AMACR Monoclonal Antibody | ABM40047

Product Overwiew:

Mouse Anti-AMACR Monoclonal Antibody

Background:

AMACR encodes a racemase. Alpha-methylacyl-CoA racemase interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Alpha-methylacyl-CoA racemase from this locus localize to both mitochondria and peroxisomes. Mutations in AMACR may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between AMACR and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.

The antibody detects endogenous AMCAR/P504S proteins.

Host:

Mouse

Sequence:

N/A

Reactivity:

Human, Mouse, Rat

Application:

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000), IF (1:100-1:200), IHC-P (1:200).

Used for:

WB, IF, IHC-P

Kit components:

N/A

Features & Benefits:

N/A

Usage Notes:

N/A

Storage buffer:

PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.

Storage instructions:

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Shipping:

Gel pack with blue ice.

Precaution:

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.