anti-CD4 (D1) | 147-020

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SKU:
ANC-147-020
Availability:
In Stock
Size:
100 µg
Form:
Pur/WA
Applications:
Blocking, EIA(capture), FC, FX 1
€243.10

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Description

anti-CD4 (D1) | 147-020

Human CD4 is a cell surface glycoprotein of 55 kd expressed on most thymocytes, on about two thirds of peripheral T cells, and on some monocyte macrophage lineage cells.  CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells (3).  The extracellular portion of CD4 is an array of four Ig-like domains.  The amino terminal region of CD4 is a receptor for the HIV-1 viral protein gp120.

 

Antibodies QS4120 and M-T441 (cat #148-020) each bind to a distinct epitope of CD4 and are suitable as a matched pair for EIA using QS4120 as capture and Biotinylated M-T441(cat# 148-030) as detector.

Isotype: Murine IgG1

Immunogen: CD4+ transfectant/human CEM

Specificity: Antibody QS4120 recognizes an extracellular epitope in the CDR2-like loop within domain 1 region of the CD4 molecule (6).

Functional Application: Antibody QS4120 will block binding of HIV-1 gp120 protein to CD4 (4) and also blocks HLA Class II Rosette formation.

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