LAG-3 Antibody [2B11] | SD8841

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SKU:
SD8841
Availability:
5 Working days
Clonality:
Recombinant Monoclonal
Tested Applications:
E, Flow, IF, IHC-P
Host Species:
Llama
Species Reactivity:
Human
Conjugate:
Unconjugated
  • LAG-3 Antibody [2B11] | SD8841
  • LAG-3 Antibody [2B11] | SD8841
  • LAG-3 Antibody [2B11] | SD8841
  • LAG-3 Antibody [2B11] | SD8841
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Description

LAG-3 Antibody [2B11]

  • HOST SPECIES: Llama
  • SPECIES REACTIVITY: Human
  • IMMUNOGEN: LAG3 antibody was raised against a recombinant protein corresponding to amino acids 23-434 of human LAG3.
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: E, Flow, IF, IHC-P
  • APPLICATION NOTE: LAG-3 antibody can be used for ELISA starting at 0.1 μg/mL. For immunohistochemistry starting at 1 μg/mL. For immunofluorescence start at 5 μg/mL. For flow cytometry at 1 μg/ml.
  • PURIFICATION: LAG3 Antibody is affinity chromatography purified via Nickel column. Antibody is supplied as a His-tagged purified protein.It also contains a myc-tag for detection.
  • CLONALITY: Recombinant Monoclonal
  • ISOTYPE: sdAb
  • PHYSICAL STATE: Liquid
  • BUFFER: LAG-3 Antibody is supplied in PBS.
  • CONCENTRATION: 1 mg/mL
  • STORAGE CONDITIONS: LAG3 antibody should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • NCBI OFFICIAL SYMBOL: LAG3
  • ADDITIONAL NAMES: LAG3 Antibody: lymphocyte activating 3, LAG-3, CD223
  • Protein Accession Number: NP_002277
  • PROTEIN GI NUMBER: 167614500
  • NCBI GENE ID NUMBER: 3902
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.
  • The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.
  • 1: Huard B, Tournier M, Hercend T, et al. Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes. Eur J Immunol 1994; 24:321621.
  • 2: Triebel F. LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. Trends Immunol 2003; 24:61922.
  • 3: Workman CJ, Wang Y, El Kasmi KC, et al. LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol. 2009; 182:188591.
  • 4: Workman CJ, Vignali DA. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol 2003; 33:9709.
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