| Pci 32765 Chemical – Pci 32765 is a potent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK). |
| Perifosine inhibitor – Perifosine interrupts the PI3K/AKT/mTOR pathway by acting as an allosteric AKT inhibitor targeting the pleckstrin homology domain of AKT. |
| Galicaftor modulator – the treatment of Cystic Fibrosis |
| Salubrinal Modulator – Salubrinal blocks eIF2α dephosphorylation by a herpes simplex virus protein and inhibits viral replication. |
| RGFP966 Inhibitor.com – The increasing number of patients suffering from chronic obstructive pulmonary disease represents a major and increasing health problem. |
| Tanzisertib inhibitor – characterization of enzymes involved in metabolism |
| Ravoxertinib Inhibitor – tagged destruction |
| Hdac Assay | Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. |
| Lgh447 Inhibitor – Single nucleotide polymorphisms in the Pim-1 gene have been associated with increased risk for lung cancer in Korean patients. |
| Subasumstat Inhibitor – decreasing anger |
| Saha Inhibitor – common disorder |
| Tie2 Receptor – The ligand for the receptor is angiopoietin-1. |
| Semaxanib Inhibitor – Semaxanib is a tyrosine-kinase inhibitor drug designed by SUGEN as a cancer therapeutic. |
| Selisistat inhibitor – AOP Orphan Pharmaceuticals AG to acquire Selisistat a clinical stage drug candidate for the treatment of Huntington’s disease |
| Mocetinostat inhibitor – Mocetinostat is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers including follicular lymphoma, Hodgkin's lymphoma and acute ... |
| Ku 60019 Inhibitor – Small molecule enzyme inhibitors include secondary metabolites. |
| Methylation Inhibitors – DNA methylation is a biological process by which methyl groups are added to the DNA molecule. |
| Pracinostat inhibitor – potential anti-tumor activity characterized |
| NVP-BSK805 inhibitor – NVP-BSK805, an inhibitor of JAK2 kinase, significantly enhanced the radiosensitivity of ESCC cells both in vitro and in vivo. |
| Alvespimycin Inhibitor – Alvespimycin is a chemical compound which is a semi-synthetic derivative of the antibiotic geldanamycin. |
| Darapladib inhibitor – discovered by Human Genome Sciences |
| Cyclosporina Inhibitor.com – Common side effects include high blood pressure, headache, kidney problems. |
| Alvocidib Inhibitor – The target of alvocidib is the positive transcription elongation factor P-TEFb. |
| BI-2852 inhibitor – The switch I/II pocket is a second pocket for which the nanomolar inhibitor BI-2852 has been discovered. |
| Immunology Inhibitor | Classical immunology ties in with the fields of epidemiology and medicine. |
| Repsox inhibitor – RepSox is a selective TGFβRI/ALK5 inhibitor |
| GX15-070 antagonist – Obatoclax is an inhibitor of the Bcl-2 family of proteins. |
| WQ1 antagonist – Sigma Receptor antagonist |
| Mirna1 | Metabolic reactions may be categorized as catabolic |
| DMF inhibitor – Dimethylformamide is odorless, but technical-grade or degraded samples often have a fishy smell due to impurity of dimethylamine. |
| Mt Receptor | For instance, aspirin is a widely used drug that acts as a suicide inhibitor of the cyclooxygenase enzyme. |
| Incb018424 inhibitor – Ruxolitinib is a janus kinase inhibitor.It was developed and marketed by Incyte Corp in the US under the brand name Jakafi, and by Novartis elsewhere in the world, under the brand ... |
| SMAD Inhibitors – Smad4 is the only known human Co-Smad, and has the role of partnering with R-Smads to recruit co-regulators to the complex. |
| Ro31 8220 Inhibitor – protein kinase C |
| Ap26113 Inhibitor – Ap26113 acts as both an anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) inhibitor. |
| Bgb 3111 Inhibitor – single arm trials |
| Hcv Protease Signal | Hcv is an small, enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae. |
| Ouabain inhibitor – used as an arrow poison |
| MAPK signals | With respect to PFK1, fructose 2,6-bisphosphate and ADP are examples of metabolites that are allosteric activators. |
| Bibw2992 inhibitor – It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer.... |
| Anisomycin activator – produced by Streptomyces griseolus |
| Tideglusib inhibitor – members of the thiazolidinedione family |
| Erlotinib Inhibitor – NSCLC with mutations |
| Tenofovir Inhibitor – Tenofovir disoproxil may be used for prevention of HIV/AIDS among those at high risk before exposure, and after a needlestick injury or other potential exposure. |
| Tipifarnib inhibitor – Farnesyltransferase inhibitors block the activity of the farnesyltransferase enzyme by inhibiting prenylation of the CAAX tail motif, which ultimately prevents Ras from binding to ... |
| GAP26 Inhibitor – gap26 attenuated the apoptosis of tubular epithelial cells |
| 1400w Inhibitor – isosorbide mononitrate |
| At9283 Inhibitor – The CCL4 protein precursor consist of 92 amino acids. |
| Canaglifloz Ininhibitor – exercise and diet |
| INCB028050 inhibitor – INCB028050 is a medication used for the treatment of rheumatoid arthritis, alopecia areata, and COVID-19. |
| Panobinostat inhibitor – Panobinostat is used in combination with the anti-cancer drug bortezomib and the corticoid dexamethasone for the treatment of multiple myeloma in adults who had received at least ... |
| Screening Libraries | The process by which a chemical or physical signal is transmitted through a cell as a series of molecular events is called signal transduction. |
| BP-1-102 inhibitor – Effects of STAT3 Inhibitor BP-1-102 on The Proliferation, Invasiveness, Apoptosis and Neurosphere Formation of Glioma Cells in Vitro |
| Tamoxifen Chemical – generic medication |
| Capecitabine Chemical – with docetaxel |
| Chlortetracycline inhibitor – Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri. |
| Loxo 195 Inhibitor – medical use |
| N-Dimethylformamide inhibitor – Commonly abbreviated as DMF (although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority ... |
| CCG-203971 inhibitor – Novel inhibitors of the Rho |
| Defactinib Inhibitor.com – Development for mesothelioma was discontinued in 2015 due to lack of efficacy in a placebo-controlled phase II trial. |
| RI-1 inhibitor – RI-1 is a selective inhibitor of RAD51, which is a central gene molecule of homologous recombination, with IC50 ranging from 5 to 30 μM. |
| Aptstat3-9r inhibitor – Addition of a cell-penetrating motif to the peptide to yield APTSTAT3-9R enabled uptake by murine B16F1 melanoma cells. |
| Epz015666 Inhibitor – The inhibitor may bind to the enzyme whether or not the substrate has already bound. |
| OICR-9429 antagonist – OICR-9429 has been shown to bind to WDR5 with KD values of 24 nM and 52 nM. |
| Idarubicin inhibitor – It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake. |
| Er Stress Inhibitors – PERK deficiency may have a significant impact on physiological states associated with ER stress. |
| Go6976 Inhibitor – cell junctions |
| C646 Inhibitor – Molecular biology has been elucidated by the work of many scientists. |
| Elesclomol Modulator – digital signal |
| Nsc754230 Inhibitor – acute gout attacks |
| Syk signal | In the natural and life sciences, the academic journal is the relevant medium. |
| Denosumab inhibitor – contraindicated in people with low blood calcium levels |
| Aprotinin Inhibitor – Aprotinin is a monomeric globular polypeptide derived from bovine lung tissue. |
| P7c3 Activator – By activating NAMPT, the P7C3 compounds result in an increase in intracellular levels of NAD. |
| NSC697855 inhibitor – used in medicine for the treatment of various helminthic |
| Bcl2 Signaling | Irreversible inhibitors are generally specific for one class of enzyme and do not inactivate all proteins. |
| Geneticin inhibitor – Geneticin is an aminoglycoside antibiotic similar in structure to gentamicin B1. |
| PPAR Signal | PPARs are modular in structure. |
| Rapamycin inhibitor – The chief advantage sirolimus has over calcineurin inhibitors is its low toxicity toward kidneys. |
| Doramapimod Inhibitor – Inhibitory control is a cognitive process and, more specifically, an executive function. |
| Cp 868596 Inhibitor – Cp 868596 is well tolerated as a single agent. |
| Elacridar inhibitor – Elacridar (GF120918, GW120918) is a potent P-gp (MDR-1) and BCRP inhibitor. |
| Ar 13324 Inhibitor – Antibiotic drug design is facilitated when an enzyme that is essential to the pathogen's survival is absent or very different in humans. |
| Methotrexate Inhibitor – folic acid |
| 4sc 202 Inhibitor – Enzymes in a metabolic pathway may be inhibited by molecules produced later in the pathway. |
| Zosuquidar modulator – In 2010, it was announced that a phase III trial for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome did not meet its primary endpoint and Eli Lilly discontinued ... |
| Milciclib Inhibitor – TrkA is a protein encoded by the NTRK1 gene. |
| T 5224 Inhibitor – c-Met stimulates cell scattering, invasion, protection from apoptosis and angiogenesis. |
| Abt494 Inhibitor – used as monotherapy |
| As1517499 Inhibitor – The presence of trypsin inhibitor has been found to result in delayed growth as well as metabolic and digestive diseases. |
| M6a Chemical – found within viruses |
| BAY1251152 inhibitor – The Phase I clinical trials of the latest, highly specific CDK9 inhibitor BAY1251152, against different solid tumors have shown good anti-tumor and on-target activities and pharmacokinetics |
| Cediranib inhibitor – Cediranib is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. |
| Anlotinib inhibitor – Anlotinib is a novel oral tyrosine kinase inhibitor. |
| Wnt inhibitors – The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. |
| Cc 5013 Chemical – Cc 5013 is a more potent molecular analog of thalidomide. |
| AZD0156 inhibitor – AZD0156 is currently being evaluated in phase I studies. |
| Bafilomycin A1 Inhibitor.com – Their chemical structure is defined by a 16-membered lactone ring scaffold. |
| Vadimezan chemical – In 2020 CRM Therapeutics, a Dutch drug-development company, initiated research for re-developing Vadimezan in combination with its proprietary targeted delivery platform. |
| Pfi 3 Inhibitor – BRD2 and BRD3 are functionally redundant and may be more important as therapeutic targets than is appreciated in studies depleting each BET protein individually. |
| Endocrinology inhibitors – Endocrinology is the study of the endocrine system in the human body. |
| 10058-f4 inhibitor – 10058-F4 is a c-Myc inhibitor that prevents c-Myc-Max dimerization and transactivation of c-Myc target gene expression. |
| NVP231 inhibitor – prohibited the emigration of M1 and M2 |
| Talniflumate chemical – developed by Laboratorios Bago |
| Iacs 10759 Inhibitor – Small molecule inhibitors include essential primary metabolites that inhibit upstream enzymes that produce those metabolites. |
| DNA Repair Inhibitors – The DNA repair process is constantly active as it responds to damage in the DNA structure. |
| PTC-209 inhibitor – on the AKT pathway in endometrial cancer cells |
| PKC412 inhibitor – Over 95% of patients with adult onset systemic mastocytosis and approximately 40% of children with cutaneous mastocytosis are positive for the D816V c-Kit activating mutation, which ... |
| Kya1797k Inhibitor – the serine residue |
| Mi 503 Inhibitor – Nutlin inhibits the interaction between HDM2 and tumour suppressor p53. |
| CC223 inhibitor – inhibits human head and neck squamous cell carcinoma cell growth |
| 3-Deazaneplanocin A – In studies on mice, the drug was also found to be effective for the treatment of Ebola virus disease, apparently interfering with the Ebola viruses ability to block interferon production,... |
| Ly3295668 Inhibitor – Reduced GFR is especially a problem if the patient is concomitantly taking an NSAID and a diuretic. |
| Atuveciclib Inhibitor – Zotiraciclib is also being explored for the treatment of DIPG, a rare pediatric cancer. |
| GDC-0980 inhibitor – A tipping-point for apoptosis following dual inhibition of HER2 signaling network by T-DM1 plus GDC-0980 maximizes anti-tumor efficacy |
| Retinoid Receptor | Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. |
| Linsitinib inhibitor – Linsitinib was granted orphan drug designation for adrenocortical carcinoma in March 2012. |
| Z-devd-fmk inhibitor – Degradation of KPNA1 induced by 2B can be inhibited in the cells pre-treated with Z-DEVD-FMK, a caspase-3 inhibitor |
| Marimastat Inhibitor – terminated |
| Dhfr Signal | DHFR is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid. |
| Bms 345541 Inhibitor – Bms 345541 is an anti-inflammatory, cell-permeable quinoxaline compound. |
| BIBF1120 Inhibitor.com – It gives important information on the efficacy and toxicity of both nintedanib and chemotherapy. |
| Plx51107 Inhibitor – Reversible inhibitors attach to enzymes with non-covalent interactions such as hydrogen bonds, hydrophobic interactions and ionic bonds. |
| FCCP inhibitor – It is referred to as an uncoupling agent because it disrupts ATP synthesis by transporting hydrogen ions through the mitochondrial membrane before they can be used to provide the energy ... |
| Pemigatinib inhibitor – Pemigatinib belongs to a group of medicines called protein kinase inhibitors. |
| Rituximab Inhibitor – Rituximab is a chimeric monoclonal antibody against the protein CD20, |
| ITF2357 inhibitor – ITF2357 was discovered at Italfarmaco of Milan, Italy. It was patented in 1997 and first described in the scientific literature in 2005. |
| Fenofibrate Agonist – off-label use |
| Cgrp Receptor | The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. |
| CB-839 inhibitor – CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. |
| Sarilumab inhibitor – Development in ankylosing spondylitis has been suspended after the drug failed to show clinical benefit over methotrexate in a phase II trial. |
| Pitavastat ininhibitor – Pitavastatin undergoes minimal metabolism so drug-drug interactions are less likely than with many other statins, but it can interact with some drugs that inhibit drug transporters.... |
| Lenalidomide Chemical – Lenalidomide is undergoing clinical trial as a treatment for Hodgkin's lymphoma. |
| Immunology Signals | Immunology has applications in numerous disciplines of medicine. |
| MLN2238 Inhibitor.com – MLN2238 is efficacious in other tumor cell types, such as osteosarcoma18 |
| Z-ietd-fmk | A molecule may be homonuclear, that is, it consists of atoms of one chemical element |
| ML323 inhibitor – USP1 inhibitor ML323 enhances osteogenic potential of human dental pulp stem cells |
| Peptide17 Inhibitor – A polypeptide that contains more than approximately 50 amino acids is known as a protein. |
| PHA-793887 inhibitor – an inhibitor of multiple cyclin-dependent kinases |
| Darunavir Inhibitor – well tolerated |
| E 64C Inhibitor – modified dipeptide |
| GW-572016 inhibitor.com – It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor pathways. |
| GDC-0084 inhibitor – In contrast, GDC-0084 led only to growth inhibition in PIK3CA wild-type cell lines in vitro. |
| E-64d inhibitor – acts as a cysteine protease inhibitor |
| Doxycycline Inhibitor – Doxycycline is available as a generic medicine. |
| C 176 – Large recreational doses of dextroamphetamine may produce symptoms of dextroamphetamine overdose. |
| RSL3 activator – RSL-3 near Concrete is one of four Remote Sprint Launch sites that were built as part of the Stanley R. Mickelsen Safeguard Complex in northeastern North Dakota. |
| Bleomycin Inhibitor – treat cancer |
| Aicar Activator – The activity of activators can be regulated. |
| Niraparib inhibitor – the treatment of epithelial ovarian |
| Bisindolylmaleimide inhibitor – This core structure includes a central maleimide group with two indole groups attached. |
| Copanlisib Inhibitor – Copanlisib has been shown to have an effect against survival and spread of cancerous B-cells. |
| IMD0354 inhibitor – Studies on the treatment of melanoma with folate acid conjugated dextran and lauryl alcohol loaded with IMD0354 |
| WNK463 inhibitor – designed for WNK1 |
| Cc 115 Inhibitor – Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible. |
| Rosiglitazone Agonist – insulin sensitizer |
| SCH900353 inhibitor – ERK Inhibitor for Oncology |
| Rgdyk inhibitor – Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX. |
| RXDX-101 inhibitor – RXDX-101 is also indicated for the treatment of adults with ROS1 positive, advanced non small cell lung cancer (NSCLC) not previously treated with ROS1 inhibitors. |
| Nec 1s Inhibitor – The binding site of inhibitors on enzymes is most commonly the same site that binds the substrate of the enzyme. |
| Inhibitor Kits | An organism requires continuous input of energy to maintain a low state of entropy. |
| Neuronal Signaling Inhibitors – A neuron or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. |
| 5-fluorouracil Inhibitor – As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts. |
| Barasertib Inhibitor – Not all irreversible inhibitors form covalent adducts with their enzyme targets. |
| Bace Signal | Some of the most well known are antiviral drugs widely used to treat HIV/AIDS and hepatitis C. |
| Abl001 Inhibitor – Asciminib and active site bcr-abl inhibitors have non-overlapping resistance mutations. |
| Sta-9090 inhibitor – STA-9090 binds to the ATP-binding domain at the N-terminus of Hsp90 and acts as a potent Hsp90 inhibitor by inducing degradation of multiple oncogenic Hsp90 client proteins. |
| Pd98059 Inhibitor – Pd98059 has an effect on the solubility of flavonoids. |
| EPZ5676 Inhibitor.com – RNA-seq analysis performed on both parental and resistant KOPN-8 and NOMO-1 cell lines supported two unique candidate pathway mechanisms. |
| Dinaciclib inhibitor – It is being evaluated in clinical trials for various cancer indications. |
| Erk signaling | Another method that is widely used in these analyses is mass spectrometry. |
| Nem Inhibitor – NEM activates ouabain-insensitive Cl-dependent K efflux in low K sheep and goat red blood cells. |
| Neferine Inhibitor – The plant contains nuciferine, neferine, and many other benzylisoquinoline alkaloids with medicinal properties. |
| GNE-7915 inhibitor – GNE-7915 concentrations in wild-type (WT) mouse sera and brain samples reached a peak at 1 h, which gradually decreased over 24 h following a single subcutaneous (100 mg/kg) injection.... |
| Dmh1 Inhibitor – The most commonly used isomer is CBD-DMH, which has the same stereochemistry as natural cannabidiol, and a 1,1-dimethylheptyl side chain. |
| Azd7648 Inhibitor – ternary complex |
| RAD140 modulator – developed by Radius Health |
| Netupitant Antagonist – antiemetic medication |
| Ym155 Inhibitor – Irreversible inhibitors covalently bind to an enzyme. |
| Mk 4827 Inhibitor – Mk 4827 is an anti-cancer medication used for the treatment of epithelial ovarian, fallopian tube, or primary peritoneal cancer. |
| Osmi 4 Inhibitor – Further optimization led to the development of OSMI-2, OSMI-3, and OSMI-4, which bind OGT with low-nanomolar affinity. |
| BI10773 inhibitor – It can be prescribed instead of metformin and has benefits over sulfonylureas. |
| GW788388 inhibitor – acts as a potent and selective inhibitor for TGF beta receptor 1 |
| Rigosertib inhibitor – Rigosertib is in phase III clinical trials for the treatment of chronic myelomonocytic leukemia. |
| Daratumumab Inhibitor – Daratumumab binds to CD38,which is overexpressed in multiple myeloma cells. |
| AT13387 inhibitor – inhibit theheat shock protein 90 |
| Triapine Inhibitor – Triapine belongs to the family of drugs called ribonucleotide reductase inhibitors. |
| Leukadherin 1 Agonist – inflammatory signals |
| Pexidartinib Inhibitor – Pexidartinib blocks the activity of the colony-stimulating factor-1 receptor (CSF-1R). |
| PCNA signal | PCNA is a member of the so called DNA |
| H-151 antagonist – inhibited STING/NF-kappaB signalling |
| Caspofung ininhibitor – It is a member of a new class of antifungals termed the echinocandins. |
| Dub Signaling | Cell division gives rise to genetically identical cells in which the total number of chromosomes is maintained. |
| I-bet 151 Inhibitor – Expression of the growth promoting transcription factor Myc is blocked by BET inhibitors. |
| Ibrutinib Chemical – a covalent bond |
| GFAP Signal | GFAP is encoded by the GFAP gene |
| Ulixertinib Inhibitor.com – Ulixertinib exposure was dose proportional to the RP2D. |
| Angiogenesis Inhibitors – Angiogenesis inhibitors have been closely studied for possible cancer treatment. |
| IPI-549 Inhibitor.com – It is a highly selective phosphoinositide 3-kinase inhibitor. |
| Ozanimod modulator – the treatment of relapsing multiple sclerosis and ulcerative colitis |
| Beta-catenin Receptor | Many drugs are small molecules. |
| Ro4929097 inhibitor – Targeting gamma secretase inhibits NOTCH signaling, which is upregulated in many forms of cancer. |
| Kd025 Inhibitor – Belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2. |
| Cyclopamine Antagonist – Cyclopamine is a naturally occurring chemical that belongs in the family of steroidal alkaloids. |
| Darolutamide ant agonist – used in the treatment of non-metastatic castration-resistant prostate cancer |
| Spautin-1 inhibitor – inhibits mitochondrial complex I |
| LY3009120 inhibitor – Pan-RAF inhibitor LY3009120 is highly synergistic with low-dose cytarabine, but not azacitidine, in acute myeloid leukemia with RAS mutations |
| Akt Inhibitor | Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. |
| Ono 7300243 Antagonist – κ opioid receptor |
| Bicuculline Inhibitor – The half-maximal inhibitory concentration (IC50) of bicuculline on GABAA receptors is 3 μM. |
| RG2833 inhibitor – FRDA patients were dosed in 4 cohorts, ranging from 30mg/day to 240mg/day of the formulated drug product of HDACi 109, RG2833. |
| GSK2399872a inhibitor – The present study aimed to investigate the RIPK3-mediated necroptosis and the effects of the RIPK3 selective inhibitor GSK'872 in early brain injury following SAH. |
| Gsk lsd1 Inhibitor – atypical depression |
| Gdc 0575 Inhibitor – synaptic cleft |
| Crenigacestat inhibitor – The starting level of Crenigacestat was 50 mg, and dose escalation was performed with a modified 3+3 scheme for the estimation of dose-limiting toxicity (DLT) at the recommended ... |
| Tauroursodeoxycholic – Ursodeoxycholic acid is produced in several countries for the treatment of gallstones and primary biliary cholangitis. |
| Sb431542 Inhibitor – SB-431542 is a drug candidate developed by GlaxoSmithKline (GSK) as an inhibitor of the activin receptor-like kinase (ALK) receptors. |
| Covid19 Signaling | Errors in signaling interactions may cause diseases such as cancer, autoimmunity, and diabetes. |
| ZD1839 Inhibitor.com – The radio-potentiating effect of ZD1839 was more apparent when radiation was administered in a fractionated protocol. |
| Liproxstatin-1 inhibitor – Liproxstatin-1 may be a promising drug for the treatment of central nervous system diseases. |
| Arq092 Inhibitor – Arq092 Inhibitor reduced phosphorylation of AKT |
| Nf Kb Inhibitors – NF-κB plays a key role in regulating the immune response to infection. |
| MS-275 Inhibitor.com – Syndax pharmaceuticals currently holds the rights to Entinostat and recently received $26.6 million in funds to advance treatments of resistant cancers using epigenetic tools. |
| Dna pksignal | Enzyme inhibitors are also important in metabolic control. |
| Sonidegibant Agonist – An agonist is a chemical that activates a receptor to produce a biological response. |
| Sgc cbp30 Inhibitor – Acetylcholinesterase is an enzyme found in animals, from insects to humans. |
| MK733 inhibitor – a type of lipid-lowering medication |
| Mm 102 Inhibitor – Substrate or product inhibition is where either an enzymes substrate or product also act as an inhibitor. |
| Mik665 inhibitor – MCL-1 compared to untreated control cells |
| Flavopiridol inhibitor – The target of alvocidib is the positive transcription elongation factor P-TEFb. |
| Ars-853 Inhibitor – escitalopram has been marketed as an allosteric serotonin reuptake inhibitor. |
| Bucladesine Activator – Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. |
| Am1241 Agonist – reduce the bone loss |
| Rgfp109 inhibitor – RGFP109, a histone deacetylase inhibitor attenuates L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset: a proof-of-concept study |
| Z-vad inhibitor – Evaluation of Z-VAD-FMK as an anti-apoptotic drug to prevent granulosa cell apoptosis and follicular death after human ovarian tissue transplantation |
| Eltanexor inhibitor – Eltanexor is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor |
| Capmatinib Inhibitor – Participants received capmatinib 400 mg orally twice daily until disease progression or unacceptable toxicity. |
| Ag14361 Inhibitor – human cancer |
| MLN0128 inhibitor – MLN0128 is an experimental small molecule inhibitor of mTOR which is administered orally. |
| 740 Y-P activator – PI3K inhibitor LY294002 enhanced and agonist 740 Y-P weakened the autophagy-promoting roles of RVS |
| Ml141 Inhibitor – tight regulation |
| Tretinoin agonist – it is applied to the skin as a cream |
| Sti571 Inhibitor – Sti571 is a 2-phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. |
| Acy 241 Inhibitor – A special case are covalent reversible inhibitors that form a chemical bond with the enzyme. |
| Mifepristone antagonist – It is also effective in the second trimester of pregnancy. |
| E2 Conjugating Signal | A genome is an organism's complete set of DNA |
| Pertuzumab Inhibitor – Pertuzumab is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer. |
| Wt161 Inhibitor – Non-inhibitory extracellular serpins also perform a wide array of important roles. |
| Abinhibitors | Surface tension results from the cohesive force due to the attraction between molecules at the surface of the liquid. |
| Vx 661 Modulator – Tezacaftor acts as a corrector to help the folding and presentation of the CFTR protein to the cell surface. |
| Vincristine inhibitor – treat a number of types of cancer |
| Raf709 Inhibitor – P-gp is a well-characterized ABC-transporter of the MDR/TAP subfamily. |
| Raf Signaling | RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. |
| AZD7762 Inhibitor – It is based on a simplified version of the bacterial CRISPR-Cas9 antiviral defense system. |
| Belvarafenib inhibitor – shows anti-tumor clinical activity in cancer patients |
| SCH772984 Inhibitor – SCH722984 in BRAF mutant melanoma was synergistic in a majority of cell lines. |
| C188 9 Inhibitor – PDE4 is the major cAMP-metabolizing enzyme found in inflammatory and immune cells. |
| Mak 683 Inhibitor – The 5α-reductase reaction is a rate-limiting step in the testosterone reduction. |
| Ngp555 Inhibitor – heart failure |
| Aurora kinase B | Aurora kinase B was identified in humans by a polymerase chain reaction screen for kinases that are overexpressed in cancers |
| Empagliflozin Inhibitor – reduces systolic |
| Hsd Signaling | Each pyruvate is then oxidized into acetyl-CoA by the pyruvate dehydrogenase complex. |
| Tie2 Kinase Inhibitor – The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. |
| Mito-tempo – In the present study, modulation of BPA toxicity by mitochondria-targeted antioxidant, mito-TEMPO was studied in male Wistar rats. |
| Abvos | The nucleus is made of one or more protons and a number of neutrons. |
| Angiogenesis Receptor | The mechanism of blood vessel formation by angiogenesis is initiated by the spontaneous dividing of tumor cells due to a mutation. |
| Bms 986165 Inhibitor – Bms 986165 acts as a highly selective allosteric inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2). |
| Bimatoprost Agonist – Bimatoprost is available as a generic medication. |
| Barbasco inhibitor – The earliest record of the now-known rotenone-containing plants used for killing leaf-eating caterpillars was in 1848, and for centuries, the same plants were used to poison fish. |
| Quisinostat Inhibitor – Quisinostat is highly potent against class I and II HDACs. |
| Brigatinib Inhibitor – NSCLC patients |
| Poziotinib Inhibitor – Poziotinib is built on an anilino-quinazoline scaffold. |
| GPCR Inhibitors – A ligand binds to the GPCR it causes a conformational change in the GPCR |
| E3 ligase signal | E3 ligases are also key players in cell cycle control, mediating the degradation of cyclins, as well as cyclin dependent kinase inhibitor proteins. |
| Dbet6 Chemical – Beta-D can be prepared as a sulfate salt or as a hydrochloride salt. |
| Dihydrotestosterone Agonist.com – The enzyme 5α-reductase catalyzes the formation of DHT from testosterone in certain tissues. |
| Hiv Protease Signals | Without effective HIV protease, HIV virions remain uninfectious. |
| Gant61 Inhibitor.com – Multiple other Hedgehog pathway inhibitors are in different phases of clinical trials. |
| Docetaxel inhibitor – chemotherapy medication |
| FG-4592 Modulator.com – HIF1α expression in haematopoietic stem cells explains the quiescence nature of stem cells. |
| Ve 821 Inhibitor – Molecular biology sits at the intersection of biochemistry and genetics. |
| Durvalumab inhibitor – It is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody that blocks the interaction of programmed cell death ligand 1 (PD-L1) with the PD-1 (CD279). |
| Plerixafor | An immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. |
| Fisogatinib Inhibitor – Potassium supplementation should be used with caution and under medical supervision owing to the hyperkalemic effect of ACE inhibitors. |
| Tyrphostin Ag-1478 – Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. |
| Bardoxolone Inhibitor – Bardoxolone methyl inhibits the pro-inflammatory transcription factor NF-κB in a tissue cultured human cell line. |
| NCT-503 inhibitor – We confirmed the effects of PHGDH inhibition through knocking down PHGDH and the effect of NCT-503 in vivo in the 5T33MM mouse model. |
| Nsc154020 Inhibitor – gynecomastia |
| GSK126 inhibitor .com – Mutation or over-expression of EZH2 has been linked to many forms of cancer. |
| CL318952 chemical – a medication used as a photosensitizer for photodynamic therapy |
| ERK Signal | The MEK phosphorylates and activates a mitogen-activated protein kinase |
| Apoptosis Blog | Biology is about nurturing and growth. |
| Aurorakinase Signals | Using biochemical, structural and cellular approaches, we show here that BlaS inhibits both translation elongation and termination in Mammalia. |
| Volasertib inhibitor – Volasertib is a novel small-molecule targeted therapy that blocks cell division by competitively binding to the ATP-binding pocket of the PLK1 protein. |
| GSK2245840 activator – GSK2245840 is a selective SIRT1 activator involved in the regulation of energy homeostasis. |
| TPX-0005 inhibitor – TPX-0005 was carried out with X-ray cocrystal structures of ALK,ROS1,TRKA,TRKB. |
| Sotrastaur ininhibitor – Sotrastaurin is an investigational immunosuppressant that blocks T-lymphocyte activation through protein kinase C inhibition. |
| Upr Inhibitors – If these objectives are not achieved within a certain time span or the disruption is prolonged, the UPR aims towards apoptosis. |
| Cyclosporine Inhibitor – Blood levels of the medication should be checked to decrease the risk of side effects. |
| SR1 Antagonist – regulation of sporulation by inhibition of kinA translation |
| ICI46474 chemical – used to prevent breast cancer in women and men |
| Chidamide Inhibitor – Chidamide is being researched as a treatment for pancreatic cancer. |
| CDK2-in-4 inhibitor – a member of the cyclin-dependent kinase family |
| LY364947 inhibitor – The TGF-beta inhibitor LY364947 was introduced to demonstrate the importance of TGF-beta signaling in anlotinib resistance via a series of functional assays. |
| Az304 Inhibitor – The inhibitor may bind to the enzyme whether or not the substrate has already bound. |
| Cisplatin Chemical – bind to DNA |
| Tki-258 Inhibitor – clinical trial |
| PF-6463922 Inhibitor – The transforming EML4-ALK fusion gene was first reported in non-small cell lung carcinoma (NSCLC) in 2007. |
| A 83 01 Inhibitor – A-83-01 inhibited the epithelial-to-mesenchymal transition induced by TGF-β. |
| UNC2025 inhibitor – Therapeutically Effective Alone |
| ZD6474 inhibitor – ZD6474 is used to treat medullary thyroid cancer in adults who are ineligible for surgery |
| Chk signals | In 1993, Beach and associates initially identified Chk1 as a serine/threonine kinase which regulates the G2/M phase transition in fission yeast. |
| Bms 1166 Inhibitor – social anxiety disorder |
| Uprosertib Inhibitor – Genital infections seem to be the most common adverse effect of gliflozins. |
| Gsk690693 Inhibitor – Protein kinases can be inhibited by competition at the binding sites where the kinases interact with their substrate proteins. |
| Chk1 Inhibitor | Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase. |
| AMN-107 inhibitor – AMN 107 was approved for medical use in the United States in 2007. |
| Cpsase Signal | In the context of neurotransmission, neurotransmitters are typically released from synaptic vesicles into the synaptic cleft via exocytosis; however, neurotransmitters can also be released ... |
| Crm1 Receptor | DNA replication is not perfect as the DNA polymerase sometimes insert bases that are not complementary to the template. |
| Entinostat Inhibitor.com – Entinostat inhibits class I HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively. |
| Hydroxyurea Inhibitor – Common side effects include bone marrow suppression, fevers, loss of appetite, psychiatric problems, shortness of breath, and headaches. |
| Thiazovivin Inhibitor.com – It is used alongside a cocktail of other growth factors and modulators in cell culture techniques for the generation of induced pluripotent stem cells. |
| Apoptosis Inhibitors – Apoptosis, or programmed cell death, is a highly regulated process used by many multicellular organisms. |
| Torkinib inhibitor – TORKinib-induced Mcl-1 reduction was rescued by proteasome inhibition. Consistently, TORKinib increased Mcl-1 ubiquitination. |
| Cpt Signal | The rate of DNA replication in a living cell was measured as 749 nucleotides added per second under ideal conditions. |
| Linagliptin inhibitor – It is generally less preferred than metformin and sulfonylureas as an initial treatment. |
| Stattic Inhibitor – Hence mixed inhibition is a combination of competitive and noncompetitive inhibition. |
| MK-2048 inhibitor – MK-2048 is the Merck & Co. designation for a molecule in its pre-clinical drug discovery that is an integrase inhibitor-class of agent intended to be used against HIV infection. |
| Hm781 36b Inhibitor – Naturally occurring enzyme inhibitors regulate many metabolic processes and are essential for life. |
| Takinib Inhibitor – TAK1 is an evolutionarily conserved kinase in the MAP3 K family and clusters with the tyrosine-like and sterile kinase families. |
| Verdinexor inhibitor – Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses |
| IU1 inhibitor – USP14 inhibitor |
| Cpi 169 Inhibitor – chemical compound |
| Opaganib inhibitor – It is under development as a potential treatment agent for several different kinds of cancer. |
| Xl413 Inhibitor – XL-413 is a drug which acts as a selective inhibitor of the enzyme cell division cycle 7-related protein kinase. |
| Verapamil Inhibitor – generic medication |
| Ly2603618 Inhibitor – Not all inhibitors are based on the structures of substrates. |
| COX signals | This mechanism occurs in the pancreas, which synthesises many digestive precursor enzymes known as zymogens. |
| Pimavanser Ininhibitor – high binding affinity |
| Mizoribine Inhibitor – Mizoribine is an immunosuppressive drug. |
| Scd Receptor | Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. |
| Fedratinib Inhibitor – Myelofibrosis is a myeloid cancer associated with anemia, splenomegaly. |
| S1p Receptor | Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine. |
| Tead Receptor | TEAD proteins are found in many organisms under different names, assuming different functions. |
| Tacrolimus inhibitor – used to treat dry eye syndrome |
| Tyrphostin AG 1296 inhibitor – Additive effect by combination of Akt inhibitor, MK-2206, and PDGFR inhibitor, tyrphostin AG 1296, in suppressing anaplastic thyroid carcinoma cell viability and motility |
| Vx 770 Activator – VX-770 is included in a combination product, lumacaftor/ivacaftor, in a single pill. |
| Ars 1620 Inhibitor – ACE inhibitors were initially approved for the treatment of hypertension. |
| 7 cl o nec1 Inhibitor – The inhibitor can bind to a site remote from the enzyme active site. |
| Ponatinib inhibitor – the treatment of chronic myeloid leukemia |
| BI-7273 inhibitor – prove to be useful in further exploring BRD9 |
| Ku 0063794 Inhibitor – Many monomers are purified industrially by distillation, which can lead to thermally initiated polymerisation. |
| Sulfasalazine Inhibitor – Sulfasalazine is in the disease-modifying antirheumatic drugs family of medications. |
| Domatinostat Inhibitor – faulty data |
| Stenabolic 0 – veterinary medicine |
| Perk signal | The PERK enzyme plays a key role in activating the brain's defence mechanism. |
| Talazoparib Inhibitor.com – Talazoparib is similar to the first in class PARP inhibitor, olaparib. |
| Simvastatin inhibitor – a type of lipid-lowering medication |
| Ikk Signaling | The IκB kinase (IkappaB kinase or IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation. |
| At406 Antagonist – constitutive activity |
| Microtubule receptor | Diisopropylfluorophosphate (DFP) is shown as an example of an irreversible protease inhibitor in the figure above right. |
| BLU9931 inhibitor – inhibited FGFR4 |
| Epz004777 Inhibitor – Many poisons produced by animals or plants are enzyme inhibitors that block the activity of crucial enzymes in prey or predators. |
| Quizartinib Chemical.com – Flt3 mutations are among the most common mutations in acute myeloid leukaemia due to internal tandem duplication of Flt3. |
| CXCR Signaling | MIF is an additional ligand of CXCR4. |
| Ha 1077 Inhibitor – Fasudil (INN) is a potent Rho-kinase inhibitor and vasodilator. |
| Aprepitant antagonist – used together with ondansetron and dexamethasone. |
| Pak Signals | PAK1 localizes in distinct sub-cellular domains in the cytoplasm and nucleus. |
| Cathepsin K | Cathepsin K is a cysteine protease expressed predominantly in osteoclasts |
| Bibr953 Inhibitor – bleeding and gastritis |
| Rg108 Inhibitor – Reserpine is a prototypical example of a vesicular reuptake inhibitor. |
| GDC-0152 antagonist – We previously reported that GDC-0152 induced apoptosis in HL-60 cells in a caspase-dependent manner. |
| Sepantronium Inhibitor – The mechanism of DNA damage by YM155 is still unknown. |
| Upr Inhibitors – The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum. |
| Oligomycin a inhibitor – Oligomycin A is an inhibitor of ATP synthase. In oxidative phosphorylation research, it is used to prevent state 3 (phosphorylating) respiration. |
| URMC-099 inhibitor – URMC-099 may have potential as a neuroprotective treatment in MS. |
| Mek Receptor | A 2007 experiment examined the way in which bottom-up and top-down processes affect attention during IOR. |
| E1activating Signaling | In signal processing, a signal is a function that conveys information about a phenomenon. |
| High-throughput Screenings | Automation is an essential element in HTS's usefulness. |
| UK5099 inhibitor – The abnormal folliculogenesis by UK5099 was partially rescued by alpha-ketoglutarate and succinate, intermediate metabolites in the TCA cycle |
| Mirna-2 | Folic acid is the oxidised form of the substrate of dihydrofolate reductase, an enzyme that is potently inhibited by methotrexate. |
| Gprotein Inhibitor | The Rab family of proteins is a member of the Ras superfamily of small G proteins. |
| Ferrostatin-1 inhibitor – Ferroptosis is initiated by the failure of the glutathione-dependent antioxidant defenses, resulting in unchecked lipid peroxidation and eventual cell death. |
| Onc201 Inhibitor – Onc201 is active against cancer stem cells and blocks cancer stem cell gene signatures. |
| Ly2886721 Inhibitor – BACE1 is an aspartic acid protease important in the formation of myelin sheaths in peripheral nerve cells. |
| Torin2 inhibitor – Molecular Target Validation of Aspartate Transcarbamoylase from Plasmodium falciparum by Torin 2 |
| ARQ 531 Inhibitor – ARQ 531 also offers a definite kinase selectivity profile |
| Sb505124 Inhibitor – SB431542 can be used in combination with LDN193189, CHIR99021 and DAPT to transform astrocytes into neurons. |
| Compound401 Inhibitor – Compound 401 can be a synthetic inhibitor of DNA-PK and mTOR |
| Ripretinib inhibitor – inhibits the activity of the kinases KIT and PDGFRA |
| Zebularine Inhibitor – Zebularine is a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. |
| Deferoxamine Inhibitor – Deferoxamine is a siderophore from the bacteria Streptomyces pilosus. |
| Abemaciclib Inhibitor – a CDK inhibitor |
| Ag 014699 Inhibitor – Ag 014699 is a first-in-class pharmaceutical drug targeting the DNA repair enzyme poly-ADP ribose polymerase-1. |
| Orlistat inhibitor – the saturated derivative of lipstatin |
| AZD8055 inhibitor – AZD8055 is a novel ATP-competitive mTOR inhibitor |
| Dup753 Antagonist – An inverse agonist can have effects similar to those of an antagonist. |
| Pdgfr Signal | Small-molecule anti-genomic therapeutics, or SMAT, refers to a biodefense technology that targets DNA signatures found in many biological warfare agents. |
| Seliciclib Inhibitor – B cell lymphomas |
| Tat-beclin 1 Activator – Tat-beclin 1 markedly inhibits Aids-1 replication in primary human monocyte-derived macrophages |
| D-lin-mc3-dma0 – heat labile |
| BVD-523 Inhibitor.com – Ulixertinib has an acceptable safety profi le with favorable pharmacokinetics. |
| ISX-9 activator – ibotenic acid and muscimol |
| Mitophagy Signaling | Two of the primary active constituents of the medicinal herb Hypericum perforatum (St. John's Wort) are hyperforin and adhyperforin. |
| Sodiumvalproate inhibitor – Common side effects of valproate include nausea, vomiting, somnolence, and dry mouth. |
| Busulfan chemical – It is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. |
| Dnapk Receptor – Many proteins have been identified as substrates for the kinase activity of DNA-PK. |
| Ver155008 Inhibitor – ACE Inhibitors reduce plasma norepinephrine levels. |
| CH-223191 | Uncompetitive inhibitors only bind once the substrate is bound, fully disrupting catalysis, and mixed inhibition is similar but with only partial disruption of catalysis. |
| DHA inhibitor – It is sold commercially in combination with piperaquine and has been shown to be equivalent to artemether/lumefantrine. |
| CGS20267 inhibitor – used in the treatment of breast cancer |
| Mdv3100 Antagonist – Mdv3100 is an antiandrogen, and acts as an antagonist of the androgen receptor. |
| Valproicacid inhibitor – They can be given intravenously or by mouth, and the tablet forms exist in both long- and short-acting formulations. |
| Dibutyryl cAMP Activator – cAMP is only able to elicit minimal responses in situations. |
| SH-4-54 inhibitor – SH-4-54 could increase mitoSTAT3 transmembrane import via GRIM-19 and reinforce the association between mitoSTAT3 and mitochondrial transcription factor A (TFAM) |
| 666-15 inhibitor – Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666- 15 |
| BAY11-7082 inhibitor – It has been shown that administration of BAY 11-7082 rescued renal functionality in diabetic-induced Sprague-Dawley rats by suppressing NF-κB regulated oxidative stress. |
| VS-4718 inhibitor – VS-4718, a novel inhibitor of focal adhesion kinase (FAK), was tested against the Pediatric Preclinical Testing Program's (PPTP's) in vitro cell line panel and showed a median relative ... |
| Homoharringtonine Inhibitor – treatment of CML |
| Gsk2334470 Inhibitor – ACE inhibitors decrease the formation of angiotensin II, a vasoconstrictor, and increase the level of bradykinin, a peptide vasodilator. |
| SB415286 inhibitor – Study of GSK3b inhibitors SB415286 and SB216763 to improve osteoblastic differentiation on microstructured titanium |
| MAP4K Receptor | MAP4K is a family of proteins involved in cellular signal transduction |
| Idoxuridine chemical – It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks ... |
| Autophagy Signal | In crinophagy, unnecessary secretory granules are degraded and recycled. |
| Etoposide Chemical – organic solvents |
| Parp Receptor | Compounds in which components share electrons are known as covalent compounds. |
| Resminostat Inhibitor – histone deacetylases |
| Jhu 083 Antagonist – Antagonist drugs interfere in the natural operation of receptor proteins. |
| Cetuximab inhibitor – Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion. |
| Tyrphostin 9 inhibitor – inhibits tyrosine kinases |
| Vinorelbine inhibitor – This includes breast cancer and non-small cell lung cancer. |
| TVB-3664 inhibitor – novel fatty acid synthase inhibitor |
| Pexmetinib Inhibitor – treatment of gynecomastia |
| BAY 87-2243 inhibitor – BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I |
| Adagrasib Inhibitor – Adagrasib is an inhibitor of the RAS GTPase family. |
| Hydroxychloroquine Inhibitor – itching and headache |
| Doxorubicin Inhibitor – breast cancer |
| Zanubrutinib Inhibitor – BTK inhibitor |
| GAP 26 agonist – a gap junction inhibitor |
| RK-33 inhibitor – RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X |
| Chir 265 Inhibitor – Subsequent to the synthesis, the racemic biaryl is resolved by classical methods. |
| Lovastatin Inhibitor – Common side effects include diarrhea, constipation, headache, muscles pains, rash, and trouble sleeping. |
| Eht1864 Inhibitor – protein aggregation |
| Adenosinekinase Signal | Other members of this family (also known as the RK family) include ribokinase (RK), inosine-guanosine kinase, fructokinase, and 1-phosphofructokinase. |
| LTX-315 Modulator – LTX-315 has been shown to induce the death of lymphoma cells within 4 h |
| UPF1069 Inhibitor – UPF-1069 may be a valuable tool to examine the different roles of PARP isoenzymes |
| Lys05 inhibitor – Lys05 – A Promising Autophagy Inhibitor in the Radiosensitization Battle: Phosphoproteomic Perspective |
| Rgs Receptor | RGS proteins have been conserved in evolution. |
| Pax Signals | A few of the selective serotonin reuptake inhibitors (SSRIs) such as the dextro-enantiomer of citalopram appear to be allosteric reuptake inhibitors of serotonin. |
| Camk Kinases | The catalytic core is typically composed of β-strands with the substrate binding site composed of α-helices. |
| Tp 0903 Inhibitor – Tp 0903 is expected to enter Phase 1 clinical trial in November 2016. |
| Albiglutide chemical – the treatment of type 2 diabetes |
| Vda Signaling | Extending the distance of the video signal is the main purpose of the VDA. |
| Sta 4783 Modulator – triggers apoptosis |
| Mlck Signaling | Binding of calcium ion to this domain increases the affinity of MYLK binding to myosin light chain. |
| IDO-in-2 inhibitor – considered a therapeutic target in cancer |
| Ltr Signal | All retroviral genomes are flanked by LTRs, while there are some retrotransposons without LTRs. |
| ARN-509 inhibitor – It is specifically indicated for use in conjunction with castration in the treatment of non-metastatic castration-resistant prostate cancer (NM-CRPC). |
| Ca3 Inhibitor – CA3 has been implicated in a number of working theories on memory and hippocampal learning processes. |
| Tno155 Inhibitor – A combination of ACE inhibitor with other drugs may increase effects of these drugs, but also the risk of adverse effects. |
| Arq621 Inhibitor – reduce goiter |
| Fgf401 Inhibitor – tissue areas that are devoid of vasculature |
| P-gp Receptor | Catch trials in which no target is presented occur with probability of 0.2. Participants had to respond to the target as quickly as possible by pressing a specified key. |
| Nlrp3 Receptor | Activated NLRP3 in turn triggers an immune response. |
| Cetp Signal | As an active transport mechanism, exocytosis requires the use of energy to transport material. |
| Endocrinology Receptor | Endocrine glands are regarded as ductless glands. |
| Irinotecan Inhibitor – cytotoxic alkaloid |
| Carfilzomib Inhibitor – analog of epoxomicin |
| Faah Signal | Broader definitions of chemicals or chemical substances can be found. |
| Mmpl3 Signaling | Some can inhibit a specific function of a protein or disrupt protein–protein interactions. |
| Nilotinib Inhibitor – Nilotinib is a medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome. |
| Pyrrolidine Dithiocarbamate – Pyrrolidine dithiocarbamate binds zinc such that the resulting complex can enter the cell and inhibit viral RNA-dependent RNA polymerase. |
| Vandetanib inhibitor – It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor |
| Ulk 101 Inhibitor – activate autophagy |
| Compstatin Inhibitor – similar entropies |
| Carboplatin inhibitor – treat ovarian cancer |
| Mkc 3946 Inhibitor – kinase domain |
| T 705 Inhibitor – generic drug |
| Fenebrutinib inhibitor – a randomized phase 2 trial |
| Azd8330 Inhibitor – COX 1 promotes the production of the natural mucus lining that protects the inner stomach and contributes to reduced acid secretion and reduced pepsin content. |
| Bms 540215 Inhibitor – hepatocellular carcinoma |
| Thiametg Inhibitor – low blood pressure |
| Deucravacitinib Inhibitor – allosteric inhibitor |
| Torin1 Inhibitor – Torin-1 shows activity against neuropathic pain. |
| YM 90709 Inhibitor – YM-90709 inhibited IL-5-prolonged eosinophil survival |
| Imatinib inhibitor – targeting multiple receptor tyrosine kinases |
| Myci361 Inhibitor – greater efficacy |
| Pi3k Inhibitors – PI3K inhibitors block the PI3K/AKT/mTOR pathway and thus slow down cancer growth. |
| Hdac Assay | TMP195 and JM63 are the most potent HDAC7 inhibitors. |
| Sofosbuvir inhibitor – taken by mouth |
| Cathepsin B Signals | Cathepsin B is synthesized on the rough endoplasmic reticulum as a preproenzyme of 339 amino acids with a signal peptide of 17 amino acids. |
| LY2835219 Inhibitor – It was developed by Eli Lilly and it acts as a CDK inhibitor selective for CDK4 and CDK6. |
| G007 lk Inhibitor – hormone therapy |
| Cabozantinib inhibitor – inhibits AXL and RET |
| tween80antagonist.com – Just another WordPress site |
| PF-04929113 inhibitor – PF-04929113 administered orally twice weekly is well tolerated and inhibits its intended target Hsp90. |
| 3 typ inhibitor – Tyrosinase carries out the oxidation of phenols such as tyrosine and dopamine using dioxygen. |
| MGCD0103 inhibitor – One clinical trial (for refractory follicular lymphoma) was temporarily put on hold due to cardiac problems but resumed recruiting in 2009. |
| Byl719 Inhibitor – BYL719 is an alpha-specific PI3K inhibitor. |
| Mg-132 inhibitor – It belongs to the class of synthetic peptide aldehydes. |
| Stat Receptor – STAT protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. |
| Dihydroartemisin ininhibitor – Dihydroartemisinin is the active metabolite of all artemisinin compounds |
| Pinometostat inhibitor – Pinometostat is a first-in-class small-molecule inhibitor of the histone methyltransferase disrupter of telomeric silencing 1-like (DOT1L). |
| Akt Signals | Fitting these data to a rate equation gives the rate of inactivation at this concentration of inhibitor. |
| Bioactive Compound Library | Bioactive compounds are commonly derived from plants, animal products, or can be synthetically produced. |
| Pi 103 Inhibitor – targeted therapy |
| Autophagy inhibitors – The first autophagy genes were identified by genetic screens conducted in Saccharomyces cerevisiae. |
| A 1331852 Inhibitor – A 1331852 inhibitor is a target of various senolytic agents. |
| Ds1001 Inhibitor – Proton pump inhibitors are well tolerated. |
| Autophagy inhibitor – Four forms of autophagy have been identified: macroautophagy, microautophagy, chaperone-mediated autophagy (CMA), and crinophagy. |
| Bosutinib inhibitor – an ATP-competitive Bcr-Abl tyrosine-kinase inhibitor |
| Er stress inhibitor | PERK dimerizes with BiP in resting cells and oligomerizes in ER-stressed cells. |
| A-1155463 inhibitor – A-1155463, a highly potent and selective BCL-XL inhibitor, was discovered through nuclear magnetic resonance (NMR) fragment screening and structure-based design. |
| G Protein Inhibitors – G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors. |
| Iwp 2 Inhibitor – The inhibitor can bind to a site remote from the enzyme active site. |
| Merestinib Inhibitor – billiary tract cancer |
| Erk Receptor | Pure vesicular reuptake inhibitors tend to actually lower synaptic neurotransmitter concentrations, as blocking the repackaging of, and storage of the neurotransmitter in question leaves ... |
| Acyltransferase Receptor | inhibitors reduce the compatibility of substrate and enzyme and this leads to the inhibition of Enzyme-Substrate complexes' formation |
| GDC-0853 inhibitor – Bruton's tyrosine kinase |
| Chk receptor | A few of the selective serotonin reuptake inhibitors (SSRIs) such as the dextro-enantiomer of citalopram appear to be allosteric reuptake inhibitors of serotonin. |
| Jak signals | An inhibitor of JAK2-STAT5, AZD1480, was pointed as having activity in primary and CRPC. |
| Hygromycin B Inhibitor – aminoglycoside kills bacteria |
| Gaba Receptor | The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid |
| Mrtx849 Inhibitor – Mrtx849 is an anticancer medication used to treat non-small cell lung cancer. |
| P5091 Inhibitor – Cells were treated with the P5091 inhibitor. |
| Cp 456773 Inhibitor – Enzyme inhibitors play an important role in all cells. |
| AM095 Antagonist – AM095, a specific LPAR1 inhibitor |
| A 485 Inhibitor – drug interactions |
| KU-55933 Inhibitor – Succinate levels were increased by KU-55933 levels and decreased by metformin. |
| EMD1214063 Inhibitor – EMD 1214063 is really a potent and selective c-Met inhibitor |
| Nutlin-3a Inhibitor – Nutlin-3 has been shown to affect the production of p53 within minutes. |
| Dyngo-4a inhibitor – inhibited TSH upregulation of TG and TPO mRNAs |
| Aromatase Receptor | Aromatase is an enzyme responsible for a key step in the biosynthesis of estrogens. |
| Mdivi 1 Inhibitor – Mdivi 1 exists as homooligomers and its function relies on its oligomerization ability. |
| Dznep inhibitor – Studies have shown that it has in vitro against a variety of different tumor cell lines. |
| PND-1186 inhibitor – PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments |
| Ars853 Inhibitor – Reserpine is an irreversible inhibitor of the vesicular monoamine transporter 2, and is a prototypical example of a vesicular reuptake inhibitor. |
| Santacruzamatea inhibitor – Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity |
| Pfk15 Inhibitor – PFK-2 undergoes covalent modification through phosphorylation/dephosphorylation based on the cell's hormonal signaling. |
| AZD5363 inhibitor – AZD5363 also significantly enhanced the antitumor activity of docetaxel, lapatinib, and trastuzumab in breast cancer xenografts. |
| Thiomyristoyl Inhibitor – Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. |
| E7080 inhibitor – Lenvatinib is absorbed quickly from the gut, reaching peak blood plasma concentrations after one to four hours. |
| ACP-196 inhibitor.com – It is a second generation Bruton's tyrosine kinase inhibitor. |
| Enoblock inhibitor – ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase. |
| BAY-1895344 inhibitor – exhibited strong monotherapy efficacy in cancer xenograft models |
| 3-methyladenine inhibitor – DNA bases are subject to a large number of anomalies: spontaneous alkylation or oxidative deamination. |
| Tigecycline inhibitor – It is a glycylcycline administered intravenously. |
| STF-31 inhibitor – a re-evaluation |
| S63845 Inhibitor.com – Diagnosis of DLBCL is made by removing a portion of the tumor through a biopsy. |
| Amuvatinib Inhibitor – TKIs are typically used as anticancer drugs. |
| Mapk Inhibitors – The signal that starts the MAPK/ERK pathway is the binding of extracellular mitogen to a cell surface receptor. |
| Geldanamycin inhibitor – HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. |
| Incb28060 Inhibitor – TKIs are typically used as anticancer drugs. |
| R406 Inhibitor – R406 blocks the activity of the enzyme spleen tyrosine kinase. |
| SHP099 inhibitor – SHP099 is a potent, selective, highly soluble, orally bioavailable, and efficacious SHP2 inhibitor |
| Lbh589 inhibitor – Panobinostat is used in combination with the anti-cancer drug bortezomib and the corticoid dexamethasone for the treatment of multiple myeloma in adults who had received at least two ... |
| Memantine Antagonist – modest improvement |
| Cell Cycle Inhibitors – The cell-division cycle is a vital process by which a single-celled fertilized egg develops into a mature organism. |
| CellCycle Receptor | DNA replication occurs during the C period. |
| Ptc124 Inhibitor – When an enzyme has multiple substrates, inhibitors can show different types of inhibition depending on which substrate is considered. |
| Lgk 974 Inhibitor – LGK 974 investigated for influencing cardiac tissue remodelling following infarction. |
| Sgk Signaling | This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). |
| XMU-mp-1 Inhibitor – XMU-MP-1 treatment inhibited MOB1 phosphorylation. |
| Daporinad Inhibitor – The metabolites were identified by ultra-high-performance liquid. |
| Mitomy C Incinhibitor – glaucoma surgery |
| Pd0325901 inhibitor – PD0325901, SB431542 and CHIR99021 in combination could significantly inhibit cell growth, suppress expression of pluripotency and EMT‑related genes, curb cell migration, cause cell ... |
| Antineoplasticandi | Phospholipids consist of glycerol that is linked to a phosphate group and two hydrocarbon chains |
| AZD8931 inhibitor – AZD8931 significantly suppressed cell growth of IBC cells and induced apoptosis of human IBC cells in vitro. |
| Thrombin Signal | Thrombin is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. |
| MCC950 inhibitor – MCC950 has been proposed as a specific small molecule inhibitor that can selectively block NLRP3 inflammasome activation. |
| Pf 06826647 Inhibitor – neural tone |
| Lonafarnib Inhibitor – Lonafarnib is an oral medication that helps prevent the buildup of defective progerin or progerin-like protein. |
| AZD2171 inhibitor – AstraZeneca completed a phase III trial comparing the efficacy of cediranib alone and cediranib with lomustine to the efficacy of lomustine alone in patients with recurrent glioblastoma.... |
| Pkc signal | Some of these natural inhibitors, despite their toxic attributes, are valuable for therapeutic uses at lower doses. |
| Adiporon agonist – activates AMPK and PPARα signaling |
| Sr 717 Agonist – acute pain |
| Wzb117 Inhibitor – Low concentrations of metformin and buformin alone or in combination with WZB-117 do not impair mitochondrial function nor induce cell death. |
| Microrna-2 | MiRNAs are abundant in many mammalian cell types and as extracellular circulating miRNAs. |
| Sr90090 – research drug |
| Cyclo inhibitor – A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase. |
| JPH203 inhibitor – JPH203 has the capability to inhibit LAT1 function through preincubation effects. |
| Arry 575 Inhibitor – inactive form |
| Pacritinib Inhibitor – Pacritinib is an anti cancer medication used to treat myelofibrosis. |
| SB1518 inhibitor – mainly inhibits Janus kinase 2 |
| Mixed lineage kinase receptor | Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. |
| Fer-1 inhibitor – Since ferroptosis is a form of regulated cell death, some of the molecules that regulate ferroptosis are involved in metabolic pathways that regulate cysteine exploitation, glutathione ... |
| BMS202 inhibitor – BMS202 inhibits PD-1 and PD-L1 binding with an IC50 of 0.018 M in an HTRF binding assay. |
| Cortisol Agonist – Cortisol has a permissive effect on the actions of hormones that increase glucose production, such as glucagon and adrenaline. |
| Lomeguatrib Inhibitor – cardiovascular benefit |
| FHPI inhibitor – FHPI is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in ... |
| Y-39983 inhibitor – Y-39983, a selective Rho-kinase inhibitor, attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination |
| Lorlatinib Inhibitor – liver enzymes |
| AP24534 inhibitor – Some forms of CML, those that have the T315I mutation, are resistant to current therapies such as imatinib. |
| Obeticholic Agonist – first FXR agonist |
| AZD2014 inhibitor – AZD2014 was more efficacious than rapamycin in inhibiting migration, invasion and EMT progression in Doc-sensitive and Doc-resistant CRPC cells. |
| Vitamin B3 inhibitor – includes three forms or vitamers |
| Hippo Inhibitor | The Hippo signaling pathway appears to be highly conserved. |
| BEZ235 Inhibitor.com – It has been shown to be toxic to Waldenström's macroglobulinemia cells. |
| Egfr Signals | Most reversible inhibitors bind in the active site of enzymes. |
| Mrt68921 inhibitor – Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities |
| Mapk Inhibitor | A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine. |
| Elafibranor agonist – Elafibranor is an experimental medication that is being studied and developed by Genfit for the treatment of cardiometabolic diseases including diabetes, insulin resistance, dyslipidemia,... |
| Antibiotics Signals | Enzymes differ from most other catalysts by being much more specific. |
| Bi d1870 Inhibitor – Some proteins act as enzyme inhibitors. |
| Taselisib Inhibitor – Taselisib is a small molecule phosphoinositide 3-kinase inhibitor targeting the PI3K isoform p110α (PIK3CA). |
| Emricasan Inhibitor.com – Conatus in turn licensed emricasan to Novartis in 2017 for exclusive development and commercialization. |
| tie-2 signaling | This ensures that the inhibitor exploits the transition state stabilising effect of the enzyme, resulting in a better binding affinity (lower Ki) than substrate-based designs. |
| Rrx 001 Inhibitor – Important amino acid residues in the esteratic site are a glutamate, a histidine, and a serine. |
| ACY-1215 inhibitor – ACY-1215 suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways |
| Fpr Signaling | Coordination complexes are distinct substances with distinct properties different from a simple mixture. |
| Ac Devd Choinhibitor – XIAP binds and inhibits initiator caspase-9, which is directly involved in the activation of executioner caspase-3. |
| Her2 Signaling | Evidence has implicated HER2 signaling in resistance to the EGFR-targeted cancer drug cetuximab. |
| Ogg1 Signaling | Ogg1 is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene. |
| Pu h71 Inhibitor – Pu h71 has been found to have a preferential binding to Hsp90. |
| Hormones inhibitors – Hormones are used to communicate between organs and tissues. |
| Dnapk Signaling | Plant growth regulators, or plant hormones, move through cells or by diffusing through the air as a gas to reach their targets. |
| Ckit Signal | Multiple transcript variants encoding different isoforms have been found for this gene. |
| Cilengitide inhibitor – It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor ... |
| Ethosuximide Inhibitor – absence seizures |
| Deferasirox chemical – the first oral medication approved in the United States |
| Chk2 Inhibitori – DNA repair |
| Tariquidar inhibitor – Tariquidar (INN/USAN) is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. |
| Inhibitor Libraries | Biotechnology is the use of cells or organisms to develop products for humans. |
| Eif Receptor | Standard reuptake inhibitors are believed to act simply as competitive substrates that work by binding directly to the plasmalemma transporter of the neurotransmitter in question |
| Il Receptor Signal | IL-1R is a cytokine receptor which binds interleukin 1. |
| Batimastat Inhibitor – Batimastat was the first MMPI that went into clinical trials. |
| PX-478 Inhibitor – PX-478 decreased HIF-1α protein in PC3 and DU 145 cells. |
| Nsc113928 Agonist – sleep disorders |
| Oxaliplatin Inhibitor – folinic acid |
| Compound991 Activator – Regulation of AMPK by CaMKK2 requires a direct interaction of these two proteins via their kinase domains. |
| JQEZ5 inhibitor – Enzyme inhibitors are a chemically diverse set of substances that range in size from organic small molecules to macromolecular proteins. |
| Pyroptosis Signaling | Pyroptosis can take place in immune cells and is also reported to occur in keratinocytes and some epithelial cells. |
| Srebp Signal | SCAP is an integral membrane protein located in the endoplasmic reticulum |
| TBK1/IKKε-IN-1 activator – TBK1 and IKKε |
| P450 signals | For example, extremes of pH or temperature usually cause denaturation of all protein structure, but this is a non-specific effect. |
| Apixaban inhibitor – used to treat and prevent blood clots |
| Almorexantant agonist – acting as a competitive antagonist of the OX1 and OX2 orexin receptors |
| Roblitinib Inhibitor – catalyzes a key aromatization step |
| Sbc 115076 Antagonist – A receptor may contain one or more binding sites for different ligands. |
| Ostarine Modulator – treatment of conditions |
| Ehop-016 inhibitor – The Rac inhibitor EHop-016 was developed as a compound with the potential to inhibit cancer metastasis. |
| Jak receptor | The name is taken from the two-faced Roman god of beginnings, endings and duality, Janus, because the JAKs possess two near-identical phosphate-transferring domains. |
| Cytoskeletal Signaling Inhibitor | A multitude of functions can be performed by the cytoskeleton. |
| STZ inhibitor – Since it carries a substantial risk of toxicity and rarely cures the cancer, its use is generally limited to patients whose cancer cannot be removed by surgery. |
| Wortmann Ininhibitor – Wortmann has an in vitro inhibitory concentration of around 5 nM. |
| WNT-c59 Inhibitor.com – For a cell therapy against damaged corticospinal tract caused by neurodegenerative diseases or insults. |
| Fgfr Signal | The inhibitor binds tightly to trypsin, preventing the trypsin activity that would otherwise be detrimental to the organ. |
| Buparlisib Inhibitor.com – It is a small molecule orally-available pan-class I phosphoinositide 3-kinase inhibitor. |
| Sodium Channel Signal | Sodium channels are highly selective for the transport of ions across cell membranes. |
| AZD6738 Inhibitor.com – It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint. |
| Wnt Inhibitors – Just another WordPress siteWnt signaling pathways use either nearby cell-cell communication or same-cell communication. |
| Procollagencprotei Signals | In slime moulds, individual cells known as amoebae aggregate together to form fruiting bodies and eventually spores, under the influence of a chemical signal, originally named ... |
| Nitazoxanide inhibitor – It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza.... |
| Trichostatin A Inhibitor – TSA is an organic compound that serves as an antifungal antibiotic. |
| SCR7 inhibitor – NHEJ inhibitor SCR7 and its different forms: Promising CRISPR tools for genome engineering |
| Nintedanib inhibitor – used for the treatment of idiopathic pulmonary fibrosis |
| Trans Isomer – Cis and trans isomers occur both in organic molecules and in inorganic coordination complexes. |
| Pi 3065 Inhibitor – Akt2 is an important signaling molecule in the insulin signaling pathway. |
| Glpg0634 Inhibitor – The signal transmission of large numbers of proinflammatory cytokines is dependent on JAK1. |
| PF-00299804 Inhibitor – It is a selective and irreversible inhibitor of EGFR. |
| Neuronal signaling inhibitors | A neuron or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. |
| DMXAA chemical – Vadimezan was discovered by Bruce Baguley and William Denny and their teams at the Auckland Cancer Society Research Centre at the University of Auckland in New Zealand. |
| Birinapant Antagonist.com – Birinapant bound to the BIR3 domains of cIAP1. |
| Nsc23766 Inhibitor – Consequently is a potent neurotoxin, with a lethal dose of less than 100 mg. |
| Neprilysin Receptor | Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins,... |
| Acadesine Activator – Acadesine has been used clinically to treat and protect against cardiac ischemic injury. |
| Sodium Channel Receptor | Sodium channels are highly selective for the transport of ions across cell membranes. |
| G Protein Inhibitor | In general, protein synthesis inhibitors work at different stages of bacterial mRNA translation into proteins. |
| Tozasertib Inhibitor – PDE4 is the major cAMP-metabolizing enzyme found in inflammatory and immune cells. |
| Rimonabantant Agonist – Antagonists bind directly to receptors in the synaptic cleft, effectively blocking neurotransmitters from binding. |
| Rg 7388 Inhibitor – RG7388 are several derivatives of nutlin. |
| LM10 inhibitor – A metsulfuron-methyl-resistant bacterium Lm10 was isolated from metsulfuron-methyl contaminated soil. |
| Bms-777607 Inhibitor – In uncompetitive inhibition,the inhibitor binds only to the enzyme-substrate complex. |
| Epoxomicin inhibitor – Epoxomicin was originally discovered in 1992. |
| Melk Receptor | MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. |
| Bcr-abl Signal | A well-characterised example of this is the ribonuclease inhibitor, which binds to ribonucleases in one of the tightest known protein–protein interactions |
| R 51619 Agonist – R 51619 is another hERG blockers |
| Cudc 907 Inhibitor – CUDC-907 is being evaluated in two separate clinical trials for the treatment of refractory. |
| Fao Signal | A ubiquitous example of a hydrogen bond is found between water molecules. |
| Pci-34051 inhibitor – HDAC8-inhibitor PCI-34051-induced exosomes inhibit human bronchial smooth muscle cell proliferation via miR-381-3p mediated TGFB3 |
| PDGF Receptor | There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. |
| Tak1 Signal | TAK1 is an evolutionarily conserved kinase in the MAP3 K family and clusters with the tyrosine-like and sterile kinase families. |
| ARQ-087 inhibitor – inhibits FGFR signaling |
| FGFR signaling | Irreversible inhibitors covalently bind to an enzyme, and this type of inhibition can therefore not be readily reversed. |
| Phosphatases | A phosphatase is an enzyme |
| SGC0946 inhibitor – inhibit DOT1L in vitro |
| SMS201995 inhibitor – a more potent inhibitor of growth hormone |
| CDKI-73 inhibitor – CDKI-73 induced cancer cells undergoing apoptosis through transcriptional downregulation of anti-apoptotic proteins Bcl-2, Mcl-1 and XIAP by majorly targeting CDK9. |
| Azd8186 Inhibitor – Azd8186 Inhibitor is PIK3CB and PIK3CD inhibitor. |
| Immunology inhibitor | Immunology has importance in reproductive medicine as the physical, chemical, and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.... |
| Gdc 0994 Inhibitor – The glycolytic pathway is a classic example. |
| Imi28 Inhibitor – gastric cancer |
| Bmn673 inhibitor – The most serious side effects in studies were related to the blood forming system and included anaemia (low red blood cell count), neutropenia (low neutrophil blood cell count) and thrombocytopenia ... |
| Novobioc ininhibitor – produced by the actinomycete Streptomyces niveus |
| Gsk621 Activator – Activators can have allosteric sites that are responsible for turning the activators themselves on and off. |
| Dc661 Inhibitor – safer alternative |
| Bptes Inhibitor – treatment of edema |
| CHD1Li 6.11 inhibitor – an orally bioavailable antitumor agent |
| Streptozotocin inhibitor – It is used in medicine for treating certain cancers of the islets of Langerhans and used in medical research to produce an animal model for hyperglycemia and Alzheimer's in a ... |
| AZ 960 Inhibitor – AZ 960 induces apoptosis and growth arrest |
| M4344 Inhibitor – ATR is activated in response to persistent single-stranded DNA. |
| Captisol Inhibitor – improve solubility |
| Blebbistat ininhibitor – Blebbistatin has been especially useful in optical mapping of the heart, and its recent use in cardiac muscle cell cultures has improved cell survival time. |
| CHIR-98014 inhibitor – The GSK-3 inhibitor CHIR-98014 similarly downregulated SHH-driven proliferation. |
| Vericiguat Modulator – Common side effects include low blood pressure and low red cell count (anemia). |
| Transferase Signal | Transferases are involved in myriad reactions in the cell. |
| Rnr Receptor | RNR is the enzyme responsible for converting NTPs to dNTPs. |
| Gpcr Inhibitor | G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates,and animals. |
| Aspirin inhibitor – Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. |
| AZD4547 Inhibitor.com – AZD4547 inhibited recombinant FGFR kinase activity in vitro and suppressed FGFR signaling and growth in tumor cell lines with deregulated FGFR expression. |
| Bmi1 Receptor | Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-... |
| KPT-335 inhibitor – KPT-335 , a Selective Inhibitor of Nuclear Export, Reduces Respiratory Syncytial Virus Replication In Vitro |
| Isoxazole activator – an oxygen atom next to the nitrogen |
| Veliparib inhibitor – Veliparib may make whole brain radiation treatment work more effectively against brain metastases from NSCLC. |
| GF120918 inhibitor – GF120918 potently reversed resistance completely for all drugs. |
| Tucidinostat inhibitor – Tucidinostat is being researched as a treatment for pancreatic cancer. |
| Ruxolitinib inhibitor – a type of myeloproliferative neoplasm that affects the bone marrow |
| ACY-738 inhibitor – ACY-738 delayed disease onset and reduced disease severity. |
| Assay Way | Enzyme assays are laboratory methods for measuring enzymatic activity. |
| Cox Receptor | Individual atoms can be held together by chemical bonds to form molecules and ionic compounds |
| Inflammation Inhibitors – Inflammation can be classified as either acute or chronic. |
| Protein Tyrosine Kinase Inhibitors – Tyrosine kinases belong to a larger class of enzymes known as protein kinases which also attach phosphates to other amino acids such as serine and threonine. |
| Gskj4 Inhibitor – Gskj4 appears to both promote and inhibit apoptosis. |
| Sphk Signal | Sphingolipids are ubiquitous membrane constituents of all eukaryotic cells. |
| Y-27632 Inhibitor – Y-27632 selectively inhibits p160ROCK, although it does inhibit other protein kinases such as PKCs at higher concentrations. |
| BV-6 inhibitor – BV6 is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. · |
| Pka Signals | PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism. |
| Oh Fmk Caspase Inhibitorvi – Inflammatory caspase-1 has been implicated in causing autoimmune diseases. |
| Sglt Signal | This also causes our attention shift to be quick for exogenous cues than for endogenous cues |
| Vx 803 Inhibitor – ALT pathway was extremely fragile with ATR inhibition. |
| Sfrp Signal | SFRPs act as soluble modulators of Wnt signaling. |
| S3i 201 Inhibitor – Important amino acid residues in the esteratic site are a glutamate, a histidine, and a serine. |
| Ftase Signal | Several FTase inhibitors are undergoing testing as anti-cancer agents. |
| Lsd1 Receptor | Signals can be non-chemical |
| JQ1 chemical – BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma. |
| Nf Kb Inhibitors – NF-κB plays a key role in regulating the immune response to infection. |
| Erdafitinib inhibitor – bile duct cancer |
| Midostaurin Inhibitor – oncogenic CD135 |
| Tucatinib inhibitor – It was developed by Array BioPharma and licensed to Cascadian Therapeutics。 |
| RJC2792 inhibitor – a type of natural phenol |
| Tyrosine kinases | A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell |
| Paxalisib inhibitor – Genome and RNA expression were used to further guide treatment strategies with targeted agents such as dual PI3K/mTOR inhibitor paxalisib. |
| BMS-907351 Inhibitor.com – It is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET. |
| Infliximab inhibitor – Common side effects include infections, acute infusion reactions, and abdominal pain. |
| Bemcentinib inhibitor – an inhibitor of AXL kinase |
| Celecoxib Inhibitor – generic medication |
| RP13057 Inhibitor – RP 13057 is really a topoisomerase II inhibitor that induces apoptosis. |
| RO91978 chemical – a tumor-selective fluoropyrimidine carbamate |
| Pomalidomide Chemical – anti angiogenic |
| Cb 5083 Inhibitor – The N-terminal peptide is cleaved from the zymogen enzyme precursor by another enzyme to release an active enzyme. |
| Nu7026 Inhibitor – Gyrase is an antibacterial target.. |
| Lenvatinib inhibitor – acts as a multiple kinase inhibitor |
| ARQ092 Inhibitor – ARQ 092 targets the PI3K/AKT path and AKT particularly |
| Hedgehog signal | Although the trypsin inhibitor is a protein, it avoids being hydrolysed as a substrate by the protease by excluding water from trypsin's active site and destabilising the transition state.... |
| VEGFR signal | This molecule is not based on a peptide and has no obvious structural similarity to a protein substrate. |
| Paclitaxel inhibitor – treat a number of types of cancer |
| Erk5 in 1 Inhibitor – KRAS mutated colorectal cancer |
| Eribulin Inhibitor – solid tumors |
| Influenzavirus Signal | The influenzavirus virion is pleomorphic. |
| AZ628 inhibitor – AZ628-loaded nanoparticles of CA and KA-modified CA were synthesized and evaluated in MCF-7 and 4T1 cell lines by measuring cytotoxicity and cellular uptake analysis. |
| XAV-939 Inhibitor.com – Progenitors are obtained by so-called direct reprogramming or directed differentiation and are also called induced somatic stem cells. |
| Lonidamine Modulator – discrete signal |
| Nivolumab inhibitor – It is a type of immunotherapy and works as a checkpoint inhibitor, blocking a signal that prevents activation of T cells from attacking the cancer. |
| Mp 470 Inhibitor – Acetazolamide is available as a generic medication. |
| SAR131675 inhibitor – Reduces the Growth of Colorectal Cance |
| Compound 3i inhibitor – compound 3i showed remarkable systemic inhibition in transgenic mice. |
| Coelenterazine inhibitor – a molecule that emits light after reaction with oxygen |
| Palmitoylethanolamide activator – lipid modulator |
| Neuro Signaling | For example, bacteria are surrounded by a thick cell wall made of a net-like polymer called peptidoglycan. |
| Mc180295 Inhibitor – The effect of the inhibitor is a result of the percent of the enzyme population interacting with inhibitor. |
| ROC-325 inhibitor – The Novel Lysosomal Autophagy Inhibitor |
| Clofarabine inhibitor – Clofarabine quickly kills leukaemia cells in the blood. |
| Cftrinh 172 Inhibitor – Cftrinh 172 is high-affinity CFTR inhibitor. |
| Topk Signals | In the kinetic theory of gases, the term molecule is often used for any gaseous particle regardless of its composition. |
| Afuresertib Inhibitor – antibiotic drug |
| CGP57380 Inhibitor – CGP 57380 was dependent on AKT activation for inhibition of β-catenin nuclear translocation |
| AZD-5153 inhibitor – AZD 5153 is a small molecule and a selective BRD4 inhibitor |
| Tie2 Signal | Angiopoietin proteins 1 through 4 are all ligands for Tie-2 receptors. |
| Msa 2 Agonist – Apomorphine, a dopamine agonist, may be used to reduce off periods and dyskinesia in late PD. |
| Dna alkylator | Catalysts accelerate chemical reactions. |
| E3 Ligase Signaling | E3 ligases interact with both the target protein and the E2 enzyme. |
| Dofetilide inhibitor – under the trade name Tikosyn by Pfizer |
| P505-15 inhibitor – P505-15 successfully inhibited SYK-mediated B-cell receptor signaling. |
| 3-ma inhibitor – 3-MA was applied for cisplatin-resistant cells intervention, Beclin1 was knocked down by plasmid transfection. Cell cycle was detected using flow cytometry assay, apoptosis with necrosis ... |
| Dpp2 Signal | The binding site of inhibitors on enzymes is most commonly the same site that binds the substrate of the enzyme. |
| Ruboxistaurin Inhibitor – Ruboxistaurin is a member of the bisindolylmaleimide family. |
| PDI Signals | PDI displays oxidoreductase and isomerase properties |
| Dpi inhibitor – G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene. |
| Hydrotropic Agents Receptor | To form a hydrotrope, an aromatic hydrocarbon solvent is sulfonated, creating an aromatic sulfonic acid. |
| Thrombin Inhibitors | Thrombin inhibitors are one type of anticoagulant medication |
| WIN55,212-2 Agonist – WIN 55,212-2 activates p42 and p44 MAP kinase via receptor-mediated signaling |
| Pj34 Inhibitor – a class of drugs |
| PGE2 chemical – It may be used within the vagina or by injection into a vein. |
| Mertk Signal | Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). |
| LY411575 inhibitor – LY411575 is a cell-permeable γ-secretase inhibitor |
| Pf 00835231 inhibitor – Pf 00835231 is a prodrug with the phosphate group being cleaved in vivo to yield the active agent PF-00835231. |
| AL3818 inhibitor – AL3818 is a highly potent and selective VEGFR2 inhibitor with IC50 less than 1 nM. |
| Secukinumab Inhibitor – Secukinumab is a human IgG1κ monoclonal antibody used for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. |
| MYCI975 inhibitor – Additional effects of MYCi on the tumor immune microenvironment including immune cell infiltration and upregulation of PD-L1 expression provide a rationale for combining MYCi with anti-... |
| Gkt137831 Inhibitor – Gkt137831 is an experimental orally bioavailable dual inhibitor of NADPH oxidase isoforms NOX4 and NOX1. |
| LDN-193189 Inhibitor.com – It has been researched for the treatment of fibrodysplasia ossificans progressiva. |
| R51211 inhibitor – used to treat a number of fungal infections |
| BTSA1 activator – BTSA1-induced BAX activation effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells. |
| Chloroquine activator – resistant strains |
| Malt1 inhibitor – Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a protein that in humans is encoded by the MALT1 gene. |
| LDC000067 inhibitor – LDC000067, helps to prevent from osteolytic disorders has not been fully elucidated. |
| Go6983 Inhibitor – Compared with adult stem cells, DFAT cells show unique advantages in abundance, isolation and homogeneity. |
| Verteporfin chemical – used as a photosensitizer for photodynamic therapy |
| Erk signal | Phencyclidine and related drugs such as benocyclidine, tenocyclidine, ketamine, and dizocilpine (MK-801), have been shown to inhibit the reuptake of the monoamine neurotransmitters. |
| Tomivosertib Inhibitor – vesicular reuptake |
| Roscovitine Inhibitor – Seliciclib is in clinical trials for B-cell lymphomas, including multiple myeloma. |
| CGK733 inhibitor – an inhibitor of ATM/ATR kinases |
| BAY 853934 Modulator – BAY 853934 stimulates production of hemoglobin and red blood cells. |
| Hiv Protease Signal | Each virion comprises a viral envelope and associated matrix enclosing a capsid. |
| Bc 2059 Antagonist – histamine receptor |
| Igf Protein | Approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP) |
| Win55 inhibitor – produces effects similar to those of cannabinoids such as THC |
| H3b 6527 Inhibitor – reuptake inhibitors |
| Tofacitinib Inhibitor – JAK inhibitor |
| FLT-3 Inhibitors | The drug is approved for use with a companion diagnostic. |
| LY294002 Inhibitor.com – LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. |
| Src Signaling – Src can be activated by receptor tyrosine kinases such as EGFR and HGF receptors. |
| VPA inhibitor – erious side effects can include liver failure, and regular monitoring of liver function tests is therefore recommended. |
| Blu 285 Inhibitor – kinase inhibitor |
| Su5416 Inhibitor – SU5416 is a potent and selective synthetic inhibitor of the Flk-1/KDR vascular endothelial growth factor (VEGF) receptor tyrosine kinase. |
| Tezacaftor Modulator – CFTR protein |
| Laq824 Inhibitor – Studies in leukemia have indicated that the histone deacetylase inhibitor LAQ824 increases apoptosis by decreasing the expression levels of the c-FLIPs. |
| Chk2 Inhibitor | Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. |
| JNJ-42756493 inhibitor – Fibroblast growth factor receptor |
| Compound 7 inhibitor – a molecule that binds to an enzyme |
| Mirdametinib inhibitor – inhibit MEK1 and MEK2 |
| 17-AAG Inhibitor.com – Heat shock protein 90 (HSP90), one of a family of molecular chaperones, is intimately involved in the survival of tumour cells. |
| Sp2509 Inhibitor – myocardial infarction |
| GF109203x inhibitor – GF109203X, a specific PKC inhibitor, abrogates anti-CD3 antibody-induced upregulation of CD4+ T cell adhesion to B cells |
| AS1842856 inhibitor – AS1842856 presents a novel proliferation inducer for the chemically defined, xeno-free expansion of hiPSC-derived CMs. |
| U73122 inhibitor – blocked hCG-stimulated mOMEC proliferation |
| Metabolism Signaling | The set of life-sustaining chemical reactions in organisms |
| Ml162 Inhibitor – enkephalinase inhibitors |
| HLS831 Inhibitor – HLS 831 inhibits basal and cyclic AMP-stimulated protein kinase activities |
| 2 methoxyestradiol Inhibitor – breast cancer |
| Abbv 744 Inhibitor – BET inhibitors can be instrumental in overcoming resistance to other targeted therapies when used in combination therapies. |
| BAY 2402234 Inhibitor – BAY 2402234 induces differentiation and inhibits proliferation in AML cell lines |
| NG52 inhibitor – inhibiting Cdc28p |
| Igf1r Signaling | With the exception of therapeutic antibodies, many proteins are degraded if administered orally and most often cannot cross cell membranes. |
| Pemrametostat inhibitor – protein arginine methyltransferase 5 |
| Dibenzazepine inhibitor – Dibenzazepine combats acute liver injury in rats via amendments of Notch signaling and activation of autophagy |
| vu661013inhibitor.com – Just another WordPress site |
| Tudca Chemical – Tudca is a naturally occurring hydrophilic bile acid which is the taurine conjugated form of ursodeoxycholic acid. |
| Abbv 075 Inhibitor – inflammatory conditions |
| Mmp signaling | The MMPs belong to a larger family of proteases known as the metzincin superfamily. |
| Survivin Signaling | Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. |
| Srt1720 activator – In animal models of obesity and diabetes SRT1720 was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increase mitochondrial ... |
| Apoptosis Signal | Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. |
| Selitrectinib Inhibitor – antineoplastic drugs |
| Auroraksp | The smallest unit of an element is an atom. |
| FRAX597 inhibitor – FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine |
| Dapagliflozin Inhibitor – hypoglycaemia |
| Obatoclax Antagonist – Obatoclax is an inhibitor of the Bcl-2 family of proteins. |
| Gsk2141795 Inhibitor – Inhibitors like TEPP modify the serine residue in the esteratic site of the cholinesterase. |
| Pepstatina inhibitor – It was originally isolated from cultures of various species of Actinomyces due to its ability to inhibit pepsin at picomolar concentrations. |
| Blasticidin S Inhibitor – Blasticidin S is a nucleoside analogue antibiotic, resembling the nucleoside cytidine. |
| Sr 4835 Inhibitor – About half of newborns exposed to ACE inhibitors are adversely affected, leading to birth defects. |
| Icg 001 Inhibitor – Icg 001 is targeted in colorectal cancer, head and neck squamous cell carcinoma. |
| LGX818 inhibitor – LGX818 is a small molecule BRAF inhibitor that targets key enzymes in the MAPK signaling pathway. |
| Beta-nicotinamide – A nicotinamide phosphoribosyltransferase with high activity was newly screened. |
| Gemcitabine Inhibitor – various carcinomas |
| PHA-848125 inhibitor – Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125 |
| GNS-1480 inhibitor – GNS-1480 is an highly potent, mutant-selective and irreversible EGFR Tyrosine-kinase inhibitors |
| ALISERTIB Inhibitor.com – Alisertib is an oral aurora kinase inhibitor which has been shown to induce cell-cycle arrest and apoptosis in preclinical studies. |
| Hsp70 Inhibitor | Membrane-bound Hsp70s have been identified as a potential target for cancer therapies. |
| Rmc 4550 Inhibitor – mode of action |
| C.I. 75535 Inhibitor – C.I. 75535 is definitely an inhibitor of TMEM16A chloride funnel activity |
| Syn-117 inhibitor – As of 2012, clinical trials to assess nepicastat as a treatment for post-traumatic stress disorder (PTSD) and cocaine dependence have been completed. |
| Fxr Agonists | A new class called Farnesoid X receptor (FXR) agonist |
| GDC-0449 Inhibitor.com – GDC-0449 is proven to be both effective and of low toxicity in several types of solid tumor In particular |
| Alk Signals | With high enough doses, occupation becomes as much as 80–90%. |
| Dpp4 Receptor | Signaling molecules can be synthesized from various biosynthetic pathways and released through passive or active transports, or even from cell damage. |
| PP242 inhibitor – PP242 directed at the ATP-binding pocket was generated. |
| Ataluren Inhibitor – Ataluren is an oxadiazole. |
| Epoxide Hydrolase | Grey iron metal and yellow sulfur are both chemical elements. |
| Fungal Signaling | Non-stoichiometric compounds are a special case. |
| SNX-5422 inhibitor – SNX-5422 is a direct, potent inhibitor of Hsp90 across a broad range of human cancer cell lines and causes degradation of important Hsp90 client proteins including HER2, AKT and ERK.... |
| Cck Receptor | A group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin. |
| AZD2281 Inhibitor – It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. |
| SLX-2119 inhibitor – Anti-adipogenic effects of SLx-2119, a ROCK2-specific inhibitor, in 3T3-L1 cells |
| Pirfenidone Inhibitor – lung fibrosis |
| Dovitinib Inhibitor – FGFR family |
| ATM signals | ATM provides functionality that uses features of circuit switching and packet switching networks. |
| Saracatinib inhibitor – It was originally under development for the treatment of cancer, but while it appeared promising in animal studies and was well tolerated in humans, it failed to show sufficient ... |
| 2hydroxy 4methylthiobutanoate – organic reaction |
| 2dg Modulator – demodulation |
| SEL120-34a inhibitor – SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. |
| Mln8237 Inhibitor – Mln8237 was investigated as a treatment for relapsed or refractory peripheral T-cell lymphoma. |
| JNJ-7706621 Inhibitor – JNJ-7706621 inhibited cell growth independent of p53, retinoblastoma, or P-glycoprotein status; activated apoptosis; and reduced colony formation |
| Lumacaftor modulator – acts as a chaperone during protein folding |
| Her2 signal | HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. |
| Iacs 13909 Inhibitor – Some believe ramipril's additional benefits may be shared by some or all drugs in the ACE-inhibitor class. |
| Isoxazole 9 antagonist – the class of compounds containing this ring |
| 3methyl Inhibitor – dissociative effects |
| GW856553X inhibitor – for the treatment of facioscapulohumeral muscular dystrophy |
| NSC293100 inhibitor – one of the chemical compounds |
| Hsp receptor | While these symptoms may indicate cancer, they can also have other causes. |
| Ispinesib Inhibitor – Mutations in the KIF11 gene convey resistance of mitotic cell lines to inhibitors such as monastrol and STLC. |
| CRET Signal | structural genes encode proteins that are not involved in gene regulation. |
| Scarlet 808 inhibitor – NADPH oxidase isoforms NOX4 and NOX1 |
| GSK2879552 inhibitor – The clinical activity of GSK2879552 given orally in participants with SCLC was evaluated by assessing disease control rate. |
| Daunorubicin Inhibitor – treating AML |
| Ipilimumab Inhibitor – Ipilimumab turns off this inhibitory mechanism and boosts the body's immune response against cancer cells. |
| SC 236 agonist – cyclooxygenase-2 or COX-2 |
| ENMD-2076 inhibitor – ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action |
| CL59806 Chemical – CL 59806 inhibits the game of caspase |
| Vlx1570 Inhibitor – MAOIs differ by their selectivity of the MAO enzyme subtype. |
| Navitoclax inhibitor – In animal studies, navitoclax was found to be a senolytic agent, inducing apoptosis in senescent, but not non-senescent cells. |
| Palomid 529 Inhibitor – Palomid 529 inhibits proliferation |
| Agerafenib inhibitor – exhibited a favorable toxicity profile |
| Dna repair Inhibitor | In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions ... |
| Nf Kb Inhibitor | NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized ... |
| NPI-0052 inhibitor – NPI-0052 entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003. |
| Jnj 7706621 Inhibitor – treatment of pruritus |
| Zm447439 Inhibitor – regulate cell cycle |
| Enasidenib inhibitor – Enasidenib is a medication used to treat relapsed or refractory acute myeloid leukemia in people with specific mutations of the isocitrate dehydrogenase 2 (IDH2) gene, determined ... |
| KPT-8602 inhibitor – KPT-8602 can be given daily compared to the two or three times weekly regimen of selinexor |
| Naporafenib Inhibitor – ovarian cancer |
| Mivebresib Inhibitor – well tolerated |
| Dca Inhibitor – DCA is typically prepared by the reduction of trichloroacetic acid. |
| ND-646 inhibitor – Metabolic profiling identifies decreased rates of glycolysis upon GW6471 treatment, consistent with transcriptome profiling. Finally, xanthohumol, 5-(tetradecyloxy)-2-furoic acid, and ... |
| Momelotinib inhibitor – The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM). |
| PQ401 Inhibitor – PQ-401 is an IGF-1R inhibitor |
| UK-383367 Inhibitor – UK-383367 inhibits bovine collagen deposition |
| Jnk in 8 Inhibitor – The downstream molecules that are inhibited by JNK activation include NFAT4, NFATC1 and STAT3. |
| Fkbp Signal | At this level of inhibition, the transporter will be considerably less efficient at removing excess neurotransmitter from the synapse and this causes a substantial increase in the extracellular ... |
| Ikk Inhibitor Vii – The Ikk kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. |
| PDGFR Signals | For example, in the figure showing trypanothione reductase from the human protozoan parasite Trypanosoma cruzi, two molecules of an inhibitor called quinacrine mustard are bound in its ... |
| AT7519 inhibitor – The cyclin-dependent kinase inhibitor AT7519 augments cisplatin's efficacy in ovarian cancer via multiple oncogenic signaling pathways |
| Abc294640 inhibitor – Sphingosine kinase 2 inhibitor ABC294640 suppresses neuronal excitability and inhibits multiple endogenously and exogenously expressed voltage-gated ion channels in cultured cells |
| Taar Signals | TAAR2–TAAR9 function as olfactory receptors for volatile amine odorants in vertebrates. |
| Ck 1827452 Activator – cardiac specific myosin |
| Colforsin | Forskolin contains some unique functional elements, including the presence of a tetrahydropyran-derived heterocyclic ring. |
| Olaparib Inhibitor – PARP inhibitor |
| CDK2-in-73 inhibitor – cell division protein kinase 2 |
| Maraviroc Antagonist – entry inhibitor |
| Nepicastat inhibitor – Nepicastat is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. |
| Mk 5108 Inhibitor – Since the drug decreases the activity of the enzyme that halts the signal, it makes this signal last for a longer period of time. |
| BAY 80-6946 inhibitor – Data for safety and efficacy of copanlisib are described in the consumer-targeted FDA Drug Trial Snapshot. |
| Crfr Receptor | CRFRs are important mediators in the stress response. |
| MK-8617 modulator – Metabolic study of hypoxia-inducible factor stabilizers BAY 87-2243, MK-8617, and PT-2385 in equine liver microsomes for doping control |
| BAY 632521 Chemical – BAY 63-2521 constitutes the first drug of the class of sGC stimulators. |
| Phosphorylase Signals | The γ subunit is the site of the enzyme's catalytic activity while the other three subunits serve regulatory functions. |
| ERK signaling | When ATP levels rise, ATP binds an allosteric site in PFK1 to decrease the rate of the enzyme reaction; glycolysis is inhibited and ATP production falls. |
| Tpor Signaling | Individual atoms can be held together by chemical bonds to form molecules and ionic compounds. |
| Mtor Signals | A kinase that in humans is encoded by the MTOR gene. |
| CETP Signal | CETP is a member of a class of drugs |
| KU-57788 inhibitor – KU-57788 is a highly potent and selective DNA-PK inhibitor |
| Inflammation Inhibitors | Inflammation has also been classified as Type 1 and Type 2 based on the type of cytokines and helper T cells involved. |
| Microbiology Receptor | Viruses have been variably classified as organisms. |
| Epigenetics Inhibitors – Epigenetics is the study of stable phenotypic changes that do not involve alterations in the DNA sequence. |
| Oat Receptor | Two molecules of water can form a hydrogen bond between them. |
| Adriamycin Inhibitor – This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. |
| Fk506 Inhibitor – Fk506 is an immunosuppressive drug. |
| Pembrolizumab Inhibitor – Pembrolizumab is given by slow injection into a vein. |
| MK-2206 Inhibitor – It is intended to be used with other cancer therapies that advanced tumours may become resistant to. |
| Taste Receptor | A type of cellular receptor which facilitates the sensation of taste. |
| GW610 agonist – an antitumor agent |
| Tanespimycin Inhibitor.com – It belongs to the family of drugs called antitumor antibiotics. |
| TAE226 inhibitor – TAE226 is a novel small molecule FAK inhibitor. |
| Gdc 0941 Inhibitor – All gdc 0941 Inhibitor that are currently approved inhibit one or more p110 isoforms of the class I PI3Ks. |
| Erastin activator – Cells treated with erastin are deprived of cysteine and are unable to synthesize the antioxidant glutathione. Depletion of glutathione eventually leads to excessive lipid peroxidation ... |
| Prep Signal | carbon can form covalent bonds with up to four other atoms |
| MRT 10 inhibitor – showing the capacity to abrogate the constitutive activity of Smo |
| Pd173074 Inhibitor – Selective FGFR inhibitors include AZD4547, BGJ398, JNJ42756493, and PD173074. |
| Estrogen Progestogen | A progestin is a synthetic progestogen. |
| Tw 37 Inhibitor – immune response |
| Ly2801653 Inhibitor – molecule inhibitor |
| Riluzole inhibitor – treat amyotrophic lateral sclerosis |
| NSC3590 chemical – treat colorectal cancer and pancreatic cancer |
| Telaglenastat Inhibitor – family Tephritidae |
| AZ960 inhibitor – induces growth arrest |
| Brusatol Inhibitor – allosteric inhibitor |
| Fps zm1 Inhibitor – The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. |
| GSK3326595 inhibitor – GSK3326595 is a promising drug to prevent SARS-CoV-2 Omicron and other variants infection by inhibiting ACE2-R671 di-methylation |
| AZD5991 inhibitor – able to induce intrinsic apoptosis in cells |
| MLN9708 inhibitor – a type of white blood cell cancer |
| Ticagrelorant Agonist – Ticagrelor is a weak CYP3A4 inhibitor. |
| Malotilate Inhibitor – liver disease |
| Nsc266046 Inhibitor – treatment for depression |
| Plx 4720 Inhibitor – PLX4720 has good affinity for the ATP binding site partially because its anchor region. |
| Ha15 Modulator – device or circuit |
| Asunaprevir Inhibitor – Asunaprevir is an inhibitor of the hepatitis C virus enzyme serine protease NS3. |
| FAAH Signal | FAAH is a member of the serine hydrolase |
| PI3K signals | This pathway is necessary, however, to promote growth and proliferation over differentiation of adult stem cells, neural stem cells specifically. |
| 4u8c inhibitor – attenuated joint inflammation in mice |
| Gs 9973 Inhibitor – Gs 9973 is an experimental drug for the treatment of various types of cancer under development by Gilead Sciences. |
| Co 1686 Inhibitor – potential treatment |
| Lalistat 2 inhibitor – lysosomal acid lipase |
| Resveratrol activator – Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts. |
| Tak165 inhibitor – It completed phase I clinical trials but appears to have been discontinued, as no new information on the drug has surfaced since December 2008. |
| Vmat Receptor | Many drugs that target VMATs act as inhibitors and alter the kinetics of the protein. |
| Fluoxetine inhibitor – sed for the treatment of major depressive disorder |
| Ilomastat inhibitor – This chemotherapy agent is considered to have application in skincare products for its antiaging properties. |
| PFTA Inhibitor.com – PFTA established the first internationally recognized standard for fair trade olive oil in coordination |
| PF-477736 inhibitor – The BRCA2 mutated V-C8 cells were 1000 more sensitive to rucaparib cytotoxicity than their matched BRCA2 corrected V-C8.B2 cells, but no more sensitive to PF-477736 despite having ... |
| PF-00562271 inhibitor – led to decreased tumor growth |
| Baricitinib Inhibitor – serious bacterial |
| AGK2 inhibitor – a selective SIRT2 inhibitor |
| Histamine Receptor Signaling | A class of G protein–coupled receptors which bind histamine as their primary endogenous ligand. |
| SB4 chemical – bone morphogenetic protein 4 |
| Jnk Signals | TrkA can prevent p75NTR-mediated JNK pathway apoptosis. |
| GGTI 298 TFA inhibitor – the inhibition of the EGFR-AKT signaling pathway |
| Glutathione Signal | The carboxyl group of the cysteine residue is attached by normal peptide linkage to glycine. |
| Icotinib Inhibitor – highly selective |
| Ly2606368 Inhibitor – Research continues into the efficacy of ly2606368 in treatment of acute myeloid leukemia. |
| Bromosporine Inhibitor – A key step for the regulation of glycolysis is an early reaction in the pathway catalysed by phosphofructokinase-1. |
| MK-1775 Inhibitor – MK-1775 Inhibitors are enzymes responsible for the activation of many proteins by signal transduction cascades. |
| GPCR inhibitors | G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. |
| Mk 0518 Inhibitor – Mk 0518 has been synthesized in several ways, which have been reviewed. |
| Cp 91149 Inhibitor – anxiety disorders |
| Nvp lde225 Antagonist – Lde225 are an important class of anti-cancer drugs. |
| Nampt Receptor | The NAMPT inhibitor FK866 has been shown to inhibit epithelial–mesenchymal transition (EMT), and may also inhibit tumor-associated angiogenesis. |
| Mi-2 inhibitor – Autoantibodies to Mi-2 alpha and Mi-2 beta in patients with idiopathic inflammatory myopathy |
| Ezh12 Signals | Inside the cell, nucleotidases may help to maintain energy levels under stress conditions. |
| Histamine Receptor | Many drug molecules are enzyme inhibitors, so their discovery and improvement is an active area of research in biochemistry and pharmacology. |
| Venetoclax Inhibitor – a BH3 mimetic |
| Nintedanib Ethanesulfonate – combination with docetaxel |
| BI-3406 inhibitor – Effective in KRAS-Driven Cancers through Combined MEK Inhibition |
| FB23-2 inhibitor – inhibit FTOs mA demethylase activity |
| R428 Inhibitor – R428 is an experimental oral small molecule that is an inhibitor of AXL kinase. |
| Enterovirus Signals | The mutations are passed on to daughter cells during mitosis |
| Vinblastine inhibitor – This includes Hodgkin's lymphoma, non-small cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer. |
| P53 Receptor | P53 is any isoform of a protein encoded by homologous genes in various organisms |
| Chk signal | This is usually done using a MALDI-TOF mass spectrometer. In a complementary technique, peptide mass fingerprinting involves digestion of the native and modified protein with a protease such ... |
| Bay63 2521 Chemical – Bay63 2521 constitutes the first drug of the class of sGC stimulators. |
| P2 Receptor Signal | P2Y family has 8 receptors. |
| MRT67307 inhibitor – The non-specificity of MRT67307 and phospho-CYLD specific antibodies. |
| Tubastatina Inhibitor – The substrate and inhibitor cannot bind to the enzyme at the same time. |
| Endocrinology Inhibitors – Hormones have many different functions and modes of action. |
| Gedatolisib Inhibitor – Gedatolisib binds to mTOR to inhibit its activity. |
| Ganetespib inhibitor – Ganetespib treatment rapidly induced the degradation of known Hsp90 client proteins, displayed superior potency to the ansamycin inhibitor 17-allylamino-17-demethoxygeldanamycin.... |
| Imidazoline Receptor | Other receptors like nuclear receptors have a different mechanism such as changing their DNA binding properties and cellular localization to the nucleus. |
| Duvelisib inhibitor – Duvelisib may cause infections, diarrhea, inflammation of the intestines and lungs, skin reactions, and high liver enzyme levels in the blood. |
| Dub Receptor | Multiple weak bonds between the inhibitor and the active site combine to produce strong and specific binding. |
| AG1343 Inhibitor – AG1343 is an orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor |
| Xanthine Oxidase Signal | Xanthine oxidase inhibitors are being investigated for management of reperfusion injury. |
| Givinostat inhibitor – Givinostat inhibits class I and class II histone deacetylases (HDACs) and several pro-inflammatory cytokines. |
| Luteolin Inhibitor – Luteolin is the principal yellow dye compound that is obtained from the plant Reseda luteola. |
| SW033291 inhibitor – play an important role in promoting tissue |
| Way 316606 Antagonist – The bound antagonists may prevent conformational changes in the receptor required for receptor activation after the agonist binds. |
| GDC-0068 Inhibitor – It is a small molecule inhibitor of AKT, which is a key component of the PI3K/AKT pathway. |
| Ulk Signals | ULK1 is an enzyme that in humans is encoded by the ULK1 gene. |
| Gs 7340 Inhibitor – Genvoya is the first TAF-based regimen to receive approval. |
| Grk Signals | Arrestin binding to phosphorylated, active receptor prevents receptor stimulation of heterotrimeric G protein transducer proteins, blocking their cellular signaling and resulting in receptor ... |
| Glutaminase Receptor | Glutaminase is expressed and active in periportal hepatocytes. |
| CBL0137 activator – The interaction of CBL0137 with the FACT complex results in simultaneous NF-kB suppression, Heat Shock Factor 1 suppression and p53 activation. |
| BI2536 inhibitor – BI 2536 is a Plk1 inhibitor with an IC50 of 0.83 nM. |
| Btk Receptor | BTK plays a crucial role in B cell development. |
| Nucleoside Analogan | Nucleotide and nucleoside analogues can also be found naturally. |
| JIB-04 inhibitor – JIB-04 is a pan-selective inhibitor known to reduce cancer growth in lung cancer and prostate cancer cell lines. |
| Bindarit inhibitor – Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties |
| PP2A Receptor | Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. |
| Otx015 Inhibitor – Otx015 is an experimental small molecule inhibitor of BRD2, BRD3, and BRD4 under investigation for the treatment of cancer. |
| Dock Signal | IOR was described as "an inhibitory effect produced by a peripheral (or exogenous) cue or target. |
| Glucocorticoidrecep Signal | Other biocatalysts are catalytic RNA molecules, called ribozymes. |
| Harmine Chemical – Harmine is useful fluorescent pH indicator. |
| GS-4997 inhibitor – these results demonstrate that combined exposure to AlNPs and CRS exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway. |
| Acbi1 Chemical – structural information |
| Ciclesonide agonist – treat asthma and allergic rhinitis |
| FTI 277 inhibitor – farnesyl transferase |
| Rsv Signal | These compounds can be natural (such as secondary metabolites) or artificial (such as antiviral drugs); they may have a beneficial effect against a disease (such as drugs) or may be detrimental ... |
| Halofuginone Inhibitor – Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme glutamyl-prolyl tRNA synthetase. |
| Regorafenib inhibitor – targets angiogenic |
| Selective PI3K inhibitor 1 – related intracellular signal transducer enzymes capable |
| Ly2157299 Inhibitor – Ly2157299 was investigated in a phase II trial for treatment of hepatocellular carcinoma. |
| Acetyl CoA Carboxyla Signal | The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids. |
| Apoptosisrelated Signals | Each trial began with the brightening of the outline of one of the peripheral boxes that was randomly selected for 150 ms. During the trial, a target (a bright filled square)... |
| HSP Signal | Yeast Hsp90 is 60% identical to human Hsp90α. |
| Vbit-4 inhibitor – inhibit the VDAC |
| DCC-2618 inhibitor – the first new drug specifically approved in the United States |
| VEGFR signaling – Canonical versus non-canonical signalling indicates VEGF-dependent versus non-VEGF-dependent activation of VEGFR2. |
| Tacedinaline Inhibitor – Benzamide is an organic compound with the chemical formula of C7H7NO. |
| Ubiquitin inhibitor | The protein modifications can be either a single ubiquitin protein (monoubiquitylation) or a chain of ubiquitin (polyubiquitylation). |
| K858 inhibitor – inhibit cell replication |
| HBX 19818 Inhibitor – HBX19818 increased PARP1, protein PARylation, and nuclear apoptosis-inducing factor |
| BI 1383298 Inhibitor – BI 1482694 is an investigational anti-cancer drug |
| Azd9291 inhibitor – Osimertinib, sold under the brand name Tagrisso, is a medication used to treat non-small-cell lung carcinomas with specific mutations. |
| Phorbol12-myristate13-acetate – p53-mediated apoptosis |
| MEK162 Inhibitor – Inappropriate activation of the pathway has been shown to occur in many cancers. |
| Su5402 inhibitor – The FGF inhibitor, SU5402, inhibited Sulf1 expression when placed in the interdigital mesoderm. |
| Hdac Signaling | This kinetic behaviour is called slow-binding. |
| Crizotinib Inhibitor – treatment of NSCLC |
| Hedgehog signaling | Hedgehogs share distant ancestry with shrews (family Soricidae), with gymnures possibly being the intermediate link, and they have changed little over the last fifteen million years.... |
| IACS-010759 inhibitor – a potent inhibitor of glycolysis-deficient hypoxic tumor cells |
| VPS34 inhibitor – phosphorylates phosphatidylinositol to produce PtdIns3P |
| Encorafenib Inhibitor – BRAF inhibitor |
| Ramucirumab Inhibitor – It was isolated from a native phage display library from Dyax. |
| Alda 1 Agonist – Alda1 is used in treatment for the alcohol flush reaction experienced by people with genetically deficient ALDH2. |
| CHF 5074 Modulator – CHF5074 doesn't display inhibitory activity on COX-1 and COX-2 enzymes |
| Pd184352 Inhibitor – enzyme activity |
| Entrectinib inhibitor – Entrectinib, sold under the brand name Rozlytrek, is an anti-cancer medication used to treat ROS1-positive non-small cell lung cancer and NTRK fusion-positive solid tumors. |
| VU0361737 Agonist – VU 0361737 can penetrate into CNS. |
| Leucovorin Chemical – be taken as a pill |
| Enzalutamide Antagonist – a 40 mg Capsule |
| Mhy1485 Activator – Activators can recruit molecules known as coactivators. |
| TGF Beta Inhibitor | It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. |
| AZD7545 inhibitor – AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. |
| Tie-2 signals | Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. |
| Bay 1143572 Inhibitor – Reduced GFR is especially a problem if the patient is concomitantly taking an NSAID and a diuretic. |
| Loxistatin Inhibitor – antiviral effects |
| 17 dmag Inhibitor – Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor. |
| Bx 795 Inhibitor – The N-terminal peptide is cleaved from the zymogen enzyme precursor by another enzyme to release an active enzyme. |
| Nvp tnks656 Inhibitor – Trk family |
| Sirtuin Signalings | A family of signaling proteins involved in metabolic regulation. |
| FCE24304 inhibitor – treat breast cancer |
| Ceralasertib Inhibitor – permanent decrease |
| A-1210477 inhibitor – Drug sensitization studies revealed that A-1210477 sensitised the cervical cancer cell lines SiHa and CaSki to ABT-263 by 11- and fivefold, respectively. |
| Rucaparib inhibitor – used as an anti-cancer agent |
| NPG 555 Modulator – NGP 555, a γ-secretase modulator |
| Abbik | Two molecules of water can form a hydrogen bond between them. |
| BAF-a1 Inhibitor.com – BafA1 may be considered to be a central modulator of both apoptosis and autophagy. |
| ABT-888 Inhibitor.com – It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer ... |
| Pevonedistat Inhibitor.com – NEDD8-activating enzyme is a heterodimeric molecule consisting of amyloid beta precursor protein-binding protein 1. |
| Bictegravir Inhibitor – Bictegravir is a second-generation integrase inhibitor (INSTI) class that was structurally derived from an earlier compound dolutegravir by scientists at Gilead Sciences. |
| Inflammation inhibitor | Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli, and is achieved by the increased movement ... |
| Foxm1 Receptor | FOXM1-null mouse embryos were neonatal lethal as a result of the development of polyploid cardiomyocytes and hepatocytes, highlighting the role of FOXM1 in mitotic division. |
| PDK1 signal | The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer, and stomach cancer. |
| Gsk3235025 Inhibitor – Inhibitors can show different types of inhibition depending on which substrate is considered. |
| Bms 863233 Inhibitor – The active centre of cholinesterases feature two important sites, namely the anionic site and the esteratic site. |
| Abt 199 Inhibitor – Venetoclax attaches to a protein called Bcl-2. |
| Iap Signal | Exocytosis occurs via secretory portals at the cell plasma membrane called porosomes. |
| Car Receptor | Chimeric antigen receptors (CARs, also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors) are receptor proteins that have been engineered to give ... |
| AZD4573 inhibitor – Suppresses MCL-1 |
| Resiquimod agonist – Resiquimod has antiviral and antitumour activity |
| Mapk Inhibitor Library | The signal that starts the MAPK/ERK pathway is the binding of extracellular mitogen to a cell surface receptor. |
| Ci994 Inhibitor – A cell must control the coiling and uncoiling of DNA around histones. |
| Linderalactone inhibitor – inhibit the proliferation of the lung cancer A-549 cells |
| Factorxa Receptor | Carbon has six electrons, two of which are located in its first shell, leaving four electrons in its valence shell. |
| Inhibitor Screening | The extent of inhibition depends only on the concentration of the inhibitor. |
| selinexor inhibitor – Selinexor was granted accelerated approval by the U.S. |
| Transmembrane transporters inhibitor | Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. |
| Asp2215 Inhibitor – Asp2215 is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK. |
| I-bet-762 Inhibitor – Molecules remained largely unknown until 2010 when both the use of JQ1 in NUT midline carcinoma and of I-BET 762 in sepsis were published. |
| Immunology Inhibitors – Cancer immunosurveillance and immunoediting are based on protection against development of tumors in animal systems. |
| ATG-019 inhibitor – We present our recent experience with ATG administration both as induction therapy and as an anti-rejection treatment |
| Compound Libraries | Minimize time & cost of screening using highly functional Compound Libraries |
| Pai1 Signal | In exocytosis, membrane-bound secretory vesicles are carried to the cell membrane, where they dock and fuse at porosomes and their contents (i.e., water-soluble molecules) are secreted into ... |
| Pges Receptor | Receptors for the series 2 prostanoids also bind with and respond to the series 1 and 3 prostanoids. |
| Antibio ticsformamm | Many therapeutic drugs and poisons are enzyme inhibitors. |
| Molecule Library | Since the drug decreases the activity of the enzyme that halts the signal, it makes this signal last for a longer period of time. |
| Protein Tyrosine Kinase | Tyrosine kinases catalyze the phosphorylation of tyrosine residues in proteins. |
| Ribosomal Peptidylt Signaling | rRNA is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. |
| Ire1 Receptor | This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.... |
| 8 bromo camp – 8 bromo is an adenosine receptor A1 antagonist. |
| AG-120 inhibitor – AG-120 is the first inhibitor of the mIDH1 enzyme to achieve clinical proof of concept in human trials. |
| Hormones Inhibitor | Hormone receptors are dynamic structures. |
| MLN4924 Inhibitor.com – NEDD8-pevonedistat adduct cannot be utilized in subsequent reactions necessary for NAE activity. |
| Cp 673451 Inhibitor – Enzymes in a metabolic pathway may be inhibited by molecules produced later in the pathway. |
| Microbiology Inhibitors – Epidemiology, the study of the patterns, causes, and effects of health and disease conditions in populations, is an important part of medical microbiology |
| Qnz Inhibitor – PDE4 is the major cAMP-metabolizing enzyme found in inflammatory and immune cells. |
| Gsk8612 Inhibitor – 5F-ADB is a potent agonist of the CB1 receptor. |
| Endocrinology inhibitor | The endocrine system consists of several glands, all in different parts of the body, that secrete hormones directly into the blood rather than into a duct system. |
| Cytoskeletal Signaling Inhibitors – A multitude of functions can be performed by the cytoskeleton. |
| ATP Citrate Lyase Signals | ATP citrate synthasese is an enzyme. |
| Proteases Inhibitors – Some of the most well known are antiviral drugs widely used to treat HIV/AIDS and hepatitis C. |
| Neuraminidase Receptor | A second type of reuptake inhibition affects vesicular transport, and blocks the intracellular repackaging of neurotransmitters into cytoplasmic vesicles. |
| Gdc0032 Inhibitor – Currently running clinical trials were continued for patients exhibiting benefit. |
| CMC-na chemical – Carboxymethyl cellulose is synthesized by the alkali-catalyzed reaction of cellulose with chloroacetic acid. |
| Natural Products | The latest published issue of Journal of Natural Products |
| T0070907 Inhibitor – The safety of using berberine for any condition is not adequately defined by high-quality clinical research. |
| Methylation Inhibitors – Methylation can change the activity of a DNA segment without changing the sequence. |
| RO180647 inhibitor – the saturated derivative of lipstatin |
| tcn201chemical.com – Just another WordPress site |
| PD151746 Inhibitor – PD 151746 is a calpain-1 inhibitor |
| BAY85-3934 modulator – The stage of clinical trials is reviewed for the anti-anaemia drug candidates FG-2216, FG-4592, GSK1278863, AKB-6548, and BAY85-3934. |
| ML210 agonist – an inhibitor of GPX4 |
| CP-640186 Inhibitor – CP-640186 is identified as a novel β-cell GLTprotective small molecule with nanomolar potency. |
| GAP 27 antagonist – a gap junction inhibitor |
| Mtor signal | However, this decarboxylation reaction is followed by the elimination of a fluorine atom, which converts this catalytic intermediate into a conjugated imine, a highly electrophilic species.... |
| Sr 18292 Inhibitor – Coagulation is highly conserved throughout biology. |
| PXD101 inhibitor – PXD101 retarded growth of 8505C ATC xenograft tumors with promising safety. |
| Eganelisib inhibitor – a highly selective phosphoinositide 3-kinase inhibitor |
| Tranilast Chemical – Tranilast is an analog of a metabolite of tryptophan, and its chemical name is 3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′) |
| Ro5126766 Inhibitor – CKI 27 |
| Mek signal | These electrophilic groups react with amino acid side chains to form covalent adducts. |
| Compound 19 inhibitor – links T-cell autophagy to autoimmunity |
| Gsk 3signals | Other examples of physiological enzyme inhibitor proteins include the barstar inhibitor of the bacterial ribonuclease barnase. |
| L189 Inhibitor – L 189 is really a novel human DNA ligase inhibitor |
| PF 429242 Inhibitor – PF-429242 could be used to prevent the ATF6-dependent down regulation of some genes. |
| Atglistatin inhibitor – Atglistatin Pretreatment Preserves Remote Myocardium Function Following Myocardial Infarction |
| Pgc1 Signal | PGC-1α is also the primary regulator of liver gluconeogenesis, inducing increased gene expression for gluconeogenesis. |
| Ifosfamide Inhibitor – Ifosfamide is in the alkylating agent and nitrogen mustard family of medications. |
| Acalabrutinib Inhibitor – Acalabrutinib blocks an enzyme called Bruton's tyrosine kinase, which helps B cells to survive and grow. |
| U0126 inhibitor – The effects of U0126 on the growth of eight human breast cancer cell lines shown that U0126 selectively repressed anchorage-independent growth of MDA-MB231 and HBC4 cells, two lines with ... |
| GPCR Inhibitor | The secretin-receptor family of GPCRs include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin and parathyroid hormone/parathyroid hormone-related peptides.... |
| Integrin Signal | Integrins are transmembrane receptors that facilitate cell-cell and cell-extracellular matrix (ECM) adhesion. |
| Choline Kinase Signal | CK is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. |
| Brd0539 Inhibitor – The main adverse effects of ACE inhibition can be understood from their pharmacological action. |
| Birb796 Inhibitor – p38 inhibitors are being sought for possible therapeutic effect on autoimmune diseases and inflammatory processes. |
| Dna Damage Signals | DNA damage and mutation have different biological consequences. |
| Cay10603 Inhibitor – Cancer cells are more sensitive to inhibition of mitosis than normal cells. |
| Abtent | Enzyme inhibitors are often designed to mimic the transition state or intermediate of an enzyme-catalyzed reaction. |
| Ox Receptor | Receptors are generally proteins located on the cell surface or within the interior of the cell such as the cytoplasm, organelles, and nucleus. |
| Rgx 104 Agonist – Relugolix is a substrate for P-glycoprotein, which may have a limiting effect on its absorption and distribution. |
| Belinostat inhibitor – Belinostat (trade name Beleodaq, previously known as PXD101) is a histone deacetylase inhibitor drug developed by TopoTarget for the treatment of hematological malignancies and solid ... |
| GNE-140 inhibitor – blocked the MSM-induced Arg1 expression in this disease model |
| GSK461364 inhibitor – GSK461364 should involve coadministration of prophylactic anticoagulation. |
| Lw6 Inhibitor – breast milk |
| VU 0357121 – a positive allosteric modulator |
| Gsk1210151a Inhibitor – A number of molecules have been described that are capable of targeting BET bromodomains. |
| AZD0530 inhibitor – AZD0530 is an inhibitor of Src and Abl family kinases1. |
| Sapitinib Inhibitor – A low concentration of the enzyme inhibitor reduces the risk for liver and kidney damage and other adverse drug reactions in humans. |
| BAM 15 inhibitor – protecting mammals from acute renal ischemic-reperfusion injury |
| Nedisertib Inhibitor – Frequently prescribed ACE inhibitors include benazepril, zofenopril, perindopril, trandolapril, captopril, enalapril, lisinopril, and ramipril. |
| Azd6244 Inhibitor – Azd6244 has also been shown to inhibit growth of GNAQ mutated uveal melanoma cell lines. |
| PF-4708671 inhibitor – PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 |
| Malt Signaling | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a protein that in humans is encoded by the MALT1 gene. |
| Camrelizumab inhibitor – Camrelizumab is an anti-PD-1 immune checkpoint inhibitor that is being investigated for hepatocellular carcinoma and Hodgkin lymphoma. |
| Cd38 Inhibitor1 – CD38 functions in cell adhesion, signal transduction and calcium signaling. |
| Wnt Agonist1 Activator – The 5-HT1A receptors in the raphe nucleus are largely somatodendritic autoreceptors, whereas those in other areas such as the hippocampus are postsynaptic receptors. |
| OSI-906 inhibitor – Phase II clinical trials were initiated for multiple myeloma, ovarian cancer, hepatocellular carcinoma, and NSCLC, but subsatisfactory results caused research for these indications ... |
| D 4476 Inhibitor – D 4476 also functions being an ALK5 inhibitor |
| BB-94 inhibitor – EPCs alone or in combination with BB-94 may exert protective effects against ischemic stroke via the reduction of MMP expression. |
| Beta Amyloid Signal | Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. |
| Pde signal | The ubiquitous presence of this enzyme means that non-specific inhibitors have a wide range of actions, the actions in the heart, and lungs being some of the first to find a therapeutic use.... |
| GSK-2894631a inhibitor – improve the recovery of tendons of adult male rats |
| CCI-779 inhibitor – mTOR is activated in tumor cells by various mechanisms including growth factor surface receptor tyrosine kinases, oncogenes, and loss of tumor suppressor genes. |
| Glasdegib inhibitor – a small molecule inhibitor of sonic hedgehog |
| Afatinib Inhibitor – harbour mutations |
| Gsk2118436 Inhibitor – Gsk2118436 is a medication for the treatment of cancers associated with a mutated version of the gene BRAF. |
| Aciclovir chemical – used for the treatment of herpes simplex virus infections |
| Devimistat inhibitor – Devimistat's mechanism of action differs from other drugs, operating on the tricarboxylic acid cycle and inhibiting enzymes involved with cancer cell energy metabolism. |
| PRT062607 inhibitor – PRT062607 demonstrated a favorable PK profile and the ability to completely inhibit SYK activity in multiple whole-blood assays. |
| CC220 chemical – CC220 is a high-affinity cereblon ligand that targets the hematopoietic transcription factors Ikaros and Aiolos for proteasomal degradation. |
| Dynasore inhibitor – Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs. |
| JNJ-63533054 Agonist – JNJ-63533054 is a human GPR139-selective agonist |
| 5 azacytidine Inhibitor – myeloid leukemia |
| SKI-606 inhibitor – src tyrosine kinase inhibitor |
| CSG452 agonist – the treatment of diabetes mellitus |
| Peptide Cost | This chart is price per residue for most standard peptides |
| Ganciclovir Inhibitor – Ganciclovir is commonly associated with a range of serious haematological adverse effects. |
| 10-deacetylbaccatin iii – organic compounds |
| Dna Damage Inhibitors – DNA damage can occur naturally or via environmental factors, but is distinctly different from mutation. |
| Leuprolide Agonist – The leuprorelin is given by intramuscular injection and the norethisterone acetate is taken by mouth. |
| Haspin Kinase Signal | In a discrete water molecule, there are two hydrogen atoms and one oxygen atom. |
| Ampa Receptor-kainat | Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. |
| Epigenetics Inhibitor | Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of normal development. |
| Pim Receptor | The algal toxin microcystin is also a peptide and is an inhibitor of protein phosphatases. |
| Abinhibitor | The polar property of water allows it to attract other water molecules via hydrogen bonds, which makes water cohesive. |
| Napabucasin inhibitor – Napabucasin is an orally administered agent. |
| Sc75741 Inhibitor – Methotrexate and the protease inhibitors used to treat HIV/AIDS. |
| SB525334 inhibitor – HPMCs were treated with TGF-β1 and/or SB525334. |
| Savolitinib inhibitor – Savolitinib is being investigated for the treatment of cancer by AstraZeneca. |
| RO-3306 Inhibitor – Cell synchrony is a vital process in the study of cells progressing |
| Adavivint Inhibitor – ACE inhibitors can be used alone or in combination with other anti-hypertensive medications. |
| Dub signal | In females, the most common types are breast cancer, colorectal cancer, lung cancer, and cervical cancer. |
| Bi 4020 Inhibitor – Enzymes in a metabolic pathway may be inhibited by molecules produced later in the pathway. |
| Blu 554 Inhibitor – Enzyme inhibitors are found in nature and also produced artificially in the laboratory. |
| Adccytotoxin Signal | An estimated 29% of currently approved drugs are enzyme inhibitors of which approximately 1/3 are kinase inhibitors. |
| Casein Kinase Signals | Kinases are needed to stabilize this reaction |
| GW4064 agonist – The possible structural modification strategies on GW4064 were also proposed. |
| Epirubicin Inhibitor – Similarly to other anthracyclines, epirubicin acts by intercalating DNA strands. |
| Survivin Signal | A family of signaling proteins involved in metabolic regulation. |
| Pralsetinib Inhibitor – Pralsetinib is a tyrosine kinase inhibitor. |
| Thapsigargin Inhibitor – Thapsigargin is classified as a guaianolide. |
| Plx3397 Inhibitor – Common side effects are increased lactate dehydrogenase. |
| PDGF Signal | PDGF signal transduction inhibition ameliorates experimental |
| LY80400 inhibitor – play an important role in all cells |
| DNA Repair Inhibitor | The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. |
| STM2457 inhibitor – a selective inhibitor of METTL3 |
| VUF10166 Antagonist – VUF10166 displayes saturable binding with a Kd of 0.18 nM |
| ZM323881 Inhibitor – ZM 323881 inhibits VEGFR-2 activity |
| Apitolisib inhibitor – Apitolisib treatment with gemcitabine and/or cisplatin synergistically reduces cholangiocarcinoma cell growth by suppressing the PI3K/Akt/mTOR pathway |
| Cytoskeletal Signaling | Microfilaments are composed of the most abundant cellular protein known as actin. |
| R41400 inhibitor – treat a number of fungal infections |
| Gamma Secretase Signal | The gamma secretase complex is thought to assemble and mature via proteolysis in the early endoplasmic reticulum. |
| Ikk Signaling | Genes are the basic unit of organism genetic. |
| ORG27569 agonist – increases the ability of CB1 agonists |
| Valproic inhibitor – used primarily in the treatment of epilepsy |
| Way 252623 Agonist – transcription factors |
| P450 signal | In addition, naturally produced poisons are often enzyme inhibitors that have evolved for use as toxic agents against predators, prey, and competing organisms. |
| FTY720 ant agonist – sequesters lymphocytes in lymph nodes |
| Pirarubicin inhibitor – intercalates into DNA and interacts with topoisomerase II |
| BAY734506 inhibitor – stromal and oncogenic receptor tyrosine kinase |
| GDC0032 Inhibitor – GDC-0032 inhibits MCF7-neo/HER2 cells proliferation |
| ST271 activator – inhibits phospholipase D |
| Garcinia Cambogia Chemical – weight loss |
| BI-894999 Inhibitor – BI 894999 is active as monotherapy in AML xenografts |
| Fens Signaling | A ubiquitous example of a hydrogen bond is found between water molecules. |
| Pravastatin Inhibitor – treatment of dyslipidemia |
| Costunolide Inhibitor – Costunolide first isolated in Saussurea costus roots in 1960. It is also found in lettuce |
| CCRG81045 chemical – taken by mouth or via intravenous infusion |
| WH-4-023 inhibitor – Treatment with dexamethasone and dasatinib also impaired engraftment of leukemia cells in vivo. |
| SB252218 chemical – developed by Kissei Pharmaceuticals |
| Mapk signal | Since ERK1 and its close relative ERK2 (MAPK1) are both involved in growth factor signaling, the family was termed "mitogen-activated". |
| Trametinib inhibitor – used for the treatment of melanoma |
| Epigenetics Inhibitor | Just another WordPress site |
| DS-1001b inhibitor – Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma |
| Thioredoxin Reductas | Thioredoxin plays a role in many important biological processes |
| Bisindolylmaleimide ix – central maleimide |
| BaptA-AM inhibitor – similarly to EGTA and EDTA |
| Upr inhibitor | The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum. |
| JNJ303 inhibitor – IKs blockade |
| Gsk2606414 Inhibitor – cognitive deficits |
| SP600125 Inhibitor.com – It is used in biochemical studies as an inhibitor of c-Jun N-terminal kinases. |
| GW4869 Inhibitor – Among the various mechanisms involved in atherogenesis. |
| Pdhk Signals | Pyruvate dehydrogenase is deactivated when phosphorylated by PDK. |
| GSK-3 signaling | In these cases, some of these inhibitors rapidly bind to the enzyme in a low-affinity EI complex and this then undergoes a slower rearrangement to a very tightly bound EI* complex (see ... |
| IPI-145 inhibitor – Common side effects include diarrhea, low white blood cells, rash, feeling tired, fever, and muscle pains. |
| Nvp aew541 Inhibitor – childhood growth |
| ONX 0912 Inhibitor – ONX0912 is active against bortezomib-resistant multiple myeloma cells |
| Inhibitor Kit | KIT is a receptor tyrosine kinase type III, which binds to stem cell factor. |
| GW786034 inhibitor – GW786034 is a vascular endothelial growth factor receptor-focused multi-tyrosine kinase inhibitor involved in inhibiting the angiogenesis pathway. |
| Obinutuzumab inhibitor – It can be used as a first-line treatment for chronic lymphocytic leukemia in combination with chemotherapy or with venetoclax, as a first-line treatment for follicular lymphoma ... |
| NVP-TAE226 inhibitor – TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis |
| Flt3 Signal | The hydrophobic tails face inwards towards other hydrophobic tails to avoid contact with water. |
| A-674563 inhibitor – a putative AKT1 inhibitor |
| Gsk503 Inhibitor – PPARδ receptor |
| Glucosylceramidesyn Receptor | Unlike ionic bonds, a covalent bond involves the sharing of electron pairs between atoms. |
| Raf Signals | RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade |
| Calpeptin Inhibitor – The main adverse effects of ACE inhibition can be understood from their pharmacological action. |
| Ustekinumab inhibitor – It is administered either by intravenous infusion or subcutaneous injection. |
| Vactosertib Inhibitor – A low concentration of the enzyme inhibitor reduces the risk for liver and kidney damage and other adverse drug reactions in humans. |
| Ubiquitin Signal | Ubiquitin is a small regulatory protein |
| Bu 4061t Inhibitor – chronic pain |
| Gsk2830371 Inhibitor – PDE4 inhibitors have proven potential as anti-inflammatory drugs. |
| TEPP-46 activator – inhibited LPS |
| CXCR Signal | CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. |
| Cox signaling | Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX. |
| Etomoxir Inhibitor – Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 on the inner face of the outer mitochondrial membrane. |
| Inhibitor library | Enzymes in a metabolic pathway may be inhibited by molecules produced later in the pathway, thus curtailing the production of molecules that are no longer needed. |
| Tacc3 Receptor | The most biologically important lipids are steroids, phospholipids, and fats. |
| Dexamethasone Modulator – treatment for croup |
| ISO-1 inhibitor – genetic analysis of structural requirements |
| Alln Inhibitor – degradative pathway |
| ACT064992 Antagonist – ACT064922 is used for the treatment of PAH |
| 4EGI-1 inhibitor – 4EGI-1 mimics the action of a class of cellular regulatory molecules that naturally inhibit the binding of two initiation factors necessary for interaction of transcribed mRNA with the ... |
| Menin mll Inhibitor – gene expression |
| Bche Receptor | This theory, known as the feature integration theory proposes that there are two types of visual searches: parallel searches and serial searches. |
| Lysyl hydroxylase signal | An enzyme that, in humans, is encoded by the LOX gene. |
| Cellcycle Inhibitor | In cells without nuclei (prokaryotes, i.e., bacteria and archaea), the cell cycle is divided into the B, C, and D periods. |
| Stem Cells Inhibitor | Adult stem cells are a small minority of cells. |
| Chir-99021 inhibitor – It has proved useful for applications in molecular biology involving the transformation of one cell type to another. |
| Hif Signals | Phencyclidine and related drugs such as benocyclidine, tenocyclidine, ketamine, and dizocilpine (MK-801), have been shown to inhibit the reuptake of the monoamine neurotransmitters. |
| Thiocolchicoside Ant – Side effects of thiocolchicoside can include nausea, allergy and vasovagal reactions. |
| Hydrocortisone Agonist – Side effects may include mood changes, increased risk of infection, and edema. |
| Reverse transcriptas | Janus kinases are another notable example of drug enzyme targets. |
| Bitopertin Inhibitor – glycine transporter 1 |
| CD31 Signal | The origin of cell and the developing course of cytobiology |
| Ppp Inhibitor – neuronal functions |
| Mitochondrialmetabo Receptor | In animal cells, specialized cells release these hormones and send them through the circulatory system to other parts of the body. |
| Lrrk2 Receptor | LRRK2 is a member of the leucine-rich repeat kinase family. |
| Calcitriol chemical – It is also known as 1,25-dihydroxycholecalciferol. |
| Sting Signal | Sting is a protein that in humans is encoded by the STING1 gene. |
| Elamipretide Inhibitor – Elamipretide is currently being tested in clinical trials. |
| Pki 587 Inhibitor – mTOR signaling serves as a central regulator of cell metabolism, growth, proliferation, and survival. |
| PKA Inhibitor | PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism. |
| Spartalizumab inhibitor – Spartalizumab inhibitor is being developed by Novartis. As of 2018, spartalizumab is undergoing Phase III trials. |
| Fxr Agonists | Obeticholic acid, 6α-ethyl-chenodeoxycholic acid, is a semi-synthetic bile acid with greater activity as an FXR agonist. |
| Ivacaftor activator – treat cystic fibrosis |
| Stemness Kinase Signaling | Phosphatases are classified by substrate specificity and sequence homology in catalytic domains. |
| BGB-290 inhibitor – BGB-290 induced PD-L1 expression via JAK2/STAT3 pathway, at least partially, in pancreatic cancer. |
| FI-6934 agonist – stimulates smooth muscle and increases digestive secretions |
| Stemregenin1 Inhibitor – risk of pneumonia |
| Nvp hsp990 Inhibitor – Nvp hsp990 failed to show efficacy in an early clinical trial. |
| Romidepsin Inhibitor – natural product |
| Pri 724 Inhibitor – Prevents CBP |
| AGI 1067 – AGI 1067 inhibits the expression of countless proinflammatory genes connected with cardiovascular. |
| Sb 3ct Inhibitor – drug interactions |
| Syk Receptor | Signals that originate from outside a cell (or extracellular signals) can be physical agents like mechanical pressure, voltage, temperature, light, or chemical signals. |
| Cell cycle inhibitors | The cell-division cycle is a vital process by which a single-celled fertilized egg develops into a mature organism, as well as the process by which hair, skin, blood cells, and ... |
| CGP30083 antagonist – potassium-sparing diuretic |
| Pf 07321332 Inhibitor – covalent inhibitor |
| Hdac Signaling | The residues modified are those with side chains containing nucleophiles such as hydroxyl or sulfhydryl groups. |
| AUM 001 Inhibitor – AUM 001 comes with an IC50s of 64 nM and 86 nM, correspondingly |
| Autophagy Compound Library | Autophagy is the major degradation pathway in eukaryotic cells. |
| Jak 1 Inhibitor | These inhibitors have therapeutic application in the treatment of cancer and inflammatory diseases such as rheumatoid arthritis. |
| SEL120 inhibitor – inhibits phosphorylation of STAT1 S727 |
| Cyc116 Inhibitor – two polymorphs |
| Bms 387032 Inhibitor – Enzymes in a metabolic pathway may be inhibited by molecules produced later in the pathway. |
| IMD354 Inhibitor – IMD354 blocks IκBα phosphorylation in NF-κB path |
| Ap-iii-a40 – Some reuptake inhibitors bind to allosteric sites and inhibit reuptake indirectly and noncompetitively. |
| RHPS4 inhibitor – in the form of salt |
| tgf-beta Inhibitors – TGF-β is a multifunctional set of peptides that controls proliferation, differentiation. |
| Ralimetinib Inhibitor – Ralimetinib is a small molecule experimental cancer drug. |
| 2-meo-e2 inhibitor – the 2-methyl ether of 2-hydroxyestradiol |
| Super-TDU inhibitor – the antitumor activity of YAP-TEAD inhibitors verteporfin |
| Glycyrrhizin inhibitor – Structurally, it is a saponin used as an emulsifier and gel-forming agent in foodstuffs and cosmetics. |
| Tivantinib Inhibitor – Tivantinib is being tested clinically as a highly selective MET inhibitor. |
| Pk26124 Inhibitor – breast tumor tissue |
| Ml385 Inhibitor – reuptake inhibitor |
| A-769662 activator – A-769662 stimulates the differentiation of bone marrow-derived mesenchymal stem cells into osteoblasts via AMP-activated protein kinase-dependent mechanism |
| Aminocaproic0 – caproic acid |
| Gsk620 Inhibitor – Mutation or over-expression of EZH2 has been linked to many forms of cancer. |
| Picropodophyllin Inhibitor – tumour cells |
| ONX0912 inhibitor – Oprozomib was granted orphan drug status for the treatment of Waldenström's macroglobulinaemia and multiple myeloma in 2014. |
| Remodelin Inhibitor – A series of histopathological and structural changes occur in the left ventricular myocardium that lead to progressive decline in left ventricular performance. |
| Ribociclib inhibitor – the treatment of certain kinds of breast cancer |
| Krn633 Inhibitor – vesicular transport |
| BAY73-4506 Inhibitor.com – Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. |
| AZD1208 inhibitor – AZD1208 is a selective pan-Pim kinase inhibitor with efficacy in AML cells, xenografts, and Flt3-internal tandem duplication or Flt3 wild-type patient samples. |
| Trastuzumab deruxtecan – consisting of the humanized monoclonal antibody trastuzumab |
| CX-5461 inhibitor – CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition |
| SANT-1 antagonist – reduced proliferation of glioma stem-like cells |
| EPZ011989 inhibitor – EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity |
| Krx-0401 inhibitor – Perifosine interrupts the PI3K/AKT/mTOR pathway by acting as an allosteric AKT inhibitor targeting the pleckstrin homology domain of AKT. |
| metabolism inhibitors – The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms. |
| Stem cells inhibitor | In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce ... |
| Asciminib Inhibitor – Asciminib is a medication used to treat Philadelphia chromosome-positive chronic myeloid leukemia. |
| Pr 619 Inhibitor – The combination therapy of angiotensin II receptor antagonists with ACE inhibitors may be superior to either agent alone. |
| Loxo 101 Inhibitor – Loxo 101 is an inhibitor of tropomyosin kinase receptors TrkA, TrkB, and TrkC. |
| Mannosidase Signals | Autocrine signaling involves a cell secreting a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes ... |
| Pikfyve Signals | A notable class of kinase drug targets are the receptor tyrosine kinases which are essential enzymes that regulate cell growth and their over-activation may result in cancer. |
| Cryptotanshinone inhibitor – Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways |
| Tat becn1 Activator – types of bacteria |
| Caspase Receptor | Caspase-8 is a caspase protein, encoded by the CASP8 gene. |
| Emtricitabine inhibitor – a nucleoside reverse-transcriptase inhibitor |
| Rg 7112 Inhibitor – RG7112 has been developed and progressed into human studies. |
| Setanaxib inhibitor – Setanaxib is a member of the pyrazolopyridine dione chemical series. The compound is the only specific NOX inhibitor that has entered into clinical trials. |
| ST271 Inhibitor – ST271 isolate belonged to serotype 3 and carried multiple resistance-determinant genes. |
| PKA Inhibitors | PDE3 is sometimes referred to as cGMP-inhibited phosphodiesterase. |
| Kpt 330 Inhibitor – Kpt 330 works by blocking the action of exportin1. |
| Pf 04928473 Inhibitor – esteratic site |
| Microtubule Associat Receptor | MAPs are proteins that interact with the microtubules of the cellular cytoskeleton |
| Pafr Signaling | Unlike ionic bonds, a covalent bond involves the sharing of electron pairs between atoms. |
| Hdac Inhibitors | A cell must control the coiling and uncoiling of DNA around histones. |
| Thymidine chemical – Deoxythymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. |
| TRPV Antagonists | All TRPVs are highly calcium selective. |
| RO111163 Inhibitor – RO 111163 induces a substantial loss of all monoamine metabolites |
| Microrna Receptor | MiRNAs appear to target about 60% of the genes of humans and other mammals. |
| ATPases Signal | Besides exchangers, other categories of transmembrane ATPase include co-transporters and pumps. |
| Gsk2110183 Inhibitor – hypertensive crisis |
| P38mapk Signals | P38mapks are a class of mitogen-activated protein kinases |
| Sb203580 Inhibitor – SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. |
| Hormones Receptor | A receptor molecule that binds to a specific hormone. |
| Aminoacid Transport | Two amino acids have side-chains that are anions at ordinary pH. |
| BCL-2PROTEIN | The over-expression of the anti-apoptotic Bcl-2 protein in lymphocytes |
| Mct Receptor | Two molecules of water can form a hydrogen bond between them. |
| JNJ28431754 Inhibitor – JNJ 28431754 decreases HbA1c levels |
| Runx Receptor | Mutations in RUNX1 are implicated in cases of breast cancer. |
| SBI-0206965 inhibitor – SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways |
| Tyrosinase Receptor | Upregulation of tyrosinase caused by tyrosinase inhibitors. |
| BLZ945 Inhibitor .com – Prophylactic BLZ945 treatment prevented excessive demyelination in the corpus callosum by reducing microglia and increasing oligondendrocytes. |
| Dub Inhibitors | WP1130 acts as a partly selective DUB inhibitor. |
| Angiogenesis Inhibitor | Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet. |
| R788 inhibitor – Fostamatinib blocks the activity of the enzyme spleen tyrosine kinase |
| Trastuzumab inhibitor – It is specifically used for cancer that is HER2 receptor positive. |
| 6-thio-dg inhibitor – high-risk neuroblastomas harbor telomerase activity |
| Ssr128129e Inhibitor – Captopril, enalapril, lisinopril and perindopril are known to be removable by hemodialysis. |
| Micro rna2 | This block of nucleotide biosynthesis is selectively toxic to rapidly growing cells, therefore methotrexate is often used in cancer chemotherapy. |
| PH-797804 inhibitor – exhibited exceptionally high specificity against MAP kinases |
| Sb 715992 Inhibitor – Drugs that inhibit enzymes needed for the replication of viruses are effective in treating viral infections. |
| Puromycin inhibitor – causes premature chain termination during translation |
| PCI29732 Inhibitor – PCI 29732 is really a selective and irreversible Btk inhibitor |
| Bacitracin inhibitor – a mixture of related cyclic peptides |
| Pf 04449913 Inhibitor – low dose cytarabine |
| Serine Hydrolase | One of the largest known enzyme classes |
| Carbohydrate Metabol | Butter, soil and wood are common examples of mixtures. |
| NSC515776 inhibitor – a PDE3 inhibitor medication |
| Dorsomorphin Inhibitor.com – Dorsomorphin treated hADSCs displayed significantly higher expression of active-axonal-growth-specific marker GAP43. |
| NVP231 Activator – NVP 231 induces cell apoptosis by growing DNA fragmentation and caspase-3 and caspase-9 cleavage. |
| Amg925 Inhibitor – contains gingerol |
| Arry 614 Inhibitor – kinesin superfamily |
| CSG 452 Inhibitor – CSG 452 is a SGLT2 inhibitor |
| Lirametostat Inhibitor – serine residue |
| TAE684 inhibitor – revealed to exert antitumor effects in several different malignancies |
| Jnk signal | Neurotoxicity can also result from the inhibition of receptors; for example, atropine from deadly nightshade (Atropa belladonna) that functions as a competitive antagonist of the muscarinic ... |
| NSC122758 agonist – used for the treatment of acne and acute promyelocytic leukemia |
| Zstk474 Inhibitor – PIK3CD |
| Igf1r signal | The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. |
| Phosphorylase Inhibitors | The inhibition of glycogen phosphorylase has been proposed as one method for treating type 2 diabetes |
| Dnapk Signaling | Many proteins have been identified as substrates for the kinase activity of DNA-PK. |
| HIF signals | Naturally occurring enzyme inhibitors regulate many metabolic processes and are essential for life. |
| Pf 8380 Inhibitor – development of obesity |
| Luminespib inhibitor – Luminespib has shown promising activity in preclinical testing against several different tumor types. |
| FX1 inhibitor – Nevertheless, the effect of FX1 in inflammatory responses and sepsis remains unknown. |
| MI-773 antagonist – exhibits anticancer effects |
| Brivanib Inhibitor – Brivanib alaninate is a multitargeted tyrosine kinase inhibitor. |
| Lipoxygenase Receptor | Lipoxygenases are found in eukaryotes |
| AK7 chemical – the mercaptan of benzimidazole |
| Smyd Signal | SMYD3 is predominantly expressed in skeletal muscles and the testis. |
| Ficz Agonist – FICZ is a chemical compound with the molecular formula C19H12N2O. |
| LY 3200882 Inhibitor – LY3200882 inhibits various pro-tumorigenic activities |
| Curcumol Inhibitor – Trypsin inhibitor is present in various foods such as soybeans, grains, cereals and various additional legumes. |
| NS11394 Modulator – NS-11394 is a drug with selectivity for the α3 and α5 subtypes. |
| VO-OHpic inhibitor – promoted M2 macrophage polarization |
| Piperlongumine Chemical – respiratory tract irritation |
| Kinesin Receptor | A kinesin is a protein belonging to a class of motor proteins found |
| Gsk1904529a Inhibitor – The N-terminal peptide is cleaved (split) from the zymogen enzyme precursor by another enzyme to release an active enzyme. |
| Bcl2 Signals | While exogenous cues are solely what stimuli are presented in one's surrounding environment, endogenous cues are based on the internal goals, beliefs, desires, and interpretation of the ... |
| Dub receptor | However, not all inhibitors are based on the structures of substrates. |
| SU 5201 Inhibitor – SU 5201 inhibits IL-2 production in PBMCs |
| Cladribine inhibitor – relapsing-remitting multiple sclerosis |
| Irak4-in-2 inhibitor – supports signaling from T-cell receptors |
| BAY80-6946 Inhibitor – BAY 80-6946 is an inhibitor of PI3K |
| Voxtalisib inhibitor – the kinase enzymes phosphatidylinositol 3-kinase |
| Urolithin A Activator – Urolithin A belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones. |
| Ykl 5 124 Inhibitor – The commonly reported adverse effects of drug combination with ACE are acute renal failure, hypotension, and hyperkalemia. |
| Sn 38 Inhibitor – SN-38 and its glucuronide are lost into the bile and intestines. |
| Pazopanib inhibitor – It is a potent and selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis. |
| Gw4869 | All organisms are able to regulate their own internal environments. |
| Fox Signaling | This test and improve cycle is repeated until a sufficiently potent inhibitor is produced. |
| Thz1 inhibitor – THZ1 was tested on HER2-positive breast cancer cells and exhibited high potency for the cells regardless of their sensitivity to HER2 inhibitors. |
| Dapt Inhibitor – DAPT is a γ-secretase inhibitor. |
| ex527 Inhibitor.com – The indole EX-527 and its derivatives are among the most potent and selective SIRT1 inhibitors. |
| Mdm2 signal | Physiological enzyme inhibition can also be produced by specific protein inhibitors. |
| Colforsin Activator – treat heart failure |
| Wp1130 Inhibitor – Setanaxib is being evaluated in investigator led trials in idiopathic pulmonary fibrosis and diabetic kidney disease. |
| Flucytosine inhibitor – used by itself or with other antifungals for chromomycosis |
| Salirasib inhibitor – sensitizes those cells to TRAIL-induced apoptosis |
| rsva405antagonist.com – inhibite both constitutive and stimulated STAT3 activity in HEK293 cells |
| Iadademstat Inhibitor – pembrolizumab |
| Vegfr-1 Inhibitor | VEGFR-1 is a kinase-defective receptor tyrosine kinase that negatively modulates angiogenesis by acting as a decoy receptor. |
| YC-1 inhibitor – YC-1 has been demonstrated to possess redundant biochemical mechanisms that confer significant stimulation upon NO- and CO-regulated, cyclase-dependent events. |
| Smn Signaling | SMN1 is the telomeric copy of the gene encoding the SMN protein. |
| Jak signal | The rate at which EI* is formed is called the inactivation rate or kinact. |
| Dactolisib Inhibitor.com – Dactolisib is an imidazoquinoline derivative acting as a PI3K inhibitor. |
| Galectin Signal | This molecular weight cutoff is also a necessary but insufficient condition for oral bioavailability as it allows for transcellular transport through intestinal epithelial cells. |
| High-content Screenings | In addition to fluorescent labeling, various label free assays have been used in high content screening. |
| Apoptosis Inhibitors | Apoptosis, or programmed cell death, is a highly regulated process used by many multicellular organisms. |
| Fludarabine Inhibitor – It is a chemotherapy medication used in the treatment of leukemia and lymphoma. |
| metabolism inhibitor – Metabolic reactions may be categorized as catabolic – the breaking down of compounds ; or anabolic – the building up of compounds . Usually, catabolism releases energy, and anabolism ... |
| Neuronalsignaling Inhibitor | The addition of ubiquitin to a substrate protein is called ubiquitylation. |
| Transmembrane Transporters Inhibitor | TP is a type of integral membrane protein that spans the entirety of the cell membrane. |
| Coumarin151 Inhibitor – fougère genre |
| Sirolimus Inhibitor – treatment of LAM |
| Smer28 Activator – The DNA site bound by the activator is referred to as an "activator-binding site". |
| EGFR signaling | Activation of TRPC6 induces the entry of calcium (Ca2+) and sodium (Na+) into the cell, which causes the effect through unknown mechanism. |
| Proteases Signaling | A protease is an enzyme that catalyzes proteolysis |
| Chk signal | If a reversible EI complex is involved the inactivation rate will be saturable and fitting this curve will give kinact and Ki. |
| Pifithrin-a Inhibitor.com – It has a molecular weight of 367.30 and is soluble in DMSO up to 20 mg/mL. Its melting point is 192.1-192.5 °C. |
| Testolone Modulator – bone loss |
| Metabolism Inhibitors | The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms. |
| Atmkinase Inhibitor – A-T fibroblasts were not radiosensitized by KU-60019. |
| Proteases Inhibitor | These protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are ... |
| TGF-beta inhibitors | TGF-β is secreted by many cell types, including macrophages, in a latent form in which it is complexed with two other polypeptides, latent TGF-beta binding protein and latency-associated ... |
| G protein inhibitors | G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from ... |
| Nrf2 Signals | Signaling molecules can belong to several chemical classes: lipids, phospholipids, amino acids, monoamines, proteins, glycoproteins, or gases. |
| Epigenetics inhibitors | The term also refers to the changes themselves: functionally relevant changes to the genome that do not involve a change in the nucleotide sequence. |
| Cp 690550 Inhibitor – CP-690550 is an inhibitor of the enzyme janus kinase 1 (JAK1) and janus kinase 3 (JAK 3). |
| Isrib Inhibitor – ISRIB treatment corrects spatial memory deficits and improves working memory in aged mice. |
| G418 inhibitor – Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3'-phosphotransferase, APT 3' II. |
| Microbiology inhibitor | Microbiology encompasses numerous sub-disciplines including virology, bacteriology, protistology, mycology, immunology, and parasitology. |
| Aloxistatin Inhibitor – antiviral effects |
| PHA-739358 inhibitor – HA-739358 inhibits all Aurora kinase family members and shows a dominant Aurora B kinase inhibition-related cellular phenotype and mechanism of action in cells in vitro and in vivo.... |
| Evp4593 Inhibitor – Many poisons produced by animals or plants are enzyme inhibitors that block the activity of crucial enzymes in prey or predators. |
| Sch727965 inhibitor – Dinaciclib is being developed by Merck & Co. It was granted orphan drug status by the FDA in 2011. |
| Coumarin 151 – Coumarin 151 has appetite-suppressing properties |
| Daptomyc ininhibitor – Daptomycin was removed from the World Health Organization's List of Essential Medicines in 2019. |
| Ivosidenib Inhibitor – AML |
| Metabolism Inhibitor | The metabolic system of a particular organism determines which substances it will find nutritious and which poisonous. |
| LPA Receptor Signaling | A protein that in humans is encoded by the LPAR1 gene. |
| Fto Signal | FTO has been demonstrated to efficiently demethylate the related modified ribonucleotide. |
| Bevacizumab inhibitor – For cancer, it is given by slow injection into a vein (intravenous) and used for colon cancer, lung cancer, glioblastoma, and renal-cell carcinoma. |
| MK-8353 inhibitor – decreases the phosphorylation of ERK1/2 |
| Gsk1363089 Inhibitor – c Met |
| Fatostatinhbr inhibitor – an inhibitor of SREBP1 |
| AGI1067 inhibitor – inhibits the expression of a number of proinflammatory genes |
| Snx 2112 Inhibitor – alcohol dependence |
| Lixisenatide Agonist – injected subcutaneously |
| CPI-1205 inhibitor – pharmacological inhibition of EZH2 in human T cells using CPI-1205 elicited phenotypic and functional alterations of the Tregs and enhanced cytotoxic activity of Teffs. |
| Palbociclib Inhibitor – HR positive |
| Thrombin Inhibitor | Mechanism of Action Argatroban is a direct thrombin inhibitor |
| AK 7 Inhibitor – AK7 increases lysine 40 (K40) acetylation of the-tubulin in neuronal cells. |
| Wnt Inhibitor | In order to ensure proper functioning, Wnt signaling is constantly regulated at several points along its signaling pathways. |
| Azithromycin Inhibitor – an azalide |
| Raf signal | RAF Signals Command in November 1958, then becoming part of Strike Command, and reverting to No. 90 (Signals) Group on 1 January 1969. |
| BI 1744 Agonist – BI 1744 is an ultra-long-acting β adrenoreceptor agonist |
| S 38093 Antagonist – S 38093 is used for the treatment of amnesic syndromes. |
| NSC407289 modulator – a type of flavonoid |
| D luciferin Inhibitor – react with oxygen |
| DNA-PK signal | DNA-PK phosphorylates AIRE in vitro at Thr68 and Ser156. |
| Fak Signal | With the exception of certain types of blood cells, most cells express FAK. |
| Mycro3 chemical – Myc-associated factor X |
| Topotecan inhibitor – a topoisomerase inhibitor |
| SIB1757 Antagonist – SIB-1757 acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5. |
| Sm 406 Antagonist – prevent nausea |
| Upadacitinib Inhibitor – treatment of moderate |
| BIX2189 inhibitor – prevents cell proliferation and induces apoptosis |
| Gsk1120212 inhibitor – It is a MEK inhibitor drug with anti-cancer activity. |
| Liver X receptor | The liver X receptor (LXR) is a member of the nuclear receptor family of transcription |
| Nkcc Signal | Like all catalysts, enzymes increase the reaction rate by lowering its activation energy. |
| Jte13 – atopic dermatitis |
| Rabusertib Inhibitor.com – Rabusertib indicated an intrinsic difference in sensitivity for the most sensitive. |
| Bulevirtide 0 – hepatitis B |
| PDK1 signaling | The top molecule is bound reversibly, but the lower one is bound covalently as it has reacted with an amino acid residue through its nitrogen mustard group. |
| ABGT-702 Inhibitor – ABT-702 inhibits Adenosine Kinase |
| Taurine0 – large intestine |
| Az20 Inhibitor – a class of drugs |
| Yk-4-279 Inhibitor – DXM is sold in syrup, instant release tablet, extended release tablet, spray, and lozenge forms. |
| Hippo Inhibitors – The Hippo signaling pathway appears to be highly conserved. |
| LY3143921 inhibitor – A low concentration of the enzyme inhibitor reduces the risk for liver and kidney damage and other adverse drug reactions in humans. |
| Ly2228820 Inhibitor – ovarian cancer |
| Omecamtiv Mecarbil Activator – the treatment of left ventricular systolic heart failure |
| Bix2188 Inhibitor – myasthenia gravis |
| PDE receptor | Many metabolic pathways in the cell are inhibited by metabolites that control enzyme activity through allosteric regulation or substrate inhibition. |
| Akt signaling | The activity will be decreased in a time-dependent manner, usually following exponential decay. |
| JTE-013 Antagonist – JTE-013 completely blocked TCA-induced protein expression |
| Vemurafenib Inhibitor – B-Raf enzyme |
| PF 4800567 Inhibitor – PF 4800567 suggests a role for CK1-ε in negative regulation of sensitivity to stimulant and opioid drugs. |
| Abt869 Inhibitor – unrelated RTKs |
| c-MET Signaling | MET is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing. |
| Pi3k inhibitor | Phosphoinositide 3-kinases, also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility,... |
| Lamivudine inhibitor – It is also used to treat chronic hepatitis B when other options are not possible. |
| Telomerase Signals | A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes. |
| Epz 6438 Inhibitor – The most common side effects are pain, fatigue, nausea, decreased appetite, vomiting and constipation. |
| LX4211 inhibitor – improved glycemic control in patients |
| Selumetinib Inhibitor – Selumetinib may cause harm to a newborn baby when administered to a pregnant woman. |
| Mi Rna2 | This compound is a potent inhibitor of cGMP specific phosphodiesterase type 5, the enzyme that degrades the signalling molecule cyclic guanosine monophosphate. |
| Vitamin Signals | Vitamin A is a fat-soluble vitamin and an essential nutrient for humans. |
| MPS1 Signaling | MPS I is divided into three subtypes based on severity of symptoms. |
| Bbi608 Inhibitor – PPI therapy |
| PF-03084014 inhibitor – Conclusion PF-03084014 was well tolerated and demonstrated promising clinical benefit in patients with refractory, progressive desmoid tumors who receive long-term treatment. |
| Edhs 206 Inhibitor – treat breast cancer |
| Tegatrabetan Antagonist – effect of orexin |
| Mitoxantrone2 Inhibitor – treat multiple sclerosis |
| SB202190 inhibitor – SB202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases |
| Hormones inhibitor | A hormone is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. |
| K02288 inhibitor – inhibited BMP9 |
| LB-100 inhibitor – LB-100 decreased activation of STAT3 and expression of its downstream proteins. |
| AMG487 antagonist – CXC chemokine receptor 3 |
| Incb054329 Inhibitor – Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. |
| Azacitidine inhibitor – a chemical analog of cytidine |
| z lehd fmk Inhibitor – P38α MAPK mediated kinase activity has been implicated in many tissues beyond immune systems. |
| N acetylcysteine Inhibitor – protect the liver |
| Dna damage inhibitor | The vast majority of DNA damage affects the primary structure of the double helix; that is, the bases themselves are chemically modified. |
| Interleukin Receptor | An interleukin receptor is a cytokine receptor for interleukins |
| Vorinostat inhibitor – Vorinostat is marketed under the name Zolinza by Merck for the treatment of cutaneous manifestations in patients with cutaneous T cell lymphoma (CTCL) when the disease persists,... |
| Dolutegravir Inhibitor – treat HIV |
| 4-hydroxytamoxifen – 4-hydroxytamoxifen is a SERM and hence acts as a tissue-selective agonist–antagonist of the estrogen receptors ERα and ERβ with mixed estrogenic and antiestrogenic activity depending ... |
| Motesanib inhibitor – It is used as the phosphate salt motesanib diphosphate. |
| ikk Receptor | Various organisms contribute to the biodiversity of an ecosystem. |
| Mtp Receptor | MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. |
| Catalase Signaling | Catalase has one of the highest turnover numbers of all enzymes. |
| Huskerchem | Ions are atoms (or groups of atoms) with an electrostatic charge. |
| Akr1c Signaling | The enzymes display overlapping but distinct substrate specificity. |
| Amg510 Inhibitor – RAS GTPase family |
| Bms 582664 Inhibitor – Brivanib is no longer in active development. |
| Betaamyloid Receptor | A chemical compound is a chemical substance that is composed of a particular set of atoms or ions |
| Oss128167 Inhibitor – The organophosphate binds first to the serine residue in the esteratic site of the cholinesterase and after transformation to a phosphate molecule, it binds the histidine residue.... |
| GSK2126458 inhibitor – Although the MTD of GSK2126458 was 2.5 mg once daily, twice-daily dosing may increase duration of target inhibition. |
| NSC757 inhibitor – Behçet's disease |
| INCB024360 Inhibitor.com – 23 pts have been treated with the selective IDO1 inhibitor INCB024360. |
| PS-341 Inhibitor.com – This includes multiple myeloma in those who have and have not previously received treatment. |
| Sumo Signal | SUMO proteins are similar to ubiquitin and are considered members of the ubiquitin-like protein family. |
| Rip Kinase Signaling | The kinase domain, while important for necroptotic (programmed necrotic) functions, appears dispensable for pro-survival roles. |
| Ac220 Chemical – Ac220 selectively inhibits class III receptor tyrosine kinases. |
| Transmembrane Transporters Inhibitors | ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. |
| CFI-400945 inhibitor – Polo-like kinase 4 inhibitor |
| SYK signal – SYK, along with ZAP70, is a member of the Syk family of tyrosine kinases. |
| 3mst Signal | Serious evolutionary thinking originated with the works of Jean-Baptiste Lamarck, who was the first to present a coherent theory of evolution. |
| Pdk Signal | ecause one's attention is shifted to the stimulus without much thought or effort, these cues are seen as a form of reflex that the person has low control over. |
| Z yvad fmk – An agonist is a chemical that activates a receptor to produce a biological response. |
| Atezolizumab inhibitor – It is a fully humanized, engineered monoclonal antibody of IgG1 isotype against the protein programmed cell death-ligand 1 (PD-L1). |
| Hif signal | Irreversible inhibition is different from irreversible enzyme inactivation. |
| Microbiology inhibitor | Eukaryotic microorganisms possess membrane-bound organelles and include fungi and protists, whereas prokaryotic organisms—all of which are microorganisms—are conventionally classified ... |
| Ru521 Inhibitor – estrogenic |
| ETC-1002 inhibitor – The most common side effects include hyperuricemia (high blood levels of uric acid), pain in arms or legs, and anemia (low red blood cell counts). |
| LLY-284 chemical – a potent and selective SAM-competitive chemical |
| Dinaciclib | Dinacliclib induces the apoptosis of osteosarcoma cells. |
| Mll Signal | This gene is ubiquitously expressed in adult tissues. |
| Purmorphamine Agonist – protein Smoothened |
| CARS signal | The CARS signal is detected on the blue side |
| Pd-1-pd-l 1 Inhibitor 1 – T cells |
| Birabresib Inhibitor – treatment of cancer |
| H89 inhibitor – H-89, derived from H-8 , was initially believed to act specifically as an inhibitor of PKA, being 30 times more potent than H-8 at inhibiting PKA and 10 times less potent at inhibiting ... |
| Phosphorylase Signal | Phosphorylase kinase is a 1.3 MDa hexadecameric holoenzyme. |
| BAY57-1293 Inhibitor – BAY 57-1293 is an antiviral helicase-primase complex inhibitor. |
| Mardepodect inhibitor – It acts as a phosphodiesterase inhibitor selective for the PDE10A subtype. |
| PRN1371 inhibitor – PRN1371 demonstrated strong FGFR potency and excellent kinome-wide selectivity in a number of biochemical and cellular assays, including in various cancer cell lines exhibiting FGFR ... |
| 2oxoglutarate inhibitor – autoantigen |
| mTOR signaling | The enzyme hydrolyses the phosphorus–fluorine bond, but the phosphate residue remains bound to the serine in the active site, deactivating it. |
| Dabrafenib Inhibitor – regulation of cell growth |
| WEE1 Signal | It is inactivated by phosphorylation through Wee1 and activated by the phosphatase Cdc25C. |
| AG556 inhibitor – Protein Tyrosine Kinase |
| LY3214996 inhibitor – Targeting ERK1/2 protein-serine/threonine kinases |
| CDK signal | Other artificial enzyme inhibitors block acetylcholinesterase, an enzyme which breaks down acetylcholine, and are used as nerve agents in chemical warfare. |
| Filgotinib Inhibitor – Filgotinib may be used as monotherapy or in combination with methotrexate. |
| Acarbose Chemical – Acarbose is a starch blocker, and inhibits alpha glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates |
| Nsc190940 Inhibitor – mitotic inhibitors |
| H3b 120 Inhibitor – mechanism of action |
| SC79 activator – SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation. |
| Kn 93 Inhibitor – decrease anger |
| Gefitinib based protac3 – an EGFR inhibitor |
| Tazemetostat inhibitor – acts as a potent selective EZH2 inhibitor |
| Peg300 | Substrate or product inhibition is where either an enzymes substrate or product also act as an inhibitor. |
| Wnt c59 | The name Wnt is a portmanteau created from the names Wingless and Int-1. |
| Vtp50469 Inhibitor – ACE inhibitors must be labeled with a boxed warning concerning the risk of birth defects when taken during the second and third trimester. |
| Protac Signals | PROTACs consist of two covalently linked protein-binding molecules: one capable of engaging an E3 ubiquitin ligase, and another that binds to a target protein meant for degradation. |
| PF-562271 inhibitor – PF-562271 is an inhibitor of FAK and Pyk2 |
| TC-DAPK6 inhibitor – death-associated protein kinase 1 |
| Z-4-hydroxytamoxifen – Afimoxifene is a SERM and hence acts as a tissue-selective agonist–antagonist of the estrogen receptors ERα and ERβ with mixed estrogenic and antiestrogenic activity depending on ... |
| Diabzisting agonist – an antagonist blocks the action of the agonist |
| Pralatrexate Inhibitor – Pralatrexate is indicated for the treatment of people with relapsed or refractory peripheral T-cell lymphoma. |
| RWJ26251 inhibitor – B-cell chronic lymphocytic leukemia |
| Fabp Receptor | Competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids. |
| Sorafenib Inhibitor – thyroid cancer |
| Gsk1349572 Inhibitor – integrase inhibitor |
| Azd1480 Inhibitor – Artificial inhibitors are often used as drugs, but can also be insecticides such as malathion. |
| Prt062070 Inhibitor – PTCL |
| HSP signal | Here we discussed the HSP function as a signal molecule to regulatory immune cells under exercise stress. |
| V-9302 antagonist – inhibits proliferation and migration of VSMCs |
| Rock Receptor | An example of a toxic peptide is alpha-amanitin, which is found in relatives of the death cap mushroom. |
| Rociletinib Inhibitor – clinical trials |
| ML210 inhibitor – a selective covalent inhibitor |
| Oleuropein chemical – The term oleuropein is derived from the botanical name of the olive tree, Olea europaea. |
| M3814 Inhibitor – Two cytokines controlled by the ROCK2 signaling pathway, IL-17 and IL-21, have a major role in the cGvHD response. |
| AMPK signal | Alternatively, some reuptake inhibitors bind to allosteric sites and inhibit reuptake indirectly and noncompetitively. |
| Ephrin Receptor | A group of receptors that are activated in response to binding with Ephrins |
| Decitabine Inhibitor – cytidine analog |
| Alpelisib Inhibitor – Alpelisib is a medication used to treat certain types of breast cancer. |
| Estradiol Agonist – Estradiol is produced in the body from cholesterol through a series of reactions and intermediates. |
| Stem cells inhibitors – They are found in both embryonic and adult organisms, but they have slightly different properties in each. |
| Gsk3 Signal | A serine/threonine protein kinase that phosphorylate either threonine or serine |
| Antiviral Signal | The adaptor protein VISA further activates the inhibitor of nuclear factor kappa-B kinase (IKK)-protein-kinase family members. |
| ANA-12 antagonist – The compound crosses the blood-brain-barrier and exerts central TrkB blockade, producing effects as early as 30 minutes (~400 nM) and as long as 6 hours (~10 nM) following intraperitoneal ... |
| PF-02341066 inhibitor – PF-02341066 inhibitor is indicated for the treatment of metastatic non-small cell lung cancer or relapsed or refractory |
| Selective JAK3 inhibitor – considered to be an attractive target for immunosuppression |
| DNA RNA synthesis Signal | DNA, RNA is assembled as a chain |
| Tremelimumab inhibitor – the treatment of hepatocellular carcinoma |
| Parg Receptor | Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. |
| TAPI-1 inhibitor – the matrix metalloproteinases |
| Fascin Receptor | Fascin binds beta-catenin,and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. |
| Nsc207895 Inhibitor – classified as reversible irreversible or quasi irreversible |
| Curcumin Inhibitor – Curcumin is a diarylheptanoid, belonging to the group of curcuminoids. |
| 5 fu Inhibitor – scarring of tissue |
| AM95 agonist – cellular proteins |
| Pi3k Inhibitor | PI3K inhibitors are also under investigation as treatments for inflammatory respiratory disease. |
| Silmitasertib inhibitor – Silmitasertib is in clinical trials for use as an adjunct to chemotherapy in the treatment of cholangiocarcinoma (bile duct cancer), and in preclinical development for other cancers,... |
| Blu 667 Inhibitor – Efficacy for RET fusion-positive NSCLC was evaluated in 87 participants previously treated with platinum chemotherapy. |
| RK 24466 Inhibitor – RK-24466 inhibits two constructs from the human lck kinase, lck (64-509) and lckcd |
| Glyr Signal | GlyR is an ionotropic receptor that produces its effects through chloride current. |
| FGFR signals | Similarly, DFP also reacts with the active site of acetylcholine esterase in the synapses of neurons, and consequently is a potent neurotoxin, with a lethal dose of less than 100 mg. |
| Mst Receptor | MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. |
| Hesperadin inhibitor – inhibits chromosome alignment and segregation |
| Netarsudil inhibitor – In the United States, in December 2017, the Food and Drug Administration (FDA) approved a 0.02% ophthalmic solution for the lowering of elevated intraocular pressure in people with ... |
| Azd5438 Inhibitor – BPF is used in the manufacture of plastics and epoxy resins. |
| IKK signal | Subsequently a chemical reaction occurs between the enzyme and inhibitor to produce the covalently modified "dead-end complex" EI* (an irreversible covalent complex). |
| Smad Inhibitors – The eight members of the Smad family are divided among these three groups. |
| Immunology Inhibitors | Immunology measures, uses charts and differentiate in context in medicine the studies of immunity on cell and molecular level, and the immune system as part of the physiological ... |
| C-met Signaling | Enzyme inhibitors also occur naturally and are involved in the regulation of metabolism. |
| Leukotriene Receptor | G protein-coupled receptors that bind and are activated by the leukotrienes. |
| Neurotensin Receptor | Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. |
| Lpa Receptor | A group of G protein-coupled receptors for lysophosphatidic acid (LPA) |
| Sar405 Inhibitor – A synthesis of the BTA involves the reaction of o-phenylenediamine, sodium nitrite, and acetic acid. |
| Smoothened Receptor | Smoothened is a protein that in humans is encoded by the SMO gene. |
| p97 Signal | Most known substrates of p97/CDC48 are modified with ubiquitin chains and degraded by the 26S proteasome. |
| Hippo Inhibitor | Mutations in this gene lead to tissue overgrowth, or a "hippopotamus"-like phenotype. |
| Dubermatinib Inhibitor – Hits from any of the above approaches can be optimised to high affinity binders that efficiently inhibit the enzyme.. |
| Osimertinib inhibitor – treat non-small-cell lung carcinomas |
| Protonpump Signal | An extreme example is orotidine 5'-phosphate decarboxylase, which allows a reaction that would otherwise take millions of years to occur in milliseconds. |
| Pidnarulex Inhibitor – modify the serine |
| Abt 737 Inhibitor – ABT-737 was superior to previous BCL-2 inhibitors given its higher affinity for Bcl-2, Bcl-xL and Bcl-w. |
| PD0332991 inhibitor – It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. |
| Plx5622 Inhibitor – neuropathic pain |
| Dna Repair Signal | The DNA repair process is constantly active |
| Abbim | Once dissolved in water, these solutes are more likely to come in contact with one another and therefore take part in chemical reactions that sustain life. |
| Dehydrogenase Signal | LDH exists in four distinct enzyme classes. |
| Camk Signaling | Substrate-specific CAM Kinases only have one target that they can phosphorylate, such as myosin light chain kinases. |
| PLX4032 Inhibitor.com – PLX4032 is a compound that selectively inhibits oncogenic B-Raf kinase. |
| Usp25 28 Inhibitoraz1 – Ubiquitin is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. |
| Pp2 Inhibitor – PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. |
| Dyrk Signals | Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. |
| Azd1080 Inhibitor – Naturally occurring enzyme inhibitors regulate many metabolic processes and are essential for life. |
| SB216763 inhibitor – a potent and selective cell permeable inhibitor |
| Lapatinib inhibitor – Lapatinib is an orally active drug for breast cancer and other solid tumours. |
| Q vd oph Inhibitor – Irreversible inhibitors form a chemical bond with the enzyme such that the enzyme is inhibited until the chemical bond is broken. |
| Gsk2656157 Inhibitor – A low concentration of the enzyme inhibitor reduces the risk for liver and kidney damage. |
| NSC178886 Inhibitor – NSC 178886 reduces COX-2 expression |
| T0901317 agonist – lipogenesis in the liver |
| LY2874455 inhibitor – LY2874455 was generally well tolerated; most toxicities were grade 1 or 2; most frequent were hyperphosphatemia, diarrhea, and stomatitis. |
| Sgx523 Inhibitor – Pharmaceuticals |
| Dyes Signal | All organisms are able to regulate their own internal environments. |
| Samotolisib inhibitor – a promising new dual inhibitor |
| SKLB610 Inhibitor – SKLB-610 is really a multi-target inhibitor from the tyrosine kinases |
| Cd4 Inhibitors | An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis |
| Flap Signal | Mixed inhibition is a type of enzyme inhibition in which the inhibitor may bind to the enzyme whether or not the enzyme has already bound the substrate but has a greater affinity for one ... |
| Natural Product | A natural product is a chemical compound or substance produced |
| MDM2 signals | The question of where life began is one of the enduring mysteries of science. |
| Cpi-613 inhibitor – A lipoic acid derivative different from standard cytotoxic chemotherapy, devimistat is currently being studied in combination with modified FOLFIRINOX to treat various solid tumors ... |
| Bumetanide Inhibitor – Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys |
| IEM1754 Inhibitor – IEM 1754 is definitely an adamantane derivative |
| Necrosulfonamide Inhibitor – protein kinase superfamily |
| Losmapimod inhibitor – a phase III clinical trial is pending approval |
| Ar 42 Inhibitor – prostate cancer |
| TEW-7197 inhibitor – inhibits protein serine threonine kinase |
| TC-O 9311 Agonist – TC-O 9311 indicates a potential role of GPR139 in neuroprotection and Parkinson's disease |
| Sodium Dichloroacetate Inhibitor – Salts of DCA have been studied as potential drugs because they inhibit the enzyme pyruvate dehydrogenase kinase. |
| ZM39923 Inhibitor – ZM 39923 is a JAK/STAT inhibitor |
| NSC 10483 Agonist – NSC 10483 reduces T-cell proliferation in dendritic cells |
| NSC85442 Inhibitor – NSC 85442 can be used to deal with various cardiac dysrhythmias |
| NSC75520 inhibitor – used primarily on the eye |
| Atorvastatin inhibitor – prevent cardiovascular disease |
| Bay439006 Inhibitor – enzyme affinity |
| Sgi 1027 Inhibitor – catalyst poisoning |
| Everolimus inhibitor – prevent rejection of organ transplants |
| Casr Signaling | Calcium-sensing receptor has been shown to interact with filamin. |
| TMP195 inhibitor – TMP195 Exerts Antitumor Effects on Colorectal Cancer by Promoting M1 Macrophages Polarization |
| Metformin chemical – used in the treatment of polycystic ovary syndrome |
| Cdk receptor | Irreversible inhibitors first form a reversible non-covalent complex with the enzyme (EI or ESI). |
| gsk3 signaling | Suicide inhibition is an unusual type of irreversible inhibition where the enzyme converts the inhibitor into a reactive form in its active site. |
| raf265inhibitor.com – Just another WordPress site |
| Plx5622 | Viral infections in animals provoke an immune response that usually eliminates the infecting virus. |
| Chk Signals | In biology, cell signaling (cell signalling in British English) or cell communication is the ability of a cell to receive, process, and transmit signals with its environment and with itself.... |
| Iberdomide chemical – Biological impact of iberdomide in patients with active systemic lupus erythematosus |
| Sb743921 Inhibitor – kinesin superfamily |
| Chaetocin inhibitor – inhibits vascular smooth muscle cell phenotype switching |
| A-205804 inhibitor – suppressed the induced expression of E-selectin |
| Gsk923295 Inhibitor – ACE inhibitors were initially approved for the treatment of hypertension. |
| FR180204 Inhibitor – FR-180204 is an ERK inhibitor |
| Vx 445 Modulator – cystic fibrosis |
| Jzl184 Inhibitor – 2 AG signaling |
| Apoptosis Inhibitor | Inhibitors of apoptosis are a group of proteins that mainly act on the intrinsic pathway that block programmed cell death, which can frequently lead to cancer or other effects for ... |
| Ldl Receptor | The LDL receptor protein is encoded by the LDLR gene on chromosome 19. |
| INCB054828 inhibitor – INCB054828 works by blocking enzymes known as protein kinases, particularly those that are part of receptors (targets) called fibroblast growth factor receptors (FGFRs). |
| Plerixafor antagonist – hematopoietic stem cells |
| Imidazole Ketone Erastin – an aromatic heterocycle |
| GGTI298 inhibitor – inhibits the processing of geranylgeranylated Rap1A |
| AZD1390 Inhibitor.com – AZD1390 radiosensitizes glioma and lung cancer cell lines |
| JNJ-31020028 Antagonist – JNJ-31020028 is a PYY receptor antagonist |
| Target Protein Ligan Signal | In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. |
| Gsk343 Inhibitor – Ezh1/2 inhibitors activate cellular antiviral pathways. |
| 2-D08 inhibitor – induced ROS accumulation mediates apoptosis |
| Cl-amidine chemical – A common route to primary amidines is the Pinner reaction. Reaction of the nitrile with alcohol in the presence of acid gives an iminoether. Treatment of the resulting compound with ... |
| Mg 101 Inhibitor – traditional NSAID |
| Cox 2 Inhibitors | Explanation of Cox-2 Inhibitors (Cox-2 inhibitor drugs) used to treat the pain of arthritis conditions |
| Staurosporine Inhibitor – Staurosporine is in the non-halogenated class. |
| Crisprcas9 Receptor | Cas9 is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering ... |
| Cytohesin Receptor | Cytohesin family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain.... |
| Smad Inhibitor | Defects in Smad signaling can result in TGF-B resistance, causing dysregulation of cell growth. |
| Hki-272 inhibitor – Neratinib (INN), sold under the brand name Nerlynx, is a tyrosine kinase inhibitor anti-cancer medication used for the treatment of breast cancer. |
| Tpca 1 Inhibitor – When an enzyme has multiple substrates, inhibitors can show different types of inhibition depending on which substrate is considered. |
| Pi3k Receptor | In the task, the salience of the target object was manipulated. In the "pop out" condition, the target stimulus was different from the distractors in both color and shape, whereas in the ... |
| PDGFR 740 y-p activator – With the help of 740 Y-P, activating the pi3k signaling pathway can partially rescue the phenotype. |
| Afimoxifene Modulator – Afimoxifene is a selective estrogen receptor modulator (SERM) of the triphenylethylene group and an active metabolite of tamoxifen. |
| Compoundc Inhibitor – A molecule consisting of atoms of only one element is therefore not a compound. |
| Cytoskeletal signaling inhibitor | A large-scale example of an action performed by the cytoskeleton is muscle contraction. This is carried out by groups of highly specialized cells working together. |
| Pten Signal | This phosphatase is involved in the regulation of the cell cycle, preventing cells from growing and dividing too rapidly. |
| Cytarabine Inhibitor – antiviral activity |
| AG555 inhibitor – inhibits tyrosine kinases |
| Par Signaling | Arrestin prevents protein-receptor interaction and the receptor becomes dephosphorylated and inhibited from signaling. |
| Ras Signal | RAS is a fairly simple protocol composed of just a few messages. |
| Grazoprevir inhibitor – used in combination with the NS5A |
| Remdesivir Inhibitor – Remdesivir is administered via injection into a vein. |
| Cobimetinib inhibitor – used in combination with vemurafenib |
| Propranolol Inhibitor – cause harmful effects |
| PF-543 inhibitor – responsible for its low metabolic stability |
| Cgas Signal | A long-term interaction is called a symbiosis. |
| Trk Receptor | A family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system |
| vu364770agonist.com – Just another WordPress site |
| IQ 3 inhibitor – inhibits LPS-induced NF-κB/AP1 |
| ON-01910 inhibitor – ON-01910 is a microtubule-destabilizing agent. |
| Bix01294 Inhibitor – Many poisons produced by animals or plants are enzyme inhibitors that block the activity of crucial enzymes in prey or predators. |
| DUB Signal | Specific genes that can be activated by inducers are called inducible genes. |
| Abt-263 inhibitor – Navitoclax inhibits not only Bcl-2, but also Bcl-XL and Bcl-w proteins. |
| Pf 3758309 Inhibitor – PAK4 localizes in sub-cellular domains of the cytoplasm and nucleus. |
| Ki16198 Antagonist – histamine receptors |
| Hsv Receptor | HSV-1 and HSV-2 are transmitted by contact with an infected person who has reactivations of the virus. |
| Gpcr Signals | G protein-coupled receptors are involved in many diseases. |
| GW3965 agonist – GW3965 dosing blunted the vasopressor effect of Ang. |
| Cpi 455 Inhibitor – heat labile |
| Ubiquitin Inhibitors – The protein modifications can be either a single ubiquitin protein (monoubiquitylation) or a chain of ubiquitin (polyubiquitylation). |
| Gap Junction Receptor | Gap junctions occur in virtually all tissues of the body |
| Vx 809 Modulator – Vx 809 was developed by Vertex Pharmaceuticals and the combination was approved by the FDA in 2015. |
| MK-8776 inhibitor – MK-8776 radiosensitizes tumor cells by mechanisms that include abrogation of the G2 block and inhibition of DSB repair. |
| Methylation Inhibitor | Methylation can change the activity of a DNA segment without changing the sequence. |
| MX69 inhibitor – MX69 had no effects on glucose tolerance and insulin sensitivity in DIO mice. |
| Lipase Signaling | Most lipases act at a specific position on the glycerol backbone of a lipid substrate. |
| Bombesin Receptor | The bombesin receptors are a group of G-protein coupled receptors which bind bombesin. |
| Ly2090314 Inhibitor – In competitive inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time. |
| RXDX-105 inhibitor – the multikinase inhibitor |
| Bicalutamide Antagonist – Bicalutamide produces abnormal liver changes necessitating discontinuation in around 1% of people. |
| ATM signaling | It can handle both traditional high-throughput data traffic and real-time, low-latency content such as voice and video. |
| Mif Receptor | Coordination complexes are distinct substances with distinct properties different from a simple mixture. |
| SB271046 Antagonist – SB-271046 was found to be potent and selective in vitro and had good oral bioavailability |
| Stemregenin1 Antagonist – reversible antagonists |
| Bay597939 Inhibitor – pulmonary emboli |
| mTOR signals | This reactive form of DFMO then reacts with either a cysteine or lysine residue in the active site to irreversibly inactivate the enzyme. |
| Bibr1532 inhibitor – Pharmacological preconditioning by TERT inhibitor BIBR1532 confers neuronal ischemic tolerance through TERT-mediated transcriptional reprogramming |
| Ro151788 Antagonist – synaptic cleft |
| Coumarin6 Inhibitor – benzene molecule |
| AS2863619 inhibitor – cyclin-dependent kinase CDK8/19 inhibitor |
| GSK1265744 inhibitor – GSK1265744 in combination with rilpivirine is indicated for the treatment of human immunodeficiency virus type-1 (HIV-1) in adults. |
| PAPCAP1-38 Agonist – PACAP 1-38 has potent, effective, and sustained stimulatory effects on supportive neuronal NPY and catecholamine production |
| N-Ethylmaleimide – contains the amide functional group |
| Azd1152 Inhibitor – Enzyme inhibitors are designed to mimic the transition state or intermediate of an enzyme-catalysed reaction. |
| Fostamatinib Inhibitor – rheumatoid arthritis |
| Wnt receptor | They appear to exert their reuptake inhibition by binding to vaguely characterized allosteric sites on each of the respective monoamine transporters. |
| Rivaroxaban Inhibitor – blood thinner |
| L189 agonist – DNA Ligase |
| Igf1r signal | It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. |
| Latrepirdine Antagonist – Latrepirdine attracted renewed interest in 2009 after being shown in small preclinical trials to have positive effects on persons suffering from Alzheimer's disease |
| GAP 27 Inhibitor – Gap 27 is extremely good at interrupting co-operative cell-cell interactions, like the synchronous beating of embryonic cardiomyocytes. |
| CDK Signaling | CDKs are the families of protein kinases first discovered for their role in regulating the cell cycle |
| Fosbretabulin Inhibitor – Anaplastic thyroid cancer typically manifests as a rapidly enlarging neck mass. |
| Apatinib Inhibitor – cancer drug |
| CAY10683 inhibitor – CAY10683 and imatinib have synergistic effects in overcoming imatinib resistance via HDAC2 inhibition in chronic myeloid leukemia |
| nsc119875chemical.com – Just another WordPress site |
| PMX205 antagonist – an antagonist of C5a |
| GSK591 inhibitor – we found that the combined interventions exerted a synergistic inhibitory effect of combined treatment with PRMT5i (GSK591) and EZH2i (GSK126) on the growth of CRC cells/xenografts in ... |
| Necrostatin 1 Inhibitor – MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells. |
| NSC-100880 inhibitor – isolated from the bark and stem of Camptotheca acuminata |
| E 64 Inhibitor – E-64 possesses a trans-epoxysuccinic acid group coupled to a modified dipeptide. |
| Ros1 Signal | This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. |
| CCG50014 Inhibitor – CCG-50014 has a RGS inhibitory activity |
| Larotrectinib Inhibitor – treat any cancer |
| Prexasertib Inhibitor – Prexasertib causes induction of DNA double-strand breaks resulting in apoptosis. |
| Unc1999 Inhibitor – UNC1999 was developed as an analogue of GSK126. |
| CAV22 inhibitor – blocker for the treatment of pain |
| Mg149 Inhibitor – RIMAs are used clinically in the treatment of depression and dysthymia. |
| 740 y p – This haplogroup is found today in significant frequencies in many areas in or near the Arabian Peninsula and Western Asia. |
| Vismodegib Inhibitor – muscle spasms |
| RGD inhibitor – acts as an inhibitor of integrin-ligand interactions |
| Chikusetsusaponin IV – Cyasterone and chikusetsusaponin IV could significantly inhibit levels of TXA2, ET, MDA, and COX-2 and promote the activities of eNOS and SOD in vitro. |
| CRT0066101 inhibitor – CRT0066101, which inhibited the activity of PRKDs, dramatically inhibited proliferation, increased apoptosis and the G1-phase population of TNBC cells in vitro, and reduced breast ... |
| Nmdar Receptor | The NMDA receptor is ionotropic, meaning it is a protein which allows the passage of ions through the cell membrane. |
| SB-297006 antagonist – inhibited the induction of 4T1 cells migration |
| AMG-706 inhibitor – It is an orally administered small molecule belonging to angiokinase inhibitor class which acts as an antagonist of VEGF receptors, platelet-derived growth factor receptors, and stem ... |
| Vistusertib inhibitor – Vistusertib is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay |
| Lificiguat inhibitor – Since 1994, Lificiguat has been synthesized, and many targets for special bioactivities have been explored. |
| Euk134 Inhibitor – lung cancer |
| Sodium Butyrate Inhibitor – human diet |
| GSK872 inhibitor – GSK872, a RIP3 specific inhibitor, inhibited the development of LN in MRL/lpr mice with down-regulation of RIP3 activation in podocytes, decreased the splenic sizes and weights and anti-... |
| Asp5878 Inhibitor – social anxiety disorder |
| Nelfinavir inhibitor – Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and like other PIs is almost always used in combination with other antiretroviral drugs. |
| Sb590885 Inhibitor – The B-Raf protein is involved in sending signals inside cells which are involved in directing cell growth. |
| Rhodamine123 modulator – used as a tracer dye |
| Bcl6 Signaling | BCL6 contains a (1) N-terminal BTB/POZ domain (Broad-complex, Tramtrack and Brick-a-brac/Pox virus and Zin finger family domain), (2) a central RN2 region, and (3) another zinc finger ... |
| WP1066 inhibitor – WP1066 was identified as a K(V) 1.3 channel inhibitor. |
| Apalutamide Inhibitor – cause seizures |
| UbiquitinInhibitor | Ubiquitylation affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein ... |
| BW759 Inhibitor – BW759 inhibitis the action of viral DNA polymerase in FHV-1 |
| LY333531 inhibitor – LY333531 is an investigational drug for diabetic retinopathy being investigated by Eli Lilly and Company. |
| CH5424802 Inhibitor.com – In cell-free assays the IC50 of CH5424802 for enzyme activity of ALK was 1.9 nM |
| ICI46474 modulator – used for Albright syndrome |
| Cil56 Inhibitor – antispasmodic drug |
| Dmx 5084 Inhibitor – a lubricant |
| 3po Inhibitor – 3PO decreases glucose uptake and increases autophagy. |
| PF-04418948 antagonist – a prostanoid EP2 receptor antagonist |
| BI 1482694 Inhibitor – BI 1482694 is an investigational anti-cancer drug. |
| Danusertib Inhibitor – The inhibitor binds only to the enzyme-substrate complex. |
| NU7441 inhibitor – Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441 |
| Capivasertib inhibitor – an investigational oral treatment |
| Foretinib inhibitor – Foretinib is an inhibitor of the kinase enzymes c-Met and vascular endothelial growth factor receptor 2. |
| Porcn Signal | The protein encoded by this gene is an endoplasmic reticulum transmembrane protein involved in processing of wingless proteins such as WNT7A. |
| Avelumab inhibitor – Common side effects include fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reactions, rash, decreased appetite and swelling of the limbs (peripheral edema). |
| GSK5959 Inhibitor – GSK5959 is really a potent and selective BRPF1 bromodomain inhibitor |
| Acat Signal | Many mutations have been identified in specific populations, and large scale studies have been performed to determine the allelic and genotypic frequency for the defective gene. |
| Orla Protein Technologies |
| SR987 inhibitor – binds to an enzyme and blocks its activity |
| JQ-EZ-05 inhibitor – Hence the discovery and refinement of enzyme inhibitors is an active area of research in biochemistry and pharmacology. |
| Proteases Inhibitors – These protease inhibitors prevent viral replication by selectively binding to viral proteases and blocking proteolytic cleavage of protein precursors that are necessary for the production ... |
| Hts Screening Blog | High-quality HTS assays are critical in HTS experiments. |
| Belnacasan Inhibitor.com – This enzyme is involved in inflammation and cell death. |
| Idotdo Signal | Amino acids can form polypeptides whereas nucleotides can form strands of nucleic acid. |
| Vorasidenib Inhibitor – Vorasidenib was well tolerated and showed preliminary antitumor activity in patients with recurrent or progressive nonenhancing mIDH LGG. |
| Oga Signal | The short isoform S-OGA, which only exhibit the glycoside hydrolase domain, was initially described as residing within the nucleus. |
| Pyridostatin modulator – Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA? |
| EFT-508 inhibitor – eFT508 showed anti-proliferative activity against multiple DLBCL cell lines. |
| Apc Receptor | A protein that in humans is encoded by the PROCR gene. |
| Gw9662 Antagonist – Silent antagonists are competitive receptor antagonists that have zero intrinsic activity for activating a receptor. |
| Hdac Signal | They occupy the transporter in place of the respective neurotransmitter and competitively block it from being transported from the nerve terminal or synapse into the pre-synaptic neuron. |
| Mtp 131 Inhibitor – Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding. |
| Mtor Inhibitor | The most established mTOR inhibitors are so-called rapalogs (rapamycin and its analogs), which have shown tumor responses in clinical trials against various tumor types. |
| Gtpch Receptor | Common types of chemical bonds include ionic bonds, covalent bonds, and hydrogen bonds. |
| Repotrectinib inhibitor – Repotrectinib can be effective both as first-line and after progression to prior ROS1-TKI. |
| Renin Pathway | Renin regulates the body's mean arterial blood pressure. |
| Adipor Signal | AdipoR1 is orientated oppositely to GPCRs in the membrane and does not associate with G proteins. |
| Adalimumab inhibitor – Common side effects include upper respiratory tract infections, pain at the site of injection, rash, and headache. |
| Sarscov Receptor | Different elements can combine to form compounds such as water |
| Gboxin Inhibitor – ACE inhibitors may also be used to help decrease excessive water consumption in people with schizophrenia resulting in psychogenic polydipsia. |
| Epz015938 Inhibitor – Irreversible inhibitors form a chemical bond with the enzyme such that the enzyme is inhibited until the chemical bond is broken. |
| COX signal | Pharmaceutical inhibition of COX can provide relief from the symptoms of inflammation and pain. |
| LEE011 inhibitor – Histologically, epithelioid sarcoma forms nodules with central necrosis surrounded by bland, polygonal cells with eosinophilic cytoplasm and peripheral spindling. |
| Jak signal | Mutations in JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders. |
| AZD3965 inhibitor – These results support the setup of clinical trials, but other important findings, namely AZD3965 enhanced activity when given in combination with other therapies, or MCT4-induced treatment ... |
| Miransertib inhibitor – prevented by the AKT inhibitor miransertib |
| 2amino6 Methylheptan – organic solvents |
| MDM2 receptor | Natural toxins are usually small organic molecules and are so diverse that there are probably natural inhibitors for most metabolic processes. |
| AMG-900 inhibitor – AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models. |
| Bgj398 Inhibitor – Bgj398 is an anti-cancer medication used to treat cholangiocarcinoma. |
| Selpercatinib Inhibitor – kinase inhibitor |
| Er Stress Inhibitor | The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. |
| mTOR receptor | Ornithine decarboxylase can catalyse the decarboxylation of DFMO instead of ornithine, as shown above. |
| Nsc27640 Inhibitor – fetal development |
| Nsc118218 Inhibitor – alkylating agents |
| Nepafenac Inhibitor – Nepafenac is a prodrug of amfenac, an inhibitor of COX-1 and COX-2 activity |
| Liraglutide Agonist – type 2 diabetes |
| Ha141 Inhibitor – obesity |
| Lansoprazole Inhibitor – Lansoprazole has been studied extensively for the short-term treatment of duodenal and gastric ulcers, reflux esophagitis, and Helicobacter pylori-positive peptic ulcer disease;... |
| Plx4720 Inhibitor – anchor region |
| SB-200646 Antagonist – SB 200646 has electrophysiological and anxiolytic qualities in vivo |
| Neuronal signaling inhibitor | A neuron or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. |
| Tgf-beta receptor | Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. |
| AC-5216 Modulator – AC-5216 is used in its 11C radiolabelled form to map the distribution of TSPO receptors in the brain |
| YKL 06-061 Inhibitor – YKL 06-061 comes with an IC50 of 6.56 nM, 1.77 nM and 20.5 nM |
| FK463 Inhibitor – FK463 works by way of concentration-dependent inhibition of 1,3-beta-D-glucan synthase |
| Repertaxin inhibitor – Repertaxin also prevented CXCL8-induced calcium influx but not CXCL8 binding to purified rat neutrophils. |
| DNA Metabolism | In various diseases, such as type II diabetes, metabolic syndrome, and cancer, normal metabolism is disrupted. |
| BIX-01294 Inhibitor – BIX-01294 a selective inhibitor of EHMT2 |
| Brefeldin A Inhibitor – protein transport |
| Pim signal | Notably, this allosteric site may be directly related to the above-mentioned PCP binding sites. |
| Sc144 Inhibitor – dental extraction |
| Vegfr-3 Inhibitor | This receptor complex has increased VEGF signalling activity in endothelial cells. |
| Onalespib inhibitor – HSP90 inhibitor |
| Molidustat modulator – It is in Phase III clinical trials for the treatment of anemia caused by chronic kidney disease. |
| CC-930 inhibitor – an orally active anti-fibrotic JNK inhibitor |
| Cret Receptor | Phosphatases can act on carbohydrates, such as intermediates in gluconeogenesis. |
| Proteases inhibitor | Proteases can be found in all forms of life and viruses. |
| Lxr 623 Agonist – diabetes and anti inflammation |
| BMY 7378 Antagonist – BMY 7378 is a α1D-adrenergic receptor antagonist |
| Pd0166285 Inhibitor – The active centre of cholinesterases feature two important sites, namely the anionic site and the esteratic site. |
| Gilteritinib Inhibitor – inhibitor of FLT3 |
| Gsk269962a Inhibitor – GSK-2696275 is a gene therapy for Wiskott–Aldrich syndrome. |
| ICA069673 Activator – ICA-069673 does not prevent channel inhibition by ML252 |
| Oprozomib inhibitor – Being an epoxyketone derivative, oprozomib is structurally related to carfilzomib and has the added benefit of being orally bioavailable. |
| Mln7243 Inhibitor – abdominal pain |
| Siponimod Agonist – treatment of SPMS |
| EML 425 antagonist – noncompetitive versus both acetyl-CoA and a histone H3 peptide |
| PAFR Signal | PAFR has won the GFOA |
| Reparixin Inhibitor – NH2-terminus is arranged as a long loop followed by a four-residue helical turn. |
| LCL161 inhibitor – LCL161 has been shown safety and efficacy in a phase I study of advanced solid tumours. |
| HER2 inhibitors,HER2 pathway - High-performance inhibitors by signalingmolecule.com |
| TCS359 inhibitor – inhibits MV4-11 |
| E3ligase signal | For example, the structure of another HIV protease inhibitor tipranavir is shown on the left. |
| Proteasome Signal | Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. |
| Oatp Receptor | OATPs belong to the Solute Carrier Family (SLC) and the major facilitator superfamily. |
| Sabutoclax inhibitor – The administration of Sabutoclax (BI-97C1), a pan-active Bcl-2 protein family antagonist mediated apoptosis in castrate-resistant PCa cells of Tgfbr2(ColTKO) mice and human subcutaneous,... |
| Osi 774 Inhibitor – Osi 774 is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor. |
| Cxcr4 Inhibitor | CXCR4 has been shown to interact with USP14. |
| Axitinib inhibitor – treat renal cell carcinoma |
| Ack Signal | The mechanism involves the production and detection of a signaling molecule, and the regulation of gene transcription in response. |
| Dna repair inhibitors – Many genes that were initially shown to influence life span have turned out to be involved in DNA damage repair and protection. |
| LLY-507 inhibitor – Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors |
| Fulvestrant Antagonist – treat ER positive |
| Avasimibe inhibitor – inhibits sterol O-acyltransferases |
| Citarinostat inhibitor – Citarinostat is under investigation in clinical trial NCT02886065 A Study of PVX-410, a Cancer Vaccine, and Citarinostat Lenalidomide for Smoldering MM. |
| SRT2104 activator – SRT-2104 is an experimental drug that was studied by Sirtris Pharmaceuticals as a small-molecule activator of the sirtuin subtype SIRT1. |
| Transmembrane Transporters | Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. |
| Pf 573228 Inhibitor – A common treatment for erectile dysfunction is sildenafil. |
| JNJ-38877605 inhibitor – small-molecule kinase inhibitors |
| GS1278 inhibitor – treat HIV/AIDS |
| Derazantinib inhibitor – an investigational drug for the treatment of cholangiocarcinoma |
| Fluorouracil Inhibitor – colorectal cancer |
| Comt Signals | Catechol-O-methyltransferase protein is encoded by the COMT gene. |
| DTP3 Activator – coverage observed in two communities |
| Gpcr Compound Library | G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates and animals. |
| Dabigatran Inhibitor – esophageal injury |
| Epigenetics Signal | Gene expression can be controlled through the action of repressor proteins that attach to silencer regions of the DNA. |
| Rad001 Inhibitor – Rad001 may have a role in heart transplantation. |
| Drug Discovery Screenings | Phenotypic screens have provided new chemical starting points in drug discovery. |
| CX-4945 Inhibitor.com – Silmitasertib interacts competitively with the ATP-binding site of CK2 subunit alpha. |
| Lc3 Signals | Biologists have sought to study and classify the various forms of life |
| Hcv Signaling | The hepatitis C virus belongs to the genus Hepacivirus, a member of the family Flaviviridae. |
| Microbiology Inhibitors – Fast and relatively simple biochemical tests can be used to identify infectious agents. |
| Pfkfb Signaling | Genes encode the information needed by cells for the synthesis of proteins. |
| Cmv Signals | Benztropine, mazindol, and vanoxerine also bind to these sites and have similar properties. |
| Cct128930 Inhibitor – Trypsin inhibitor can be essential for biological processes within the plant. |
| Tak-242 inhibitor – Tak-242 may show potential as an add-on treatment alongside conventional chemotherapy drugs. |
| Decarboxylase Signals | GAD67 and GAD65 are expressed in the brain where GABA is used as a neurotransmitter. |
| Cangrelor Inhibitor – Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. |
| Histonemethyltransf Signal | The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4. |
| AG-1478 inhibitor – Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin |
| Cpi 637 Inhibitor – Binding of a target protein to NCBD will cause it to fold into three helices specifically functioned to associated with the disordered domains of its binding partners. |
| ARP100 inhibitor – MMP-2 |
| ATB346 inhibitor – a novel hydrogen sulphide-releasing derivative |
| Sns 032 Inhibitor – ACE inhibitors are ADEC pregnancy category D. |
| LTX-315 modulator – a clinical-stage peptide |
| GSK2636771 inhibitor – Application to a pharmacokinetic study in rat plasma |
| Azd5582 Inhibitor – The FGFR3 gene produces various forms of the FGFR3 protein. |
| Unc0646 Inhibitor – ACE is found in the pulmonary circulation and in the endothelium of many blood vessels. |
| Aldose Reductase Signal | A cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. |
| Uk49858 Inhibitor – downstream changes |
| Finerenone antagonist – non-fatal heart attacks |
| Gprotein Signal | Rab GTPases regulate many steps of membrane trafficking |
| Nicotinamide Inhibitor – treat pellagra |
| Ccs 1477 Inhibitor – prostate cancer |
| Pemetrexed Inhibitor – folic acid |
| Osu-03012 Inhibitor – anti tumour effects |
| PNU-282987 Agonist – PNU-282987 has been shown to initiate signaling that leads to adult neurogeneis in mammals. |
| NSC76751 inhibitor – an O-methylated flavone |
| Sns314 Inhibitor – reuptake inhibitor |
| Fimepinostat inhibitor – effectively reverses HIV-1 latency ex vivo without T cell activation |
| MRS2578 Inhibitor – MRS2578 microinjection reversed visceral hypersensitivity of PMS rats |
| Ch5126766 Inhibitor – avutometinib |
| MSDC-0160 modulator – not different from those associated with pioglitazone |
| Sodiumoxamate Inhibitor – oxalic acid |
| Pha665752 Inhibitor – c-Met inhibitor |
| 5fluorouracil inhibitor – colorectal cancer |
| Sirtuin Signal | These tight-binding inhibitors may show kinetics similar to covalent irreversible inhibitors. |
| TBK1/IKKε-IN-1 Inhibitor – TBK1/IKKε-IN-1 is an enzyme with kinase activity. Specifically with serine / threonine protein kinase. |
| P53 signals | This led researchers to speculate that tumors might compensate for therapy directed against one cancer cell development pathway by turning on a different one. |
| Lmk 235 Inhibitor – biological processes |
| TG101348 inhibitor – treat myeloproliferative diseases |
| SKLB610 inhibitor – multi-target inhibitor of the tyrosine kinases |
| Lalistat 2 – Lalistat 2 is a specific inhibitor of LAL which allows the determination of LAL in DBS |
| Nvpadw742 Inhibitor – certain substance |
| 2pcpa Inhibitor – irritable bowel syndrome |
| Parmodulin2 Inhibitor – Parmodulin2 has shown significant promise for its cytoprotective effects |
| BMS56224701 inhibitor – treat and prevent blood clots |
| Gtx 024 Modulator – stroke and liver damage |
| BRL 49653 Agonist – BRL 49653 works as an insulin sensitizer |
| Acetazolamide Inhibitor – open angle glaucoma |
| Ketoconazole inhibitor – used to treat a number of fungal infections |
| EED226 inhibitor – leading to loss of PRC2 activity |
| SCH56592 inhibitor – treat invasive Aspergillus and Candida infections |
| PD-169316 Inhibitor – PD 169316 is a p38 MAPK inhibitor |
| Az960 Antagonist – treatment of insomnia |
| LY3023414 inhibitor – LY3023414 inhibits both osteogenesis and osteoclastogenesis through the PI3K/Akt/GSK3 signalling pathway |
| Azaindole-1 Agonist – enzyme Rho kinase |
| CP43 inhibitor – TAO Kinase inhibitor |
| Pad Signaling | Medicinal enzyme inhibitors often have low dissociation constants, meaning that only a minute amount of the inhibitor is required to inhibit the enzyme. |
| Microtubule signals | An example is the inhibitor of polyamine biosynthesis, α-difluoromethylornithine or DFMO, which is an analogue of the amino acid ornithine, and is used to treat African trypanosomiasis ... |
| Azaindole1 Inhibitor – Azaindole1 has Vasodilatory Effects |
| Mptp Chemical – toxic molecules |
| Gsk046 Inhibitor – isoforms of PI3Ks |
| Td 139 Inhibitor – acute rejection reactions |
| TCR Signal | Transcription is regulated by proteins called sigma factors. |
| Nvp-auy922 inhibitor – NVP-AUY922 has shown promising activity in preclinical testing against several different tumor types. |
| CGS21680 agonist – an organic hydrochloride salt |
| CID 1375606 Agonist – CID 1375606 is a GPR27 agonist. |
| Roxadustat Modulator – increase VEGF |
| Gsk J4 | For speciation to occur, there has to be reproductive isolation. |
| Elenbecestat Inhibitor – When an enzyme has multiple substrates, inhibitors can show different types of inhibition depending on which substrate is considered. |
| Pim Signaling | In contrast to plasmalemmal reuptake inhibitors, vesicular reuptake inhibitors do not increase the synaptic concentrations of a neurotransmitter. |
| Krpep 2d Inhibitor – Annonaceae family |
| CH-223191 antagonist – The activation of AhR was confirmed using selective AhR inhibitor CH-223191 and by evaluating expression of the target CYP1A1 gene. |
| Dutasteride Inhibitor – Dutasteride is sometimes used as a component of hormone therapy for transgender women in combination with an estrogen and/or another antiandrogen such as spironolactone |
| Tak 243 Inhibitor – skin cancer |
| Bms 1 Inhibitor – highly selective |
| Proteintyrosinekinase Inhibitor | Tyrosine kinases belong to a larger class of enzymes known as protein kinases which also attach phosphates to other amino acids such as serine and threonine. |
| BW1592 inhibitor – the prevention and treatment of HIV infection in adults and children |
| AMG337 inhibitor – blocks MET signaling |
| Letrozole Inhibitor – Letrozole is contraindicated in women having a pre-menopausal hormonal status, during pregnancy and lactation. |
| Cerdulatinib Inhibitor – plaque psoriasis |
| Mitoquinone Inhibitor – reduced biosynthesis |
| Mth1 Signal | During DNA repair, the enzyme hydrolyses oxidized purines and prevents their addition onto the DNA chain. |
| AG-494 Inhibitor – Ag-494 inhibits EGF-dependent cell growth |
| XL888 inhibitor – The HSP90 inhibitor, XL888, enhanced cell apoptosis via downregulating STAT3 after insufficient radiofrequency ablation in hepatocellular carcinoma |
| BAY 1217389 Inhibitor – BAY-1217389 is a TTK inhibitor |
| Inflammation Inhibitor | Acute inflammation is the initial response of the body to harmful stimuli, and is achieved by the increased movement of plasma and leukocytes from the blood into the injured tissues.... |
| Methylation Signal | DNA methylation is essential for normal development |
| PD-0332991 inhibitor – the cyclin-dependent kinases CDK4 and CDK6 |
| Sb225002 Antagonist – non selective |
| Lomitapide inhibitor – the treatment of familial hypercholesterolemia |
| YO-01027 inhibitor – The spatial distribution showed that the gamma-secretase inhibitor compound YO-01027 with the dibenzoazepine structure exhibits potent inhibiting activity against SPP in vitro and ... |
| BKM120 inhibitor.com – Buparlisib was under investigation as a treatment for advanced breast cancer but was abandoned due to negative results. |
| Galunisertib Inhibitor – Galunisertib is a TGF-b inhibitor. |
| Wnt Inhibitor | Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). |
| G6PDi-1 inhibitor – inhibit G6PD |
| VPS34-in1 inhibitor – in platelet production and thrombus growth |
| Tat beclin1 Activator – intracellular signals |
| Pamiparib inhibitor – Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor |
| Compound3 Inhibitor – Compound 3 is really a potent inhibitor of RIP2 kinase with higher kinase specificity. |
| Odm 201 Antagonist – androgen receptor |
| Selleck Bio – amino acids |
| 3c-likeprotease Signals | With the exception of therapeutic antibodies, many proteins are degraded if administered orally and most often cannot cross cell membranes. |
| Glyt Receptor | Some weak and/or non-selective GlyT blockers include amoxapine and ethanol (alcohol). |
| Tyrosine Kinase inhibitor|Tyrosine Kinase|Receptor Tyrosine Kinase - High-performance inhibitors by invitroscreeningblog.com |
| Endocrinology Inhibitor | Specializations include behavioral endocrinology and comparative endocrinology. |
| Tgf Beta Inhibitor | TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. |
| HBC530 inhibitor – imaging RNA in live cells |
| Sodium Phenylbutyrate Inhibitor – Sodium phenylbutyrate is taken orally or by nasogastric intubation as a tablet or powder. |
| Cytoskeletal Signaling Inhibitors – A multitude of functions can be performed by the cytoskeleton. |
| Upr Inhibitor | UPR is a cellular stress response related to the endoplasmic reticulum (ER) stress. |
| Methylation Inhibitor | Methylation can change the activity of a DNA segment without changing the sequence. |
| E3 Ligase Ligand Receptor | Proteins are the most diverse of the macromolecules |
| Protein Tyrosine Kinase Inhibitor | Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. |
| Plk Receptor | PLK1 consists of 603 amino acids and is 66kDa. |
| Raas Signaling | The study of enzymes is called enzymology and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis,... |
| Nos Signals | Carbon can form very long chains of interconnecting carbon–carbon bonds such as octane or ring-like structures such as glucose. |
| Pkr Signal | Protein kinase-R is activated by double-stranded RNA (dsRNA), introduced to the cells by a viral infection. |
| DNA Damage Inhibitors – DNA damage is an abnormal chemical structure in DNA, while a mutation is a change in the sequence of base pairs. |
| Serotonin Transporte | SERT is a type of monoamine transporter protein that transports serotonin from the synaptic cleft back to the presynaptic neuron. |
| Zoledronic Inhibitor – Zoledronic acid is a medication used to treat a number of bone diseases. |
| Z-ietd-fmk Inhibitor – the poly-caspase probe KMB01 8 was added to label residual caspase active sites for an additional 30 min. |
| Drug Linkerconjugat | All compounds are substances, but not all substances are compounds. |
| PF-2545920 inhibitor – The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities |
| Dna-methyl Transferas | Since ricin is a catalytic irreversible inhibitor, this allows just a single molecule of ricin to kill a cell. |
| S3i201 Inhibitor – joint pain |
| Gsk3368715 Inhibitor – eating disorders |
| AMD3100 antagonist – used to mobilize hematopoietic stem cells |
| Nutlin3 Antagonist – p53 MDM2 |
| ARV-825 chemical – treated TPC-1 tumor tissue |
| Lilly110140 inhibitor – the treatment of major depressive disorder |
| Potassium Channel Signal | Potassium channel is an integral membrane protein |
| NSC2146 Inhibitor – NSC 2146 is really a naturally sourced methoxy-substituted catechol |
| Acetylcysteine Inhibitor – dietary supplement |
| Proteasome Signal | Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called ... |
| NSC374551 Inhibitor – NSC37455 is a synthetic retinoid |
| NSC652287 Activator – NSC 652287 also inhibits MDM2-p53 interaction |
| NSC27223 Inhibitor – NSC 27223 induces autophagy and stimulates mitophagy. |
| Hormones Inhibitors – Hormone secretion occurs in response to specific biochemical signals. |
| NSC167409 inhibitor – a saponin used as an emulsifier |
| Pdgfr Signaling | Escitalopram has been marketed as an allosteric serotonin reuptake inhibitor. |
| SGC946 inhibitor – blocks H3K79 methylation in A431 cells |
| NSC 9221 Inhibitor.com – NSC 9221 is really a stimulator of recombinant SIRT1 |
| NSC21548 Chemical – NSC21548 is a pyrimidine nucleoside |
| NSC651520 chemical – a standardized extract of the milk thistle seeds |
| Hif signaling | HIF1A contains a basic helix-loop-helix domain near the C-terminal, followed by two distinct PAS (PER-ARNT-SIM) domains, and a PAC (PAS-associated C-terminal) domain. |
| 125b11 Inhibitor – gynecomastia |
| NSC95100 Inhibitor – NSC 95100 is a Na,K ATP-ase inhibitor |
| Fingolimod ant agonist – used for treating multiple sclerosis |
| NSC319726 Activator – NSC319726 exhibits growth inhibition in cells expressing mutant p53 |
| ACSS2 inhibitor – This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. |
| Fin56 Activator – Activators can recruit molecules known as coactivators. |
| bml 277 Inhibitor – compound is disputed |
| ipatasertib inhibitor – It is a small molecule inhibitor of AKT, which is a key component of the PI3K/AKT pathway. |
| Idasanutlin Inhibitor – Not all irreversible inhibitors form covalent adducts with their enzyme targets. |
| NDI-091143 inhibitor – inhibits the production of ADP |
| JNK signals | Although many natural toxins are secondary metabolites, these poisons also include peptides and proteins. |
| l name Inhibitor – Drugs that inhibit enzymes needed for the replication of viruses are effective in treating viral infections. |
| BAM15 Activator – BAM15 protects from acute renal ischemic-reperfusion injury and cold-induced microtubule damage |
| Raltegravir Inhibitor – targets integrase |
| Ly335979 modulator – Other drugs with this mechanism include tariquidar and laniquidar. |
| SD0006 inhibitor – the p38MAPK/HDAC4 pathway |
| AZ3146 Inhibitor – AZ3146 could decrease HCC cell growth |
| Selonsertib inhibitor – Forty-eight weeks of selonsertib monotherapy had no antifibrotic effect in patients with bridging fibrosis or compensated cirrhosis due to NASH. |
| Mdm2 Signaling | This enzyme is a glycosidase that inactivates ribosomes. |
| BMS-754807 inhibitor – BMS-754807 effectively inhibits the growth of a broad range of human tumor types in vitro. |
| Sotorasib Inhibitor – target mutation |
| Raltitrexed Inhibitor – Raltitrexed is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca |
| BVT 2733 Inhibitor – BVT.2733, a selective 11β-HSD1 inhibitor |
| Jnk receptor | The c-Jun N-terminal kinases consist of ten isoforms derived from three genes: JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms). |
| NSC14613 Inhibitor – NSC14613 inhibits stearoyl-coA desaturase 1 |
| UAMC-3203 inhibitor – A Novel Ferroptosis Inhibitor |
| Sotagliflozin inhibitor – A Review in Type 1 Diabetes |
| Mubritinib inhibitor – Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia |
| Resatorvid inhibitor – It has antiinflammatory |
| Ddr Signaling | Carbon can form very long chains of interconnecting carbon–carbon bonds such as octane or ring-like structures such as glucose. |
| Arq197 Inhibitor – The mechanism of action of tivantinib is still unclear. |
| Onatasertib inhibitor – the activity of mTOR |
| Inflammation Signal | This is a good website. |
| AZD6094 inhibitor – AZD6094 treatment resulted in tumor regressions, whereas sunitinib or crizotinib resulted in unsustained growth inhibition. |
| Gsk2982772 Inhibitor – Acetylcholinesterase is the primary member of the cholinesterase enzyme family. |
| DMOG inhibitor – inhibits alveolar bone resorption |
| Kribb11 inhibitor – Promotes Microglial Process Elongation and Suppresses Neuroinflammation |
| Favipiravir Inhibitor – treat influenza |
| SB939 inhibitor – based on hydroxamic acid |
| Shikonin inhibitor – used as a food colouring |
| Kira6 Inhibitor – Episodic acute psychosis can occur when high doses of dextromethorphan are taken for recreational use. |
| Hsp990 Inhibitor – Hyperkalemia may decrease the velocity of impulse conduction in the nerves and muscles, including cardiac tissues. |
| Pde Signal | The metabolic processes targeted by natural poisons encompass more than enzymes in metabolic pathways. |
| Belumosudil inhibitor – known as serine-threonine kinase inhibitors |
| Tws119 Inhibitor – glycogen synthesis |
| Camp Receptor | CRP can regulate the transcription of more than 100 genes. |
| TRO 19622 Chemical – TRO 19622 is used as a treatment for a range of neuromuscular disorders |
| Tatbeclin1 Chemical – risk of offending |
| SMAD Inhibitor | Smad4 is the only known human Co-Smad, and has the role of partnering with R-Smads to recruit co-regulators to the complex. |
| GSK1838705a inhibitor – GSK 1838705 is a potent insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) inhibitor |
| Nirogacestat inhibitor – Nirogacestat is currently in Phase 2 clinical trials for unresectable desmoid tumors. |
| Stat Inhibitors – Inhibitors of STAT proteins are being developed for use in cancer therapy. |
| ARV-771 chemical – a small-molecule pan-BET degrader |
| Mapk Inhibitors – The signal that starts the MAPK/ERK pathway is the binding of extracellular mitogen to a cell surface receptor. |
| Ixazomib Inhibitor – multiple myeloma |
| Protein tyrosine kinase inhibitor – Most tyrosine kinases have an associated protein tyrosine phosphatase, which removes the phosphate group. |
| miRna assay|miRNA|mirnaassay.com |
| Glut Signal | GLUT4 is the insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle. |
| Jh re 06 Inhibitor – drugs of abuse |
| Mnk Signal | With the exception of water, nearly all the molecules that make up each organism contain carbon. |
| Hydroxylase Signaling | Some enzymes are used commercially, for example, in the synthesis of antibiotics. |
| Adavosertib inhibitor – t is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. |
| Avapritinib Inhibitor – Avapritinib showed a median PFS of 4.2 months compared to 5.6 months for regorafenib. |
| Trifluridine inhibitor – Trifluridine was approved for medical use in 1980. |
| LDK378 inhibitor – Ceritinib is an anaplastic lymphoma kinase (ALK) inhibitor primarily used for the treatment of ALK positive metastatic NSCLC. |
| TTP22 inhibitor – displays selectivity for CK2 over JNK3 |
| Proteasome Signals | Enzymes and receptors are often activated or inhibited by endogenous protein, but can be also inhibited by endogenous or exogenous small molecule inhibitors or activators, which can ... |
| Ca 074me Inhibitor – cancer treatment |
| Nct 501 Inhibitor – Natural toxins are usually small organic molecules. |
| Mycophenolate inhibitor – Specifically it is used following kidney, heart, and liver transplantation. |
| VU0364439 Agonist – VU 0364439 is really a mGlu4 PAM |
| Epacadostat Inhibitor.com – Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase-1. |
| Angiogenesis Inhibitors – Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet. |
| CYT387 inhibitor – CYT-387 is being developed as a drug for myelofibrosis and currently undergoes Phase clinical trials. |
| European Cytology Association – European Cytology Association |
| Tadalafil inhibitor – benign prostatic hyperplasia |
| EAAT Signals | the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT) family |
| Aminopeptidase receptor | Aminopeptidase N is located in the small-intestinal and renal microvillar membrane. |
| Ampk signaling | A living organism's survival depends on the continuous input of energy |
| Ci 1040 Inhibitor – cellular proliferation |
| Nocodazole inhibitor – Nocodazole has been shown to decrease the oncogenic potential of cancer cells via another microtubules-independent mechanisms. |
| Sbe13 Inhibitor – active metabolites |
| NSC13128 inhibitor – used as a dietary supplement and medication |
| Interleukin Receptor | An interleukin receptor is a cytokine receptor for interleukins |
| Nsc125973 Inhibitor – taxane family |
| Nsc269420 Inhibitor – antiandrogenic activity |
| NSC 693627 Inhibitor – NSC 693627 is definitely an isomer with IC50 of 230 nM |
| NSC 89303 – NSC 89303 inhibits ferric iron reduction by catecholates |
| AMPK Signaling – AMPK is regulated allosterically mostly by competitive binding to the CBS sites on its γ subunit between ATP, ADP and AMP |
| Jak Signaling | Phosphorylation of these dual tyrosines leads to the conformational changes in the JAK protein to facilitate binding of substrate. |
| Plk signal | PLK1 consists of 603 amino acids and is 66kDa. In addition to the N-terminus kinase domain, there are two conserved polo-box regions of 30 amino acids at the C-terminus. |
| Hoechst 33342 Chemical – Hoechst 33342 bind to adenine–thymine-rich regions of DNA and can decrease its density |
| AMG-208 Inhibitor – AMG 208 suppressed proliferation and induced apoptosis in human tumor xenograft models |
| Ramelteon Agonist – Ramelteon is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset |
| Ro 31-8959 Inhibitor – Ro 31-8959 binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus |
| Topiramate Inhibitor – Topiramate may impair heat regulation, especially in children. Use caution with activities leading to an increased core temperature, such as strenuous exercise, exposure to extreme ... |
| RHC 80267 Inhibitor – RHC80267 is an inhibitor of diacylglycerol lipase. |
| Amisulpride Antagonist – Amisulpride is an antiemetic and antipsychotic medication used at lower doses intravenously to prevent and treat postoperative nausea and vomiting; and at higher doses by mouth ... |
| Cp724714 Inhibitor – Hydrazines |
| cell-pathway.com – Cell pathway include the duplication of its DNA and some of its organelles, the partitioning of its cytoplasm, chromosomes and other components into two daughter cells |
| Nsc70931 Inhibitor – high potential |
| NSC667219 inhibitor – a first-line treatment in rheumatoid arthritis |
| NSC632839 Inhibitor – NSC 632839 inhibits USP2, USP7, and SENP2 |
| Plk Signaling | Kinase activity is regulated at least in part. |
| NSC 122750 Inhibitor – NSC 122750 particularly disrupts glucocorticoid receptor association |
| NS 3728 Inhibitor – NS 3728 blocks the amount Volume Regulated Anion Channels |
| Src receptor | Other example of these substrate mimics are the protease inhibitors, a very successful class of antiretroviral drugs used to treat HIV. |
| S64315 inhibitor – Just another WordPress site |
| NT157 inhibitor – inhibit IGF-1R and STAT3 |
| Corn oil chemical – used as delivery vehicle for fat-soluble compounds |
| AX20017 Inhibitor – AX20017, inhibits PknG with high specificity |
| VU0365114 Modulator – VU 0365114 is really a positive allosteric modulator (PAM) by having an EC50 of two.7 µM |
| TGF-beta signal | The structure of ritonavir, a protease inhibitor based on a peptide and containing three peptide bonds, is shown on the right. |
| Gcn2ib Inhibitor – multidomain protein |
| LY3039478 inhibitor – Phase 1 study to evaluate Crenigacestat (LY3039478) in combination with dexamethasone in patients with T-cell acute lymphoblastic leukemia and lymphoma |
| Abatacept0 – fusion protein |
| 2-DG modulator – labeled with tritium |
| 2-deoxy-d-glucose modulator – has the 2-hydroxyl group replaced by hydrogen |
| Andarine Agonist – muscle wasting |
| 3aminobenzamide Inhibitor – benzamide |
| NSC405020 Inhibitor – NSC 405020 is really a noncatalytic inhibitor of MT1-MMP |
| NSC4170 inhibitor – an analog of 1,4-naphthoquinone |
| 10074-g5 inhibitor – inhibited the growth of Daudi Burkitt's lymphoma cells |
| Oct Signals | When two monosaccharides such as glucose and fructose are linked together, they can form a disaccharide such as sucrose. |
| NSC9704 agonist – progestogen sex hormone |
| NSC 105327 Inhibitor – Indirubin may be the active component of Danggui Longhui Wan |
| Mycro 3 Inhibitor – Mycro 3 also shows weak inhibitory activity against AP-1. |
| Mdm2 Signaling | Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor. |
| Tgx 221 Inhibitor – abdominal pain |
| Gsk2256098 Inhibitor – FAK activity can be attenuated by expression of its endogenous inhibitor known as FAK-related nonkinase. |
| Wee1 signals | Benztropine, mazindol, and vanoxerine also bind to these sites and have similar properties. |
| Gefitinib inhibitor – used for certain breast |
| VX-689 inhibitor – Many drug molecules are enzyme inhibitors that inhibit an aberrant human enzyme or an enzyme critical for the survival of a pathogen such as a virus, bacterium or parasite. |
| PLK Receptor | Many natural poisons act as neurotoxins that can cause paralysis leading to death and have functions for defence against predators or in hunting and capturing prey. |
| Rosuvastatin Inhibitor – HMG CoA reductase |
| Pf 06651600 Inhibitor – PF 06651600 is in phase II in pipelines at Pfizer for alopecia areata, rheumatoid arthritis, and ulcerative colitis. |
| Ex229 Activator – At times, RNA polymerase can pause shortly after leaving the promoter. |
| PI103 Inhibitor – PI3K inhibitor |
| Ca4p Inhibitor – ACE inhibitors are often the first drug choice, particularly when diabetes is present. |
| PDGF Receptor | PDGF receptors-mediators of autocrine tumor growth |
| Jnk signal | Inhibition of this enzyme causes an uncontrolled increase in the acetylcholine neurotransmitter, muscular paralysis and then death. |
| Apilimod Inhibitor – a potential antiviral |
| Necrostatin 2 inhibitor – a racemic mixture |
| CP526555 Agonist – CP 526555 induces dose-dependent and sustains increases in striatal DRD2/3 in rats, especially in the ventral striatum. |
| Compound 11 agonist – exhibits favourable pharmacokinetics in rats |
| HTS Blog – Through HTS process one can quickly recognize active compounds, antibodies, or genes that modulate a particular biomolecular pathway |
| Su11274 Inhibitor – M1268T |
| BIBO 3304 Antagonist – BIBO 3304 shows low interest in Human Y2 receptor, human and rat Y4 receptor and for humans and rat Y5 receptor |
| Cabotegravir inhibitor – It is an integrase inhibitor with a carbamoyl pyridone structure similar to that of dolutegravir. |
| Alk signal | They occupy the transporter in place of the respective neurotransmitter and competitively block it from being transported from the nerve terminal or synapse into the pre-synaptic neuron. |
| Etc 159 Inhibitor – PORCN inhibitor |
| NS-1738 Modulator – NS-1738 can protect against pCMB-induced labeling of the α1(L231C) residue |
| BAY 2666605 Inhibitor – BAY 2666605 inhibits tumor growth of PDX models of sarcoma and ovarian cancer in vivo |
| Ac fltd cmk Inhibitor – opium alkaloid |
| Autocamtide 2 – Autocamtide 2, amide is really a substrate for Calcium/Calmodulin Stimulated Protein Kinase family assays. |
| PMX 205 – PMX 205 functions like a potent C5a receptor (C5aR, CD88) antagonist |
| SB-242235 Inhibitor – SB-242235 inhibits p38 MAP kinase caused by IL-1ß |
| NSC752 inhibitor – treat acute myeloid leukemia |
| Megestrol Inhibitor – Megestrol is a progestin medication which is used mainly as an appetite stimulant to treat wasting syndromes such as cachexia |
| Autocamtide 2 chemical – CaMK |
| BSO inhibitor – a cell-permeable inhibitor |
| KY12420 Inhibitor – KY 12420 blocks autophagosome formation |
| Peptides Cost | We strive to provide high quality peptides at a competitive price |
| Tbk1 Signaling | This kinase is mainly known for its role in innate immunity antiviral response. |
| Thr Signal | Thr is an amino acid that is used in the biosynthesis of proteins. |
| Leupeptin Inhibitor – organic compound |
| Palomid529 Antagonist – particular affinity |
| Camptothecin Inhibitor – CPT binds both to the enzyme and DNA with hydrogen bonds. |
| Eflornithine Inhibitor – melarsoprol and nifurtimox |
| NSC641530 inhibitor – prevent mother to child spread during birth |
| Tasquinimod Inhibitor – Tasquinimod reduces tumor angiogenesis. |
| Temozolomide chemical – glioblastoma and anaplastic astrocytoma |
| CH7233163 inhibitor – a noncovalent ATP-competitive inhibitor |
| Ruxotemitide Modulator – device or circuit |
| Ikk 16 Inhibitor – IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. |
| Carmofur Inhibitor – Carmofur prodrug is ingested and taken up in the intestine, overcoming the problem of 5-FU degradation by dihydropyrimidine dehydrogenase |
| ALK Receptor | NPM-ALK is a different variation/fusion of ALK that drives anaplastic large-cell lymphomas (ALCLs). |
| NSC292567 Modulator – NSC 292567 can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
| Doxercalciferol Chemical – Docercalciferol is the vitamin D2 analogue of alfacalcidol |
| Cdk signaling | Biology is the earliest groups divided according to the subject, such as botany, zoology, microbiology, etc |
| GSK1059615 Inhibitor – GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway |
| TCN-201 Antagonist – TCN-201 prevents glycine from binding to its binding site on the GluN1-subunit |
| FPL 62064 Inhibitor – FPL 62064 has potent anti-inflammatory activity. |
| Argipressin – Argipressin infusions are in use for septic shock patients not responding to fluid resuscitation or infusions of catecholamines (e.g., dopamine or norepinephrine) to increase the blood pressure ... |
| Meropenem Chemical – Meropenem rapidly reduces serum concentrations of valproic acid. As a result, people who use valproic acid for epilepsy are at increased risk of seizures |
| Debio 0123 Inhibitor – Debio 0123 inhibits phospho-CDC2 and abrogates the G2 check point. |
| P450 signal | Irreversible inhibitors display time-dependent inhibition and their potency therefore cannot be characterised by an IC50 value. |
| Thrombin signal – Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. |
| ROCK signaling – The ROCK signaling pathway can be activated by various activated membrane receptors |
| Rhodamine 123 Inhibitor – Rhodamine 123 fluorescence can also be used as a measure of membrane polarization in live cell assays both within mitochondria |
| EGFR signal – EGFR inhibitors when used in conjunction with anti-PD-1 mAb could increase the efficacy of immunotherapy in lung adenocarcinomas. |
| S6 Kinase Signal | A key step for the regulation of glycolysis is an early reaction in the pathway catalysed by phosphofructokinase-1 (PFK1). |
| Fluconazole Inhibitor – Fluconazole is a first-generation triazole antifungal medication. It differs from earlier azole antifungals (such as ketoconazole) in that its structure contains a triazole ring ... |
| Igf1r Receptor – Binding to the IGF1R initiates intracellular signaling. |
| Dacomitinib Inhibitor – irreversible inhibitor |
| Gatifloxacin Inhibitor – Gatifloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV |
| Celastrol Inhibitor – Celastrol inhibits IKK-NF-κB signaling via multiple molecular targets: direct inhibition of IKKα and β kinases, inactivation of CDC37 and p23, which are HSP90 chaperone proteins, ... |
| 1592u89 Inhibitor – well tolerated |
| Sulforhodamine 101 – Sulforhodamine 101 has been reported to affect excitability of neurons and should therefore be used with caution. |
| vegfr receptor | Not all irreversible inhibitors form covalent adducts with their enzyme targets. |
| 21hindol3ylacetate chemical – quorum sensing |
| Dasatinib inhibitor – treat certain cases of chronic myelogenous leukemia |
| Peg300 Chemical – treat disimpaction |
| Omeprazole Inhibitor – Omeprazole irreversibly blocks the enzyme system on parietal cells that is needed for the secretion of gastric acid |
| CDZ 173 Inhibitor – CDZ 173 is a kinase inhibitor. |
| GI254023X inhibitor – inhibit ADAM10 |
| Prasugrel Antagonist – Prasugrel is a platelet inhibitor and an irreversible antagonist of P2Y12 ADP receptors and is of the thienopyridine drug class |
| Vx702 Inhibitor – stress stimuli |
| Oxcarbazepine Inhibitor – Oxcarbazepine is an anticonvulsant used to reduce the occurrence of epileptic episodes, and is not intended to cure epilepsy |
| NSC256857 inhibitor – used to relieve pain |
| Atpase receptor | Transmembrane ATPases import metabolites necessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes. |
| Nsc241240 Inhibitor – heat labile |
| SR11237 Agonist – SR 11237 form and transactivate a reporter gene that contains a RXR-response element. |
| Dienogest Chemical – Dienogest is a progestin medication which is used in birth control pills and in the treatment of endometriosis |
| GNE 2861 Inhibitor – GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells |
| SM-324405 Agonist – SM 324405 is really a potent and selective Toll-like receptor 7 agonist |
| Wz3146 Inhibitor – glycosylated |
| Neurokinin Signal | NKA is a neurologically active peptide translated from the pre-protachykinin gene. |
Warranty Information
Guarantee Santa Cruz (SC-) qPCR primers quality. Please store at the appropriate temperature for Research Use Only.
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1 Review
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Decent Quality
We usually buy these Santa Cruz qPCR Primers from Maxanim Gentaur. Thank you for the good quality.
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Cy5 channel
Very easy Lab Reseaerch kit with the Cy5 channel.
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