anti-Caspase-1 (p20) (mouse), mAb (Casper-1) | AG-20B-0042-C100

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SKU:
AG-20B-0042-C100
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100 µg
  • anti-Caspase-1 (p20) (mouse), mAb (Casper-1) | AG-20B-0042-C100
  • anti-Caspase-1 (p20) (mouse), mAb (Casper-1) | AG-20B-0042-C100
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Description

anti-Caspase-1 (p20) (mouse), mAb (Casper-1) | AG-20B-0042-C100

Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1β (IL-1β) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

 
Properties
Clone Casper-1
Isotype Mouse IgG1
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Recombinant mouse caspase-1.
Application

Western Blot (see online protocol): (1μg/ml) (no need to precipitate the cell supernatant for the detection of caspase-1 (mouse) upon inflammasome activation)
Immunohistochemistry: (1:500; paraffin sections)
Immunoprecipitation: (1:200)

Crossreactivity Mouse
Rat
Specificity

Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1. Described to cross-react with full-length and activated (p20 fragment) of rat caspase-1 (Lit. #30 & 34).

Purity ≥95% (SDS-PAGE)
Purity Detail Protein G-affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
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