Mitomycin C | sc-3514A
- SKU:
- sc-3514A | sc-3514 | sc-3514B
- Availability:
- In Stock
- CAS Number:
- 50-07-7
- Molecular Weight:
- 334.33
- Molecular Formula:
- C15H18N4O5
Description
Mitomycin C | sc-3514A
Mitomycin C is part of a family of azidine natural products. It is a DNA crosslinking and damaging agent, making it a useful antibiotic and antitumor compound. When crosslinking, Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation of caspase-3, caspase-8, and caspase-9 activating both the intrinsic and extrinsic pathway for apoptosis.
Usage :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Protect from light, moisture sensitive.
Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces caespitosus
Solubility :
Soluble in water (0.5 mg/ml), 100% ethanol (warm) (1 mg/ml), DMSO (15 mg/ml), and methanol.
Storage :
Store at -20° C
Melting Point :
>360° C
Boiling Point :
~581.8° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Cytotoxicity against PC3 cells : EC5050 = 0.14 µM (human); Cytotoxicity against A549 cells: EC5050 = 0.43 µM (human); 2780/DOX ovarian cancer cell line: IC50 = 0.2 µM; promyelocytic leukemic (HL-60) cells: IC50 = 0.05 µM (human); SMMC-7721 (Hepatocellular carcinoma cells): IC50 = 2.44 µg/ml (Homo sapiens); P388 (Lymphoma cells): IC50 = 0.01 µg/ml (Mus musculus)
pK Values :
pKa: 3.2, 6.5, 13.27, pKb: 5.08
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