ABM Knockout Cell Line

abm | Araf CRISPR Knocked out RAW264.7 Stable cell Cell Line (Mouse) T3-3 | T9529Araf Stable Knockout Mouse RAW264.7 Cell Line is established via CRISPR/Cas9 mediated frameshift mutation of the Araf gene (NM_009703) using the following guide RNA...

abm | Araf CRISPR Knocked out RAW264.7 Stable cell Cell Line (Mouse) T1-19 | T9511Araf Stable Knockout Mouse RAW264.7 Cell Line is established via CRISPR/Cas9 mediated frameshift mutation of the Araf gene (NM_009703) using the following guide RNA...

abm | NLK Stable Knockout Human A549 Cell Line | T9510NLK Stable Knockout Human A549 Cell Line is established via CRISPR/Cas9 mediated frameshift mutation of the NLK gene (NM_016231) using the following guide RNA sequence: ACACCATCTTCATCCGGGGT. NLK gene...

abm | LIN28B Stable Knockout Human A2780 Cell Line | T9506LIN28B Stable Knockout Human A2780 Cell Line is established via CRISPR/Cas9 mediated frameshift mutation of the LIN28B gene (NM_001004317) using the following guide RNA sequence:...

abm | FRK Stable Knockout Human H1299 Cell Line | T9505FRK Stable Knockout Human H1299 Cell Line is established via CRISPR/Cas9 mediated frameshift mutation of the FRK gene (NM_002031) using the following guide RNA sequence: GAGGACTTGAGCTTCCGAGC. FRK...

abm | JWA Stable Knockout Human MHCC97L Cell Line | T9504JWA Stable Knockout Human MHCC97L Cell Line is established via CRISPR/Cas9 mediated frameshift mutation of the JWA gene (NM_006407) using the following guide RNA sequence: AGAGCAGGTTGCTCACTACG...

abm | FLNC Stable Knockout Human A2780 Cell Line | T9503FLNC Stable Knockout Human A2780 Cell Line is established via CRISPR/Cas9 mediated frameshift mutation of the FLNC gene (NM_001458) using the following guide RNA sequence: GCTGCTTGGGCGTCTGTTTG...

abm | GAB1 Stable Knockout Human 8505c Cell Line | T9501GAB1 Stable Knockout Human 8505c Cell Line is established via CRISPR/Cas9 mediated frameshift mutation of the GAB1 gene (NM_002039) using the following guide RNA sequence: CCTGGCAGCTCTTTACAAGC...

abm | ATG5 Stable Knockout HEK293 Cell Line | T6438Biosafety:IIOrganism:Human (H. sapiens)Source Organ:KidneyGrowth Properties:AdherentMorphology:EpithelialClones:N/APassage Number:N/APopulation Doner:30 - 40 hoursSeeding Density:50,000...

abm | GOT2 Knockout Stable HEK293 Cell Line (Clone A7) | T6426CRISPR/Cas9 was used to introduce a disruption of the GOT2 gene in HEK293 cells. The resulting CRISPR/Cas9 GOT2-knockout HEK293 cell line is homozygous for 205dup.Biosafety:IIOrganism:Human...

abm | GOT2 Knockout Stable HEK293 Cell Line (Clone A6) | T6425CRISPR/Cas9 was used to introduce a disruption of the GOT2 gene in HEK293 cells. The resulting CRISPR/Cas9 GOT2-knockout HEK293 cell line is compound heterozygous for...

abm | GOT2 Knockout Stable HEK293 Cell Line (Clone A3) | T6424CRISPR/Cas9 was used to introduce a disruption of the GOT2 gene in HEK293 cells. The resulting CRISPR/Cas9 GOT2-knockout HEK293 cell line is compound heterozygous for 205dup/202_203insA...

abm | PIWIL1 Knockout Stable AGP01 Cell Line | T6410PIWIL1 was knocked out of the AGP01 cells via CRISPR/Cas9. May be used to study the potential functions of the PIWIL1 gene.Biosafety:IIOrganism:Human (H. sapiens)Source Organ:StomachGrowth...

abm | TP53 Stable Knockout K9 Fetus 1 Cell Line | T6405TP53 was knocked out of the K9 Fetus 1 cells via CRISPR/Cas9. May be used as a cellular system to examine novel oncogenic functions, and effects of developing anti-cancer therape\utics...

abm | MCT4 Knockout PC-3 Cell Line | T6328 Biosafety:IIOrganism:N/ASource Organ:N/AGrowth Properties:AdherentMorphology:N/AClones:N/APassage Number:N/APopulation Doner:N/ASeeding Density:N/AMarkers:N/AApplications:For Research Use OnlyDoner...

abm | COX10 Stable Knockout Mouse Fibroblast Cell Line | T6303To generate the COX10 Stable Knockout Mouse Fibroblast Cell Line, a primary skin fibroblast culture was established from a knockin mouse homozygous for the floxed COX10 (exon 6). Cells were...

abm | KtyI Stable Knockout Mouse Keratinocyte Cell Line | T6293KtyI Stable Knockout Mouse Keratinocyte Cell Line was derived from mice lacking keratins and was spontaneously immortalized. The lack of keratins (ktyl) have been found to reduce desmosome...

abm | ACΔ3-6 Stable Knockout HEK293 Cell Line | T6291AC3 and AC6 encoded by the ADCY3 and ADCY6 genes, are the most abundant adenylyl cyclase (AC) isoforms in HEK293 cells. ACΔ3/6 Stable Knockout HEK293 Cell Line was generated by knocking out the AC3...

abm | BVRA Stable Knockout Hepa1c1c7 Cell Line | T6282BVRA (biliverdin reductase A) was knocked out of the mouse Hepa1c1c7 cells using sgRNAs inserted into the GuideIt-zsGreen plasmid. The plasmid was transfected and clones were selected via FACS...

abm | BVRA Stable Knockout MCT Cell Line | T6281BVRA (biliverdin reductase A) was knocked out of the mouse proximal tubule cells (MCT) using sgRNAs inserted into the GuideIt-zsGreen plasmid. The plasmid was transfected and clones were selected via FACS...

abm | Gnpat Stable Knockout Mouse Myoblast (14.11) Cell Line | T6279Cells were isolated from cross-breed pups of Gnpat Knockout mice (Gnpat tm1Just) crossed with SV40 carrying Tg(H2‐K1‐tsA58)11Kio mice to obtain the Gnpat Stable Knockout Mouse Myoblast...

abm | Gnpat Stable Knockout Mouse Myoblast (21.15) Cell Line | T6278Cells were isolated from cross-breed pups of Gnpat Knockout mice (Gnpattm1Just) crossed with SV40 carrying Tg(H2‐K1‐tsA58)11Kio mice to obtain the Gnpat Stable Knockout Mouse Myoblast...

abm | IFN-α-β Stable Knockout Macrophage Cell Line | T6238Biosafety:IIOrganism:MouseSource Organ:Bone MarrowGrowth Properties:AdherentMorphology:RoundClones:N/APassage Number:N/APopulation Doner:26 - 36 hoursSeeding Density:20,000 - 40,000...

abm | NOD1 Stable Knockout AGS (41H8) Cell Line | T6188CRISPR/Cas9 gene editing was used to generate NOD1 KO clones. For this, AGS cells were transformed with vectors expressing “Cas9 nickase” nuclease and pairs of guide RNAs (gRNAs) specific for the...

abm | NOD1 Stable Knockout AGS (41A8) Cell Line | T6187CRISPR/Cas9 gene editing was used to generate NOD1 KO clones. For this, AGS cells were transformed with vectors expressing “Cas9 nickase” nuclease and pairs of guide RNAs (gRNAs) specific for the...

abm | PTEN Stable Knockout MEF Cell Line | T6179PTEN Stable Knockout MEF Cell Linewere established via the 3T9 protocol, and the expression of PTEN was knocked out. MEF cells were derived from wild-type mouse with stable expression of PTEN. PTEN...

abm | Pax6 KnockOut U251N Cell Line | T6167CRISPR-Cas9 was utilized to knockout PAX6 from the U251N cells to establish Pax6 KnockOut U251N Cell Line (2.10 KO cells). Knockout was verified via Western blot and immunocytochemistry. PAX6 KnockOut U251N...

abm | ADRM1 Stable Knockout HCT116 (Clone B11) Cell Line | T6162ADRM1 or Adhesion regulating molecule 1, is a component of the proteosome and ubiquitin receptor that recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Known...

abm | CBFβ Stable Knockout HepG2 Cell Line | T6161CBFβ is the non-DNA-binding subunit of the core binding factor (CBF) transcription factor. Derived from HepG2 cells, CBFβ was knocked out using CRISPR/Cas9. This cell line was developed for research...

abm | APPL1 Stable Knockout MEF Cell Line | T6158APPL1 Stable Knockout MEF Cell Line was derived from E13.5 mouse embryo which had been cross-bred to express null APPL1. May be used alongside with APPL1 Stable Wildtype MEF Cell Line (T6159) to study the...

abm | RNH1 Stable Knockout K562 Cell Line | T6157Biosafety:IIOrganism:HumanSource Organ:Bone marrowGrowth Properties:SuspensionMorphology:RoundClones:N/APassage Number:N/APopulation Doner:N/ASeeding Density:N/AMarkers:PuromycinApplications:For Research...

abm | PD-L1 Knockout Stable NBK Cell Line | T6156Biosafety:IIOrganism:N/ASource Organ:N/AGrowth Properties:N/AMorphology:EpithelialClones:N/APassage Number:N/APopulation Doner:70 - 80 hoursSeeding Density:20,000 - 30,000...

abm | GALK2 Stable Knockout HEK293T Cell Line | T6154The Galactokinase 2 (GALK2) is an efficient kinase of N-acetylgalactosamine in primary pathway for galactose metabolism the Leloir pathway that also acts as a galactokinase when galactose...

abm | GALK1 Stable Knockout HEK293T Cell Line | T6153The Galactokinase 1 (GALK1) is major enzyme in the Leloir pathway, the primary pathway for galactose metabolism. Specifically, this enzyme modifies galactose with a phosphate group to generate...

abm | GALK2+GALE Stable Knockout HEK293T Cell Line | T6152The UDP-galactose-4 epimerase (encoded by GALE) and Galactokinase 2 (GALK2) are both major enzymes in the Leloir pathway, the primary pathway for galactose metabolism. UDP-galactose-4 epimerase...

abm | GALK1+GALE Stable Knockout HEK293T Cell Line | T6151The UDP-galactose-4 epimerase (encoded by GALE) and Galactokinase 1 (GALK1) are both major enzymes in the the Leloir pathway, the primary pathway for galactose metabolism. Both enzymes modify the...

abm | GALE Stable Knockout HEK293T (Clone 4) Cell Line | T6150The GALE gene encodes UDP-galactose-4 epimerase which operates in the Leloir pathway, the primary pathway for galactose metabolism. This pathway is critical for the generation of UDP-sugars...

abm | SP100 Stable Knockout HEp-2 Cell Line | T6135Nuclear domain 10 (ND10) bodies are membrane-less cellular components found in the nucleus that affect transcription and are implicated in some immune functions. ND10 bodies are able to detect and...

abm | p47phox Stable Knockout Mouse Aortic Endothelial (iMAEC-p47) Cell Line | T3181Immortalization using polyoma middle-sized T-antigen (PmT) methodBiosafety:IIOrganism:MouseSource Organ:HeartGrowth...

abm | eNOS Stable Knockout Mouse Aortic Endothelial (iMAEC-eNOS) Cell Line | T3180The eNOS Stable Knockout Mouse Aortic Endothelial (iMAEC-eNOS) Cell Line was derived from primary mouse aortic endothelial cells isolated from the thoracic and abdominal...

abm | Caveolin-1 Stable Knockout Mouse Aortic Endothelial (iMAEC-cav1) Cell Line | T3179Immortalization using polyoma middle-sized T-antigen (PmT) methodBiosafety:IIOrganism:MouseSource Organ:HeartGrowth...

abm | SIRT1 Knockout Stable 293T Cell Line | T3176SIRT1 Knockout Stable 293T Cell Line was established via CRISPR/Cas9 mediated knockout of the endogenously expressing SIRT1 gene also known as Sirtuin 1. This cell line may be used with the SIRT1 Wiltype...

abm | SIRT1 Knockout Stable DLD-1 Cell Line | T3174SIRT1 Knockout Stable DLD-1 Cell Line was established via CRISPR/Cas9 mediated knockout of the endogenously expressing SIRT1 gene also known as Sirtuin 1. This cell line may be used with the SIRT1...

abm | SIRT1 Knockout Stable RKO Cell Line | T3172SIRT1 Knockout Stable RKO Cell Line was established via CRISPR/Cas9 mediated knockout of the endogenously expressing SIRT1 gene also known as Sirtuin 1. This cell line may be used with the SIRT1 Wiltype...

abm | TLR9 Knockout Immortalized Mouse Dendritic Cell Line | T3035As messengers bridging the innate and adaptive immune system, the conventional tissue-resident DC (cDC) acts as sentinels in secondary lymphoid organs and other tissues for antigen...

abm | TLR3 Knockout Immortalized Mouse Dendritic Cell Line | T3034As messengers bridging the innate and adaptive immune system, the conventional tissue-resident DC (cDC) acts as sentinels in secondary lymphoid organs and other tissues for antigen...

abm | PARP-1 Knockout Immortalized Mouse Heart Endothelial (HYKO6) Cell Line | T3031Poly(ADP-ribose) polymerase 1 (PARP-1) is an ADP-ribosylating enzyme that plays a critical role in DNA damage repair, in addition to functioning as a context- specific...

abm | Atg7 Knockout Immortalized Mouse Kidney Epithelial Cell Line | T3028Autophagy is a catabolic process in which proteins and cellular organelles are degraded under metabolic stress through the lysosomal pathway. Essential autophagy-related genes (i...

abm | Atg5 Knockout Immortalized Mouse Kidney Epithelial Cell Line | T3027Autophagy is a catabolic process in which proteins and cellular organelles are degraded under metabolic stress through the lysosomal pathway. Essential autophagy-related genes (i...

abm | Bax-Bak Double Knockout Immortalized Mouse Kidney Epithelial Cell Line | T3026Key regulators of apoptosis, such as members of the BCL-2 family, have long been linked to the development of cancer. The Bax/Bak Double Knockout Immortalized Mouse...

abm | Bak Knockout Immortalized Mouse Kidney Epithelial Cell Line | T3025Key regulators of apoptosis, such as members of the BCL-2 family, have long been linked to the development of cancer. The Bak Knockout Immortalized Mouse Kidney Epithelial Cells...

abm | Bax Knockout Immortalized Mouse Kidney Epithelial Cell Line | T3024Key regulators of apoptosis, such as members of the BCL-2 family, have long been linked to the development of cancer. The Bax Knockout Immortalized Mouse Kidney Epithelial Cells...

abm | AT1A-AT1B Double Knockout Immortalized Mouse Renal Proximal Tubule Cell Line | T0628The proximal tubule is part of the nephron duct system in the kidney, involved in regulating the renin-angiotension system. Cells of this region aid in regulating...

abm | AT1B Knockout Immortalized Mouse Renal Proximal Tubule Cell Line | T0627The proximal tubule is part of the nephron duct system in the kidney, involved in regulating the renin-angiotension system. Cells of this region aid in regulating sodium and...

abm | AT1A Knockout Immortalized Mouse Renal Proximal Tubule Cell Line | T0626The proximal tubule is part of the nephron duct system in the kidney, involved in regulating the renin-angiotension system. Cells of this region aid in regulating sodium and...

abm | AT2 Knockout Immortalized Mouse Renal Proximal Tubule Cell Line | T0625The proximal tubule is part of the nephron duct system in the kidney, involved in regulating the renin-angiotension system. Cells of this region aid in regulating sodium and...