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Introduction to Engineered CRISPR Systems Engineered CRISPR-Cas systems have revolutionized genome and RNA editing by enabling precise modifications at multiple targets. Advances in CRISPR-Cas9, CRISPR-Cas12a, and CRISPR-Cas13 have facilitated enhanced RNA editing applications, expanding the potential for therapeutic interventions, synthetic biology, and functional genomics. Understanding CRISPR-Cas Systems in RNA Editing CRISPR-Cas systems function through programmable guide RNA (gRNA) sequenc …