anti-CD252(OX40L) | 400-020

Human CD252 (CD134L, OX40 Ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells.  CD252 binds to CD134(OX40) present on  activated T cells, providing a costimulatory signal (1). This pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (4). Blockade of this interaction in mouse abrogated immunological effects in several models of  inflammation and rejection (5,6,7,8).

Isotype: Murine IgG1 Kappa

Immunogen: Human HUVEC and Recombinant soluble human CD252

Specificity: Antibody ANC10G1 binds to CD252 on the cell surface of HUVEC in Flow cytometry, and blocks binding of recombinant CD134-muIg.

 Functional Application: Antibody ANC10G1 blocks binding of Recombinant CD134 to CD134L on HUVEC.