Recombinant Human Activin A | GFH6-10

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SKU:: GFH6-10
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Availability:: In Stock
Source:: E. coli
Purity:: ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level:: ≤1.00 EU/μg as measured by kinetic LAL
Formulation:: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 75 mM sodium chloride, pH 7.5
Stability and Storage:: 12 months from date of receipt when stored at -20°C to -80°C as supplied.
Packing:: 50 ug

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Description

Recombinant Human Activin A | GFH6-10

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PODS® Growth Factors

This growth factor is also available as PODS® for sustained release, see here.

Description

Activin A is a member of the Transforming Growth Factor β (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin β A chains. Human Activin A shares 100% amino acid sequence identity with mouse, rat, porcine, bovine, and feline Activin A proteins.

Activity Assay

Human Activin A is fully biologically active when compared to standard. The activity is determined using MPC-11 cells and it is typically 1.6 - 3.1 ng/ml. In addition to the standard assay, the activity of this product has been verified in the lab of Dr Josué Mfopou Kunjom (VUB - Diabetes Research Centre) - by analysis of CXCR4 in definitive endoderm.