Nampt (Visfatin/PBEF) (human) ELISA Kit | AG-45A-0006YEK-KI01

(No reviews yet) Write a Review
SKU:
AG-45A-0006YEK-KI01
Availability:
In Stock
Package:
96 wells
€874.90

 Select your currency from the header

Description

Nampt (Visfatin/PBEF) (human) ELISA Kit | AG-45A-0006YEK-KI01

Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDA adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. It has been shown that Nampt expression is increased in different diseases, like diabetes, obesity, fetal growth retardation, sepsis, inflammatory bowel disease, Crohn’s disease and rheumatoid arthritis. Furthermore, Nampt might be a marker of pre-eclampsia and of endothelial health. Recently it was reported that Visfatin levels were higher in the unstable carotid atherosclerotic plaque than in non-atherosclerotic mammary artery secretomes, suggesting a possible link between visfatin and unstable carotid atherosclerotic plaque. Recently NAMPT extracellular (eNAMPT) has been shown to be secreted from macrophages in muscles and to triggers a proliferative signal of muscle stem cell (MusC) by binding to CCR5 located at the surface receptor of MusC.

More Information
Product Details
Synonyms Nicotinamide Phosphoribosyltransferase; PBEF1; Pre-B Cell Colony Enhancing Factor 1
Product Type Kit
Properties
Application Set Quantitative ELISA
Specificity Detects human Nampt. Weakly cross-reacts (<15%) with mouse Nampt and rat Nampt. Does not cross-react with human adiponectin, human resistin, human vaspin or human RBP4. Has been shown to specifically detect the physiologically relevant Nampt dimer in human serum samples.
Crossreactivity Human
Quantity 1 x 96 wells
2 x 96 wells (Twin Plex)
Sensitivity 30pg/ml
Range 0.125 to 8ng/ml
Sample Type Serum
Assay Type Sandwich
Detection Type Colorimetric
Other Product Data Note: Does not work with plasma samples.
 
View AllClose

0 Reviews

View AllClose