Antiserum to Human Alpha-1-Acid Glycoprotein made in goat | 123002

Found in human plasma in concentrations of 55-140 mg per 100 ml. Classical standard glycoprotein for studies on the structure of the oligosaccharide units. Carbohydrate content is 40%. Its biological significance is unknown although it can bind progesterone 15 times as strongly as albumin. Sialic-acid-deficient alpha-1-AG has an affinity for vitamin B-12. Clinically, alpha 1 acid glycoprotein is an acute-phase reactant that together with haptoglobin is an indicator of acute inflammation. The alpha 1 acid glycoprotein:haptoglobin ratio is useful in studies of bone marrow disorders, hemolytic processes and metastases.

Ref: Schmid, K. et al. 1973. Biochemistry. 12, 2711; Putnam, F.W. 1984. The Plasma Proteins. (Putnam, F.W., ed.) 2nd Ed. Vol. IV, 5.

Citations:
Brown, L. J., et al. "Miniaturized ultra high field asymmetric waveform ion mobility spectrometry combined with mass spectrometry for peptide analysis." Analytical chemistry 82.23 (2010): 9827-9834.