Copper Oxidized Human Low Density Lipoproteins (Oxidized LDL) | ABMC-P23

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Copper Oxidized Human Low Density Lipoproteins (Oxidized LDL) | ABMC-P23

Concentration:	1 mg / ml, determined by the Lowry method
Source:	From fresh human plasma that has tested negative for Hepatitis C, HIV-I and HIV-II antibodies as well as Hepatitis surface antigens.
Purification:	After series ultra centrifugations, Low Density Lipoprotein (LDL) is isolated from Human plasma (Density: 1.063) and then oxidized with Copper (Cu++).
Purity:	LDL purity ≥ 98 % by SDS-PAGE.
Buffer:	10 mM PBS, 140 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.0.
Storage:	2°C-8°C for Short and long-term storage. Centrifuge Before Use. DO NOT FREEZE!

*The products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.

IMPORTANCE

There is a large body of evidence suggesting that oxidative modifications of low-density lipoproteins (LDL) contribute significantly to the initiation and/or progression of atherosclerosis. Circulating LDL particles are able to penetrate the endothelium of arterial walls and become oxidized, promote inflammation, and drive injury to the overlying endothelium and surrounding smooth muscle cells (Ross, 1999).

The oxidation of LDL in vitro is accelerated significantly by metal ions and is inhibited by chelating agents. Ox-LDL exhibited chemical and biological properties similar but not identical to cell-modified LDL (Steinbrecher et al. 1984). Many investigators studying oxidized LDL have used Cu2+-catalyzed oxidation as an experimental model (Gebicki et al. 1991). The Cu2+ oxidation model has been useful in exploring many facets of the LDL oxidation process and may have biological relevance.

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