abm | GNAO1 Stably Expressing Immortalized Human Mammary Epithelial Cell Line | T6201

abm | GNAO1 Stably Expressing Immortalized Human Mammary Epithelial Cell Line | T6201

GNAO1 Stably Expressing Immortalized Human Mammary Epithelial Cell line expresses GNAO1, the protein of which represent the alpha subunit of the G0 heterotrimeric G-protein signal-transducing complex and is partially responsible for smooth muscle contraction and depressing neuronal activity. They function to inhibit of adenylate cyclase , open K+-channels (via β/γ subunits), and close Ca2+-channels. Researchers may use this cell line to study G-protein signal-transducing pathways in humans. Defects in the GNAO1 gene are known as a cause of early-onset epileptic encephalopathy. This cell line was made using retrovirus transduction. It carries flag tag and expresses GFP.

Biosafety:

II

Organism:

Human

Source Organ:

Skin

Growth Properties:

Adherent

Morphology:

Endothelial-like

Clones:

N/A

Passage Number:

N/A

Population Doner:

N/A

Seeding Density:

N/A

Markers:

G418 resistance

Applications:

For Research Use Only

Doner Gender:

N/A

Donor Ethnicity:

N/A

Knockdown Method:

N/A

Induction:

N/A

Overexpression:

N/A

Freeze Thaw:

N/A

Propagation:

The base medium for this cell line is Prigrow IV available at abm

Preservation:

N/A

Quality Control:

N/A

Tumorgenicn:

N/A

Shipping Conditions:

Dry Ice

Storage Contidions:

-180°C