TCF4 Rabbit pAb | A1141
- SKU:
- A1141
- Availability:
- In Stock
- Host species:
- Rabbit
- Purification method:
- Affinity purification
- Isotype:
- IgG
- Reactivity:
- Human, Mouse, Rat
- Storage buffer:
- Store at -20℃
Description
TCF4 Rabbit pAb | A1141
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described.
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