Human Superoxide Dismutase (SOD) Protein (Active) | abx060221

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SKU:
abx060221
Availability:
Shipped within 5-10 working days.
Clonality:
N/A
Tested Applications:
SDS-PAGE
Host:
E. coli
Conjugation:
Unconjugated
Dry Ice:
No
лв660.66 - лв13,042.95

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Description

Human Superoxide Dismutase (SOD) Protein (Active). Cat# abx060221. Supplier: abbexa.

Human SOD Protein is a recombinant protein expressed in E. coli. Superoxide dismutases (SOD) are enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. Thus, they are an important antioxidant defense in nearly all cells exposed to oxygen. Several common forms of SOD exist: they are proteins cofactored with copper and zinc, or manganese, iron, or nickel. Thus, there are three major families of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types (which bind either iron or manganese), and the Ni type, which binds nickel. Three forms of superoxide dismutase are present in humans, in all other mammals, and most chordates. SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. Mutations in the first SOD enzyme (SOD1) can cause familial amyotrophic lateral sclerosis (ALS, a form of motor neuron disease). The other two isoforms of SOD have not been linked to any human diseases, however, in mice inactivation of SOD2 causes perinatal lethality and inactivation of SOD1 causes hepatocellular carcinoma.

Target SOD
Origin Human
Expression Recombinant
Tested Applications SDS-PAGE
Host E. coli
Conjugation Unconjugated
Form Lyophilized
Purity > 95% (HPLC and SDS-PAGE). Contains < 1% Dimers (SDS-PAGE)
Reconstitution Reconstitute with sterile 18 MΩ-cm H2O.
Storage Aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P00441 (UniProt, ExPASy)
UniProt Entry Name SODC_HUMAN
GeneID 6647
OMIM 147450
KEGG hsa:6647
String 9606.ENSP00000270142
Molecular Weight 16 kDa
Buffer Prior to lyophilization: 10 mM Phosphate buffer and 200 mM NaCl (pH 7.0). Does not contain preservatives.
Activity Active
Biological Activity 8000 U/mg by Pyrogallic Acid method.
Endotoxin Level < 0.1 ng/µg (1 EU/µg) by LAL test.
Availability Shipped within 5-10 working days.
Note This product is for research use only.

Not for human consumption, cosmetic, therapeutic or diagnostic use.

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