Recombinant Human Manganese Superoxide Dismutase (rhMn-SOD)
- SKU:
- GEN-NRPA38S
- Other name:
- Superoxide dismutase 12 (SOD2)
- Formulation:
- lyophilized from sterile water
- Mol. Weight:
- Recombinant human SOD2 consists of 199 amino acids and has a calculated molecular mass of 22.3 kDa. It migrates as a 25 kDa band on SDS-PAGE under reducing conditions.
- Resources:
- Escherichia coli (E. coli)
- Purity:
- ≥95% by SDS-PAGE analysis
- Endotoxin:
- <1.0 µg
- Storage condition:
- -20 °C in a dark place
- Storage period:
- 3 years
Description
Mitochondrial superoxide dismutase [Mn] (SOD2), a member of the iron / manganese superoxide dismutase family, can form a homotetramer and bind to one manganese ion per subunit. The expression of SOD2 is regulated by KRIT1. Mutations in the SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), sporadic motor neuron disease, and cancer. In addition, Mn-SOD (SOD2) activity is essential to achieve optimal training-induced protection against cardiac arrhythmias induced by ischemia / reperfusion (IR) and infarction.
Remarks:
It is recommended to reconstitute the product with sterile water to a final concentration of
1 mg / ml (10 KU / ml). Store the reconstituted product in aliquots at -20 ° C in a dark place. Avoid multiple freeze-thaw cycles and exposure to frequent temperature changes.
The use of strong acids and alkalis, strong oxidizers and high concentrations of organic solvents should be avoided to protect the product from denaturation.
For research only!
Recombinant Human Manganese Superoxide Dismutase (rhMn-SOD) DataSheet
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