4 Hydroxynonenal modified Bovine Serum Albumin (4 HNE-BSA) | ABMC-P27
- SKU:
- ABMC-P27
- Availability:
- Usually shipped in 5 working days
Description
4 Hydroxynonenal modified Bovine Serum Albumin (4 HNE-BSA) | ABMC-P27
| Concentration: | 1 mg / ml, determined by the Lowry method |
| Source: | Bovine Serum Albumin purchased from Boehringer Mannheim and modified with 4- HNE. |
| Buffer: | In 10 mM PBS, 0.15 M NaCl, 0.5 mM EDTA, 0.01 % NaN3, pH 7.4. |
| Storage: | -20°C for short and long-term storage. Aliquot to avoid repeated freezing and thawing. |
*The products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.
IMPORTANCE
Modifications on lysine residues, with formation of carboxylmethyl-lysine (CML), malondialdehyde (MDA) and hexitol-lysine are advanced glycation end-products (AGE), and the coupling with reactive aldehyde compounds, such as 4-hydroxynonenal (4-HNE) may appear from lipid oxidation (Guichardant et al., 1998). These modifications feature the oxidative byproducts which react with NH2 groups and form Schiff-base adducts (Mark et al., 1996).
LDL treated with HNE or oxidatively modified by Cu++ or by cultured endothelial cells give rise to Michael addition-type HNE adducts that are recognized by HNE-specific antibodies.
Related Products
Carboxymethyl-lysine modified Bovine Serum Albumin (CML-BSA), 50% glycerol | ABMC-P26
Malondialdehyde modified Bovine Serum Albumin (MDA - BSA), 50% glycerol | ABMC-P24
Nitrated Bovine Serum Albumin (Nitrated BSA) | ABMC-P25
Carbamylated Bovine Serum Albumin (CBL-BSA) | ABMC-P28
