anti-Asc, pAb (AL177) | AG-25B-0006-C100

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SKU:: AG-25B-0006-C100
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Package:: 100 µg

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Description

anti-Asc, pAb (AL177) | AG-25B-0006-C100

Asc promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. It is a component of the inflammasome, a protein complex which also includes NLRP3/NALP3,
CARD8 and CASP1 and whose function is the activation of proinflammatory caspases

Product Specifications

Specificity

Recognizes human and mouse Asc

Species Crossreactivity

Human / Mouse

Application

Flow Cytometry (1:1000; Reference 21)
Immunocytochemistry (1:200)
Immunohistochemistry: (1:500; paraffin sections)
Immunoprecipitation: (1:200)
Western Blot: (1:1000)
Functional Application: (see Protocol)
The antibody AL177 can be used to measure inflammasome activation in vivo, detecting Asc speck formation by immunofluorescence and by Flow Cytometry.

Formulation

Liquid. In PBS containing 0.02% sodium azide.
Concentration 1mg/ml

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