Monoclonal Antibodies to Renin | NBP0234

Monoclonal Antibodies to Renin | NBP0234 | Bioworld

Host: mouse

Expression: N/A

Tag: N/A

Isotype: IgG1 kappa

Determination Method: immunochromatography or chemiluminescent immunoassay

Application: N/A

General Information: Renin is a highly specific endopeptidase that mediates the cleavage of the circulating substrate angiotensinogen to yield Angiotensin I. Angiotensinconverting enzyme I (ACE) then completes the conversion from Angiotensin I to Angiotensin II which is significant in the regulation of electrolyte balance and blood pressure. Sympathetic stimulation (b1-adrenergic receptors), renal artery hypotension and decreases in sodium delivery to the distal tubules of the kidney signal the release of Renin. The Renin-Angiotensin system (RAS) is essential for regulating blood volume, arterial pressure and normal cardiac and vascular function. Renin is synthesized and secreted by modified smooth muscle cells in the juxtaglomerular apparatus (JGA) of the kidney. Expression of Renin in other tissues, including brain, has been verified although the homeostatic role it may play is yet to be firmly established.

Recomendation: N/A

Product Buffer: PBS, pH7.4.

Purity: >95% as determined by SDS-PAGE.

Storage: Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

Specificity: Recognizes native Renin

Source: N/A

Molecular weight: N/A

Note: N/A