CD9 Antibody (N-term)

Species Reactivity:

Mouse

Published species:

Mouse

Host/Isotype:

Rat / IgG2a, kappa

Class:

Monoclonal

Type:

Antibody

Clone:

eBioKMC8 (KMC8)

Conjugate:

Unconjugated

Form:

Liquid

Concentration:

0.5 mg/mL

Purification:

Affinity chromatography

Storage buffer:

PBS, pH 7.2

Contains:

0.09% sodium azide

Storage conditions:

4° C

RRID:

AB_823138

Target Information:

CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.