HLA-B Antibody| F40002-0.08ML/F40002-0.4ML/R33615-100UG

HLA-B Antibody| F40002-0.08ML/F40002-0.4ML/R33615-100UG | Gentaur UK, US & Europe Distribution

Background: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Format: Purified

Clone: 528CT10.4.1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgM

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:100-1:250

Application Note: Titration of the HLA-B antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This HLA-B antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 62-90 from the human protein was used as the immunogen for this HLA-B antibody.

Storage: Aliquot the HLA-B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A