anti-Polyglutamylation Modification, mAb (GT335) | AG-20B-0020-C100

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AG-20B-0020-C100
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100 µg
  • anti-Polyglutamylation Modification, mAb (GT335) | AG-20B-0020-C100
  • anti-Polyglutamylation Modification, mAb (GT335) | AG-20B-0020-C100
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Description

anti-Polyglutamylation Modification, mAb (GT335) | AG-20B-0020-C100

Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on the modified protein. It is evolutionarily conserved and the most prominent substrate is tubulin, the microtubule (MT) building block. Polyglutamylation has been proposed to be involved in the functional adaptation of MTs, as it occurs within the carboxy-terminal tubulin tails that participate directly in the binding of many structural and motor MT-associated proteins. The recent identification of new substrates of polyglutamylation indicates that this post-translational modification could be a potential regulator of diverse cellular processes and be involved in cell cycle and cell proliferation.

More Information
Product Details
Synonyms Polyglutamylated Tubulin; Glutamylated Tubulin; Postranslational Protein Glutamylation
Product Type Monoclonal Antibody
Properties
Clone GT335
Isotype Mouse IgG1κ
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Octapeptide EGEGE*EEG, modified by the addition of two glutamyl units onto the fifth E (indicated by an asterisk).
Application

Electron Microscopy (see Lit. 3)
Immunocytochemistry: (1:2000)
Immunohistochemistry: (paraffin sections; 1:1000)
Immunoprecipitation
Western Blot: (1:4000)
Optimal conditions must be determined individually for each application.

Crossreactivity All
Specificity

Recognizes the posttranslational modification (poly)glutamylation on proteins. Reacts with polyglutamylated α- and β-tubulin.

Purity ≥95% (SDS-PAGE)
Purity Detail Protein G-affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 0.02% sodium azide.
 
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