B7-H3(4Ig) [B7-H3b] (human) (rec.) (His) | CHI-HF-201B7H3B-C050

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SKU:: CHI-HF-201B7H3B-C050
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Size:: 50 µg
Source/Host:: HEK 293 cells

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B7-H3(4Ig) [B7-H3b] (human) (rec.) (His)| CHI-HF-201B7H3B-C050

B7-H3(4Ig) or B7-H3b has two additional Ig-like domains (one V- type and one C- type) and shows a ubiquituous expression pattern. B7-H3(4Ig) is expressed on dendritic cells as well as activated T, B and NK cells. Human (4Ig) binding to an undefined receptor has shown to be inhibitory to NK cell illing and cytokine release. It also seems to be required for late stage osteoblast differentiation.

Sequence	Human B7-H3(4Ig) [B7-H3b] (aa 27-461) is fused at the C-terminus to a His-tag.
Crossreactivity	Human
Biological Activity	Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
MW	~65kDa (SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.01EU/μg protein (LAL test; Lonza).
Reconstitution	Reconstitute 50µg vial with 100 µl sterile water to a concentration of 0.5mg/ml. Add 1X PBS to the desired protein concentration.
Formulation	Lyophilized from 0.2μm-filtered solution in PBS.
Other Product Data	NCBI reference NP_001019907.1: B7-H3b (human)
Declaration	Manufactured by Chimerigen.