Recombinant Human B-lymphocyte antigen CD20 (MS4A1) - VLPs (Active)

Recombinant Human B-lymphocyte antigen CD20 (MS4A1) - VLPs (Active) from Gentaur in Stock & Available in 3-7 business days.

Recombinant human B-lymphocyte antigen CD20-VLP (virus-like particle) is produced by the expression of the DNA fragment corresponding to 1-297aa of the human CD20 protein in HEK293 cells. This full-length CD20 protein is fused with a 10xHis-tag at the C-terminus. It has been validated to be active. In the functional ELISA, this recombinant CD20 protein can bind to the anti-CD20 antibody. The EC₅₀ is 3.243-7.085 ng/mL. As a VLP, this recombinant CD20 antigen is highly immunogenic and can induce an immune response similar to a natural infection but fail to replicate in the body. It can be used in cancer studies. And it is available now.

The CD20 antigen is a hydrophobic transmembrane protein expressed during B cell differentiation from the pro-B cell phase until the plasma cell stadium. It is therefore a marker for B cells. It is co-expressed on B cells with CD19. CD20 plays an essential role in the regulation of B-cell development and differentiation, B-cell receptor (BCR) signaling, and cell cycle initiation.

Research Areas: Cancer

Uniprot NO: P11836

Gene Names: MS4A1

Species: Homo sapiens (Human)

Source: Mammalian cell

Expression Region: 1-297aa

Sequence: MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP

Protein Description: Full Length

Tag Info: C-terminal 10xHis-tagged

Mol. Weight: 34.4 kDa

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/mL can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL.

Endotoxin: Less than 1.0 EU/ug as determined by LAL method.

Form: Liquid

Buffer: PBS, pH 7.4, 6% trehalose

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Alternative Name/ Alias: (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)

Purity: Testing in progress.