Recombinant Human Epidermal Growth Factor (rh-EGF)

Mature Human Epidermal Growth Factor (HGF) is a low molecular weight, single chain polypeptide composed of 53 amino acids, with a molecular weight of approximately 6.2 kda. It contains 6 cysteines in the molecule and forms 3 pairs of disulfide bonds in the chain. It is acid, alkali and heat stable, and can resist the degradation of trypsin, chymotrypsin and pepsin. It is one of the most stable protein polypeptides. HGF can play a variety of biological functions by binding to the EGF receptor (EGFR) which is cell surface specific. It can be used to treat surgical trauma, skin ulcers, gastrointestinal ulcers, corneal damage, tissue repair, etc.

HGF can automatically combine with EGFR on the cell membrane near the wound, activate protein kinase, accelerate the synthesis of DNA, RNA and protein, promote and regulate the growth and increase of epidermal cells , heal the wound quickly and repair skin tissue. Therefore, adding HGF to cosmetics has the function of removing blemishes, acne and acne. HGF also has a protective effect on normal skin, mainly by delaying aging, increasing the elasticity and luster of the skin.

Recombinant human epidermal growth factor (RH EGF) was expressed by extracellular secretion. The amino acid sequence and molecular structure were compatible with natural HGF, and it had biological activity.

16% tricine-SDS-PAGE

M ： Standard protein marker rh-EGF stimulates BALB / c 3T3 Cell proliferation test

Track 1 ： rh-EGF

For research only！

Recombinant Human Epidermal Growth Factor (rh-EGF) DataSheet

Biological activity: Fully biologically active compared to the standard. The ED50 as determined by a cell proliferation assay using murine Balb / c 3T3 cells is less than 0.1 ng / ml, corresponding to a specific activity of> 1.0 × 107 IU / mg.

Application: research, laboratory or other evaluation purposes. NOT FOR HUMAN USE.

GG stability amplifier; storage conditions:

Samples are stable for up to twelve months from date of receipt between -20 ℃ and -80 ℃
Store it in sterile conditions between -20 ℃ and -80 ℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Advancing frontiers ：

Partial renal coverage after EVAR with suprarenal fixation does not appear to be associated with early renal failure

Author: Taneva Gergana T GT, Valdivia Andrés Reyes AR, Pitoulias Georgios A GA, El Amrani Mehdi M, Donas Konstantinos P KP, Guaita Julia Ocaña JO

Journal: Ann Vasc Surg 2019-10-18 DOI: 10.1002 / smll.201802403

Summary: + Efforts to achieve optimal sealing during endovascular aortic aneurysm repair (EVAR) can produce partial coverage of the lowest renal artery and, in some cases, even occlusion.

Regulatory cytokines prescribe the result of inflammation in the process of PEX production

Author: Sarenac Vulovic Tatjana T, Pavlovic Sladjana S, Lutovac Mitar M, Zdravkovic Vladimir V, Sreckovic Suncica S

Journal: J Chin Med Assoc 2019-10-14 DOI: 10.1002 / smll.201802403

Summary: + The aim of this study is to reveal the participation of different regulatory cytokines in the process of pseudoexfoliation (PEX).

Development of a new genetic signature in patients without gastric cancer infected with Helicobacter pylori

Author: Lv Xuemei X, Zhao Yanyun Y, Zhang Liwen L, Zhou Shuqi S, Zhang Bing B, Zhang Qiang Q, Jiang Longyang L, Li Xueping X, Wu Huizhe H

Journal: J. Cell. Biochem. 10/21/2019 DOI: 10.1002 / smll.201802403

Summary: + Gastric cancer (GC) is one of the deadliest cancers in the world.